Clinical trials: Acute Respiratory Tract Infections
SARS-CoV Infection, Immune System Disorder
Co-Sér: Serological Analysis and Viral Neutralization in People With a Documented COVID-19 Infection
In light of the current coronavirus disease 2019 (COVID-19) pandemic, the investigators want to better study the immunological characteristics of Severe Acute Respiratory Syndrome-Coronavirus 2 (SARS-CoV2) infections in adults.
- Trial name
- Coser (NCT05000307)
- Testing
- Blood sample
- Where
- Belgium
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Post COVID-19 Condition, Long COVID
Pycnogenol® in Post-COVID-19 Condition
To determine the effect of Pycnogenol® versus placebo on patient-reported health status in people with post COVID-19 condition.
- Trial name
- PYCNOVID (NCT05890534)
- Testing
- Pycnogenol®
- Where
- Switzerland
- Volunteers
- 153 people
- Sponsor
- University of Zurich
Long COVID, Post-COVID-19 Condition
Mitochondrial Function in Peripheral Blood Mononuclear Cells, Muscle, and Skin of Long COVID Patients
Mitochondria are structures inside cells that are responsible for producing energy from nutrients through a series of steps, using oxygen.
- Trial name
- MitoLoCo (NCT07134673)
- Where
- Belgium
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Sinusitis
Guidelines for Acute Sinusitis
Viral upper respiratory infections occur frequently during childhood (6-8 per year) and are, for the most part, self-limited episodes that resolve spontaneously and do not require antibiotic therapy.
- Trial name
- NCT00132275
- Testing
- Amoxicillin potassium clavulanate
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- University of Pittsburgh
Chronic Obstructive Pulmonary Disease, Chronic Cough
Study of AffloVest in At-Risk Respiratory Patients During COVID-19 Pandemic
The purpose of the study is to investigate the addition of high frequency chest wall oscillation (HFCWO) therapy to the prescribed care regimen to support the diaphragm during airway clearance among post-COVID patients with COPD…
- Conditions
- Chronic Obstructive Pulmonary Disease, Chronic Cough, Covid19
- Trial name
- NCT04654481
- Testing
- HCFWO, Standard Care Plus Monitoring
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Acute Respiratory Infections (ARIs)
Nudging Guideline-concordant Antibiotic Prescribing Using Public Commitments
Inappropriate antibiotic prescribing for acute respiratory infections (ARIs) persists despite decades of intervention efforts. Negative outcomes of inappropriate antibiotics include increased costs of care, adverse drug…
- Trial name
- NCT01767064
- Testing
- Posted commitment letter
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Southern California
Severe Acute Respiratory Syndrome Coronavirus 2
Vagus Nerve Stimulation ARDS Prevention Trial for COVID-19 Hospitalized Patients
This trial is designed to determine if the inflammation modulating effect of vagus nerve stimulation can improve pulmonary function and limit progression to ARDS in hospitalized COVID-19 hospitalized patients.
- Trial name
- NCT04379037
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation
- Where
- Argentina
- Volunteers
- 50 people
- Sponsor
- Nemechek Technologies
Bronchiolitis Obliterans Syndrome, Graft Rejection
Azithromycin in Bronchiolitis Obliterans Syndrome
Preventive treatment with azithromycin reduces the prevalence fo Bronchiolitis Obliterans Syndrome after lung transplantation.
- Conditions
- Bronchiolitis Obliterans Syndrome, Graft Rejection, Lymphocytic Bronchiolitis, Respiratory Infection
- Trial name
- AZI001 (NCT01009619)
- Testing
- Azithromycin
- Where
- Belgium
- Volunteers
- 83 people
- Sponsor
- KU Leuven
Bronchiolitis, Viral
The Effectiveness of Oral Dexamethasone for Acute Bronchiolitis
This study will compare a single dose of oral dexamethasone to placebo in a multicenter, randomized, double blind trial of infants aged 2 to 12 months with first-time bronchiolitis (defined as wheezing within 7 days of onset).
- Trial name
- NCT00119002
- Testing
- dexamethasone
- Where
- United States
- Volunteers
- 598 people
- Sponsor
- University of Utah
COVID-19 Acute Respiratory Distress Syndrome, COVID-19
Plerixafor in Acute Respiratory Distress Syndrome Related to COVID-19 (Phase IIb)
This phase IIb study, LEONARDO is a multicenter, randomized, double-blind, placebo- controlled, parallel group study, to assess the therapeutic efficacy and safety of Plerixafor in patients over 18 years of age, with acute…
- Trial name
- LEONARDO (NCT05411575)
- Testing
- Plerixafor 20 MG/ML [Mozobil]
- Where
- 14 sites in Bulgaria, France
- Sponsor
- 4Living Biotech
Pneumonia, Viral
Severe Acute Respiratory Infection - Preparedness (COVID-19 and Influenza)
Severe Acute Respiratory Infection (SARI) is defined by the World Health Organization (WHO) as acute respiratory infection with a history of fever ≥38°C and cough for less than 10 days duration that requires hospital admission.
- Trial name
- SARI-PREP (NCT04786301)
- Where
- 2 sites in United States
- Volunteers
- 1,200 people
- Sponsor
- University of Washington
Acute Febrile Illnesses
Etiologies of Fever Among Adults in Dar es Salaam
Following the decline of malaria in Sub-Saharan Africa, clinicians face febrile patients in whom an alternative diagnosis has to be made. This situation has led to an overuse of antibiotics by clinicians.
- Trial name
- NCT01947075
- Where
- Tanzania
- Volunteers
- 538 people
- Sponsor
- Swiss Tropical & Public Health Institute
Upper Respiratory Tract Infections, Acute Respiratory Tract Infection
Implementation of Academic Detailing Interventions on Prescribing of Antimicrobial Drugs in Primary Health Care
World increase in mortality from consequences of antimicrobial resistance (AMR) represents a significant public health problem. Irrational prescribing of antimicrobial drugs (AMD) in general population is one of the main causes…
- Conditions
- Upper Respiratory Tract Infections, Acute Respiratory Tract Infection, Viral Infection
- Trial name
- NCT05090475
- Testing
- Academic detailing intervention
- Where
- Croatia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- General Hospital Koprivnica
Covid19, SARS-CoV Infection
An Efficacy and Safety Clinical Trial of an Investigational COVID-19 Vaccine (BBV152) in Adult Volunteers
The BBV152 vaccine is being developed to prevent COVID-19, the disease resulting from Severe Acute Respiratory Syndrome coronavirus (SARS-CoV-2) infection.
- Trial name
- NCT04641481
- Testing
- BBV152
- Where
- India
- Volunteers
- 25,800 people, healthy volunteers welcome
- Sponsor
- Bharat Biotech International Limited
COVID-19
Vitamin D Supplementation in Patients With COVID-19
Coronavirus disease 2019 (COVID-19) was declared an emergency public health problem by the World Health Organization (WHO) in March 2020.
- Trial name
- NCT04449718
- Testing
- Vitamin D
- Where
- Brazil
- Volunteers
- 240 people
- Sponsor
- University of Sao Paulo
Acute Respiratory Tract Infections, Diarrhea
Home Based Child Care to Reduce Mortality and Malnutrition in Tribal Children of Melghat, India: CRCT
Melghat is poorly developed tribal area in India with very high child mortality \& malnutrition prevalence (grossly inadequate medical facilities). Important health problems.
- Conditions
- Acute Respiratory Tract Infections, Diarrhea, Malaria, Neonatal Sepsis
- Trial name
- HBCC (NCT02473796)
- Testing
- Home based child care
- Where
- India
- Volunteers
- 7,594 people
- Sponsor
- MAHAN Trust
Acute Respiratory Distress Syndrome, COVID19 Infection
Sedation With Sevoflurane Versus Propofol in Patients With Acute Respiratory Distress Syndrome Caused by COVID19 Infection
It is a multicenter, national, randomized 1:1 ratio, controlled, parallel, open study. Patients with severe ARDS-CoVid19 will be included in the trial within the first 24 hours.
- Trial name
- SEVO-COVID19 (NCT04359862)
- Testing
- Sevoflurane, Propofol
- Where
- 5 sites in Spain
- Volunteers
- 19 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Covid19, Coronavirus
Lung Ultrasound Changes in Covid 19 Patients Discharged From Hospital
Lung ultrasound has been used to help diagnose COVID-19 as an alternative to CT scanning and chest X-ray. CT scanning is onerous and there are difficulties taking critically unwell patients there as well as decontamination…
- Conditions
- Covid19, Coronavirus, Coronavirus Infection, SARS-CoV Infection
- Trial name
- NCT05062603
- Where
- United Kingdom
- Volunteers
- 23 people
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Respiratory Tract Infections, Pneumonia, Bacterial
Procalcitonin in Early Antibiotic Interruption in Patient With Bacterial Pulmonary infeCtion and Acute Heart Failure
Introduction: Acute Heart Failure is frequently decompensated by pulmonary infection, but the diagnosis of pulmonary infection sometimes is difficult in these patients due to similar signals and clinical symptoms in both…
- Conditions
- Respiratory Tract Infections, Pneumonia, Bacterial, Heart Failure
- Trial name
- EPICAD (NCT02787603)
- Testing
- Interruption of antibiotic treatment due to PCT measurement
- Where
- Brazil
- Volunteers
- 46 people
- Sponsor
- University of Sao Paulo General Hospital
Acute Respiratory Infection, Sinusitis
Middle Meatal Bacteriology During Acute Respiratory Infection in Children
The purpose of this study is to find out whether the children with respiratory infection and the presence of pathogenic bacteria (S. pneumoniae, H. influenzae or M.
- Trial name
- NCT00545961
- Testing
- amoxicillin clavulanate acid
- Where
- 3 sites in Finland
- Volunteers
- 120 people
- Sponsor
- Oulu University Hospital