Clinical trials: Acute Post-surgical Pain
Anxiety, Postoperative Pain
Developing a Virtual Reality (VR)-Based Prototype for Perioperative Care - a Proof of Concept Study
Preoperative anxiety and acute post-operative pain are common and have been associated with the development of chronic post-surgical pain and longer hospitalisation.
- Conditions
- Anxiety, Postoperative Pain, Pain, Acute
- Trial name
- NCT05564013
- Testing
- Virtual reality
- Where
- 2 sites in Singapore
- Volunteers
- 160 people
- Sponsor
- Changi General Hospital
Pain
Remote Ischemic PreConditioning Effect on Postsurgical Pain
Remote Ischemic PreConditioning (RIPC) will improve the postoperative pain experience in patients undergoing abdominal surgery. Although abdominal surgery can be a lifesaving procedure many people have a significant amount of…
- Trial name
- RIPCEPP (NCT01383317)
- Testing
- Thigh Tourniquet (VBM Single Use Tourniquet Cuff Items 20-34-722SLZ-1)
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Wake Forest University Health Sciences
Pain, Postoperative
The Interest of the Xylocaine® and Ketamine on the Management of Acute and Chronic Ain After Colectomy by Laparoscopy
Recent clinical studies in abdominal surgery have shown that the use of Xylocaine® parenterally intraoperative at plasma concentrations below the toxic threshold of 5 .mu.g / ml, had an analgesic effect and decreased…
- Trial name
- KETALIDO (NCT02969733)
- Testing
- Xylocaine, Ketamine, isotonic saline serum intravenous administration
- Where
- France
- Volunteers
- 135 people
- Sponsor
- University Hospital, Lille
Acute Pain
Bunionectomy Study (0000-063)
We are interested in whether bunionectomy can be used as a model to study the treatment of acute pain. It has been used to study the effect of Non-Steroidal Anti-inflammatory (NSAIDS) medications (such as ibuprofen) and other…
- Trial name
- NCT00601458
- Testing
- pregabalin, naproxen sodium
- Volunteers
- 100 people
- Sponsor
- Merck Sharp & Dohme LLC
Cesarean Section, Pain, Postoperative
Regional Analgesia After Cesarean Section
All patients will be anaesthetized with spinal technique. Each patient will be treated with intravenous morphine - patient controlled analgesia (PCA).
- Conditions
- Cesarean Section, Pain, Postoperative, Pain, Neuropathic
- Trial name
- NCT03244540
- Testing
- TAP (transversus abdominis plane block), QLB (quadratus lumborum block), Stimuplex Ultra 360 needle
- Where
- 2 sites in Poland
- Volunteers
- 105 people
- Sponsor
- Medical University of Lublin
Acute Postoperative Pain
Cryoneurolysis for Acute Postoperative Pain Following Total Knee Arthroplasty
Cryoneurolysis is a regional anaesthetic technique that works by freezing peripheral sensory nerves. This technique can potentially provide analgesia after total knee arthroplasty (TKA).
- Trial name
- CRISPP (NCT06088602)
- Testing
- Cryoneurolysis
- Where
- Denmark
- Volunteers
- 44 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Cervical, Erector Spinae Plane Block
Cervical Erector Spinae Plane Block vs Cervical Plexus Block in Controlling Acute Postoperative Pain After Thyroidectomy
This study aims to compare the efficacy and safety of cervical erector spinae plane block vs. cervical plexus block in controlling acute postoperative pain after thyroidectomy.
- Conditions
- Cervical, Erector Spinae Plane Block, Cervical Plexus Block, Postoperative Pain
- Trial name
- NCT06974630
- Testing
- Cervical erector spinae plane block, Cervical plexus block
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Pain, Acute Post-Operative, Dexmedetomidine
Esmolol Versus Dexmedetomidine for Opioid-sparing in Laparoscopic Gynecological Surgery
The aim of this study is to investigate and compare the effects of a continuous infusion of low-dose esmolol and dexmedetomidine versus placebo on intraoperative and postoperative opioid consumption and analgesic efficacy in…
- Conditions
- Pain, Acute Post-Operative, Dexmedetomidine, Analgesia, Esmolol
- Trial name
- NCT07846722
- Testing
- Esmolol hydrochloride, Dexmedetomidine, Normal (0.9%) saline
- Where
- Greece
- Volunteers
- 90 people
- Sponsor
- Vasiliki Samartzi
Post-operation Pain
A Feasibility Dose-escalating Study of MDT-10013 for Acute Postoperative Pain Following Total Knee Arthroplasty
This is an open-label dose-escalating study to evaluate the tolerability and systemic exposure of MDT-10013 in men and women at least 18 years of age who are undergoing primary unilateral TKA.
- Trial name
- NCT02263222
- Testing
- MDT-10013
- Where
- 3 sites in United States
- Sponsor
- Medtronic Spinal and Biologics
Acute Post Operative Pain, Third Molar Extraction Surgery
A Phase 1 Study of ARC-001 in Participants Undergoing Third Molar Extraction
The study will test the investigational product gel against placebo (which contains no active ingredient) to determine if it is safe after wisdom tooth extraction. The main questions the study will answer are: 1.
- Trial name
- NCT06864884
- Testing
- ARC-001
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Arcato Laboratories, Inc.
Ankle Surgery
High Ankle Block Versus Regional Block for Acute Pain Control After Ankle Surgery
Researchers are trying to determine if a high ankle block during ankle surgery provides the same pain relief as the standard regional block.
- Trial name
- NCT03894098
- Testing
- Nerve block
- Where
- United States
- Sponsor
- Mayo Clinic
Postoperative Pain, Chest Pain
Transversus Thoracis Muscle Plane Block for Postoperative Pain in Adult Cardiac Surgery
Inadequate pain control after coronary artery bypass graft surgery increases mortality and results in a higher incidence of persistent poststernotomy pain syndrome.
- Conditions
- Postoperative Pain, Chest Pain, Coronary Artery Bypass, Sternotomy
- Trial name
- NCT04591119
- Testing
- Transversus Thoracic Muscle Plane Block, Parasternal Intercostal Plane Block
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Muğla Sıtkı Koçman University
Breast Cancer, Postoperative Pain
Prediction of Pain After Breast Cancer Surgery With EEG
1. Rationale The inter-individual pain experience immediately after surgery is considerable. In addition, a number of patients develop chronic post surgery pain (CPSP).
- Conditions
- Breast Cancer, Postoperative Pain, Chronic Pain
- Trial name
- NCT01392248
- Where
- Netherlands
- Volunteers
- 4 people
- Sponsor
- Maastricht University Medical Center
Dental Pain
Evaluation of the Efficacy and Safety of Diclofenac HPBCD 25, 50 mg/ml in the Treatment of Post-surgical Pain Following Dental Surgery
The present study is proposed to evaluate the efficacy and safety of single doses of Diclofenac HPBCD subcutaneous (s.c.) (25 mg/1 ml and 50 mg/1 ml) in the treatment of acute moderate-to-severe pain after dental impaction…
- Trial name
- NCT00942448
- Testing
- Diclofenac HPBCD
- Where
- 6 sites in Poland, United Kingdom
- Volunteers
- 306 people
- Sponsor
- IBSA Institut Biochimique SA
Acute Postoperative Pain, Chronic Postoperative Pain
Femoral and Epidural Block After Total Knee Arthroplasty
Total knee prosthetic replacement causes severe postoperative pain. Various analgesic techniques have been used in pain control.
- Trial name
- NCT02115945
- Testing
- DN4 test, The SF 12 test, HAD scale
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Breast Surgery
ER-One: A Double-blind Trial of Erector Spinae Block (ESP) Versus Paravertebral Block (PVB) Before Breast Cancer Surgery
The block (ESP or PVB) will be performed preoperatively in the recovery room under standard monitoring. After setting a peripheral venous access, patient will be installed on lateral decubitus position on the opposite side of the…
- Trial name
- ER-One (NCT04827030)
- Testing
- Ropivacaïne Hydrochloride by Erector Spinae block, Ropivacaïne Hydrochloride by Paravertebral block
- Where
- 5 sites in France
- Volunteers
- 292 people
- Sponsor
- Institut Curie
Analgesia, Post Operative Pain
Clinical Utility of the Numerical Verbal Scale (NVS) and the Pain and Functional Activity Scale (PFAS) in the Management of Rescue Analgesia in Acute Postoperative Pain. Randomized Study.
Adequate postoperative pain management, along with mobilization and early oral nutrition, is the foundation for optimal recovery after surgery.
- Conditions
- Analgesia, Post Operative Pain, Acute Pain, Functional; Anesthesia
- Trial name
- EVN/EDAF (NCT07310953)
- Testing
- Group A: Rescue analgesia if NVS>4, Group B: Rescue analgesia if NVSm > 4 + FAS C
- Where
- Spain
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Fundacin Biomedica Galicia Sur
Kidney Transplantation, Anxiety
The Effects of Pre-operative Anxiety on Anesthetic Recovery and Post-operative Pain in Donor Nephrectomy
Kidney transplant is the most effective choice of treatment for patients with end-stage kidney failure in terms of quality of life and longevity. Today, 20-25% of kidney transplantations are implemented with living donors.
- Conditions
- Kidney Transplantation, Anxiety, Pain, Acute, Anesthesia Recovery Period
- Trial name
- NCT03131258
- Testing
- Donor Nephrectomy
- Volunteers
- 48 people
- Sponsor
- Ege University
Pain, Pain, Postoperative
Prediction and Characterization of Acute and Chronic Postoperative Pain
Despite enormous progress insufficient postoperative pain management remains a frequent problem in the early postoperative phase after surgery.
- Conditions
- Pain, Pain, Postoperative, Funnel Chest
- Trial name
- NCT01308385
- Testing
- Conditioned pain modulation
- Where
- Denmark
- Volunteers
- 52 people
- Sponsor
- University of Aarhus
Acute Appendicitis
Laparoscopic-Assisted TAP Block VErsus Trocar-site Infiltration After Laparoscopic Appendectomy
This randomized controlled trial compared laparoscopic-assisted transversus abdominis plane (TAP) block with trocar-site local anesthetic infiltration for postoperative pain management in adult patients undergoing laparoscopic…
- Trial name
- NCT07849751
- Testing
- laparoscopic-assisted transversus abdominis plane block, trocar-site local anesthetic infiltration
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital