Clinical trials: Acute Post-surgical Pain
Acute Post Operative Pain, Postsurgical Pain Management
Intravenous Methocarbamol for Acute Pain After Spine Surgery
The goal of this target trial emulation is to evaluate the impact of intravenous (IV) methocarbamol on postoperative pain and opioid use in adults undergoing elective spine surgery.
- Conditions
- Acute Post Operative Pain, Postsurgical Pain Management, Spine Surgery, Acute Pain, Postoperative
- Trial name
- IMAPSS (NCT06659965)
- Testing
- Intravenous Methocarbamol
- Where
- United States
- Volunteers
- 1,270 people
- Sponsor
- The University of Texas Health Science Center, Houston
Pain, Acute, Anxiety Acute
Brief Postoperative Pain Management Intervention: Meaning Making Amendment
This single-site, two-arm, parallel-group randomized controlled trial will enroll adults undergoing total knee or hip replacement surgery.
- Trial name
- NCT07676500
- Testing
- Mindfulness + Meaning Making Questions, Mindfulness + Implementation Questions
- Where
- United States
- Volunteers
- 576 people
- Sponsor
- University of Utah
Postoperative Pain
Comparison of the Efficacy and Safety of Q8003 Versus Its Individual Components in Bunionectomy Patients
This is a randomized, double-blind, multicenter, fixed dose factorial study of Q8003 12 mg/8 mg and Q8003 6 mg/4 mg versus its individual morphine sulfate and oxycodone hydrochloride components for the management of acute…
- Trial name
- NCT00831051
- Testing
- Q8003, Morphine sulfate, Oxycodone HCl
- Where
- 6 sites in United States
- Volunteers
- 197 people
- Sponsor
- QRxPharma Inc.
Total Knee Arthroplasty Postoperative Pain, Opioid Reduction After TKA
NEUROCUPLE™ as an Opioid Alternative Following Total Knee Arthroplasty
The goal of this clinical trial is to learn if the NEUROCUPLE device can reduce pain and opioid use after primary unilateral total knee arthroplasty (TKA) in adults.
- Trial name
- NCT07439666
- Testing
- NEUROCUPLE™ Patch, Enhanced Recovery After Surgery (ERAS) Standard of Care
- Where
- 3 sites in United States
- Volunteers
- 274 people
- Sponsor
- Jacques E. Chelly
Postoperative Pain, Acute
Comparison of the Effects of Tenoxicam and Paracetamol on Postoperative Pain
Postoperative pain is generally caused by inflammation and oedema related to tissue trauma. Surgical tissue trauma is caused by many factors such as cotery-related burns, surgical incisions, dissections, and instrumental…
- Trial name
- NCT05508451
- Testing
- Double jaw surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Pain, Postoperative, Pain, Acute
Parecoxib in Total Knee Arthroplasty
Early mobilization and rehabilitation can be difficult after total knee arthroplasty (TKA) due to a high incidence of moderate to severe postoperative pain.
- Conditions
- Pain, Postoperative, Pain, Acute, Analgesia, Analgesic Nephropathy
- Trial name
- NCT05924412
- Testing
- Intravenous study drug, Intravenous saline solution
- Where
- Chile
- Volunteers
- 40 people
- Sponsor
- University of Chile
Pain Measurement, Acute Pain
Development and Validation of New "SNU Illustrated Pain Rating Scale" as a Tool for Postoperative Pain Assessment
The numeric rating scale (NRS), one of the most widely used pain scales in clinical practice, although convenient, is often subject to bias because it requires abstract thinking from both the patient and the evaluator.
- Conditions
- Pain Measurement, Acute Pain, Postoperative Pain, Anesthesia
- Trial name
- NCT03764046
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Hospital
Acute Postoperative Pain, Chronic Postoperative Pain
Femoral and Epidural Block After Total Knee Arthroplasty
Total knee prosthetic replacement causes severe postoperative pain. Various analgesic techniques have been used in pain control.
- Trial name
- NCT02115945
- Testing
- DN4 test, The SF 12 test, HAD scale
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Postoperative Pain, Kidney Transplant; Complications
Thread Embedding Acupuncture vs Sham on Acute Pain and Quality of Life After Laparoscopic Nephrectomy of Living Donor
This randomized, double-blind controlled study aims to evaluate the effectiveness of thread implantation acupuncture at EX-B2 L1 in reducing postoperative pain and improving quality of life in patients undergoing laparoscopic…
- Trial name
- NCT07243301
- Testing
- Thread implantation acupuncture
- Where
- Indonesia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Acute Pain, Surgery
NSS-2 BRIDGE Device in Post-Operative Pain Management
The current opioid epidemic has led to a renewed interest in exploring non-pharmacological techniques to treat post-operative pain.
- Conditions
- Acute Pain, Surgery, Abdominal Cancer
- Trial name
- NCT03555266
- Testing
- NSS-2 Bridge
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Jacques E. Chelly
Pain, Postoperative, Acute Pain
Comparison of Postoperative Pain With or Without Apical Patency Technique in Asymptomatic Necrotic Teeth
Apical patency is a technique in which the apical portion of the canal is maintained free of soft tissue remnants and dentinal debris by recapitulation with a small #10k file through the apical foramen.
- Trial name
- NCT05574088
- Testing
- Apical patency with file
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Prime Foundation
Anesthesia, Postoperative Pain
Opioid-free Anesthesia and Acute Postoperative Pain
Control of intraoperative and postoperative pain with the use of opioids constitutes normal practice. Opioid free anesthesia (OFA) is a relatively recent anesthesiology practice according to which opioids are not administered…
- Conditions
- Anesthesia, Postoperative Pain, Cognitive Impairment, Variable
- Trial name
- NCT04976842
- Testing
- OFA, OBA
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- Attikon Hospital
Anesthesia, Opioid Use
Opioid-Free Anesthetic for Tonsillectomy
Prospective randomized controlled trial to determine if opioid-free anesthetic for tonsillectomy is non-inferior to standard opioid-containing anesthetic
- Conditions
- Anesthesia, Opioid Use, Tonsillitis, Sleep Disorder
- Trial name
- NCT04528173
- Testing
- Ketorolac, Dexmedetomidine, Morphine
- Where
- 2 sites in United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Perioperative Pain in Robotic Prostatectomy
Tramadol / Magnesium in Ropivacaine Solution in UG-bilateral TAP Block and Analgesia in Robotic Radical Prostatectomy
Tramadol and magnesium have already been researched in recent decades for their different roles in pain control. This clinical study will compare and re-evaluate their effect on the duration and quality of analgesia provided by a…
- Trial name
- NCT07289321
- Testing
- Ultrasound - guided bilateral transversus abdominis plane block (TAP) in patients undergoing robotic-assisted radical prostatectomy.
- Where
- Greece
- Volunteers
- 105 people
- Sponsor
- Aretaieion University Hospital
Pain, Postoperative, Pain, Chronic
fMRI and IVCM Cornea Microscopy of CXL in Keratoconus
Evaluation of neuroplasticity of pain pathways and corneal afferent nerve regeneration following corneal crosslinking (CXL) in keratoconus patients using fMRI and corneal In Vivo Confocal Microscopy (IVCM).
- Conditions
- Pain, Postoperative, Pain, Chronic, Pain, Acute, Surgical Injury
- Trial name
- NCT04439552
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Post Operative Pain
Acute Postoperative Pain and Catastrophizing in Patients Undergoing Unicompartmental Knee Arthroplasty
Advantages of unicompartmental knee arthroplasty (UKA) compared to total knee arthroplasty (TKA) include shorter hospital stays, faster recovery, fewer infections and readmission, and lower costs.
- Trial name
- KATUKA (NCT05510947)
- Where
- Denmark
- Volunteers
- 146 people
- Sponsor
- Copenhagen University Hospital, Hvidovre
Acute Pulpitis
Evaluation of the Effect of Root Canal Preparation by TF and M-Pro on Post-Operative Pain After Single Visit Endodontic Treatment
A study to comparatively evaluate the post operative pain between root canal preparation by reciprocating file (TF) and full rotation file (M-Pro) in patients with single rooted teeth with acute irreversible pulpits.
- Trial name
- NCT03412318
- Testing
- Twisted file, Mpro
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pain, Acute, Opioid Use
Comparison of Short-term Sustained-release Opioid in Open Abdominal Urologic Surgeries
The advantage of slow-release opioid allows for less fluctuation in drug (pain killer) levels in the blood and an extended period within the effective range for pain relief.
- Trial name
- NCT05375916
- Testing
- Hydromorphone
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- University of Alberta
Phantom Limb Pain, Pain, Chronic
Continuous Sciatic Nerve Block vs Epidural Analgesia in Lower Limb Amputation for Postoperative Pain
Controlled clinical trial of two parallel groups, with random assignment 1:1, non-inferiority, blinded for the patient, for who administers the intervention and for who analyzes the data. 112 participants
- Trial name
- Ampupain (NCT05608733)
- Testing
- Epidural catheter, Continuous sciatic nerve block
- Where
- Colombia
- Volunteers
- 112 people
- Sponsor
- Universidad de Antioquia
Acute Post-operative Pain, Chronic Post Operative Pain
Duloxetine Impact on Postoperative Pain Control and Outcomes
1. Evaluate differences between patients taking Duloxetine or placebo following lateral lumbar interbody fusion for postoperative narcotic consumption. 2.
- Conditions
- Acute Post-operative Pain, Chronic Post Operative Pain, Narcotic Use, Opioid Use
- Trial name
- NCT05611749
- Testing
- Duloxetine 60 MG
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Scripps Health