Clinical trials: Acute Pain
Infant Development, Pain, Procedural
Parental Touch Trial (Petal)
This is a two centre two-arm randomised controlled interventional trial. We aim to determine whether parental touch prior to a painful clinical procedure provides effective analgesia in neonates.
- Conditions
- Infant Development, Pain, Procedural, Parents
- Trial name
- Petal (NCT04901611)
- Testing
- Parental touch
- Where
- United Kingdom
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Paediatric Neuroimaging Research Group
Immunisation Anxiety Related Reaction, Pain, Acute
Substance P as a Biomarker to Evaluate the Reduction of Multiple Immunization Pain
Immunization is one of the most significant preventive health measures in reducing morbidity and mortality caused by infectious diseases.
- Trial name
- NCT04103801
- Testing
- Sucrose
- Where
- Jordan
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Lung Diseases
The Effectiveness of Acupressure for Managing Postoperative Pain and Anxiety in Patients With Thoracoscopic Surgery
The purpose of this study is to explore the effectiveness of acupressure for managing postoperative pain, anxiety, analgesia consumption, early ambulation, and comfort in patients with thoracoscopic surgery.
- Trial name
- NCT04595253
- Testing
- acupressure
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Wei-Fen Ma
Acute Pain, Pain Perception
Effects of Transcutaneous Vagus Nerve Stimulation on Pain and Brain Activity in Healthy Adults
The goal of this clinical trial is to learn whether stimulating a nerve in the neck changes how much pain people feel. It also looks at whether this stimulation changes brain activity.
- Conditions
- Acute Pain, Pain Perception, Healthy Adult Participants
- Trial name
- NCT07827690
- Testing
- Active transcutaneous vagus nerve stimulation, Cold pressor test
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- David A. Purger
Healthy
Effect of Spinal Ketorolac After Acute Opioid Exposure
This research study is being done because pain is a significant problem for patients with a variety of medical problems and following surgery or traumatic injury.
- Trial name
- NCT00693160
- Testing
- ketorolac, remifentanil, Capsaicin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wake Forest University
Acute Pain, Anxiety
The Effect of ShotBlocker on Pain, Anxiety, and Satisfaction During Peripheral Intravenous Catheterization
This randomized controlled trial aims to evaluate the effect of the ShotBlocker device on pain, anxiety, and patient satisfaction during peripheral intravenous catheterization (PIVC).
- Trial name
- SB-PIVC (NCT07553624)
- Testing
- ShotBlocker
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kirsehir Ahi Evran Universitesi
Opioid; Intoxication, Perception Disturbance (Acute), Acute Pain
Pupillary Unrest in Ambient Light, and Relationship to Opioid-Induced Respiratory Depression
Volunteers will receive a weight-based opioid (remifentanil) infusion for 10 minutes. In the first run, serial pupillary measurements (pupillary unrest, pupil diameter) will be taken at baseline, and at 2.5-minute intervals…
- Conditions
- Opioid; Intoxication, Perception Disturbance (Acute), Acute Pain, Overdose of Opiate, Respiratory Depression
- Trial name
- NCT04301895
- Testing
- Continuous conversational interaction, Remifentanil infusion
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Coronary Angiography, Chest Pain
Coronary Computed Tomography for Systematic Triage of Acute Chest Pain Patients to Treatment (CT-STAT)
This is a prospective, randomized multicenter trial comparing MSCT to standard of care (SOC) diagnostic treatment in the triage of Emergency Department (ED) low to intermediate risk chest pain patients.
- Trial name
- CTSTAT (NCT00468325)
- Testing
- Multi-slice computed tomography, Rest-stress Nuclear Myocardial Perfusion Imaging
- Where
- 16 sites in United States
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- Corewell Health East
Acute Coronary Syndrome, Depression
MBCT Delivered Via Group Videoconferencing for ACS Patients With Elevated Depression Symptoms
The objective of this study is to identify Acute Coronary Syndromes (ACS) patients' specific needs and preferences for depression treatment via in-person or virtual individual interviews to (a) guide MBCT adaptation; and identify…
- Conditions
- Acute Coronary Syndrome, Depression, Myocardial Infarction, Unstable Angina
- Trial name
- NCT03878160
- Testing
- Individual Interview
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Acute Pain
Pain Response to Open Label Placebo in Induced Acute Pain in Healthy Male Adults
Open Label Placebo application has been shown to be effective in treatment of chronic pain (low back pain) and disease like the irritable bowel Syndrome. Data about effects on acute pain are spare.
- Trial name
- POLAP (NCT03361579)
- Testing
- Education
- Where
- Switzerland
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
No Disease or Condition is Being Studied
Acute Psychological and Physiological Effects of Cannabigerol
The purpose of this study is to examine the acute effects of cannabigerol (CBG) on various psychological (e.g., anxiety, stress, mood, memory, impairment, intoxication, side effects) and physiological (blood pressure, cortisol…
- Trial name
- CBG (NCT06638996)
- Testing
- CBG Intervention
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Washington State University
Chest Pain, Acute Coronary Syndrome
The FOVUS-ER Study: Focused Vascular Ultrasound to Risk Stratify Patients With Chest Pain in the ER
Broad Goal: To demonstrate that focused vascular ultrasound (FOVUS) can accurately risk stratify patients with chest pain in the emergency department (ED).
- Conditions
- Chest Pain, Acute Coronary Syndrome, Carotid Artery Plaque
- Trial name
- FOVUS-ER (NCT02947360)
- Testing
- Focused vascular ultrasound of the carotid arteries
- Where
- Canada
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- Queen's University
Acute Pain
Sub-dissociative Dose Ketamine Dosing Study
Goal is to determine if in adults presenting to the Emergency Department (ED) with moderate to severe acute pain, Ketamine administered at 0.15 mg/kg will provide similar pain relief to Ketamine administered at 0.3 mg/kg, with…
- Trial name
- NCT03714620
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Loyola University
Obstetric Pain, Postpartum Depression
Ketamine to Improve Recovery After Cesarean Delivery - Part 1
The objective of this study is evaluate the breastmilk transfer and pharmacokinetics (Part 1) and effectiveness (Part 2) of a post-cesarean delivery intravenous ketamine bolus-and-infusion strategy, as a preventive analgesic…
- Conditions
- Obstetric Pain, Postpartum Depression, Breastfeeding, Pain, Acute
- Trial name
- KINETIC (NCT04037085)
- Testing
- Ketamine
- Where
- 2 sites in United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Grace Lim, MD, MS
Acute Pain, Cancer Pain
Usefulness of Acetaminophen Associated With Strong Opioids for Acute Pain in Cancer Patients
Cancer pain is one of the most frequent and relevant symptoms in cancer patients and has a great impact on a patient's quality of life.
- Trial name
- NCT04779567
- Testing
- Acetaminophen
- Where
- Chile
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Postoperative Pain
Total Knee Replacement TIVA With Robotic Arm Assisted
Total knee replacement (TKR) is a commonly performed surgical procedure, and is associated with moderate to severe acute postoperative pain.
- Trial name
- NCT04002271
- Testing
- Propofol, Sevoflurane, Spinal anaesthesia
- Where
- 2 sites in Hong Kong
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Pain, Acute
Ibuprofen Plus Acetaminophen for Enhanced Pain Reduction
Combination of analgesics with different modes of action have the potential to offer enhanced pain relief with reduced dosage. Ibuprofen and acetaminophen have different modes of action.
- Trial name
- NCT04630834
- Testing
- Ibuprofen, Acetaminophen
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- New York City Health and Hospitals Corporation
Pain, Acute
Bilateral Ultrasound-Guided Intra Muscular Quadratus Lumborum Block Versus Trans Muscular Quadratus Lumborum Block for Peri-Operative Analgesia in Abdominal Surgeries in Pediatric Patients. A Comparative Controlled Randomized Study.
To compare between the intra muscular quadratous lamborum and the Trans muscular quadratous lamborum in pediatric population under going abdominal surgeries regards to first request of rescue analgesia, degree of pain relief…
- Trial name
- NCT04029987
- Testing
- Bilateral Ultrasound-Guided Transmuscular Quadratus Lumborum Block., Bilateral Ultrasound-Guided intra smuscular Quadratus Lumborum Block., Control
- Where
- Egypt
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Pain, Acute Pain
Pain Induced by m-Cresol as Preservative
Preservatives such as m-Cresol are essential components in many subcutaneously injected medications, including insulin or human growth hormone, to prevent bacterial growth.
- Conditions
- Pain, Acute Pain, Healthy Volunteer Study
- Trial name
- NCT07600814
- Testing
- m-Cresol 0.1%, m-Cresol 0.25%, Control Solution
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Acute Pain
JKN2306 in Healthy Subjects: Single Ascending Dose and Food Effect Study
This first-in-human, single-center study in China evaluated the safety, tolerability, and pharmacokinetics of single oral doses of JKN2306 tablets in healthy adult subjects and assessed the effect of a high-fat, high-calorie meal…
- Trial name
- NCT07412938
- Testing
- JKN2306
- Where
- China
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Joincare Pharmaceutical Group Industry Co., Ltd