Clinical trials: Acute Respiratory Failure (ARF)
Abdominal Sepsis, Acute Respiratory Failure
Evaluation of Regional Ventilation Distribution in Patients Affected by Abdominal Sepsis After Emergent Laparotomy
The goal of this clinical trial is to evaluate regional ventilation distribution in patients admitted to the intensive care unit after emergent laparotomy due to abdominal sepsis.
- Conditions
- Abdominal Sepsis, Acute Respiratory Failure, Ventilation Therapy; Complications, Emergencies
- Trial name
- CHESTOMY (NCT05726500)
- Testing
- Arterial blood gas analysis, Venous blood gas analysis, Esophageal pressure monitoring
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Università degli Studi di Ferrara
Acute Respiratory Failure
Evaluation of Perfusion and Ventilation Distribution in Children: a Pilot Study.
Electrical impedance tomography (EIT) is a recent monitoring technique that provides information on regional ventilation distribution.
- Trial name
- PELUCHE 2 (NCT07532811)
- Testing
- Evaluation of perfusion with Electrical impedance tomography using sodium chloride or sodium bicarbonate
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Acute Respiratory Failure, Treatment With Noninvasive Positive Pressure Ventilation
Pilot Study of High-flow Humidified Nasal Oxygen During Breaks From Noninvasive Ventilation
The purpose of this study is to assess whether Optiflow, a high-flow humidified oxygen delivery system, is superior to standard oxygen therapy during breaks off noninvasive ventilation in patients affected by acute respiratory…
- Trial name
- OPTINIV (NCT01925534)
- Testing
- High-flow humidified nasal oxygen delivery system, Standard oxygen therapy
- Where
- 2 sites in United States
- Volunteers
- 47 people
- Sponsor
- Tufts Medical Center
Respiratory Failure, Acute Respiratory Failure Requiring Intubation
Intra-operative Inspiratory Oxygen Fraction and Postoperative Respiratory Complications
Respiratory complications represent the second most frequent type of postoperative complications with an incidence estimated to range from 2.0% to 7.9% It has been shown that intra-operative protective ventilation is associated…
- Conditions
- Respiratory Failure, Acute Respiratory Failure Requiring Intubation, Pulmonary Edema, Pneumonia
- Trial name
- NCT02399878
- Testing
- Inspiratory oxygen
- Volunteers
- 70,000 people
- Sponsor
- Massachusetts General Hospital
Severe Sepsis, Acute Respiratory Failure
Effect of Different Electric Muscle Stimulation in Patients With Severe Sepsis and Respiratory Failure
Rationale : Electric muscle stimulation reduced critical-illness related weakness in patients with severe sepsis and septic shock. But optimal protocol of the stimulation in unknown.
- Conditions
- Severe Sepsis, Acute Respiratory Failure, Muscle Hypotonia, Inflammation
- Trial name
- NCT01895647
- Testing
- EMS
- Where
- Taiwan
- Volunteers
- 25 people
- Sponsor
- Mackay Memorial Hospital
Acute Renal Failure (ARF), Acute Tubular Necrosis
Use of QRX3 for Acute Tubular Necrosis Type of Renal Failure in Hospitalized Patients ( QRX-3 in ARF)
Use of QRX-3 in hospitalized patients with pediatric and adult patients with acute tubular necrosis renal failure
- Trial name
- QRX3 in ARF (NCT07161843)
- Testing
- QRX-3
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Ebima Clifford Okundaye
Acute Dyspnea, Acute Respiratory Failure
Diaphragm Response in Elderly for Acute Monitoring
Acute dyspnea is a common cause of emergency department admissions among elderly patients. Acute respiratory failure is often multifactorial and requires rapid and reliable evaluation.
- Conditions
- Acute Dyspnea, Acute Respiratory Failure, Diaphragmatic Ultrasound
- Trial name
- DREAM (NCT07132268)
- Where
- 9 sites in France
- Volunteers
- 145 people
- Sponsor
- Centre Hospitalier de Bethune
Sepsis and Septic Shock, Acute Respiratory Failure
Eduction in ImmunoSuppressive Regimen Among Kidney Transplant Recipients Patients Admitted to the Intensive Care Unit for Septic Shock and/or Acute Respiratory Failure
Kidney transplantation is the treatment of choice for end-stage chronic kidney disease. Kidney transplantation is at the first rank of solid organ transplantation in France, with 3,376 grafts performed in 2022.
- Conditions
- Sepsis and Septic Shock, Acute Respiratory Failure, Kidney Transplant Recipients, Immunosuppressive Agents
- Trial name
- REDIS (NCT06881927)
- Testing
- Hydrocortisone Hemisuccinate: 200 mg per day., reduction of the level of immunosuppression
- Where
- France
- Volunteers
- 212 people
- Sponsor
- University Hospital, Strasbourg, France
COVID, Mechanical Ventilation
PRactice of VENTilation in COVID-19 Patients (PRoVENT-COVID)
The purpose of this national, multicenter service review is to determine and compare ventilation management in COVID-19 patients in the Netherlands, and to determine whether certain ventilation settings have an independent…
- Conditions
- COVID, Mechanical Ventilation, Acute Respiratory Failure
- Trial name
- PRoVENT-COVID (NCT04346342)
- Where
- 22 sites in Netherlands
- Volunteers
- 1,122 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Respiratory Insufficiency
Non-invasive Ventilation and Dex in Critically Ill Adults
Non-Invasive ventilation (NIV) is a life saving intervention for patients with acute respiratory failure (ARF). Some patients are not able to tolerate the NIV intervention and ultimately fail, requiring the use of invasive…
- Trial name
- inDEX (NCT04878510)
- Testing
- Dexmedetomidine
- Where
- 3 sites in Australia, Canada and 1 more
- Volunteers
- 24 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Weaning Failure, Acute Respiratory Failure
Impact of Nasal High-flow vs Venturi Mask Oxygen Therapy on Weaning Outcome: a Multicenter, Randomized, Controlled Trial
The purpose of this study is to determine whether, as compared with the Venturi mask, a nasal, high-flow oxygenation device (Optiflow) may reduce the extubation failure rate in patients needing oxygen therapy after extubation.
