Clinical trials: Acute Stroke, open to volunteers
Acute Ischemic Stroke
Butylphthalide for Brain Edema After Endovascular Treatment
This is a prospective, multicenter, randomized controlled clinical study aimed at evaluating the efficacy of butylphthalide in improving the severity of cerebral edema and prognosis in patients with acute anterior circulation…
- Trial name
- NCT07528456
- Testing
- Butylphthalide
- Where
- 10 sites in China
- Volunteers
- 100 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Cerebral Ischemia
Study on the Role of Human Serum Albumin in Large Acute Ischemic Stroke of Anterior Circulation After Thrombectomy
This project intends to explore the therapeutic efficacy of human serum albumin in mitigating postoperative cerebral edema and enhancing clinical outcomes following mechanical thrombectomy in patients with acute anterior…
- Trial name
- NCT06629116
- Testing
- Patients with AIS receive intravascular therapy, and within 10 minutes after the surgery, they are administered 100ml of 20% human albumin intravenously (infused within 30 minutes).
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Tingyu-Yi
Mild Disabling Acute Ischemic Stroke
Effects of Butylphthalide Enhanced With Tenecteplase on Neurological Function in Mild Disabling Acute Ischemic Stroke
Abstract Background Intravenous thrombolysis is the cornerstone of early treatment for acute ischemic stroke (AIS), but some still have a poor prognosis, especially in patients with mild disabling stroke.
- Trial name
- BENEFIT-2 (NCT07369999)
- Testing
- Combination Group, Control Group
- Where
- 15 sites in China
- Volunteers
- 1,062 people
- Sponsor
- Xiangya Hospital of Central South University
Acute Ischemic Stroke
Efficacy and Safety of Human Urinary Kallidinogenase for Acute Ischemic Stroke Patients Receiving Reperfusion Treatment
This study aims to explore the efficacy and safety of Human Urinary Kallidinogenase for acute ischemic stroke patients receiving intravenous thrombolysis and/or endovascular treatment.
- Trial name
- UNITE (NCT06848894)
- Testing
- Human urinary kallidinogenase (HUK)
- Where
- China
- Volunteers
- 1,204 people
- Sponsor
- Beijing Tiantan Hospital
Stroke
Implementation of a HABIT-ILE Intervention at William Lennox Neurological Hospital (NeuREHA) - Adult
Using a randomized controlled trial design, in an hospital environment, possible changes induced by the "Hand-arm Bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE)" treatment program will be investigated in…
- Trial name
- Ad-NeuREHA (NCT06931795)
- Testing
- HABIT-ILE, Conventional intervention
- Where
- 3 sites in Belgium
- Volunteers
- 40 people
- Sponsor
- Université Catholique de Louvain
Ischemic Stroke, Acute Disease
Adjunctive Intra-arterial Tenecteplase Following Mechanical Thrombectomy (ALLY) II Trial
The study objective is to evaluate the safety and efficacy of Intra arterial (IA) Tenecteplase (TNK) as an adjunctive therapy in acute ischemic stroke (AIS) patients with large vessel occlusions (LVO) in the anterior circulation…
- Trial name
- ALLY II TNK (NCT06949228)
- Testing
- tenecteplase
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- ProMedica Health System
Stroke, Thrombectomy
Results of the Use of Two Stentrievers Simultaneosly Compared With One as a Primary Treatment in Acute Ischemic Stroke
Several studies have demonstrated that simultaneous treatment with two stentrievers (STs) as rescue treatment is very effective, with high recanalization rates even in this group of patients where other revascularization…
- Conditions
- Stroke, Thrombectomy, Arterial Occlusive Diseases
- Trial name
- DIVERSO (NCT05930145)
- Testing
- Double stentriever, Single stentriever
- Where
- 4 sites in Germany, Spain
- Volunteers
- 200 people
- Sponsor
- Fundación EPIC
Stroke, Ischemic, Medium Vessel Occlusions
Advancing Reperfusion Therapy for Ischemic Stroke (ARTS): Tenecteplase in Medium Vessel Occlusion (MeVO) for Acute Ischemic Stroke
Results from recent several trials provided data showing limits to the effectiveness of thrombectomy for ischemic stroke due to medium vessel occlusions.The benefit-risk profile of thrombolysis for these patients has never been…
- Trial name
- ARTS-MeVO (NCT07047014)
- Testing
- Tenecteplase (0.25mg/kg), Standard medical treatment
- Where
- 7 sites in China
- Volunteers
- 596 people
- Sponsor
- Beijing Tiantan Hospital
Basilar Artery Occlusion, Ischemic Stroke
Basilar Artery Occlusion Chinese Endovascular Trial in Patients With Large Core Infarct
This study evaluates the safety and efficacy of endovascular therapy for acute basilar artery occlusion with large core infarcts in a multicenter randomized trial.
- Conditions
- Basilar Artery Occlusion, Ischemic Stroke, Large Core Infarct
- Trial name
- BAOCHE3 (NCT07046299)
- Testing
- Endovascular Therapy Plus Best Medical Treatment, Best Medical Treatment Alone
- Where
- China
- Volunteers
- 314 people
- Sponsor
- Capital Medical University
Acute Ischemic Stroke
German Stroke Registry - Endovascular Treatment
The German Stroke Registry (GSR) Endovascular Treatment is an academic, independent, prospective, multicentre, observational registry study.
- Trial name
- GSR-ET (NCT03356392)
- Testing
- telephone call d90
- Where
- Germany
- Volunteers
- 10,000 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Stroke
Effects Of Neurocognitive Therapy With And Without Soft Robotic Hand On Hand Function
To determine the effect of neurocognitive therapy with and without a soft robotic hand on manual ability, dexterity, strength, spasticity and upper limb function in sub-acute stroke.
- Trial name
- NCT06927284
- Testing
- Neurocognitive Therapy with Soft Robotic Hand, Neurocognitive Therapy without Soft Robotic Hand
- Where
- Pakistan
- Volunteers
- 46 people
- Sponsor
- Riphah International University
Stroke, Acute
Registration of Intravenous Thrombolysis for Acute Ischemic Stroke in Southwestern China（IVTIS）
This study aims to observe the safety and effectiveness of intravenous thrombolysis for acute ischemic stroke in real-world clinical practice.
- Trial name
- IVTIS (NCT06131385)
- Testing
- intravenous thrombolysis
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Zhengzhou Yuan
Acute Ischemic Stroke
OPtimizing REperfusion by Primary Intra-Arterial ThRomboLysis for Medium Vessel Occlusion
PEARL-MeVO is an investigator-initiated, multicenter, prospective, randomized controlled, open-label, blinded endpoint (PROBE) clinical trial aiming at evaluating the efficacy and safety of primary intra-arterial thrombolysis in…
- Trial name
- PEARL-MeVO (NCT07137832)
- Testing
- Primary intra-arterial thrombolysis, Standard medical treatment
- Where
- China
- Volunteers
- 530 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Stroke (Subacute)
Comparative Effects of Functional Electrical Stimulation and Mirror Therapy for Foot Clearance Among Patients With Sub-acute Stroke
This study aims to evaluate the effectiveness of two rehabilitation techniques- Functional Electrical Stimulation (FES) and Mirror Therapy (MT)-in improving motor recovery among stroke survivors.
- Trial name
- FES MT CVA (NCT07448532)
- Testing
- Neuromodulators, Sensory Agumentation
- Where
- 2 sites in Pakistan
- Volunteers
- 38 people
- Sponsor
- Lahore University of Biological and Applied Sciences
Dysphagia, Stroke
Investigation of the Effect of Neuromuscular Electrical Stimulation Techniques on Suprahyoid Muscles and Swallowing Function in Acute Hemiparetic Stroke Patients
This randomized controlled trial aims to investigate the effects of sensory, motor, and modified combined neuromuscular electrical stimulation (NMES) protocols on swallowing function in patients with acute stroke-related…
- Conditions
- Dysphagia, Stroke, Hemiparesis
- Trial name
- NMESWAL (NCT07445204)
- Testing
- Conventional Swallowing Therapy, Vitalstim-Sensory NMES, Vitalstim-Motor NMES
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Istanbul Arel University
Stroke, Ischemia Stroke
Minocycline in Stroke Study at Maimonides
The goal of this study is to determine if Minocycline, when added to standard care, can improve survival and functional outcomes in patients with moderate acute stroke (ischemic or hemorrhagic) aged 18 years and older.
- Conditions
- Stroke, Ischemia Stroke, Hemorrhagic Strokes, Mortality
- Trial name
- NCT07237048
- Testing
- Minocycline 200mg
- Where
- United States
- Volunteers
- 1,164 people
- Sponsor
- Joyce Chen
Acute Ischemic Stroke, Cerebral Autoregulation
Ultra-early Identification of Futile Recanalization After Reperfusion Therapy in Acute Ischemic Stroke Based on Cerebral Autoregulation
This multicenter, prospective, observational diagnostic accuracy study enrolls patients undergoing thrombectomy with intraoperative cerebral autoregulation monitoring and follows them up at predefined time points up to 90 days…
- Trial name
- CAREFUL-CA (NCT07556068)
- Testing
- diagnostic accuracy study
- Where
- 4 sites in China
- Volunteers
- 129 people
- Sponsor
- Beijing Shijitan Hospital, Capital Medical University
Stroke, Acute, Biological Specimen Banks
Thrombus Composition in Ischemic Stroke: Analysis of the Correlation With Plasma Biomarkers, Efficacy of Treatment, Etiology and Prognosis
The recent validation of thrombectomy in addition to thrombolysis with intravenous administration of alteplase suggests a major revolution in the management of acute strokes.
- Conditions
- Stroke, Acute, Biological Specimen Banks, Biomarkers, Etiology
- Trial name
- COMPO-CLOT (NCT03268668)
- Testing
- Collection of thrombus that is responsible for stroke and blood sample
- Where
- 12 sites in France
- Volunteers
- 1,200 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Ischemic Stroke, Acute
A Multicenter Study Based on Multi-omics Analysis to Predict the Early Prognosis and Recurrence Risk of Acute Ischemic Stroke
Through a multicenter prospective AIS cohort study, we analyze the potential association of human proteome, microbiome and metabolome alterations with AIS prognosis, searching for key proteins, differential organisms and…
- Trial name
- NCT06584565
- Testing
- microbiome; metabolomics; proteomics
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Acute Ischemic Stroke
Metformin in Acute Ischemic Stroke
The goal of this clinical trial is to study the efficacy of oral Metformin in Acute Ischemic Stroke (AIS). The main hypothesis is to study the efficacy of oral Metformin in patients with acute ischemic stroke presenting within 72…
- Trial name
- NCT07899307
- Testing
- Metfomin
- Where
- 4 sites in India
- Volunteers
- 440 people
- Sponsor
- All India Institute of Medical Sciences