Clinical trials: Acute Non-ST Elevation Myocardial Infarction
Cardiogenic Shock, Acute Myocardial Infarction
National Cardiogenic Shock Initiative
This study evaluates the use of early mechanical circulatory support in patients presenting with acute myocardial infarction and cardiogenic shock.
- Conditions
- Cardiogenic Shock, Acute Myocardial Infarction, STEMI - ST Elevation Myocardial Infarction, NSTEMI - Non-ST Segment Elevation MI
- Trial name
- NCSI (NCT03677180)
- Where
- 75 sites in United States
- Volunteers
- 406 people
- Sponsor
- Henry Ford Health System
Coronary Artery Disease, Angina, Unstable
Distal vs. Forearm Radial Artery Access
The Distal Radial Access (DRA) to the coronaries has emerged recently. It's done via the distal radial artery in the radial fossa, which is known as the snuff-box.
- Conditions
- Coronary Artery Disease, Angina, Unstable, Angina, Stable, Non STEMI
- Trial name
- DRAvsFRA (NCT04125992)
- Testing
- distal radial artery access in coronary angiography and angioplasty, Forearm radial artery access in coronary angiography and angioplasty
- Where
- Palestinian Territories
- Volunteers
- 212 people
- Sponsor
- An-Najah National University
Myocardial Ischemia, Acute Coronary Syndrome
EARLY ACS: Early Glycoprotein IIb/IIIa Inhibition in Patients With Non-ST-segment Elevation Acute Coronary Syndrome (Study P03684AM2)(COMPLETED)
The purpose of this study is to see if early INTEGRILIN® (eptifibatide) therapy in patients with non-ST-segment elevation acute coronary syndrome (ACS) reduces the occurence of death, heart attack and urgent cardiac intervention…
- Trial name
- NCT00089895
- Testing
- Eptifibatide (Integrilin)
- Volunteers
- 9,406 people
- Sponsor
- Organon and Co
ACS - Acute Coronary Syndrome
European Unified Registries for Heart Care Evaluation and Randomised Trials Italy
Major advances in cardiovascular medicine have been driven by innovations in basic research in biological and technical sciences.
- Trial name
- EuroHeart ITA (NCT07283809)
- Testing
- Adherence to European Society of Cardiology (ESC) quality indicators
- Where
- 57 sites in Italy
- Volunteers
- 5,000 people
- Sponsor
- Heart Care Foundation
Myocardial Infarction
Randomized Trial of Immediate Versus Early and Selective Invasive Percutaneous Coronary Intervention in NSTEMI
In non-ST-elevation the optimal time of percutaneous coronary intervention (PCI) is unclear. Some studies showed benefit of very early PCI, some others early PCI between 12-48 hours and others even showed a benefit of a selective…
- Trial name
- LIPSIA-NSTEMI (NCT00402675)
- Testing
- Timing of percutaneous coronary intervention
- Where
- 5 sites in Germany
- Volunteers
- 600 people
- Sponsor
- University of Leipzig
Acute Coronary Syndromes (ACS), NSTEMI - Non-ST-Segment Elevation Myocardial Infarction
The CORE - μFR Clinical Trial
Acute coronary syndromes (ACS) are frequently associated with multivessel coronary artery disease (CAD), and current guidelines recommend complete revascularization beyond the culprit lesion.
- Conditions
- Acute Coronary Syndromes (ACS), NSTEMI - Non-ST-Segment Elevation Myocardial Infarction, STEMI - ST Elevation Myocardial Infarction, Multivessel Coronary Artery Disease
- Trial name
- NCT07598565
- Testing
- Angiography-guided PCI, μFR based-PCI
- Where
- Italy
- Volunteers
- 350 people
- Sponsor
- University of Roma La Sapienza
Acute Coronary Syndrome, STEMI
AI-Powered ECG Detecting Culprit Vessel Blood Flow Abnormality in ACS
AI ECG TIMI is an investigator-initiated, international, and multicenter registry of acute coronary syndrome patients aimed to identify electrocardiographic findings detected by an AI model predicting coronary blood flow…
- Conditions
- Acute Coronary Syndrome, STEMI, Coronary Occlusion, Coronary Syndrome
- Trial name
- AI-ECG-TIMI (NCT06528821)
- Where
- 9 sites in Austria, Belgium and 1 more
- Volunteers
- 800 people
- Sponsor
- Powerful Medical
Peri-operative Myocardial Infarction, Non-ST Elevation Myocardial Infarction
Study of Coronary Plaque Rupture in Heart Attack Following Surgery Using Optical Coherence Tomography (OCT)
Background It is commonly believed that a heart attack is caused by rupture of a plaque in the wall of the coronary artery, resulting in blood clots which impede blood flow.
