Clinical trials: Acute Post-surgical Pain
Post-operative Chronic Pain
Shifting Pain Modulation From Pro-to Anti-nociceptive
To create a data base that will facilitate the enrichment of the insights regarding post-operative pain development, and to identify those individuals with the potential to develop this kind of pain.
- Trial name
- NCT02672202
- Testing
- Duloxetine, Pregabalin
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Infectious Complications, Postoperative Pain
Early Postoperative Pain and 30-day Complications Following Major Abdominal Surgery: an Observational Study
In this retrospective cohort study, we assess the relationship between the intensity of early postoperative pain and the risk of infectious- and non-infectious complications within 30 days after major abdominal surgery.
- Conditions
- Infectious Complications, Postoperative Pain, Acute Pain, Postoperative Complications
- Trial name
- NCT05244655
- Where
- Netherlands
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Postoperative Pain, Acute, Postoperative Depression
REmotely-delivered Supportive Programs for Improving Surgical Pain and disTrEss
The purpose of this research study is to learn how two different supportive programs may help women feel better after surgery. This study will measure if one type of supportive program is more useful than the other for improving…
- Conditions
- Postoperative Pain, Acute, Postoperative Depression, Anxiety, Sleep Disturbance
- Trial name
- NCT05625360
- Testing
- eHealth Mindful Movement and Breathing, Life Impacts Reflection, PROMIS Questionnaires
- Where
- 2 sites in United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Acute Post Operative Pain
Postoperative Analgesic Comparison of SPSI Block and SAP Block in Video-Assisted Thoracoscopic Surgery (VATS)
In our study, we primarily aimed to compare the postoperative analgesic effectiveness of the Serratus Posterior Superior Intercostal Plane Block and the Serratus Anterior Plane Block, both routinely applied in patients undergoing…
- Trial name
- NCT06778642
- Testing
- Serratus Posterior Superior Intercostal Plane Block, Serratus Anterior Plane Block
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Uludag University
Acute Post-operative Pain
Ibuprofen Use on Post-operative Pain Following Cholecystectomy
In this study, the investigators compared the effects of IV forms of ibuprofen and acetaminophen on pain perception and opioid consumption following laparoscopic cholecystectomy.
- Trial name
- NCT06478758
- Testing
- Ibuprofen 400 mg, Acetaminophen 100 MG/ML
- Where
- Turkey (Türkiye)
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Giresun University
Circadian Rhythm, Postoperative Pain
The Effect of Circadian Rhytm on Postoperative Pain Undergoing Pediatric Surgery
These circadian rhythms are self-sustained, endogenous oscillations generated by circadian clocks that persist with a period of around 24 -h under constant conditions.
- Trial name
- NCT05379192
- Testing
- Group 1, Group 2, Group 3, Group 4
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Faruk Cicekci
Acute Postoperative Pain
Safety, Tolerability, Pharmacokinetic and Pharmacodynamic Profile of HYR-PB21 in Healthy Volunteers
This study is the first time into human study (FTIH) for HYR-PB21 for injection. The study will evaluate the safety, pharmacokinetics (PK) and pharmacodynamics (PD) of single ascending and single subcutaneous dose of HYR-PB21 for…
- Trial name
- NCT04169256
- Testing
- HYR-PB21, Liposomal bupivacaine, Normal Saline
- Where
- Australia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Fruithy Medical Pty Ltd
Breast Cancer, Mastectomy
Preoperative Regional Nerve Block for Acute and Chronic Post-Operative Pain Following Mastectomy
The purpose of this study is to see if pre-operative regional nerve blocks compared to a placebo nerve block can decrease chronic post mastectomy pain, immediate postoperative pain and postoperative narcotic consumption.
- Conditions
- Breast Cancer, Mastectomy, Anesthesia, Local, Narcotic Use
- Trial name
- RELIEF (NCT04019834)
- Testing
- regional nerve block with local anesthesia of bupivacaine with steroid
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Postoperative Pain, Acute
Effectiveness of Fentanyl-Added TAP Block in Laparoscopic Cholecystectomy
The aim of this study is to evaluate the effectiveness of adding fentanyl to the TAP block in laparoscopic cholecystectomy cases.
- Trial name
- NCT06778668
- Testing
- TAP block with bupivacaine only, TAP block with bupivacaine and fentanyl
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Uludag University
Post Operative Pain, Acute
Effect of Preoperative Oral Pregabalin Versus Intraoperative Fentanyl on Postoperative Analgesia
Pregabalin is a structural analogue of gamma amino butyric acid (GABA). It binds to presynaptic alpha-2-delta subunit of voltage gated calcium channels in the brain and the spinal cord.
- Trial name
- NCT05150795
- Testing
- Pregabalin 150mg, Fentanyl 100 micrograms ampoule
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Pain, Acute Postoperative
Comparison Of Outcome Of Wound Closure After Thyroid Surgery With And Without Platysma Suturing
Comparison Of Outcome Of Wound Closure After Thyroid Surgery With And Without Platysma Suturing in terms of wound scar and pain.
- Trial name
- NCT06485011
- Testing
- Paltysma suturing, Without Platysma suturing
- Where
- Pakistan
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Children Hospital and Institute of Child Health, Lahore
Acute Pain, Postoperative Pain, Acute
REctus Sheath Trial
Regional anesthesia techniques (or nerve blocks) are used to provide sensory blockade over the abdominal wall. The most established technique is thoracic epidural.
- Trial name
- REST (NCT07068243)
- Testing
- 1.0% lidocaine with epinephrine (1:100,000)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Duke University
Pain, Post-operative, Third Molar
Controlled Trial to Determine Most Effective Post-Operative Analgesia After Third Molar Extraction
This is a prospective randomized clinical trial that will investigate which post-operative medications in conjunction with a multimodal analgesia approach can most effectively control post-operative pain and reduce opioid…
- Conditions
- Pain, Post-operative, Third Molar, Oral Surgery, Pain, Acute
- Trial name
- NCT06484439
- Testing
- Ketorolac, Oxycodone, Acetaminophen
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Appendectomy, Pain, Postoperative
Comparison of Outcomes After Laparoscopic Versus Open Appendectomy in Acute Appendicitis
A comparison study was performed between laparoscopic appendectomy and open appendectomy in acute setting in tertiary hospital to access the outcome of postoperative pain and hospital stay.
- Conditions
- Appendectomy, Pain, Postoperative, Length of Stay
- Trial name
- NCT03947372
- Testing
- Appendectomy
- Where
- Pakistan
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Services Hospital, Lahore
Pain Postoperative, Analgesia
Phase II, Randomized, Double-blind, Placebo-controlled Clinical Trial to Evaluate the Efficacy and Safety of Omega-3 Fatty Acids as an Adjunct to Morphine in Acute Postoperative Pain
This is a single-center, randomized, double-blind, placebo-controlled, parallel-group proof-of-concept study to evaluate the analgesic efficacy and safety of omega-3 fatty acids as an adjunct to morphine for acute postoperative…
- Trial name
- O3MORPH (NCT07657468)
- Testing
- Omega-3 fatty acids + Morphine group
- Where
- Argentina
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National University of La Rioja
Post Operative Pain, Acute, Renal Transplant Donor of Left Kidney
Effectiveness of Thread Embedding Acupuncture Analgesia at the EX-B2 Point Combined With Standard Therapy After Laparoscopic Living Donor Nephrectomy
Kidney transplantation is the main option besides hemodialysis and continuous ambulatory peritoneal dialysis (CAPD) to prolong and improve the quality of life for patients with end-stage renal disease.
- Conditions
- Post Operative Pain, Acute, Renal Transplant Donor of Left Kidney, Quality of Life, Acupuncture Analgesia
- Trial name
- NCT06197620
- Testing
- Thread embedding acupuncture and standard therapy
- Where
- Indonesia
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Acute, Post-operative Pain
Single Ascending Dose Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of ST-2427
This randomized, double-blind, placebo controlled, study will be conducted to evaluate the safety, tolerability, and pharmacokinetics of ST-2427.
- Trial name
- NCT04475198
- Testing
- ST-2427
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- SiteOne Therapeutics, Inc.
Anesthetics, Local Anesthetics
Lidocaine Versus ESP - After Bariatric Surgery
The Erector Spinal Block (ESP) is based on the deposition of the local anesthetic in the inter-fascial space between the dorsal extensor muscle and the intercostal muscles at the height of the transverse processes.
- Trial name
- NCT05700214
- Testing
- Ropivacaine injection, Lidocaine IV
- Where
- Poland
- Volunteers
- 279 people, healthy volunteers welcome
- Sponsor
- Jagiellonian University
Pain
Multimodal Analgesia Utilization and Acute Postoperative Pain After Major Surgery at Mulago National Referral Hospital
The goal of this observational study is to understand the approach to pain management before, during, and after surgery at Mulago National Referral Hospital. It is focussed on adult patients undergoing major surgery.
- Trial name
- NCT06887153
- Where
- Uganda
- Volunteers
- 449 people, healthy volunteers welcome
- Sponsor
- Makerere University
Surgical Procedure, Unspecified, Pain, Postoperative
Experimental Pain Reporting Accuracy and Clinical Post-operative Pain
Pain is a subjective experience that differs in intensity from one person to another. Appropriate medical care relies on an accurate assessment of the patients' condition.
- Conditions
- Surgical Procedure, Unspecified, Pain, Postoperative, Ear, Nose, and Throat (ENT) Disease
- Trial name
- NCT03854669
- Testing
- pain reporting accuracy
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Carmel Medical Center