Clinical trials: Acute Post-surgical Pain
Infusion, Dexmedetomidine
Infusion of Dexmedetomidine Versus Lidocaine in Management of Acute Postoperative Pain After Modified Radical Mastectomy
This study aims to compare the effect of intraoperative intravenous infusion of dexmedetomidine and lidocaine in the management of acute postoperative pain after mastectomy.
- Conditions
- Infusion, Dexmedetomidine, Lidocaine, Acute
- Trial name
- NCT06974656
- Testing
- Dexmedetomidine, Lidocaine
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Breast Cancer, Mastectomy
Music Intervention for Preoperative Anxiety and Acute Pain Among Mastectomy Patients
Anxiety is a common thing that patients experience when they are preparing to have a surgery. When this anxiety is not properly treated, the patients tend to consume more drugs in the operating room and it also cause their pain…
- Conditions
- Breast Cancer, Mastectomy, Pain, Postoperative
- Trial name
- NCT04824183
- Testing
- Music intervention
- Where
- 3 sites in Malawi, Nigeria
- Volunteers
- 36 people
- Sponsor
- Chinese University of Hong Kong
Acute Pain, Opioid Analgesic Adverse Reaction
the Efficacy and Safety of Oliceridine Fumarate Injection for Acute Pain After Abdominal Surgery
The goal of this clinical trial is to learn if Oliceridine fumarate injection works to treat acute pain after abdominal surgery. It will also learn about the safety of Oliceridine fumarate injection.
- Trial name
- NCT06530563
- Testing
- Oliceridine Injection [Olinvyk], Sufentanil Citrate
- Where
- China
- Volunteers
- 606 people
- Sponsor
- Xiangya Hospital of Central South University
Acute Pain Management, Analgesic, Nonopioid
A Pilot Clinical Trial of Oral Ketamine for Acute Pain Management After Amputation Surgery
The purpose of this pilot study is to test the safety of oral ketamine to treat acute pain after amputation surgery. The objective of the proposed research is to conclusively determine if oral ketamine is a safe alternative…
- Conditions
- Acute Pain Management, Analgesic, Nonopioid, Amputation of Lower Extremity, All Causes
- Trial name
- NCT02341963
- Testing
- Oral Ketamine
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Rush University Medical Center
Tonsillectomy, Pharyngoplasty
Suzetrigine in Tonsillectomy for Opioid-sparing Pain Management
The goal of this clinical trial is to learn if a non-opioid pain medicine called suzetrigine can lower how much opioid pain medicine adults need after tonsil surgery (tonsillectomy) or a similar throat surgery.
- Conditions
- Tonsillectomy, Pharyngoplasty, Suzetrigine, Opioid
- Trial name
- STOP (NCT07821931)
- Testing
- Suzetrigine, Acetaminophen, oxycodone
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Stanford University
Postoperative Pain, Acute, Hemodynamics
Nalbuphine Timing Effects on Hemodynamics and Analgesia in Elderly Patients
In total knee arthroplasty (TKA), the use of a tourniquet and controlled hypotension is common. However, ischemia-reperfusion injury induced by the tourniquet and inappropriate controlled hypotension can lead to cardiac and…
- Conditions
- Postoperative Pain, Acute, Hemodynamics, Total Knee Arthroplasty (TKA)
- Trial name
- TKA (NCT07271849)
- Testing
- Nalbuphine Hydrochloride injection was administered during anesthesia induction., Nalbuphine Hydrochloride injection was administered after cement implantation., Standard general anesthesia regimen ( nalbuphine was not administered throughout the entire anesthesia process.)
- Where
- China
- Volunteers
- 162 people
- Sponsor
- Qianfoshan Hospital
Pain, Postoperative, Pain, Acute
Comparison of Quadratus Lumborum Intramuscular and Transmuscular in Postoperative Pain
Acute pain is reported in approximately 80% of patients undergoing postoperative care for various types of surgical procedures in the United States.
- Conditions
- Pain, Postoperative, Pain, Acute, Cesarean Section Complications
- Trial name
- NCT05005871
- Testing
- Quadratus lumborum block after C-section surgery as postoperative pain management
- Where
- Indonesia
- Volunteers
- 48 people
- Sponsor
- Udayana University
Postoperative Nausea and Vomiting, Postoperative Pain, Acute
The Correlation Between Intraoperative End Tidal Carbon Dioxide, Perfusion Index and Pulse Variability Index on Postoperative Nausea Vomiting and Pain
Postoperative pain, which is frequently encountered in laparoscopic operations, has been examined in different studies with end tidal CO2 (end tidal carbon dioxide), total insufflated gas amount and PI (Perfusion index)…
- Conditions
- Postoperative Nausea and Vomiting, Postoperative Pain, Acute, End Tidal Carbon Dioxide, Perfusion Index and Pleth Variability Index
- Trial name
- NCT06865378
- Testing
- Carbon dioxide (CO2) gas insufflation
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Naime Yalçın
Pain, Postoperative, Pain, Acute
Opioid-free Anesthesia in Laparoscopic Cholecystectomies
The aim of this study will be to investigate the effect of an opioid-free anesthesia regimen with a mixture of dexmedetomidine-lidocaine-ketamine in the same syringe versus fentanyl analgesia in elective laparoscopic…
- Conditions
- Pain, Postoperative, Pain, Acute, Pain, Chronic, Cholecystectomy
- Trial name
- NCT05089526
- Testing
- ketamine-lidocaine-dexmedetomidine, fentanyl
- Where
- Greece
- Volunteers
- 70 people
- Sponsor
- Aretaieion University Hospital
Pain, Postoperative Pain
Dose-Response Study of MR-107A-01 in The Treatment of Post-Surgical Dental Pain
MR-107A-01 is being studied to investigate its efficacy, safety, and dose-response after dental surgery.
- Conditions
- Pain, Postoperative Pain, Pain, Acute
- Trial name
- NCT04571515
- Testing
- MR-107A-01
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Mylan Inc.
Post Operative Pain, Urolithiasis
Intra-nasal Ketorolac for Acute Ureteral Stent-associated Pain Following Ureteroscopy for Stone Disease
Objective: To improve quality-of-life and health care delivery to patients receiving ureteral stents. Specific Aims: Evaluate the feasibility, practicality, and qualitative outcomes of utilizing intra-nasal ketorolac in patients…
- Conditions
- Post Operative Pain, Urolithiasis, Ureter Calculi, Stent Complication
- Trial name
- NCT06158620
- Testing
- intra-nasal ketorolac, oral diclofenac
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Texas Southwestern Medical Center
Arthroplasty
A Study to Evaluate the Effectiveness and Safety of Tapentadol(CG5503) in the Treatment of Acute Pain After Hip Replacement Surgery Compared With Oxycodone and Placebo Followed by a Voluntary Open-Label Extension For Safety
The purpose of this study is to test in patients who have had hip replacement surgery the effectiveness (level of pain control) and the safety of 3 different dose levels of CG5503 compared with placebo and with 10-mg oxycodone…
- Trial name
- NCT00364533
- Testing
- Tapentadol IR (CG5503), Oxycodone HCL IR
- Where
- 77 sites in United States, Belgium and 6 more
- Volunteers
- 367 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Acute Pain
Preventive Treatment of Pain After Dental Implant Surgery
The objective of this prospective randomized double-blind study was to evaluate the effects of the preoperative administration of dexketoprofen trometamol (DKT) on the pain perceived by patients after oral surgery for implant…
- Trial name
- UMU (NCT03107338)
- Testing
- DEXKETOPROFEN TROMETAMOL
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universidad de Murcia
Postoperative Pain
Paravertebral Block Versus Erector Spinae Plane Block for Analgesia in Modified Radical Mastectomy
The study is planned to be a single-center randomized, prospective double-blind study and includes patients who planned to be done unilateral MRM (modified radical mastectomy) operation in Istanbul University Istanbul Faculty of…
- Trial name
- NCT05080985
- Testing
- TPVB, ESPB, Bupivacain
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people
- Sponsor
- Istanbul University
Pain, Acute
Optimal Timing of Parasternal Intercostal Nerve Block Application for Acute Pain Management in Cardiac Surgery
Patients experiencing pain after undergoing cardiac surgery may also experience prolonged immobilization, insufficient respiratory functions, and the inability to cough due to median sternotomy.
- Trial name
- NCT05363540
- Testing
- pre-incisional parasternal intercostal block, post-incisional parasternal intercostal block
- Where
- Egypt
- Volunteers
- 51 people
- Sponsor
- Benha University
Cholecystitis/Cholelithiasis
Effects of Intravenous Ibuprofen on Acute Pain After Laparoscopic Cholecystectomy
This clinical trial is a medical intervention study to evaluate the necessity and effectiveness of intravenous ibupropan for postoperative acute pain relief after laparoscopic cholecystectomy in benign gallbladder disease.
- Trial name
- NCT05676892
- Testing
- Laparoscopic cholecystectomy
- Where
- South Korea
- Volunteers
- 140 people
- Sponsor
- Seoul St. Mary's Hospital
Postoperative Pain, Acute
Percutaneous Auricular Neuromodulation for Postoperative Analgesia
The moderate-to-severe pain many patients experience following surgery is often treated with opioids, which are associated with side effects such as nausea/vomiting, sedation, and respiratory depression (and a risk of abuse…
- Trial name
- NCT05521516
- Testing
- Active Percutaneous Auricular Neuromodulation with NSS-2 Bridge
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- University of California, San Diego
Pain, Postoperative, Preemptive Peripheral Nerve Block
Preemptive Analgesic Effects of Popliteal Sciatic Nerve Block in Patients With Bilateral Hallux Valgus Surgery
The purpose of this study was to investigate the preemptive effect of ultrasound guided popliteal scistic nerve block on postoperative acute pain in patients with bilateral hallux valgus.
- Conditions
- Pain, Postoperative, Preemptive Peripheral Nerve Block, Acute Pain
- Trial name
- NCT03414593
- Testing
- Ultrasound guided popliteal sciatic nerve block with 0.2% ropivcaine
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Asan Medical Center
Pain
From ACute To Chronic Postoperative Shoulder Pain in Patients for Elective Lobectomy
Shoulder pain is a well known problem after thoracical surgery. The pathogenesis of the pain is uncertain, but mainly a mix of referred pain and mechanical strain to the shoulder. It is believed to last a few days.
- Trial name
- FACTS2 (NCT01552746)
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Odense University Hospital
Acute Pain
Effect of Rectus Sheath Block on Diaphragmatic Function After Elective Upper Abdominal Surgery
This study will be undertaken to investigate the respiratory and analgesic effects of ultrasound guided rectus sheath block analgesia after elective abdominal surgery with midline incision.
- Trial name
- Rectus (NCT03725527)
- Testing
- Rectus Sheath Block
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University