Clinical trials: Acute Post-surgical Pain
Transversus Abdominis Plane (TAP) Block
Postoperative Pain Difference for 'IV Paracetamol' and TAP Block' in Acute Cholecystitis
Patients with acute cholecystitis or pancreatitis due to gallstones benefit from emergency laparoscopic cholecystectomy (LC). Patients with emergency LC show improvement in their quality of life within one month compared to those…
- Trial name
- NCT04767542
- Testing
- Intravenous Infusion, Local anesthesia
- Volunteers
- 42 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Postoperative Pain
Virtual Reality in Postoperative Acute Pain Management in Thoracic Surgery
This randomized controlled study is to investigate the effectiveness of VR headsets in reducing postoperative pain intensity among patients after having undergone thoracic surgical procedures.
- Trial name
- VRThx (NCT06097520)
- Testing
- VR Intervention
- Where
- Switzerland
- Volunteers
- 39 people
- Sponsor
- University Hospital, Basel, Switzerland
Hip Arthropathy, Postoperative Pain, Acute
Pericapsular Nerve Group Block (PENG) for Hip Surgery
This will be a randomized comparison of pericapsular nerve group (PENG) blocks with bupivacaine and a placebo control (PENG blocks with normal saline).
- Conditions
- Hip Arthropathy, Postoperative Pain, Acute, Pain, Postoperative
- Trial name
- NCT05118620
- Testing
- Active bupivacaine 0.375% PENG block
- Where
- United States
- Sponsor
- University of California, San Diego
Postoperative Pain, Acute
The Effect of Preemptive Pregabalin on Postoperative Pain and Respiratory Dynamics in Robotic Prostatectomy Operation.
The study aimed to investigate the impact of preemptive pregabalin on the postoperative pain severity and the requirement of analgesic drugs in patients undergoing robotic radical prostatectomy surgery as primary outcome.
- Trial name
- NCT06170359
- Testing
- robotic surgery under general anaesthesia
- Volunteers
- 90 people
- Sponsor
- Umraniye Education and Research Hospital
Postoperative Pain, Kidney Transplant; Complications
Thread Embedding Acupuncture vs Sham on Acute Pain and Quality of Life After Laparoscopic Nephrectomy of Living Donor
This randomized, double-blind controlled study aims to evaluate the effectiveness of thread implantation acupuncture at EX-B2 L1 in reducing postoperative pain and improving quality of life in patients undergoing laparoscopic…
- Trial name
- NCT07243301
- Testing
- Thread implantation acupuncture
- Where
- Indonesia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Postoperative Pain
Risk Factors and a Predictive Nomogram for Acute Moderate-to-severe Postoperative Pain After Achilles Tendon Surgery
This is a single-center retrospective cohort study to identify independent risk factors and develop a predictive nomogram for moderate-to-severe pain within 24 hours after Achilles tendon surgery.
- Trial name
- NCT07558512
- Testing
- No Study-Specific Intervention
- Where
- China
- Volunteers
- 489 people
- Sponsor
- Min Li
Postoperative Care
Efficacy of Liposomal Bupivacaine Scalp Nerve Block for Postoperative Pain Management After Supratentorial Craniotomy
This is a prospective, randomized, controlled trial conducted at Beijing Tiantan Hospital to evaluate the efficacy and safety of liposomal bupivacaine for scalp nerve block in managing postoperative pain after elective…
- Trial name
- NCT07344181
- Testing
- Preoperative scalp nerve block
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Beijing Tiantan Hospital
Hallux Valgus
A Study to Evaluate the Effectiveness and Safety of Tapentadol (CG5503) in the Treatment of Acute Pain From Bunionectomy Compared With Placebo
The purpose of this study is to evaluate the analgesic efficacy and safety of tapentadol immediate-release (IR [CG5503]) for use in the relief of moderate to severe acute pain, compared with placebo, in adult Taiwanese patients…
- Trial name
- NCT01813890
- Testing
- Tapentadol IR 50 mg, Tapentadol IR 75 mg
- Where
- 3 sites in Taiwan
- Volunteers
- 60 people
- Sponsor
- Janssen-Cilag International NV
Acute Pain, Post Operative Analgesia
Analgesic Efficacy of Combined PECS II and PIP Block Versus Thoracic Paravertebral Block Post-Mastectomy
Postoperative pain management is crucial for patients undergoing mastectomy for breast cancer. Regional analgesia techniques, such as the Thoracic Paravertebral Block (TPVB), are commonly used to reduce pain and opioid…
- Conditions
- Acute Pain, Post Operative Analgesia, Post Operative Pain, Acute, Breast Cancer
- Trial name
- PECS-TPVB (NCT07738770)
- Testing
- Combined PECS II and Superficial PIP Block, Thoracic paravertebral block (TPVB)
- Where
- Indonesia
- Volunteers
- 72 people
- Sponsor
- Dharmais National Cancer Center Hospital
Post Operative Pain, Pain, Acute
Post-thoracotomy Pain Management With Active External Warming and Ice Application
The aim of study is to investigate the effects of active external warming of patient concurrently with application of ice to incision site on thoracotomy pain and analgesic consumption.
