Clinical trials: Acute Necrotizing Pancreatitis
Necrotizing Pancreatitis, Walled Off Necrosis
Pancreatic Duct Stent for Acute Necrotizing Pancreatitis
The research design is a randomized prospective clinical study comparing the incidence of Walled Off Necrosis (WON) in patients with acute necrotizing pancreatitis.
- Trial name
- NCT03115918
- Testing
- Pancreatic Duct Stent Placement, No Pancreatic Duct Stent Placement
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- AdventHealth
Pancreatic Necrosis
Timing of Necrosectomy After Endoscopic Drainage of Walled-off Pancreatic Necrosis (WON)
Walled-off pancreatic necrosis (WON) is associated with a mortality of 20-30%. The current evidence supports a minimally invasive drainage approach to infected WON.
- Trial name
- NCT05252897
- Testing
- Endoscopic necrosectomy with step up approach, Endoscopic necrosectomy with direct approach
- Where
- 9 sites in Australia, Hong Kong and 4 more
- Volunteers
- 108 people
- Sponsor
- Chinese University of Hong Kong
Necrotizing Pancreatitis
Molecular Analysis of Microbial DNA in Infected Necrotizing Pancreatitis
Necrotizing pancreatitis is a severe form of inflammation of the pancreas with subsequent destruction of the pancreas (necrosis).
- Trial name
- NCT01815489
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Acute Necrotizing Pancreatitis, Walled Off Necrosis
Plastic Stents vs. NAGI Bi-flanged Metal Stent for Endoscopic Ultrasound Guided Drainage of Walled-off Necrosis
Introduction: Walled off necrosis (WON) is defined as a well circumscribed pancreatic and/or peri pancreatic necrosis containing a variable amount of necrotic tissue.
- Trial name
- NCT04479228
- Testing
- Endosonography guided transmural drainage
- Volunteers
- 80 people
- Sponsor
- Asian Institute of Gastroenterology, India
Pancreatitis, Acute Necrotizing
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics Investigation of GSK3335065 Intravenous (IV) Infusion in Healthy Adults
GSK3335065 is being developed as a treatment for acute pancreatitis with the intent of reducing 3-hydroxykynurenine (3HK) levels to the normal range (or lower) and maintaining them at this level throughout the treatment period.
- Trial name
- NCT03245619
- Testing
- GSK3335065
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Pancreatic Fluid Collection, Walled-off Necrosis
Immediate Necrosectomy vs. Step-up Approach for Walled-off Necrosis
Walled-off necrosis (WON) is a pancreatic fluid collection, which contains necrotic tissue after four weeks of the onset of acute pancreatitis.
- Conditions
- Pancreatic Fluid Collection, Walled-off Necrosis, Pancreatitis, Acute Necrotizing, Pancreatic Pseudocyst
- Trial name
- WONDER-01 (NCT05451901)
- Testing
- Immediate necrosectomy, Step-up approach
- Where
- 21 sites in Japan
- Volunteers
- 70 people
- Sponsor
- Tokyo University
Necrotizing Pancreatitis
Endoscopic Large Caliber Drainage vs. Complete Necrosectomy for Treatment of Walled-off Pancreatic Necrosis
The purpose of this study is to determine optimal treatment strategies for symptomatic walled-off pancreatic necrosis( WON).
- Trial name
- NCT02564965
- Testing
- Double Pigtail Plastic Stent, AXIOS Metal Stent
- Sponsor
- Mayo Clinic
Pancreatic Necrosis, Necrosis Pancreas
Endoscopic Necrosectomy Versus Step-up Endoscopic Intervention
This trial is to compare clinical outcomes between patients undergoing immediate endoscopic necrosectomy compared to step-up endoscopic interventions in patients undergoing endoscopic therapy for infected necrotizing pancreatitis.
- Trial name
- DESTIN (NCT04113499)
- Testing
- Direct Endoscopic Intervention, Step-up Endoscopic Intervention
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- AdventHealth
Pancreatitis, Acute Necrotizing
Effect of Traditional Chinese Medicine on GI Function Recovery and Nutrition Support in SAP
With multicenter randomized control clinical evaluation investigations, the effect of traditional Chinese medicine on gastrointestinal function recovery and nutrition support in early stage of severe acute pancreatitis (SAP) was…
- Trial name
- NCT00508729
- Testing
- Qingyi granules
- Where
- 10 sites in China
- Volunteers
- 300 people
- Sponsor
- Tianjin Nankai Hospital
Pancreatitis, Acute Necrotizing
Dexmedetomidine Hydrochloride in the Prevention of Organ Failure Following Severe Acute Pancreatitis
Cytokines such as such as TNF-a, IL-1, IL-6 correlate with the severity of pancreatitis.Neuroendocrine pathways, such as the sympathetic nervous system or parasympathetic nervous system, in turn, have some impact on the immune…
- Trial name
- DHPOFFSAP (NCT02691598)
- Testing
- Infusion
- Where
- China
- Volunteers
- 314 people
- Sponsor
- Nanjing University School of Medicine
Acute Pancreatitis With Uninfected Necrosis, Unspecified
Hemoperfusion Efferon СT for the Treatment of Patients With Acute Pancreatitis
Mortality from severe acute pancreatitis reaches 42%. The prognosis of acute pancreatitis is associated with the development of acute inflammatory response syndrome (SIRS) and multiple organ failure (MOF).
- Trial name
- NCT05695001
- Testing
- Efferon CT
- Where
- Russia
- Volunteers
- 34 people
- Sponsor
- Efferon JSC
Acute Necrotizing Pancreatitis, Acute Respiratory Distress Syndrome
Risk Factors for ARDS in Patients With Acute Necrotizing Pancreatitis
Try to collect about 350 cases of acute necrotizing pancreatitis at the First Affiliated Hospital with Nanjing Medical University and Nanjing General Hospital of Nanjing Military Command.
- Trial name
- NCT02641964
- Volunteers
- 350 people
- Sponsor
- Nanjing Medical University
Acute Pancreatitis
Pentoxifylline Treatment of Acute Pancreatitis
The purpose of this study is to determine the effects (good and bad) of giving a drug called pentoxifylline to patients with acute pancreatitis, to see if it can improve blood tests associated with inflammation (tissue damage).
- Trial name
- NCT01292005
- Testing
- Pentoxifylline
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Mayo Clinic
Necrotizing Pancreatitis
Organ Dysfunction Change in Acute Necrotizing Pancreatitis Patients With Sepsis After Open Necrosectomy
The purpose of this study is to characterize organ dysfunction change in acute necrotizing pancreatitis patients with sepsis after open necrosectomy.
- Trial name
- NCT06380842
- Testing
- Necrotizing Pancreatitis patients' organ dysfunction progression
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Chunling Jiang
Pancreatitis, Acute Necrotizing
Videoendoscopic Drainage of Infected Pancreatic Collections
The VARD (Videoendoscopic Assisted Retroperitoneal Drainage) approach as treatment for necrotizing pancreatitis proposes an alternative to standard complicated open abdomen treatment methods.
- Trial name
- NCT00061269
- Testing
- Videoscopic-Assisted Retroperitoneal Debridement (VARD)
- Where
- 6 sites in United States, Canada
- Volunteers
- 40 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Pancreatitis, Acute Necrotizing, Walled Off Necrosis
Lumen-apposing Metal Stent With or Without Coaxial Plastic Stent for Treatment of Walled-off Pancreatic Necrosis
A prospective randomized cohort study to compare whether the placement of a double-pigtail plastic stent (DPS) within a lumen-apposing metal stent (LAMS) may improve the efficacy and safety of endoscopic ultrasound guided…
- Trial name
- NCT03923686
- Testing
- EUS-guided drainage using LAMS with DPS, EUS-guided drainage using LAMS alone
- Where
- Czechia
- Volunteers
- 67 people
- Sponsor
- Palacky University
Acute Pancreatitis
Enteral Nutrition in Acute Pancreatitis
The purpose of this prospective randomised clinical trial is to compare beneficial and harmful effects of the use enteral nutrition versus a nil-by-mouth and intravenous fluid replacement principle of treatment in patients with…
- Trial name
- NCT01965873
- Testing
- Enteral nutrition
- Volunteers
- 214 people
- Sponsor
- University Hospital Rijeka
Acute Pancreatitis (AP)
Endoscopic Pancreatic Duct Stent Placement Versus Conventional Approach in the Treatment of Early Phase Acute Pancreatitis
The planned multicenter randomized study is aimed to assess the efficacy and safety of endoscopic pancreatic duct stenting in adult patients with acute pancreatitis.
- Trial name
- NCT07093996
- Testing
- Endoscopic pancreatic duct stent placement, Conventional treatment of acute pancreatitis in early phase
- Where
- 7 sites in China, Russia
- Volunteers
- 200 people
- Sponsor
- Almazov National Medical Research Centre
Pancreatic Necrosis, Pancreatitis, Acute Necrotizing
Endoscopic Step-up Approach vs Aggressive Debridement of Large Pancreatic Walled-off Necrosis
The goal of this clinical trial is to compare a conventional endoscopic step-up approach with an accelerated treatment algorithm using direct endoscopic necrosectomy in patients with acute necrotizing pancreatitis and walled of…
- Trial name
- NCT05601687
- Testing
- Direct Endoscopic Necrosectomy, Step-up Approach
- Where
- Denmark
- Volunteers
- 25 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Pancreatitis, Acute Necrotizing
Thymosin Alpha 1 in the Prevention of Pancreatic Infection Following Acute Necrotizing Pancreatitis
Infected pancreatic necrosis and its related septic complications are the major cause of death in patients with acute pancreatitis, therefore prevention of pancreatic infection is of great clinical value in the treatment of AP.
- Trial name
- TRACE (NCT02473406)
- Testing
- Thymosin Alpha 1, normal saline
- Where
- 2 sites in China
- Volunteers
- 508 people
- Sponsor
- Weiqin Li