Clinical trials: Acute Necrotizing Pancreatitis
Pancreatic Necrosis, Pancreatitis
Surgical vs Endoscopic Resection of Walled Off Pancreatic Necrosis Using the Powered Endoscopic Debridement System
Goal: The goal of this clinical trial is to compare the effectiveness and safety of two different but highly effective treatment approaches for walled-off necrosis (WON) resulting from severe acute pancreatitis.
- Trial name
- SERPENT (NCT06691919)
- Testing
- Direct Endoscopic Necrosectomy with Powered Endoscopic Debridement, Transgastric Surgical Necrosectomy
- Sponsor
- Stanford University
Acute Pancreatitis, Pancreatic Pseudocyst
Registry of Patients Undergoing Endoscopic Management of Pancreatic Fluid Collections
Acute pancreatitis is one of the most common gastrointestinal disorders requiring hospitalization worldwide. Pancreatic fluid collections can occur as a consequence of acute and chronic pancreatitis and can result in significant…
- Conditions
- Acute Pancreatitis, Pancreatic Pseudocyst, Pancreatic Necrosis
- Trial name
- NCT06179459
- Testing
- Endoscopic management of pancreatic fluid collections
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Orlando Health, Inc.
Acute Pancreatic Necrosis, Acute Pancreatitis (AP)
Serum TAM Receptor Tyrosine Kinase Ligands in Acute Pancreatitis
AXL and MERTK are homologous members of the TAM (TYRO3, AXL, MERTK) receptor tyrosine kinase family. They function as critical regulators of antiviral immunity, autoimmune responses, and tumor microenvironment modulation through…
- Trial name
- NCT07023055
- Where
- China
- Volunteers
- 896 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Acute Necrotizing Pancreatitis, Portal Hypertension
A Study to Evaluate Splenectomy on Debridement for Acute Necrotizing Pancreatitis With Pancreatic Sinistral Portal Hypertension
This study is a prospective, single-center, randomized controlled trial focusing on patients with acute necrotizing pancreatitis (ANP) complicated by pancreatic sinistral portal hypertension (PSPH).
- Trial name
- NCT07080697
- Testing
- Splenectomy, Control
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Zhejiang University
Pancreatic Necrosis, Acute Pancreatitis
Necrosectomy With Cryotechnology for Accelerated Removal
Pancreatic necrosis is a serious complication of acute pancreatitis. Pancreatic necrosis involves the irreversible death of pancreatic tissue, which can lead to severe health issues, including infections and an increased risk of…
- Conditions
- Pancreatic Necrosis, Acute Pancreatitis, Acute Pancreatic Necrosis, Necrosis
- Trial name
- NECTAR (NCT06553651)
- Testing
- Cryotechnology Necrosectomy Procedure
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Christopher C. Thompson, MD, MSc
Pancreatic Pseudocyst, Pancreatic Necrosis
EUS-guided Transenteric Drainage With a Novel Lumen-apposing Metal Stent
To evaluate clinical efficacy and safety of a novel lumen-apposing FCSEMS for EUS-guided transenteric drainage of PFC or of biliary tree including GB
- Conditions
- Pancreatic Pseudocyst, Pancreatic Necrosis, Biliary Obstruction, Acute Cholecystitis
- Trial name
- NCT03002051
- Testing
- EUS-guided drainage
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Chinese University of Hong Kong
Walled Off Necrosis, Pancreatitis
Encapsulation-oriented vs. Timing-oriented Strategies for Necrotizing Pancreatitis
This multicenter, randomized controlled trial (WONDER-03 study) investigates the optimal timing for endoscopic ultrasound (EUS)-guided drainage in patients with necrotizing pancreatitis.
- Conditions
- Walled Off Necrosis, Pancreatitis, Acute Necrotic Collection, Necrotizing Pancreatitis
- Trial name
- WONDER-03 (NCT07106346)
- Testing
- The timing of endoscopic intervention for necrotizing pancreatitis is determined based on the degree of encapsulation, EUS-guided drainage based on the interval from the onset of acute pancreatitis
- Where
- 36 sites in Japan
- Volunteers
- 224 people
- Sponsor
- Tokyo University
Acute Pancreatitis Necrotizing
Impact of Transmural Plastic Stent on Recurrence of Pancreatic Fluid Collection After Metal Stent Removal in Disconnected Pancreatic Duct
Walled of necrosis (WON) is severe local complication of acute necrotizing pancreatitis. Disconnected pancreatic duct syndrome(DPDS) is commonly seen (50-60%) after necrotizing pancreatitis and has long term implication like…
- Trial name
- NCT03436043
- Testing
- Transmural Plastic stenting
- Where
- India
- Volunteers
- 90 people
- Sponsor
- Asian Institute of Gastroenterology, India
Pancreatitis, Acute Necrotizing
The Study of Laparoscopic-assisted Percutaneous Catheter-directed Drainage to Treat Early Severe Acute Pancreatitis
The purpose of this study is to analyze the effect of laparoscopic-assisted percutaneous catheter drainage of early SAP(severe acute pancreatitis).We are going to select 60 cases SAP patients from April 2014 to April 2015 who…
- Trial name
- NCT02133014
- Testing
- laparoscopic-assisted percutaneous catheter drainage, 0.5% 5-fluorouracil normal saline
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Zhujiang Hospital
Acute Necrotizing Pancreatitis, Pancreatic Exocrine Insufficiency
Pancreatic Enzyme Replacement in Acute Necrotizing Pancreatitis
In this multicenter, double blinded, placebo-controlled, 1:1 parallel group RCT, the investigators propose to evaluate the impact of pancreatic exocrine replacement therapy on patients with acute necrotizing pancreatitis (ANP).
- Trial name
- PERiANP (NCT07441824)
- Testing
- Pancreatic enzyme capsules
- Where
- 4 sites in India
- Volunteers
- 140 people
- Sponsor
- Asian Institute of Gastroenterology, India
Acute Pancreatic Necrosis, Acute Pancreatitis
EndoRotor DEN (Direct Endoscopic Necrosectomy)Trial
A prospective, single arm, open label, multi-center, trial to evaluate the safety and effectiveness of the Interscope EndoRotor® Resection System in subjects requiring direct endoscopic necrosectomy (DEN) with walled off…
- Conditions
- Acute Pancreatic Necrosis, Acute Pancreatitis, Necrotizing Pancreatitis
- Trial name
- NCT03694210
- Testing
- EndoRotor Therapy
- Where
- 10 sites in United States, Germany and 1 more
- Volunteers
- 30 people
- Sponsor
- Interscope, Inc.
Pancreatitis, Acute, Pancreatitis, Acute Necrotizing
The Role of Double Pigtail Plastic Stents During Endoscopic Transmural Drainage of Pancreatic Fluid Collections.
The goal of this clinical trial is to learn about clinical usefulness of double pigtail plastic stents during endoscopic transmural drainage of post-inflammatory pancreatic and peripancreatic fluid collections with use of…
- Conditions
- Pancreatitis, Acute, Pancreatitis, Acute Necrotizing, Pancreatic Pseudocyst, Pancreatic Necrosis
- Trial name
- NCT06134024
- Testing
- Introduction of double pigtail plastic stents through the LAMS during endoscopic transmural drainage of post-inflammatory pancreatic and peripancreatic fluid collections, Endoscopic transmural drainage of post-inflammatory pancreatic and peripancreatic fluid collections with use of LAMS only
- Volunteers
- 200 people
- Sponsor
- Nicolaus Copernicus University
Acute Necrotizing Pancreatitis
CMV Reactivation in Acute Necrotizing Pancreatitis
Patients with the diagnosis of acute necrotizing pancreatitis (ANP) present with a wide spectrum of severity. These patients frequently require intensive care management.
- Trial name
- NCT05898048
- Where
- India
- Volunteers
- 41 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Pancreatitis,Acute Necrotizing
Randomized Trial of Immediate Endoscopic Necrosectomy vs. Step-up Endoscopic Interventions in Necrotizing Pancreatitis
This is a randomized trial comparing immediate endoscopic necrosectomy vs. step-up endoscopic interventions in patients with necrotizing pancreatitis.
- Trial name
- DESTIN (NCT05043415)
- Testing
- Immediate endoscopic necrosectomy, Step-up endoscopic interventions
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Orlando Health, Inc.
Pancreatitis, Acute Necrotizing
Immediate vs. On-demand Endoscopic Necrosectomy in Infected Walled-off Pancreatic Necrosis
Acute pancreatitis is one of the most common diagnoses made in gastroenterology wards worldwide which causes a great deal of pain and expense along with fatal complications.
- Trial name
- NCT05530772
- Testing
- Endoscopic necrosectomy
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- University of Tehran
Acute Necrotizing Pancreatitis
Early Enteral Nutrition for Severe Acute Pancreatitis
There is increasing evidence that indicates early enteral nutrition may be associated with improved outcome in acute pancreatitis patients.
- Trial name
- NCT00995098
- Testing
- early enteral nutrition, Parenteral nutrition
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Sichuan Academy of Medical Sciences
Pancreatitis, Acute Necrotizing
Strategic Timing of Endoscopic Interventions in Infected Necrotizing Pancreatitis
Pancreatic necrosis complicates approximately 20-30% of severe acute pancreatitis cases. While many collections resolve without intervention, persistent symptomatic collections-particularly when infected-are associated with…
- Trial name
- STEP-IN (NCT07406698)
- Testing
- EUS-guided transluminal drainage of necrotic collection
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Orlando Health, Inc.
Pancreatic Trauma, Pancreatic Duct Injury
A Retrospective Analysis of Pancreatic Injuries and Treatment Outcomes
The goal of this observational study is to compare the presentation, treatment, and outcomes in patients suffering traumatic pancreatic injuries from blunt or penetrating trauma. The questions this study aims to answer are: 1.
- Conditions
- Pancreatic Trauma, Pancreatic Duct Injury, Pancreas Necrosis, Pancreas Cyst
- Trial name
- NCT06227871
- Testing
- Exploratory laparotomy
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Kern Medical Center
Pancreas Necrosis
Imaging Modalities for Pancreatic Collections
The purpose of this project is to provide appropriate administrative and technical supports for the warehousing and use of imaging data in pancreatic necrosis data for research purposes.
- Trial name
- NCT03556501
- Testing
- Endoscopy
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Acute Necrotizing Pancreatitis, Infected Pancreatic Necrosis
Integrating Plasma Metagenomics and Host Response for Accurate Diagnosis of Infected Pancreatic Necrosis in a Prospective Multicenter Cohort of Acute Necrotizing Pancreatitis
This study is being done to find a faster and more accurate way to tell whether the necrosis in patients with acute necrotizing pancreatitis (ANP) has become infected.
- Trial name
- PROMOTE (NCT07308600)
- Volunteers
- 200 people
- Sponsor
- Xiangya Hospital of Central South University