Clinical trials: Acute Pancreatitis Necrotizing
Pancreatitis,Acute Necrotizing
Lumen Apposing Metal Stents vs Double Pigtail Stents
While the majority of patients with acute pancreatitis suffer a mild and uncomplicated course of disease, up to 20% develop a more severe course with development of pancreatic and/or peripancreatic necroses.
- Trial name
- NCT04057846
- Testing
- EUS guided transgastric drainage
- Where
- Denmark
- Volunteers
- 42 people
- Sponsor
- John Gasdal Karstensen
Walled Off Pancreatic Necrosis
AXIOS Lumen Apposing Metal Stent for Walled Off Necrosis Drainage IDE Study
To demonstrate safety and effectiveness of lumen-apposing metal stents for resolution of walled off pancreatic necrosis (WONs) in patients with WONs with solid component >30%.
- Trial name
- NCT03525808
- Testing
- AXIOS
- Where
- 5 sites in United States
- Volunteers
- 40 people
- Sponsor
- Boston Scientific Corporation
Necrotizing Pancreatitis
ABTHERA ADVANCE™ Use Without Wittman Patch
The objective of this study is to evaluate the use of the ABTHERA ADVANCE for patients requiring open abdomen due to necrotizing pancreatitis.
- Trial name
- NCT04986943
- Testing
- Using ABTHERA Advance without a Wittmann Patch
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Wake Forest University Health Sciences
Acute Necrotizing Pancreatitis, Acute Respiratory Distress Syndrome
Risk Factors for ARDS in Patients With Acute Necrotizing Pancreatitis
Try to collect about 350 cases of acute necrotizing pancreatitis at the First Affiliated Hospital with Nanjing Medical University and Nanjing General Hospital of Nanjing Military Command.
- Trial name
- NCT02641964
- Volunteers
- 350 people
- Sponsor
- Nanjing Medical University
Acute Pancreatitis
Use of Streptokinase for Enhancement of Percutaneous Drainage of Pancreatic Necrosis
Around 20 per cent of patients with acute pancreatitis develop pancreatic or peripancreatic necrosis with or without peripancreatic collection.
- Trial name
- NCT01977118
- Testing
- streptokinase, Saline irrigation
- Where
- India
- Volunteers
- 28 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Pancreatitis, Acute Necrotizing
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics Investigation of GSK3335065 Intravenous (IV) Infusion in Healthy Adults
GSK3335065 is being developed as a treatment for acute pancreatitis with the intent of reducing 3-hydroxykynurenine (3HK) levels to the normal range (or lower) and maintaining them at this level throughout the treatment period.
- Trial name
- NCT03245619
- Testing
- GSK3335065
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Acute Necrotizing Pancreatitis
Acute Necrotizing Pancreatitis and Infected Pancreatic Necrosis
Acute necrotizing pancreatitis is a frequent and potentially lethal disease, especially in case of infected pancreatic necrosis (IPN). IPN usually occurs after the first week of evolution.
- Trial name
- PANIC (NCT03234166)
- Testing
- Non interventional study
- Where
- 4 sites in France
- Volunteers
- 72 people
- Sponsor
- Nantes University Hospital
Pancreatitis, Acute Necrotizing
Videoendoscopic Drainage of Infected Pancreatic Collections
The VARD (Videoendoscopic Assisted Retroperitoneal Drainage) approach as treatment for necrotizing pancreatitis proposes an alternative to standard complicated open abdomen treatment methods.
- Trial name
- NCT00061269
- Testing
- Videoscopic-Assisted Retroperitoneal Debridement (VARD)
- Where
- 6 sites in United States, Canada
- Volunteers
- 40 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Acute Necrotizing Pancreatitis, Walled Off Necrosis
Plastic Stents vs. NAGI Bi-flanged Metal Stent for Endoscopic Ultrasound Guided Drainage of Walled-off Necrosis
Introduction: Walled off necrosis (WON) is defined as a well circumscribed pancreatic and/or peri pancreatic necrosis containing a variable amount of necrotic tissue.
- Trial name
- NCT04479228
- Testing
- Endosonography guided transmural drainage
- Volunteers
- 80 people
- Sponsor
- Asian Institute of Gastroenterology, India
Pancreatic Pseudocyst, Pancreatic Necrosis
EUS-guided Transenteric Drainage With a Novel Lumen-apposing Metal Stent
To evaluate clinical efficacy and safety of a novel lumen-apposing FCSEMS for EUS-guided transenteric drainage of PFC or of biliary tree including GB
- Conditions
- Pancreatic Pseudocyst, Pancreatic Necrosis, Biliary Obstruction, Acute Cholecystitis
- Trial name
- NCT03002051
- Testing
- EUS-guided drainage
- Where
- China
- Volunteers
- 114 people
- Sponsor
- Chinese University of Hong Kong
Pancreatitis,Acute Necrotizing
Randomized Trial of Immediate Endoscopic Necrosectomy vs. Step-up Endoscopic Interventions in Necrotizing Pancreatitis
This is a randomized trial comparing immediate endoscopic necrosectomy vs. step-up endoscopic interventions in patients with necrotizing pancreatitis.
