Clinical trials: Acute Pancreatic Necrosis
Acute Necrotizing Pancreatitis, Pancreatic Exocrine Insufficiency
Pancreatic Enzyme Replacement in Acute Necrotizing Pancreatitis
In this multicenter, double blinded, placebo-controlled, 1:1 parallel group RCT, the investigators propose to evaluate the impact of pancreatic exocrine replacement therapy on patients with acute necrotizing pancreatitis (ANP).
- Trial name
- PERiANP (NCT07441824)
- Testing
- Pancreatic enzyme capsules
- Where
- 4 sites in India
- Volunteers
- 140 people
- Sponsor
- Asian Institute of Gastroenterology, India
Acute Necrotizing Pancreatitis
Early Enteral Nutrition for Severe Acute Pancreatitis
There is increasing evidence that indicates early enteral nutrition may be associated with improved outcome in acute pancreatitis patients.
- Trial name
- NCT00995098
- Testing
- early enteral nutrition, Parenteral nutrition
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Sichuan Academy of Medical Sciences
Gastric Outlet Obstruction, Biliary Obstruction
Prospective Registry Of Therapeutic EndoscopiC ulTrasound
This registry aims to analyze long-term outcomes of therapeutic EUS (T-EUS) procedures, as well as to describe clinical and technical variables potentially predicting clinical success or adverse events, for a better selection of…
- Conditions
- Gastric Outlet Obstruction, Biliary Obstruction, Acute Pancreatic Fluid Collection, Acute Pancreatitis With Infected Necrosis
- Trial name
- PROTECT (NCT04813055)
- Testing
- Therapeutic EUS, Percutaneous Procedures, Surgical Interventions
- Where
- Italy
- Volunteers
- 510 people
- Sponsor
- Paolo Giorgio Arcidiacono, MD
Severe Acute Pancreatitis
Relationship Between Acute Severe Pancreatitis and Mitochondrial DNA
Plasma mtDNA analysis aids in predicting pancreatic necrosis in severe acute pancreatitis patients.After the onset of severe acute pancreatitis, pancreatic necrosis and the content of mtDNA in plasma will increase, showing a…
- Trial name
- NCT04079777
- Testing
- Clinical treatment
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- First People's Hospital of Chenzhou
Children, Pancreatic Fistula
The Study of the Natural Way of Development of External Pancreatic Fistulas in Children with Necrotizing Pancreatitis
The external pancreatic fistula (EPF) is characterized by the leakage of pancreatic juice outward through an area of skinor through a drainage tube.
- Conditions
- Children, Pancreatic Fistula, Pancreatitis,Acute Necrotizing, Pancreatitis, Acute
- Trial name
- NCT06706440
- Testing
- no intervention, observational study
- Where
- Russia
- Volunteers
- 26 people
- Sponsor
- Moscow Regional Research and Clinical Institute (MONIKI)
Pancreas Necrosis, Pancreatic Collection
EUS-guided Transmural Drainage of Walled-off Pancreatic Necrosis: Plastic vs Metallic Protesis.
Randomized multicenter study comparing plastic stents and self-expanding metallic stents in the eus-guided transmural drainage of walled-off pancreatic necrosis.
- Trial name
- PROMETHEUS (NCT03100578)
- Testing
- WOPN TRANSMURAL DRAINAGE: PLASTIC STENT, WOPN TRANSMURAL DRAINAGE: METALLIC STENT
- Where
- 8 sites in Spain
- Volunteers
- 99 people
- Sponsor
- Hospital Universitari de Bellvitge
Acute Pancreatitis
Imipenem Prophylaxis in Patients With Acute Pancreatitis
This is a prospective, single-center, randomized, placebo-controlled, double-blind clinical trial that aims to investigate the beneficial and harmful effects of prophylactic use of imipenem in patients with predicted severe acute…
- Trial name
- IMPROWE (NCT02897206)
- Testing
- Imipenem
- Where
- Croatia
- Volunteers
- 98 people
- Sponsor
- University Hospital Rijeka
Pancreatitis, Acute Necrotizing
Immediate vs. On-demand Endoscopic Necrosectomy in Infected Walled-off Pancreatic Necrosis
Acute pancreatitis is one of the most common diagnoses made in gastroenterology wards worldwide which causes a great deal of pain and expense along with fatal complications.
- Trial name
- NCT05530772
- Testing
- Endoscopic necrosectomy
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- University of Tehran
Acute Necrotizing Pancreatitis
CMV Reactivation in Acute Necrotizing Pancreatitis
Patients with the diagnosis of acute necrotizing pancreatitis (ANP) present with a wide spectrum of severity. These patients frequently require intensive care management.
- Trial name
- NCT05898048
- Where
- India
- Volunteers
- 41 people
- Sponsor
- Sanjay Gandhi Postgraduate Institute of Medical Sciences
Pancreatitis,Acute Necrotizing, Pancreas Necrosis
Perform Necrotic Cavity Lavage or Not After Debridement of Infected Pancreatic Necrosis
The infected pancreatic necrosis (IPN) should be treated by debridement and drainage. In recent years, the results of clinical research show that minimally invasive debridement such as video-assisted (laparoscope, nephroscope…
- Trial name
- NCLAD (NCT04275466)
- Testing
- necrotic cavity lavage
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Xuanwu Hospital, Beijing
Pancreatitis, Acute Necrotizing
A Study to Determine if Antibiotics Prevent Infection in the Pancreas of Patients Where Part of the Pancreas Has Died
This is a research study in patients having a condition known as necrotizing pancreatitis. This is inflammation of the pancreas (an intestinal organ which assists with digestion) that has resulted in the damage and death of some…
- Trial name
- NCT00061438
- Testing
- meropenem
- Where
- 11 sites in United States, Canada
- Volunteers
- 240 people
- Sponsor
- Pfizer
Acute Pancreatitis, Pancreatic Fluid Collection
Management and Outcomes of Local Complications of Acute Pancreatitis and Postoperative Pancreatic Fistula
This multicenter prospective observational registry will evaluate the clinical characteristics and treatment outcomes of adults with local complications of acute pancreatitis or postoperative pancreatic fistula.
- Conditions
- Acute Pancreatitis, Pancreatic Fluid Collection, Postoperative Pancreatic Fistula
- Trial name
- WONDERFUL (NCT07862088)
- Testing
- Routine Clinical Management of Local Complications
- Where
- 12 sites in Japan
- Volunteers
- 5,000 people
- Sponsor
- Tokyo University
Acute Necrotizing Pancreatitis, Infection
PancRea: Risk Factors and Outcomes of Infected Pancreatic Necrosis
Severe acute pancreatitis is a common reason for intensive care unit (ICU) admission and is associated with prolonged hospital stays and high morbidity and mortality rates.
- Conditions
- Acute Necrotizing Pancreatitis, Infection, Pancreatitis
- Trial name
- PancRea (NCT03253861)
- Testing
- No intervention
- Where
- France
- Volunteers
- 148 people
- Sponsor
- Nantes University Hospital
Necrosis of Pancreas, Infected Pancreatic Necrosis
Minimally Invasive Surgery vs. Endoscopy Randomized (MISER) Trial for Necrotizing Pancreatitis
Prospective, randomized controlled trial comparing Endoscopic Ultrasound (EUS) Guided cystogastrostomy or cystoduodenostomy and endoscopic necrosectomy to minimally invasive surgical necrosectomy, in patients with necrotizing…
- Trial name
- MISER (NCT02084537)
- Testing
- Endoscopic treatment, Minimally invasive surgical necrosectomy
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- AdventHealth
Pancreatitis, Acute Necrotizing
Strategic Timing of Endoscopic Interventions in Infected Necrotizing Pancreatitis
Pancreatic necrosis complicates approximately 20-30% of severe acute pancreatitis cases. While many collections resolve without intervention, persistent symptomatic collections-particularly when infected-are associated with…
- Trial name
- STEP-IN (NCT07406698)
- Testing
- EUS-guided transluminal drainage of necrotic collection
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Orlando Health, Inc.
Pancreatitis, Acute, Pancreatitis, Acute Necrotizing
The Role of Double Pigtail Plastic Stents During Endoscopic Transmural Drainage of Pancreatic Fluid Collections.
The goal of this clinical trial is to learn about clinical usefulness of double pigtail plastic stents during endoscopic transmural drainage of post-inflammatory pancreatic and peripancreatic fluid collections with use of…
- Conditions
- Pancreatitis, Acute, Pancreatitis, Acute Necrotizing, Pancreatic Pseudocyst, Pancreatic Necrosis
- Trial name
- NCT06134024
- Testing
- Introduction of double pigtail plastic stents through the LAMS during endoscopic transmural drainage of post-inflammatory pancreatic and peripancreatic fluid collections, Endoscopic transmural drainage of post-inflammatory pancreatic and peripancreatic fluid collections with use of LAMS only
- Volunteers
- 200 people
- Sponsor
- Nicolaus Copernicus University
Necrotizing Pancreatitis
Molecular Analysis of Microbial DNA in Infected Necrotizing Pancreatitis
Necrotizing pancreatitis is a severe form of inflammation of the pancreas with subsequent destruction of the pancreas (necrosis).
- Trial name
- NCT01815489
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences