Clinical trials: Acute Pulpitis
Effect of Drug
Comparing Trypsin-Chymotrypsin and Naproxen Sodium for Post-endodontic Treatment Pain
This study aims to compare the pain reduction efficacy of Trypsin-Chymotrypsin and Naproxen sodium after root canal treatment in patients with symptomatic irreversible pulpitis.
- Trial name
- NCT06562816
- Testing
- Trypsin-Chymotrypsin, Naproxen Sodium 550mg
- Where
- Pakistan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Pulpitis, Acute Pain
Effect of Low Power Laser in Tooth Pain Modulation Caused by Irreversible Inflammation
Anxiety, pain and discomfort are common stressful situations that occur during the dentistry practice, especially in the urgency endodontic practice.
- Trial name
- NCT02169102
- Testing
- No additional Intervention (control), Laser 1 (at 0,16 Joules/point of irradiation), Laser 2 (1,6 Joules/point of irradiation)
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
Pulpitis, Pulpitis - Irreversible
Comparison of Aquaporin -4, -5, -9 and IL-8 Levels in GCF, Dentin Fluid and Pulp Samples
This study aimed to compare the changes in AQP -4, -5, -9, and IL-8 levels in pulp tissue, GCF, and dentin fluid samples routinely obtained during the treatment of healthy and symptomatic teeth diagnosed with irreversible…
- Conditions
- Pulpitis, Pulpitis - Irreversible, Pulp Inflammation, Healthy Pulp
- Trial name
- NCT06938191
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Healthy Subjects, Hyperalgesia
Effect of High-dose Naloxone Following Third Molar Extraction
Recent studies have focused on the role of endogenous opioids on central sensitization. Central sensitization is known to be impaired or altered in chronic pain conditions, as fibromyalgia or chronic tension headache.
- Conditions
- Healthy Subjects, Hyperalgesia, Inflammations, Endodontic, Pain, Acute
- Trial name
- TME (NCT02976337)
- Testing
- Naloxone, Normal Saline
- Where
- Denmark
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- mads u werner
Pulpitis - Irreversible
Post Operative Pain of Root Canal Preparation With Wave One and Neolix in Acute Irreversible Pulpitis
the aim in this prospective in vivo randomized clinical trial to evaluate the influence of instrumentation technique ( reciprocation single file (wave one ) versus rotation single file (neolix) ) on post operative pain …
- Trial name
- NCT02952300
- Testing
- neolix, wave one
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Cairo University
Post Operative Pain
Assessment of Post-Operative Pain After Using Cryotherapy and Dexamethasone
Evaluation and comparing the effect of cryotherapy and dexamethasone on inflammatory mediators and post-operative pain in symptomatic irreversible pulpitis with acute apical periodontitis.
- Trial name
- NCT07738302
- Testing
- cold NaOCl , dexamethasone, NaOCl, dexamethasone, cold NaOCl and cold saline
- Volunteers
- 60 people
- Sponsor
- Suez Canal University
Acute Pulpitis
The Effect of Premedication With Curcumin on Post-endodontic Pain
Will premedication with Curcumin in single endodontic treatment in patients having acute pulpitis in mandibular molars affect post- operative pain? This the present study hopes to bring an evidence based decision on the…
- Trial name
- NCT04012424
- Testing
- curcumin group:Curcumin is an ancient coloring spice . Interestingly, it has various pharmacological activities including analgesic, anti-inf, 400mg starch
- Where
- Egypt
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Cairo University
Teeth With Acute Irreverseble Pulpitis
Evaluation of the Effect of Intra-ligamentary Injection of Diclofenac Potassium Versus Articaine on Anaesthetic Efficacy in Mandibular Molars With Symptomatic Irreversible Pulpitis.
This study aims to assess the effect the intraligamentary injection of Diclofenac Potassium versus Articaine 4% on the anaesthetic efficacy \& intensity of intraoperative \& postoperative pain during single visit root canal…
- Trial name
- NCT06500871
- Testing
- Diclofenac Potassium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cairo University
Post Operative Pain, Acute
Postoperative Pain After Dexamethasone Injection by Two Techniques in Irreversible Pulpitis
The aim of this randomized clinical trial to evaluate the effect of dexamethasone in two different techniques on postoperative pain by dividing patients randomly into three groups: Group I: buccinator injection of dexamethasone.
- Trial name
- Dex/postop (NCT07755306)
- Testing
- dexamethasone 8mg
- Where
- Egypt
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Irreversible Pulpitis, Apical Periodontitis
Bite Force Measurements
ABSTRACT: Acute dental pain from untreated decay often drives patients to emergency rooms (ERs), where the lack of definitive dental treatment results in nearly 75% of these patients receiving analgesics, predominantly opioids.
- Conditions
- Irreversible Pulpitis, Apical Periodontitis, Pulpal Necrosis
- Trial name
- NCT06843525
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- Rutgers, The State University of New Jersey
Acute Irreversible Pulpitis With Apical Periodontitis
Ketorolac Irrigant on Post Operative Pain
Endodontic post-treatment pain management is one of the most challenging problems in the clinical practice of endodontics. Although this pain is decreased after root canal treatment, there may be residual symptoms due to…
- Trial name
- NCT04319549
- Testing
- Ketorolac Tromethamine irrigant, sodium hypochlorite irrigant
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Cairo University
Symptomatic Irreversible Pulpits
Effect of Emergency Pulpotomy Versus Pulp Extirpation on Anesthetic Efficacy in Endodontic Treatment of Acute Pulpitis
Irreversible pulpitis is an inflammatory condition of the dental pulp, highly painful, and one of the main reasons for seeking emergency dental treatment.
- Trial name
- NCT04599244
- Testing
- emergency pulpotomy
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Cairo University
Acute Pulpitis
Evaluatıon of the Effect of Pulpotomy Treatments wıth dıfferent bıomaterıals on postoperatıve paın ın Permanent Molars
The aim of this study was to evaluate the results of partial and total pulpotomy with mineral trioxide aggregate (BIO MTA+) and bioceramic sealer (Well Root PT) in terms of pain and vitality in permanent molars with exposed pulp…
- Trial name
- NCT06784622
- Testing
- Treatment as usual
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Irreversible Acute Pulpitis, Root Canal Treatment
Evaluation of the Effects of Different Irrigation Solutions and Activation Methods on Postoperative Pain and Quality of Life in Root Canal Treatment
Brief Summary: This prospective randomized controlled clinical trial aims to evaluate the effects of different irrigation solutions (NaOCl, HEDP) and activation methods (conventional syringe irrigation, EDDY, diode laser) on…
- Trial name
- NCT07241650
- Testing
- Irrigation with Sodium Hypochlorite and Conventional Syringe, Irrigation with Sodium Hypochlorite and EDDY, Procedure: Irrigation with Sodium Hypochlorite and Diode Laser
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Ankara Yildirim Beyazıt University
Anesthesia; Reaction, Pain
Anesthetic Efficacy of Gow-Gates Versus Conventional Inferior Alveolar Nerve Block Techniques
The purpose of this study is to determine whether Gow Gates block injection is more effective than conventional alveolar nerve block in anesthetising mandibular molars with acute pulpitis.
- Trial name
- NCT01329874
- Testing
- Type of block injection
- Where
- Iran
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mashhad University of Medical Sciences
Acute Pulpitis
Postoperative Pain Associated With Three Endodontic Rotary Systems
Assessment of postoperative pain after root canal treatment using different rotary systems.
- Trial name
- NCT03065777
- Testing
- ONE ENDO, F6 SKYTaper, ProTaper Universal
- Where
- Egypt
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Cairo University
the Effect of Instrumentation Kinematics on Intraoperative and Post-operative Pain
Effect of Instrumentation Kinematics on Intraoperative and Post-operative Pain in Maxillary Premolars With Acute Irreversible Pulpitis
Post-endodontic pain refers to the discomfort experienced following endodontic procedures. The incidence of post-operative pain is reported to be 25-40% regardless of the pulp and periradicular condition.
- Trial name
- Instrumentatio (NCT07250399)
- Testing
- EdgeOne Fire reciprocating system, JZ file system
- Where
- Egypt
- Volunteers
- 56 people
- Sponsor
- Al-Azhar University
Symptomatic Irreversible Pulpitis, Acute Apical Periodontitis of Pulpal Origin
The Effect of Central Sensitization on Assessment Capacity of Patients
the aim of this study is to evaluate the effect of dental hyperalgesia and mechanical allodynia on the assessment capacity of individuals in a local Turkish population.
- Trial name
- NCT03553641
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Symptomatic Irreversible Pulpitis
Vital Pulp Therapy Versus Root Canal Treatment for Irreversible Pulpitis With Incipient Apical Periodontitis Diagnosed Using Artificial Intelligence This Keeps: the Main Intervention (Vital Pulp Therapy) the Comparison (Root Canal Treatment) the Condition (Irreversible Pulpitis With Incipient Apic
This study evaluates postoperative pain and treatment outcomes following vital pulp therapy and root canal treatment in patients with symptomatic teeth.
- Trial name
- NCT07549620
- Testing
- Vital Pulp Therapy, Root Canal Treatment
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Ain Shams University
Pulpitis - Irreversible
Enhancing Anaesthetic Success in Mandibular Molars With Symptomatic Irreversible Pulpitis: A Comparative Randomized Controlled Trial
The goal of this clinical trial is to assess the effect of Preoperative intraligamentary corticosteroids injection Cryotherapy which is cold application on : Hard tooth structure ( crown of the tooth ) Soft tissue overlying roots…
- Trial name
- NCT06330519
- Testing
- Dexamethasone sodium phosphate injection, 1,1,1,2 tetrafluoroethane, intraoral soft tissue cryotherapy
- Where
- Egypt
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Ain Shams University