Clinical trials: Acute Stress Reaction
Acute Disease, Telomere Shortening
Telomere Length in Relation to Acute Stress Response in Critical Care Patients
the investigators studied the impact of severe stress (in this case any event or illness leading to a necessity of critical care) on telomere length.
- Trial name
- NCT03982589
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Rabin Medical Center
Acute Stress Reaction, Acute Stress Disorder
Prevention/Reduction of ASRs and PTSD to Sustain Civilian Performance With Sublingual Cyclobenzaprine HCl (TNX-102 SL)
This study will examine the safety and efficacy of TNX-102 SL to reduce ASR symptoms and behavioral changes among patients presenting to the emergency department (ED) after motor vehicle collision (MVC).
- Conditions
- Acute Stress Reaction, Acute Stress Disorder, Neurocognitive Function, Post-traumatic Stress
- Trial name
- OASIS (NCT06636786)
- Testing
- Cyclobenzaprine HCl
- Where
- 9 sites in United States
- Volunteers
- 180 people
- Sponsor
- University of North Carolina, Chapel Hill
Alcohol Use Disorder (AUD), Alcoholism
Cue Effects in Human Addiction: Pavlovian to Instrumental Transfer
Individuals with substance use disorders (SUD) have to cope with drug-related cues and contexts, which can affect instrumental drug seeking as shown with Pavlovian to instrumental transfer (PIT) paradigms in animals and humans.
- Conditions
- Alcohol Use Disorder (AUD), Alcoholism, Substance Use Disorders, Smoking, Tobacco
- Trial name
- ReCoDe (NCT05992272)
- Testing
- fMRI imaging (BOLD), sMRI (structure), Trier Social Stress Test
- Where
- 2 sites in Germany
- Volunteers
- 300 people
- Sponsor
- Charite University, Berlin, Germany
Anxiety Disorder
SSRI Administration to Reduce Acute Stress Disorder Symptoms and Prevent Depression and PTSD in Physical Trauma Victims
The purpose of this study is to examine the efficacy of escitalopram compared to placebo in reducing Acute Stress Disorder (ASD) symptoms and in preventing the emergence of Post-Traumatic Stress Disorder (PTSD) in patients with…
- Trial name
- NCT00114374
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Post-traumatic Stress Disorder, Acute Stress Disorder
Feasibility Study of the Self-Care Immediate Stabilization Procedure (ISP) ® After a Traumatic Experience
The study aims to assess the feasibility of an online intervention platform based on the Immediate Stabilization Procedure (ISP®). This intervention targets early trauma reactions, aiming to reduce the risk of future PTSD.
- Trial name
- NCT06277973
- Testing
- Eye Movement Desensitization and Reprocessing (EMDR)
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tel Aviv University
Post-traumatic Stress Disorder (PTSD), Acute Stress Disorder
EMDR Flash Group Protocol for Earthquake Survivors
This pilot randomized controlled trial evaluated the preliminary effects of the online EMDR Flash Group Protocol among adults affected by the 2023 Kahramanmaraş earthquakes in Türkiye.
- Conditions
- Post-traumatic Stress Disorder (PTSD), Acute Stress Disorder, Anxiety, Depression
- Trial name
- FlashGP-EQ (NCT07672613)
- Testing
- EMDR Flash Group Protocol
- Where
- Turkey (Türkiye)
- Volunteers
- 410 people, healthy volunteers welcome
- Sponsor
- Istanbul Galata University
Anxiety
Integrative Medicine for Hospital Workers Exposed to War
During the "Iron Swords" war in Israel in 2023, the residents of the Gaza Strip and the surrounding area, along with the soldiers of the security service, were exposed to a very high intensity of trauma.
- Trial name
- NCT06190964
- Testing
- Integrative medicine
- Where
- Israel
- Volunteers
- 500 people
- Sponsor
- Bnai Zion Medical Center
Ischemic Stroke, Hyperglycemia
Assessment of Markers of Stress in Acute Ischemic Stroke With Hyperglycemia
Hyperglycemia is present in 50 percent of patients with acute ischemic stroke. Patients with hyperglycemia have higher in hospital, 30 and 90 day mortality and morbidity.
- Trial name
- ASIIST (NCT03318679)
- Testing
- No intervention is planned.
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- University of Minnesota
Acute Stress Disorder, Anxiety
GASA-CIR Trail (Guidance and the Symptoms of Acute Stress and Anxiety in Critically Ill Patients Relatives in Intensive Care Unit)
A randomized clinical trial 1:1 among relatives of patients admitted to an intensive care unit, the intervention group will be composed by family members who receive a printed brochure and will be encouraged to visit a website…
- Conditions
- Acute Stress Disorder, Anxiety, Depression
- Trial name
- GASA-CIR (NCT03812458)
- Testing
- website and brochure
- Where
- Brazil
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Federal University of Rio Grande do Sul
Healthy Participants
Influence of Dopaminergic Blockade on Stress Responses, Motivation and Emotional Reactivity in Humans.
The study aims to identify whether partial blockade of human dopamine signaling with antipsychotic drugs affects human stress responses, motivation and emotion.
- Trial name
- NCT03863691
- Testing
- Amisulpride 300 MG
- Where
- Germany
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Acute Stress Disorder, Anxiety
Safety & Efficacy of Intranasal Dexmedetomidine, Fentanyl & Midazolam in the Pediatric Emergency Room
The hypothesis is that intranasal dexmedetomidine will provide significantly more effective analgesia and anxiolysis for subjects undergoing a simple laceration repair when compared to either intranasal fentanyl or intranasal…
- Conditions
- Acute Stress Disorder, Anxiety, Pain
- Trial name
- NCT05057689
- Testing
- Intranasal Dexmedetomidine (4 mcg/kg), Intranasal Fentanyl (2 mcg/kg), Intranasal Midazolam (5 mg/kg)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Acute Stress Response During Orthodontic Mini-screw Placement
Effects of Music Therapy on Stress During Orthodontic Mini-screw Placement
This randomized clinical trial evaluated acute stress responses during orthodontic mini-screw placement and whether listening to music during the procedure influenced these responses.
- Trial name
- NCT07793669
- Testing
- Music Listening Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Himmet YILDIRIM
Adults, Acute Stress Reaction
Impact of MetaCalm on Stress of Healthy People With Acute Stress
This Open-Label, Non-Randomized Clinical Study involving 280 participants who will undergo a total participation of 6 hours.
- Trial name
- NCT07507669
- Testing
- 2 chewable tablets of MetaCalm, 4 chewable tablets of MetaCalm
- Where
- Italy
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Metagenics, Inc.
Healthy
Exercise-induced Effects on Immune Parameters in Healthy Participants
Exercise has been shown to influence the immune system and, for example, improve anti-viral immune response. However, knowledge of how exercise impacts the immune system is still lacking.
- Trial name
- INHALE (NCT05826496)
- Testing
- Exercise
- Where
- Denmark
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Per thor Straten
Anxiety Disorders, Trauma
Respiratory Training in the Treatment of Transdiagnostic Pathological Anxiety
Purpose of the Research: The primary aim of the proposed study is to conduct a randomized parallel-group 2-arm clinical trial investigating capnometry-guided respiratory intervention (CGRI) for pathological anxiety.
- Conditions
- Anxiety Disorders, Trauma, Generalized Anxiety Disorder, Panic Disorder
- Trial name
- NCT05427708
- Testing
- Capnometry-Guided Respiratory Intervention, Psycho-Education
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Texas at Austin
Posttraumatic Stress Disorder, Acute Stress Disorder
Prevention of Intrusive Memories and Posttraumatic Stress Symptoms After Emergency Cesarean Section
This pilot study aims to investigate the effects of a brief computerized intervention (the computer game "Tetris") on intrusive memories and other posttraumatic stress symptoms following an emergency cesarean section.
- Trial name
- NCT02502513
- Testing
- Brief computerized intervention
- Where
- Switzerland
- Volunteers
- 56 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Benign Lesions in Left Liver
Laparoscopic Versus Open Left Hemihepatectomy for Liver Benign Lesions
The purpose of this study is to investigate the influence of the laparoscopic and open left hemihepatectomy on acute surgical trauma and stress response.
- Trial name
- NCT01768728
- Testing
- Laparoscopic left hemihepatectomy, Open left hemihepatectomy
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Sir Run Run Shaw Hospital
Acute Stress Reaction
Neuronal Correlates of Neurexan® Action in Mildly to Moderately Stressed Probands
The purpose of this study is to explore the effect of Neurexan® on the brain response when participants undergo an emotional stressful condition in verum compared to placebo.
- Trial name
- NEURIM (NCT02602275)
- Testing
- Neurexan
- Where
- Germany
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Biologische Heilmittel Heel GmbH
Acute Stress Disorder
Needs, Perceptions and Acute Stress of Healtcare Workers Caring for COVID-19 Patients in South America
The pressure on care and the demand for critical decision-making generated by the current SARS-CoV-2 (COVID-19) pandemic, together with the situation of extreme social alarm and the adverse conditions in which care work must be…
- Trial name
- NCT04486404
- Testing
- Online survey
- Where
- 5 sites in Argentina, Chile and 3 more
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Universidad Miguel Hernandez de Elche
Stress Disorders, Post-Traumatic
Probabilistic Risk Modeling for Disorder Post Traumatic Stress (PTSD) After the Attacks in Paris In November 2015
The scientific approach of this project proposes to build a cohort of "psychological injuries" post-attack of 13 November 2015. This is called patients "involved", ie patients who directly witnessed the events and having the most…
- Trial name
- BV13 (NCT02853513)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours