Clinical trials: Acute Stroke, open to volunteers
Ischemic Stroke, Acute, Rehabilitation Outcome
Cerebrolysin in Early Stroke Rehabilitation - Tertiary Study
The study evaluates the effect and safety of Cerebrolysin administered during early rehabilitation in patients with moderate neurological impairment after acute ischemic stroke, conducted at the Department of Vascular Neurology…
- Conditions
- Ischemic Stroke, Acute, Rehabilitation Outcome, Cerebrolysin
- Trial name
- NCT07043686
- Testing
- Cerebrolysin treatment, Standard treatment (including neurorehabilitation) of acute ischemic stroke
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
Stroke, Acute, Dysphagia
Post Stroke Dysphagia: Effect of Adding rTMS to Conventional Therapy on the Prevalence of Pneumonia.
BACKGROUND: Dysphagia is one of the most life-threatening stroke complications. Dysphagic stroke patients are at increased risk of aspiration pneumonia.
- Conditions
- Stroke, Acute, Dysphagia, Pneumonia
- Trial name
- NCT06123650
- Testing
- Repetitve transcranial magnetic stimulation
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Cairo University
Cerebral Edema, Ischemic Stroke, Acute
A Trial of Adacolumn on Cerebral Edema After Anterior Circulation Ischemic Stroke
The primary objective is to investigate whether treatment with Adacolumn can ameliorate the progression of cerebral edema within 72 hours in patients with anterior circulation ischemic stroke.
- Conditions
- Cerebral Edema, Ischemic Stroke, Acute, Malignant Cerebral Edema, Anterior Circulation Brain Infarction
- Trial name
- NCT07386262
- Testing
- Adacolumn®, Standard Reperfusion Therapy, Standard Medical Management
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Ischemic Stroke, Hemorrhagic Stroke
Cohort of Neurovascular Diseases Treated in the Acute Phase and Followed at Lariboisière
Neurovascular diseases can cause ischaemic or haemorrhagic strokes. While the most common, such as atherosclerosis are widely studied, others are less well known, such as arterial dissections or cerebral angiopathies.
- Trial name
- NERVAL (NCT06026696)
- Testing
- follow-up
- Volunteers
- 5,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Stroke, Myocardial Injury
Mechanisms And Prognosis of Stroke-Heart Syndrome
The incidence of stroke-heart syndrome following acute stroke, which encompasses both acute ischemic stroke and acute intracerebral hemorrhage, is notably high and is strongly associated with increased mortality and poor outcomes…
- Conditions
- Stroke, Myocardial Injury, Heart Failure, Acute Coronary Syndromes
- Trial name
- MAP-SHS (NCT06954103)
- Where
- China
- Volunteers
- 658 people
- Sponsor
- Chensheng Pan
Acute Ischemic Stroke
CHinese ischEmic Stroke Beyond 4.5 Hours With TeNecteplase Under Optimized Non-Contrast CT Selection
The CHESTNUT trial is a multicenter, open-label, blinded-endpoint, randomized, controlled, phase 3 trial. The primary objective of this study is to explore the efficacy and safety of the dose of 0.25 mg/kg tenecteplase (TNK) in…
- Trial name
- CHESTNUT (NCT06994975)
- Testing
- 0.25mg/kg TNK, Standard medical treatment
- Where
- 2 sites in China
- Volunteers
- 890 people
- Sponsor
- Huashan Hospital
Ischemic Cerebrovascular Disease, Acute Ischemic Stroke
Efficacy and Safety of Calculus Bovis Sativus (CBS) for Ischemic Cerebral Vascular Disease (CBSinICVD)
The most common cause of death for Chinese patients is ischemic cerebrovascular diseases(ICVD), particularly cerebral infarction.
- Conditions
- Ischemic Cerebrovascular Disease, Acute Ischemic Stroke, Cerebral Small Vessel Diseases
- Trial name
- NCT06474507
- Testing
- Calculus bovis sativus (CBS)
- Where
- 2 sites in China
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Ischemic Stroke
Different Treatment Strategies on Prognosis of Acute Ischemic Stroke(AISDTS)
AISDTS is a prospective registry study, in which clinical information, examination and imaging data of patients with acute ischemic stroke receiving different treatment strategies were collected, grouped and statistically…
- Trial name
- NCT05410457
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Stroke, Ischemic, Cerebral Edema
Early Prophylactic Decompressive Hemicraniectomy Following Endovascular Therapy in Large Hemispheric Infarct Trial
Early Decompressive Hemicraniectomy for High-Risk Large Ischemic Core Stroke Post-EVTAcute Ischemic Stroke (AIS), particularly Anterior Circulation Large Vessel Occlusion (LVO), is a major cause of global disability and death.
- Trial name
- NCT07118345
- Testing
- Early prophylactic decompressive hemicraniectomy
- Where
- 2 sites in China
- Volunteers
- 380 people
- Sponsor
- Xuanwu Hospital, Beijing
Acute Stroke
Direct-to-angio Approach From loCal hOspitals Based on a PoInt-of-care bLOod Test for LVO
Direct-to-angio approach from loCal hOspitals based on a PoInt-of-care bLOod Test for LVO (COPILOT) is a multi-center, prospective, cluster-randomized crossover trial that will evaluate if the triage assessment to thrombectomy…
- Trial name
- COPILOT (NCT06910163)
- Testing
- Diagnostic standard of care, LVOne Test
- Where
- Puerto Rico
- Volunteers
- 520 people
- Sponsor
- Juan Vicenty
Ischemic Stroke, Acute, Large Vessel Occlusion
Image Detection of Impaired Microcirculatory Reperfusion
Stroke affects one patient every 40 seconds in the United States. It is most commonly caused by blood clots that develop in the blood vessels of the brain.
- Trial name
- ID IMR (NCT07099599)
- Testing
- CT Perfusion
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Cincinnati
Acute Ischemic Stroke
SLGT2i for Neuroprotection in Patients With Acute Ischemic Stroke
Stroke is a leading cause of disability and mortality globally. With population aging, ischemic stroke (80% of cases) has become China's primary cause of adult disability.
- Trial name
- NCT07105917
- Testing
- SGLT-2 inhibitors, Standard medical treatment
- Volunteers
- 1,050 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Stroke, Acute Ischemic Stroke
Intravenous Thrombosis and Patients with Prior Ischemic Stroke Within 3 Months
The primary hypothesis being tested in this trial is that ischemic stroke patients with prior ischemic stroke within 3 months will have improved clinical outcomes when given intravenous thrombolysis compared to standard care.
- Trial name
- NCT06841978
- Testing
- Intravenous Thrombolysis
- Volunteers
- 306 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Ischemic Stroke
Registry of Acute Ischemic Stroke With Large- or Medium-vessel Occlusion
This study is designed to observe the treatment options in real-world clinical practice as well as the safety and efficacy of different treatment strategies.
- Trial name
- LOMEVO (NCT05779215)
- Testing
- Visit at D90
- Where
- China
- Volunteers
- 50,000 people
- Sponsor
- Xuanwu Hospital, Beijing
Stroke
EEG Changes and DNA Markers Related to taVNS in Stroke Patients: a Preliminary Study
In the United States, more than 795,000 people have a stroke every year. Motor impairment after a stroke is common and can be debilitating.
- Trial name
- StrokeVNS (NCT06226493)
- Testing
- Transcutaneous vagus nerve stimulation
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Stroke, Acute, Carotid Stenosis
Endovascular Acute Stroke Intervention - Tandem OCclusion Trial
Patients with tandem occlusion or tandem lesion (TL), that is, stroke with an acute intracranial anterior circulation occlusion and an ipsilateral cervical ICA (c-ICA) high-grade stenosis or occlusion, constitute about 15-20% of…
- Conditions
- Stroke, Acute, Carotid Stenosis, Carotid Artery Diseases
- Trial name
- EASI-TOC (NCT04261478)
- Testing
- Carotid artery stenting, Antiplatelet Agents
- Where
- Canada
- Volunteers
- 458 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Stroke, Stroke, Acute
Treatment With Endovascular Intervention for STroke Patients With Existing Disability
TESTED will compare the risks and benefits of endovascular thrombectomy (EVT) to medical management (no EVT) in ischemic stroke patients who have a blockage in one of the large blood vessels in the brain and have a…
- Conditions
- Stroke, Stroke, Acute, Stroke, Ischemic
- Trial name
- TESTED (NCT05911568)
- Testing
- Endovascular Stroke Treatment, Medical Management
- Where
- 35 sites in United States
- Volunteers
- 1,060 people
- Sponsor
- University of Cincinnati
Stroke, Ischemic Stroke
Point-of-care Low-field MRI in Acute Stroke
Consecutive patients accessing the emergency department with suspected stroke dispatch will be recruited at 3 study units: 1) ASL Abruzzo 1, hospitals of L'Aquila and Avezzano; 2) ASL Abruzzo 2, hospital of Chieti; 3) IRCCS…
- Conditions
- Stroke, Ischemic Stroke, Hemorrhagic Stroke, Magnetic Resonance Imaging
- Trial name
- POCS (NCT05816213)
- Testing
- Portable low-field MRI
- Where
- 4 sites in Italy
- Volunteers
- 300 people
- Sponsor
- University of L'Aquila
Acute Ischemic Stroke
Acute Subcutaneous SemaglutidE in Acute Ischemic sTroke
Can Semaglutide help reduce the damage caused by a stroke? ASSET trial is a national, multicenter, clinical trial, investigating the safety and efficacy of Semaglutide in non-diabetic patients with acute ischemic stroke.
- Trial name
- ASSET (NCT05630586)
- Testing
- Semaglutide, Standard care
- Where
- Denmark
- Volunteers
- 380 people
- Sponsor
- Aarhus University Hospital
Intracerebral Hemorrhage
Recombinant Factor VIIa (rFVIIa) for Hemorrhagic Stroke Trial - Part 2
The objective of the rFVIIa for Acute Hemorrhagic Stroke Administered at Earliest Time (FASTEST) Trial is to establish the first treatment for acute spontaneous intracerebral hemorrhage (ICH) within a time window and subgroup of…
- Trial name
- FASTEST Part 2 (NCT07227246)
- Testing
- Recombinant Factor VIIa
- Where
- 89 sites in United States, Canada and 4 more
- Volunteers
- 350 people
- Sponsor
- Joseph Broderick, MD