- Trial name
- OPTIMUS (NCT01555177)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Victar Hsieh
Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD)), Acute Coronary Syndromes
AI-Assisted Coronary Syndrome Subtyping From Admission History of Present Illness: A Clinician Reader Study
This study will evaluate whether an OCR-LLM-based clinical decision support framework improves clinicians' accuracy in classifying coronary syndrome subtypes from admission history of present illness.
- Conditions
- Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD)), Acute Coronary Syndromes, ST-segment Elevation Myocardial Infarction (STEMI), Non-ST-Segment Elevation Myocardial Infarction (NSTEMI)
- Trial name
- OCR-LLM-CHD (NCT07449429)
- Testing
- OCR-Prompt-LLM Information Extraction and Classification Workflow (OCR-Prompt-LLM), Manual Clinical Data Review
- Where
- China
- Volunteers
- 10 people
- Sponsor
- China National Center for Cardiovascular Diseases
Cardiovascular Disease, Myocardial Infarction
EVOLVE-MI: EVOLocumab Very Early After Myocardial Infarction
The primary objective of this study is to evaluate the effectiveness of early treatment with evolocumab plus routine lipid management vs routine lipid management alone when administered in the acute setting to reduce myocardial…
- Conditions
- Cardiovascular Disease, Myocardial Infarction, Stroke, Coronary Revascularization
- Trial name
- EVOLVE-MI (NCT05284747)
- Testing
- Evolocumab, Routine Lipid Management
- Where
- 120 sites in United States, Brazil and 1 more
- Volunteers
- 6,019 people
- Sponsor
- Amgen
Myocardial Infarction
Acute Versus Subacute Angioplasty in Patients With NON-ST-Elevation Myocardial Infarction
Patients with acute myocardial infarction (AMI) are categorized according to the electrocardiogram (ECG) findings into: 1) patients with ST-Elevation Myocardial Infarction (STEMI), 2) patients with Bundle Branch Block Myocardial…
- Trial name
- NONSTEMI (NCT01638806)
- Testing
- Group I: Primary PCI
- Where
- Denmark
- Volunteers
- 500 people
- Sponsor
- Aarhus University Hospital Skejby
Acute Coronary Syndrome Without ST Elevation on Electrocardiogram, Acute Coronary Syndromes (ACS)
Occurrence of Severe Cardiac Rhythm and Conduction Disturbances in Emergency Department Patients With Non-ST Elevation Acute Coronary Syndrome
Cardiovascular diseases are the leading cause of death worldwide. Among them, coronary artery disease-especially in its acute form, known as acute coronary syndrome (ACS)-is the most frequent cause of cardiovascular death.
- Conditions
- Acute Coronary Syndrome Without ST Elevation on Electrocardiogram, Acute Coronary Syndromes (ACS), Myocardial Infarction, Unstable Angina Pectoris, Sudden Cardiac Death, Stroke, Peripheral Artery Disease
- Trial name
- SurvSCA (NCT07112547)
- Where
- 10 sites in France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Strasbourg, France
Angina, Unstable, Non-ST-Segment Elevation Myocardial Infarction (NSTEMI)
Rehabilitation After Acute Coronary Syndrome: a New Telemonitoring Strategy
Cardiac rehabilitation after an acute coronary syndrome is recognised in the latest guidelines and recommendations published by the major scientific societies as a class I indication.
