Clinical trials: Acute Pain, completed
Acute Coronary Syndrome, Pulmonary Embolism
Prehospital Translation of Chest Pain Tools
Decision aids such as the HEART Pathway, Emergency Department Assessment of Chest Pain Score (EDACS), Revised Geneva Score and PERC Score have similar ability to accurately risk stratify Emergency Department (ED) patients with…
- Trial name
- RESCUE (NCT03494556)
- Testing
- Data Collection
- Where
- 2 sites in United States
- Volunteers
- 365 people
- Sponsor
- Wake Forest University Health Sciences
Acute Coronary Syndrome, Angina Pectoris
Comparison of BIOdegradable Polymer and DuRablE Polymer Drug-eluting Stents in an All COmeRs PopulaTion (BIO-RESORT)
The introduction of drug-eluting stents (DES) in the treatment of coronary artery disease has led to a significant reduction in morbidity.
- Conditions
- Acute Coronary Syndrome, Angina Pectoris, Angina, Unstable, Myocardial Infarction
- Trial name
- BIO-RESORT (NCT01674803)
- Testing
- Orsiro, Synergy, Resolute Integrity
- Where
- Netherlands
- Volunteers
- 3,514 people
- Sponsor
- Foundation of Cardiovascular Research and Education Enschede
Pain, Postoperative
Thoracic Paravertebral Blockade in Video Assisted Thoracoscopic Surgery (VATS)
Video-assisted thoracoscopic surgeries (VATS) include severe postoperative acute pain which is also a predictor of chronic pain.
- Trial name
- VATS (NCT02302586)
- Testing
- Thoracic paravertebral block (TPVB), Patient Controlled Analgesia (IV PCA)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul University
Vitamin C, Post-mastectomy Pain Syndrome
Vitamin C on Acute and Chronic Post Mastectomy Pain
This prospective randomized double-blinded controlled study will be conducted to evaluate the effect of perioperative vitamin C on acute and chronic post mastectomy pain after breast cancer surgery
- Trial name
- NCT05770596
- Testing
- vitamin C group
- Where
- Egypt
- Volunteers
- 204 people
- Sponsor
- Tanta University
Pain, Acute
Ethyl Chloride for NPWT
Negative pressure wound therapy (NPWT) has been shown to improve wound care outcomes for acute and chronic wounds as well as for surgical incision sites.
- Trial name
- NCT04635696
- Testing
- Ethyl chloride, Tissue culture grade water
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- ProMedica Health System
Pain
Preoperative Gabapentin for Acute and Chronic Post-thoracotomy Analgesia
One dose of either gabapentin or placebo will be given to patients prior to thoracotomy. Patients will also receive an epidural infusion, intravenous patient-controlled analgesia with fentanyl, oral acetaminophen and intravenous…
- Trial name
- NCT00588159
- Testing
- Gabapentin, Diphenhydramine
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Michelle Kinney
Acute Pain
A Study of TRV130 for the Treatment of Pain After Bunionectomy
The primary objective is to evaluate the analgesic efficacy of IV TRV130 compared with placebo in patients with acute postoperative pain after bunionectomy.
- Trial name
- NCT02100748
- Testing
- TRV130, Morphine
- Where
- 4 sites in United States
- Volunteers
- 333 people
- Sponsor
- Trevena Inc.
Pain, Acute Pain
A Phase 1, Randomized, Placebo-Controlled Safety and Tolerability Study Of Intravenous SBS-1000 in Healthy Adults
This study will be a single-center, double-blind, randomized placebo-controlled, adaptive, single ascending dose study.
- Trial name
- NCT05721287
- Testing
- SBS-1000
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Sparian Biosciences, Inc
Acute Coronary Syndrome, Chest Pain
Randomized Investigation of Chest Pain Diagnostic Strategies
Clinical decision units (CDUs) improve resource utilization and are a recommended care option by the American College of Cardiology / American Heart Association, but are underutilized in non-low risk chest pain patients due to…
- Trial name
- NCT01035047
- Testing
- Clinical decision unit care, coupled with cardiac MRI
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Wake Forest University Health Sciences
Facial Pain
Capsaicin to Control Pain Following Third Molar Extraction
This study will test the effectiveness of the drug capsaicin in controlling pain after third molar (wisdom tooth) extraction. Capsaicin, the ingredient in chili peppers that makes them "hot," belongs to a class of drugs called…
- Trial name
- NCT00008476
- Testing
- Capsaicin
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Acute Coronary Syndrome, Chest Pain
Are Serial Electrocardiograms Additive to SeriAl Second-generations Troponins in Predicting Acute CoronAry Syndromes in PatienTs With Undifferentiated cHest Pain
Our research will examine whether the presence or absence of serial electrocardiogram (ECG) changes aids in reclassifying participants' risk for major adverse cardiac events (MACE) over and above serial blood testing.
- Trial name
- ASAP Cath (NCT01953276)
- Testing
- Serial Electrocardiograms
- Where
- United States
- Volunteers
- 382 people
- Sponsor
- Wake Forest University Health Sciences
Acute Appendicitis
Management of Acute Appendicitis Pain in the Emergency Department
This study aims to compare the effectiveness of TAP (Transversus Abdominal Plane) block, ESPB (Erector Spinal Plane Block), and tramadol in preoperative pain management for patients diagnosed with acute appendicitis and…
- Trial name
- NCT06808087
- Testing
- Transversus abdominis plane blockage, Erector spinae plane blockage, Tramadol
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Ankara City Hospital Bilkent
Acute Pain, Surgery
Prescribing Vs. Recommending Over-The-Counter (PROTECT) Analgesics for Patients with Postoperative Pain:
This is a research project in which two standard of care practices will be evaluated to examine the difference in outcomes. The goal is to improve patient care and safety.
- Trial name
- PROTECT (NCT05370404)
- Testing
- Prescription by surgical team, Recommendation by surgical team
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Michigan
Local Anesthetic, Ultrasound
TAP Block With Methyl-prednisolone as a Pain Treatment Modality After Total Abdominal Hysterectomy Procedures
The aim of this work to compare between the efficacy of ultrasound guided TAP block with dexamethasone as an adjuvant versus ultrasound guided TAPB with methyl prednisolone as an adjuvant to local anesthetic for postoperative…
- Conditions
- Local Anesthetic, Ultrasound, Pain, Acute
- Trial name
- NCT06131593
- Testing
- TAPB with dexamethasone as an adjuvant to local anesthetics, TAPB with methylprednisolone as an adjuvant to local anesthetics
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Kasr El Aini Hospital
Primary Dysmenorrhea
Virtual Reality-Based Relaxation and Exergaming vs. Traditional Relaxation for Primer Dysmenorrhea
The goal of this clinical trial is to investigate the acute effects of virtual reality-based relaxation (immersive VR relaxation) and exergaming (non-immersive VR) compared to traditional Jacobson's relaxation on symptoms of…
- Trial name
- NCT06728306
- Testing
- Immersive Virtual Reality-Based Relaxation, Non-immersive VR-Based Exergaming, Jacobson's Relaxation
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 43 people
- Sponsor
- Trakya University
Acute Coronary Syndrome
Vaccination Against Influenza to Prevent Cardiovascular Events After Acute Coronary Syndromes
Cardiovascular disease has a great burden in the context of public health, as well as the low pharmacological adherence of patients who have chronic non-transmissible diseases.
- Trial name
- VIP-ACS (NCT04001504)
- Testing
- Double Dose Quadrivalent Influenza Vaccine, Standard Dose Quadrivalent Influenza Vaccine
- Where
- 22 sites in Brazil
- Volunteers
- 1,801 people
- Sponsor
- Hospital Israelita Albert Einstein
Pain
Effectiveness and Feasibility of Patient Controlled Analgesia in the ED
Background: Inadequate pain management is common in the Emergency Department (ED). Optimal treatment of pain necessitates titration to effective dose due to the large inter-individual variability in opioid requirement.
- Trial name
- NCT01775371
- Testing
- Patient controlled analgesia (PCA), Usual Care
- Where
- 3 sites in United States
- Volunteers
- 636 people
- Sponsor
- Albert Einstein College of Medicine
Thoracic Surgery, Video-Assisted
Intercostal Cryoanalgesia for Acute Pain After VATS Lung Resection
Intercostal cryoanalgesia is a technique that allows extensive and prolonged analgesia of the hemithorax. The aim of this study is to demonstrate the efficacy of intercostal cryoanalgesia as an adjunct to a single-injection…
- Conditions
- Thoracic Surgery, Video-Assisted, Cryotherapy Effect, Paravertebral Block
- Trial name
- CRYO-VATS (NCT05896150)
- Testing
- Cryoanalgesia AND single-injection paravertebral block, Single-injection paravertebral block
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Acute Pain
Preemptive Analgesia in Total Knee Arthroplasty
Acute Pain is the most common early complication after total knee arthroplasty that caused delayed mobilization, demands of morphine, and higher operative cost.
- Trial name
- NCT03523832
- Testing
- Celecoxib and Pregabaline
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Acute Low Back Pain
A Randomized Study of Three Medication Regimens for Acute Low Back Pain
Low back pain causes 2.4% of visits to US emergency departments (ED) resulting in 2.7 million visits annually. In a general low back pain (LBP) population, prognosis is poor.
- Trial name
- NCT01587274
- Testing
- Naproxen, Cyclobenzaprine, Oxycodone/ acetaminophen
- Where
- United States
- Volunteers
- 323 people
- Sponsor
- Montefiore Medical Center
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