- Conditions
- Post Operative Pain, Pain, Acute, Thoracic Injury
- Trial name
- NCT05299788
- Testing
- Active external warming, Ice application
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Akdeniz University
Microbial Substitution, Tryptophan Metabolism Alterations
Impact of Gut Microbiota and Tryptophan Metabolites on Acute Pain in Lumbar Disc Herniation Surgery Patients
It is well-established that the gut microbiota plays a crucial role in various pain mechanisms, including visceral pain, inflammatory pain, headache, neuropathic pain, and opioid tolerance.
- Conditions
- Microbial Substitution, Tryptophan Metabolism Alterations, Postoperative Pain, Acute
- Trial name
- NCT06502223
- Testing
- Pain Perception in Patients Undergoing Lumbar Disc Herniation Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 37 people
- Sponsor
- Dokuz Eylul University
Other Acute Postoperative Pain
Study of Indomethacin Capsules to Treat Pain Following Bunionectomy
The purpose of this study is to determine whether Indomethacin [Test] Capsules are safe and effective for the treatment of postoperative bunionectomy pain.
- Trial name
- NCT01626118
- Testing
- Indomethacin
- Where
- 4 sites in United States
- Volunteers
- 373 people
- Sponsor
- Iroko Pharmaceuticals, LLC
Hysterectomy, Postoperative
A Study to Evaluate the Efficacy and Safety of Tapentadol (CG5503) in the Treatment of Acute Pain After Abdominal Hysterectomy
The main objective of this study is to demonstrate the efficacy and safety of multiple-dose application of three different oral doses of CG5503 IR (tapentadol immediate release) compared to placebo in women undergoing abdominal…
- Trial name
- NCT00478023
- Testing
- Morphine, CG5503 IR
- Where
- 52 sites in Hungary, Latvia and 7 more
- Volunteers
- 854 people
- Sponsor
- Grünenthal GmbH
Pain, Postoperative, Pain Syndrome
Bilateral Erector Spinae Plane Block (ESPB) in Laparoscopic Cholecystectomies
The aim of the trial is to study the efficacy of bilateral Erector Spinae Plane Block (ESPB) in managing perioperative pain in patients who undergo elective laparoscopic cholecystectomy
- Conditions
- Pain, Postoperative, Pain Syndrome, Pain, Acute, Anesthesia
- Trial name
- NCT04587973
- Testing
- Group Dexmedetomidine, Group Ropivacaine, Group Control
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Aretaieion University Hospital
Postoperative Pain After Thoracic Surgery, Postoperative Pain
Comparison of IV Analgesia Protocols After the Regional Block's Effect Diminishes in Thoracic Surgery
The purpose of this study is to compare the effectiveness of three different intravenous (IV) patient-controlled analgesia (PCA) regimens-Fentanyl, Tramadol, and Ibuprofen-in managing postoperative pain and respiratory…
- Conditions
- Postoperative Pain After Thoracic Surgery, Postoperative Pain, Thoracic Surgery, Video Assisted, Patient Controlled Analgesia
- Trial name
- NCT07610408
- Testing
- Fentanyl IV PCA, Tramadol IV PCA, Ibuprofen IV PCA
- Where
- Turkey (Türkiye)
- Volunteers
- 135 people
- Sponsor
- Ankara Etlik City Hospital
Chest Pain, Surgery
Assessment of Intercostal Block Scheduling in Preventing Acute Surgical and Post-surgical Pain in Thoracoscopic Surgery
It is well known that chest surgery patients suffer from high level pain in the perioperative period. The transition to thoracoscopic approaches reduced surgical pain.
- Trial name
- NCT02469610
- Testing
- Intercostal block Bupivacaine based
- Where
- Israel
- Volunteers
- 65 people
- Sponsor
- Carmel Medical Center
Acute Pain
A Study of TRV130 for the Treatment of Pain After Bunionectomy
The primary objective is to evaluate the analgesic efficacy of IV TRV130 compared with placebo in patients with acute postoperative pain after bunionectomy.
- Trial name
- NCT02100748
- Testing
- TRV130, Morphine
- Where
- 4 sites in United States
- Volunteers
- 333 people
- Sponsor
- Trevena Inc.
Pain, Acute
Tap Block vs Peritoneal Infiltration After Major Gynecological Surgeries
It is a randomized controlled trial to determine the total tramadol consumption after major gynecological studies. Intervention groups include TAP block or local infiltration by the surgeon.
- Trial name
- NCT04037878
- Testing
- Transversus Abdominis Plane Block(TAP Block), Intra-peritoneal infiltration, PCIA Tramadol
- Where
- Pakistan
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Paravertebral Peripheral Nerve Block, Acute Pain Management
Ultrasound-Assisted Paravertebral Block v. Traditional Paravertebral Block For Pain Control
The overall purpose of this research study is to compare the effectiveness of ultrasound assisted paravertebral block placement versus traditional "blind" technique for postoperative analgesia following thoracotomy or visually…
- Trial name
- NCT01949480
- Testing
- Thoracotomy, Video-Assisted Thoracoscopic Surgery (VATS)
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- University of Pittsburgh
Pain, Postoperative, Pain, Acute
Opioid Sparing Anesthesia in Cervical Spine Surgery
The aim of this double blind randomized study will be to investigate the effect of an opioid-free anesthesia regimen with a mixture of lidocaine and ketamine in the same syringe versus remifentanyl analgesia in cervical spine…
- Conditions
- Pain, Postoperative, Pain, Acute, Pain, Chronic, Pain, Nociceptive
- Trial name
- NCT05717361
- Testing
- ketamine-lidocaine, Remifentanil
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Evangelismos Hospital