- Conditions
- Angina, Unstable, Non-ST-Segment Elevation Myocardial Infarction (NSTEMI), ST-segment Elevation Myocardial Infarction (STEMI)
- Trial name
- NCT04942977
- Testing
- telemonitoring, Centre-based cardiac rehabilitation
- Where
- 2 sites in Spain
- Volunteers
- 67 people
- Sponsor
- Catcronic Salut SL
Non-STEMI Acute Coronary Syndrome
Single Center Registry of Non-STEMI Acute Coronary Syndrome Patients Treated With Bivalirudin
This is a registry of patients with non ST segment elevation Myocardial Infarction (heart attack) and/or unstable acute coronary artery syndrome treated with a standardized protocol including Bivalirudin.
- Trial name
- NCT00842374
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Minneapolis Heart Institute Foundation
Coronary Artery Disease, Endothelial NO-synthase
Regulation and Signaling of Red Blood Cell (RBC) Endothelial Nitric Oxide Synthase (eNOS) in Patients With Stable and Unstable Coronary Artery Disease
The aim of this study is measurement of expression and activity of RBC eNOS in different clinical cohorts of patients with coronary artery disease and acute coronary syndrome and to investigate the importance of the NO-stimulated…
- Trial name
- NCT02265016
- Where
- Germany
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Coronary Artery Disease, Myocardial Ischemia
BIOFLOW-III Hungary Satellite Registry
This registry is a clinical post-market evaluation of the Orsiro LESS in subjects requiring coronary revascularization with Drug Eluting Stents (DES)
- Trial name
- NCT01892917
- Where
- 13 sites in Hungary
- Volunteers
- 2,000 people
- Sponsor
- Biotronik Hungária Kft.
PreDiabetes, Acute Myocardial Infarction
Metformin and Prevention of Cardiovascular Events in Patients With Acute Myocardial Infarction and Prediabetes (MIMET)
Prediabetes is associated to an increased risk of cardiovascular disease and mortality. Although metformin can delay progression to diabetes there is a lack of RCTs evaluating the effect of metformin on cardiovascular outcomes.
- Conditions
- PreDiabetes, Acute Myocardial Infarction, Non ST Elevation Myocardial Infarction, ST Elevation Myocardial Infarction
- Trial name
- MIMET (NCT05182970)
- Testing
- Metformin
- Where
- Sweden
- Volunteers
- 5,160 people
- Sponsor
- Karolinska Institutet
Acute Coronary Syndrome, Depression
MBCT Delivered Via Group Videoconferencing for ACS Syndrome Patients With Depressive Symptoms
Brief Summary: The aim of this study is to explore the initial feasibility and acceptability of (a) Mindfulness-Based Cognitive Therapy (MBCT) adapted for ACS patients; (b) the group videoconferencing delivery medium; and (c)…
- Conditions
- Acute Coronary Syndrome, Depression, Myocardial Infarction, Unstable Angina
- Trial name
- NCT04231097
- Testing
- MBCT intervention for ACS patients
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Massachusetts General Hospital
Stable Angina, Unstable Angina
Differential Effects of Lipids on Cardiovascular Diseases: A CALIBER Study
The role of lipids as risk factors for cardiovascular events is well-documented, although events studied have largely been broad classes without specific detail. This study will examine a more refined set of endpoints.
- Conditions
- Stable Angina, Unstable Angina, Non ST Elevation Myocardial Infarction, ST Elevation Myocardial Infarction
- Trial name
- NCT01687686
- Where
- United Kingdom
- Volunteers
- 175,872 people
- Sponsor
- University College, London
Non ST Elevation Myocardial Infarction (NSTEMI), Frailty
Frailty as an INstrument for Evaluation of Elderly Patients With Non ST Elevation Myocardial Infarction (NSTEMI)
The purpose of this study is to describe patients, 75 years old or older, with Non ST Elevation Myocardial Infarction (NSTEMI) especially regarding the following variables: cardiovascular risk, co-morbidity and frailty.
- Trial name
- FINE75+ (NCT01049997)
- Where
- Sweden
- Volunteers
- 307 people
- Sponsor
- Linkoeping University