- Trial name
- RINO (NCT02107183)
- Testing
- Optiflow (Fisher & Paykel Healthcare), Venturi mask
- Where
- 14 sites in France, Greece and 2 more
- Volunteers
- 500 people
- Sponsor
- Catholic University of the Sacred Heart
Acute Respiratory Failure
Bougie Use in Emergency Airway Management
This prospective, open-label trial randomizes adult patients intubated in the ED with a Macintosh blade to use or not use a bougie for the first intubation attempt. The primary outcome is first pass success.
- Trial name
- BEAM (NCT02902146)
- Testing
- Bougie, Endotracheal tube
- Where
- United States
- Volunteers
- 757 people
- Sponsor
- Hennepin Healthcare Research Institute
Critical Illness, Acute Respiratory Failure
Feasibility of Upright Bed Position in ARDS Patients
Lower lobe atelectasis of the lung is common in Acute Respiratory Distress Syndrome (ARDS) and has the potential to adversely impact lung compliance and intra-pulmonary shunt.
- Conditions
- Critical Illness, Acute Respiratory Failure, Adult Syndrome
- Trial name
- NCT02160561
- Testing
- Intervention Arm
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Wake Forest University Health Sciences
Respiratory Failure
Awake Prone Position to Reduce Ventilation Inhomogeneity in COVID-19 Acute Respiratory Failure
Evaluation of awake prone position on ventilation inhomogeneity in COVID-19 associated respiratory failure.
- Trial name
- ProneSpontCov (NCT04632602)
- Testing
- physiological effects of awake prone position in COVID 19 patients
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Hypoxemic Respiratory Failure
HFNC and Prone Positioning in Awake Patients With Severe COVID-19
The investigators evaluate the effects of High-flow nasal cannula (HFNC) in association with prone in patients with Covid-19 severe ARF.
- Trial name
- NCT04982341
- Testing
- prone position
- Where
- Tunisia
- Volunteers
- 120 people
- Sponsor
- Hôpital Universitaire Fattouma Bourguiba
ARDS, Human, Mechanical Ventilation Complication
Awake Prone Positioning to Reduce Invasive VEntilation in COVID-19 Induced Acute Respiratory failurE
Prone positioning (PP) is an effective first-line intervention to treat moderate-severe acute respiratory distress syndrome (ARDS) patients receiving invasive mechanical ventilation, as it improves gas exchanges and lowers…
- Conditions
- ARDS, Human, Mechanical Ventilation Complication, COVID19
- Trial name
- APPROVE-CARE (NCT04347941)
- Testing
- Prone Positioning, Standard of care.
- Where
- Ireland
- Volunteers
- 24 people
- Sponsor
- University College Hospital Galway
Respiration Disorders
Multicenter Prospective Observational Study on Diaphragmatic Function Assessment by Ultrasound in Patients With Acute Respiratory Failure Receiving Non-invasive Mechanical Ventilation or High Flow Nasal Canula
The primary goal of this study is to assess diaphragm function in patients with acute respiratory failure before and during the use of high-flow oxygen and/or non-invasive breathing support.
- Trial name
- DIAFUSION (NCT06892912)
- Testing
- Diaphragmatic ultrasound
- Where
- Colombia
- Volunteers
- 100 people
- Sponsor
- Foro Internacional en Cuidado Crítico
Respiratory Insufficiency
Description of Fluid Balance in Patients With Acute Respiratory Failure
The specific aim of this study is to gather data on fluid balance, intravenous medication administration, electrolyte balance, and diuretic and dialysis use in patients with acute respiratory failure who might benefit from a…
- Trial name
- NCT02523872
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Smiths Medical, ASD, Inc.
Acute Respiratory Failure, Pulmonary Fibrosis
RENOVATE Fibrosis:HFNC Versus NIPPV in Acute Respiratory Failure in Patients With Pulmonary Fibrosis
A pilot multicentric randomized controlled study investigating the feasibility of recruiting 50 pulmonary fibrosis patients in acute respiratory failure within18 months.
- Trial name
- Fibrosis (NCT04253405)
- Testing
- High Flow Nasal Catheter, Noninvasive positive pressure ventilation (NIPPV)
- Where
- 6 sites in Brazil
- Volunteers
- 3 people
- Sponsor
- Hospital do Coracao
Bradyarrhythmia, Dyspnea
The Safety and Efficacy of FFR Protocol in NTUH System
FFR-guided PCI has been performed in National Taiwan University Hospital(NTUH) for many years. Nevertheless, the method of FFR measurement in NTUH is different from that in literature.
- Conditions
- Bradyarrhythmia, Dyspnea, Acute Respiratory Failure
- Trial name
- NCT03693157
- Where
- Taiwan
- Volunteers
- 250 people
- Sponsor
- National Taiwan University Hospital Hsin-Chu Branch