- Trial name
- DESTIN (NCT05043415)
- Testing
- Immediate endoscopic necrosectomy, Step-up endoscopic interventions
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Orlando Health, Inc.
Pancreatitis,Acute Necrotizing
Multi-center Clinical Study of Early Antibios of Severe Acute Pancreatitis
Strategy of antibiotic therapy in SAP,De-escalate (cefoperazone+metronidazole) or Escalate (meropenem) therapy,which one is better.
- Trial name
- NCT01992198
- Testing
- cefoperazone + metronidazole, oral care by chlorhexidine gluconate, enteral nutrition
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Erzhen Chen
Pancreatitis, Acute Necrotizing
Thymosin Alpha 1 in the Prevention of Pancreatic Infection Following Acute Necrotizing Pancreatitis
Infected pancreatic necrosis and its related septic complications are the major cause of death in patients with acute pancreatitis, therefore prevention of pancreatic infection is of great clinical value in the treatment of AP.
- Trial name
- TRACE (NCT02473406)
- Testing
- Thymosin Alpha 1, normal saline
- Where
- 2 sites in China
- Volunteers
- 508 people
- Sponsor
- Weiqin Li
Acute Pancreatitis (AP), Acute Pancreatitis With Infected Necrosis
Comparison of MIPPED-C and Surgical Necrosectomy in Pancreatic Necrosis Outcomes
This study is a retrospective, single-center, pre-post controlled clinical study. Patients (n=48) who underwent the MIPPED-C surgical procedure after January 1, 2019 were designated as the treatment group.
- Trial name
- NCT07097753
- Where
- China
- Volunteers
- 144 people
- Sponsor
- Ruijin Hospital
Pancreatitis
Management of Pancreatitis: the Role of Supportive and Drainage Treatment
This study aims to investigate the natural clinical course, diagnostic possibilities and treatment modalities in moderately severe (MSAP) and severe acute pancreatitis (SAP).
- Trial name
- NCT02648815
- Testing
- Percutaneous catheter drainage, Abdominal paracentesis evacuation
- Volunteers
- 100 people
- Sponsor
- University Clinical Center Tuzla
Pancreatic Necrosis, Pancreatitis
Surgical vs Endoscopic Resection of Walled Off Pancreatic Necrosis Using the Powered Endoscopic Debridement System
Goal: The goal of this clinical trial is to compare the effectiveness and safety of two different but highly effective treatment approaches for walled-off necrosis (WON) resulting from severe acute pancreatitis.
- Trial name
- SERPENT (NCT06691919)
- Testing
- Direct Endoscopic Necrosectomy with Powered Endoscopic Debridement, Transgastric Surgical Necrosectomy
- Sponsor
- Stanford University
Pancreatitis,Acute Necrotizing, Pancreas Necrosis
Perform Necrotic Cavity Lavage or Not After Debridement of Infected Pancreatic Necrosis
The infected pancreatic necrosis (IPN) should be treated by debridement and drainage. In recent years, the results of clinical research show that minimally invasive debridement such as video-assisted (laparoscope, nephroscope…
- Trial name
- NCLAD (NCT04275466)
- Testing
- necrotic cavity lavage
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Xuanwu Hospital, Beijing
Necrotizing Pancreatitis
Organ Dysfunction Changes in Acute Necrotizing Pancreatitis Patients With Sepsis Following Open Necrosectomy
The purpose of this retrospective study was to characterize the changes in organ dysfunction among patients with acute necrotizing pancreatitis complicated by sepsis who underwent open necrosectomy.
- Trial name
- NCT07201246
- Testing
- Necrotizing Pancreatitis patients' organdysfunction progression
- Where
- China
- Volunteers
- 700 people
- Sponsor
- West China Hospital
Acute Necrotizing Pancreatitis, Infection
PancRea: Risk Factors and Outcomes of Infected Pancreatic Necrosis
Severe acute pancreatitis is a common reason for intensive care unit (ICU) admission and is associated with prolonged hospital stays and high morbidity and mortality rates.
- Conditions
- Acute Necrotizing Pancreatitis, Infection, Pancreatitis
- Trial name
- PancRea (NCT03253861)
- Testing
- No intervention
- Where
- France
- Volunteers
- 148 people
- Sponsor
- Nantes University Hospital
Acute Pancreatitis (AP)
Endoscopic Pancreatic Duct Stent Placement Versus Conventional Approach in the Treatment of Early Phase Acute Pancreatitis
The planned multicenter randomized study is aimed to assess the efficacy and safety of endoscopic pancreatic duct stenting in adult patients with acute pancreatitis.
- Trial name
- NCT07093996
- Testing
- Endoscopic pancreatic duct stent placement, Conventional treatment of acute pancreatitis in early phase
- Where
- 7 sites in China, Russia
- Volunteers
- 200 people
- Sponsor
- Almazov National Medical Research Centre