Clinical trials: Acute Stroke, open to volunteers
Endovascular Thrombectomy, Large Vessel Occlusion
Triage of Patients Presenting Beyond 24 Hours With Acute Ischemic Stroke Due to Large Vessel Occlusions (TRACK-LVO Late)
The objective of this study is to create a comprehensive, multi-center, TRACK-LVO registry-linked cohort of consecutive patients with acute ischemic stroke (AIS) caused by large vessel occlusions (LVO) and presenting to each…
- Conditions
- Endovascular Thrombectomy, Large Vessel Occlusion, Acute Ischemic Stroke
- Trial name
- TRACK-LVO Late (NCT06200753)
- Testing
- Mechanical Thrombectomy
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Tianjin Huanhu Hospital
Acute Ischemic Stroke
Treatment of Acute Ischemic StroKe With Intravenous UroKinase Real-world Research: a Multicenter, Prospective Study
The purpose of this study is to to compare the safety and effectiveness of IV urokinase with IV alteplase in the treatment of AIS in patients up to 6 hours from symptom onset.
- Trial name
- NCT06194968
- Testing
- Urokinase, Alteplase
- Where
- 16 sites in China
- Volunteers
- 1,800 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Stroke, Acute Ischemic
Establishing Mechanical Thrombectomy at a Limited-volume Stroke Center - Effects on Patient Morbidity and Mortality
The regional health authorities of South-East Norway has commissioned Sørlandet Hospital (SSHF), Norway to establish mechanical thrombectomy in large-vessel occlusion stroke.
- Trial name
- NCT04942041
- Testing
- Simulation based quality program
- Where
- Norway
- Volunteers
- 300 people
- Sponsor
- Sorlandet Hospital HF
Acute Ischemic Stroke
Effect of Postoperative Prolonged Sedation With Dexmedetomidine After Successful Reperfusion With EVT on Long-term Prognosis in Patients With AIS (PPDET)
Dexmedetomidine can attenuate the activity of the sympathetic nervous system under stress response and improve ischemia-reperfusion injury.
- Trial name
- NCT04916197
- Testing
- Dexmedetomidine prolonged sedation, 0.9% saline
- Where
- China
- Volunteers
- 368 people
- Sponsor
- Beijing Chao Yang Hospital
Acute Ischemic Stroke, Coronary Artery Disease
Cardiac CT Angiography in Patients With Acute Ischemic Stroke
Mortality rates after acute ischemic stroke remain high despite continuously improving treatment. In this context, it is important to note that a relevant portion of acute ischemic stroke patients die from adverse cardiovascular…
- Trial name
- ACUTE (NCT06176872)
- Testing
- Cardiac Computed Tomography Angiography
- Volunteers
- 165 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Acute Ischemic Stroke
Quelling of Excitotoxicity in Acute Stroke With Ketamine
The investigators plan to undertake a phase II study to investigate the efficacy and side effects of intravenous ketamine to reduce neuroexcitotoxicity, and thus provide neuroprotection in patients diagnosed with acute ischemic…
- Trial name
- QUEST-KETA (NCT03223220)
- Testing
- Ketamine, Normal Saline, Midazolam injection
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Lower Merion Neurology Research Foundation
Acute Coronary Syndrome, Myocardial Infarction
What is the Optimal Antithrombotic Strategy in Patients With Atrial Fibrillation Undergoing PCI?
The optimal antithrombotic management in patients with coronary artery disease (CAD) and concomitant atrial fibrillation (AF) is unknown.
- Conditions
- Acute Coronary Syndrome, Myocardial Infarction, Atrial Fibrillation, Atrial Flutter
- Trial name
- WOEST-3 (NCT04436978)
- Testing
- 30-day DAPT, Guideline-directed therapy
- Where
- 20 sites in Belgium, Netherlands
- Volunteers
- 2,000 people
- Sponsor
- St. Antonius Hospital
Acute Ischemic Stroke, Functional Outcomes
Effects of Human Urinary Kallidinogenase on Early Improvement and Functional Outcomes in Acute Ischemic Stroke (TK-SPEED)
The primary purpose of this trial is to evaluate the effects of Human Urinary Kallidinogenase on improvement of neurological outcome, and early cerebral perfusion in acute ischemic stroke.
- Trial name
- NCT06132880
- Testing
- Human Urinary Kallidinogenase, Clinical Routine Treatment
- Volunteers
- 540 people
- Sponsor
- Beijing Tsinghua Chang Gung Hospital
Stroke, Acute, Comorbidities and Coexisting Conditions
Giessen Stroke Registry
The aim of the planned study project is to assess the current situation regarding the treatment of patients with stroke. Specifically, various treatment strategies are to be associated and correlated with clinical endpoints…
- Conditions
- Stroke, Acute, Comorbidities and Coexisting Conditions, Critical Care
- Trial name
- GIST (NCT05295862)
- Where
- Germany
- Volunteers
- 2,000 people
- Sponsor
- University of Giessen
Stroke, Acute Ischemic, Endovascular Procedures
Triage of Patients With Acute Ischemic Stroke Due to Large Vessel Occlusions-2
The objective of this study is to create a comprehensive, real-world, multi-center observational registry of consecutive patients admitted to hospitals with acute ischemic stroke (AIS) caused by large vessel occlusions (LVO), who…
- Conditions
- Stroke, Acute Ischemic, Endovascular Procedures, Large Vessel Occlusion
- Trial name
- TRACK-LVO-2 (NCT05659160)
- Testing
- Endovascular Therapy
- Where
- 4 sites in China
- Volunteers
- 5,000 people
- Sponsor
- Tianjin Huanhu Hospital
Stroke, Acute
Registration of Intravenous Thrombolysis for Acute Ischemic Stroke in Southwestern China（IVTIS）
This study aims to observe the safety and effectiveness of intravenous thrombolysis for acute ischemic stroke in real-world clinical practice.
- Trial name
- IVTIS (NCT06131385)
- Testing
- intravenous thrombolysis
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Zhengzhou Yuan
Acute Ischemic Stroke
Hyperbaric Oxygen Therapy in Acute Ischemic Stroke Ischemic Stroke Recovery (Pro00061930)
This study will critically examine the feasibility, safety and efficacy of HBOT during inpatient rehabilitation (IPR) after acute ischemic stroke measured by non-disruption of 3 hours of daily therapy, frequency of neurological…
- Trial name
- NCT06148285
- Testing
- Hyperbaric Oxygen Therapy
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- LCMC Health
Acute Ischemic Stroke
Registration of Acute Ischemic Stroke With Large and Medium-sized Vascular Occlusion in Southwest China(LMVOS)
This study is designed to observe the treatment options in real-world clinical practice as well as the safety and efficacy of different treatment strategies.
- Trial name
- LMVOS (NCT06125236)
- Testing
- Visit at D90
- Where
- China
- Volunteers
- 8,000 people
- Sponsor
- Zhengzhou Yuan
Stroke, Acute, Stroke
Yield of Implantable Cardiac Monitoring Device in Patients With Acute Ischemic Stroke.
In this prospective cohort study, the investigators aim to investigate the incidence of ICM-detected AF in unselected ischemic stroke patients and its association with anticoagulation initiation and stroke recurrence.
- Conditions
- Stroke, Acute, Stroke, Stroke, Ischemic, Atrial Fibrillation
- Trial name
- NCT05494034
- Testing
- Reveal LINQTM
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- National and Kapodistrian University of Athens
Stroke, Acute Ischemic
Role of Hypothermia in Endovascular Stroke Thrombectomy
Reducing or suspending the increase of the infarcted core, i.e., "freezing" the ischemic penumbra, may help improve the efficacy of mechanical thrombectomy.
- Trial name
- COOLING (NCT06109376)
- Testing
- hypothermia, thrombectomy
- Volunteers
- 200 people
- Sponsor
- Xinqiao Hospital of Chongqing
Stroke, Acute Ischemic, PCSK9 Inhibitor
The Effect of Early Administration of PCSK9 Inhibitor to Acute Ischemic Stroke Patients Associated With Atherosclerosis on the Stroke Prognosis and Lipid Profile
The goal of this clinical trial is to test the effect of proprotein convertase subtilisin/kexin type 9 (PCSK9 inhibitors) in acute ischemic stroke patients associated with atherosclerosis by investigating 1.
- Trial name
- NCT06083961
- Testing
- Alirocumab
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Sun U. Kwon
Acute Ischemic Stroke, Type 2 Diabetes
Efficacy and Safety of Urinary Kallidinogenase in the Treatment of Acute Ischemic Stroke Combined With Type 2 Diabetes Mellitus
This study is a multicenter, randomized, double-blind, placebo parallel control study, aim to evaluate the efficacy and safety of human urinary kallidinogenase in the treatment of acute ischemic stroke with type 2 diabetes.
- Trial name
- TK-SEEK (NCT06085378)
- Testing
- Urinary Kallidinogenase for injection
- Where
- China
- Volunteers
- 630 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Acute Ischemic Stroke
Improving Low ASPECTS Stroke Thrombectomy
Improving Low ASPECTS Stroke Thromectomy (I-LAST) is an academic, independent, prospective, multicenter, observational registry study.
- Trial name
- I-LAST (NCT04862507)
- Testing
- Telephone call on day 90, Quantification of lesion water uptake by CT densitometry
- Where
- 8 sites in Germany, Switzerland
- Volunteers
- 500 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Acupuncture, Acute Ischemic Stroke
Efficacy and Safety of Head Acupuncture After Mechanical Thrombectomy for Acute Ischemic Stroke
To evaluate the efficacy and safety of head acupuncture combined with endovascular therapy for cerebral infarction compared with endovascular therapy alone
- Conditions
- Acupuncture, Acute Ischemic Stroke, Mechanical Thrombectomy
- Trial name
- HEALTH (NCT05561088)
- Testing
- Scalp Acupuncture, The treatment recommended in the guidelines for acute ischemic stroke was administered
- Where
- China
- Volunteers
- 272 people
- Sponsor
- Xi'an No.3 Hospital
Acute Ischemic Stroke
Association of Prophylactic Use of Stress Ulcer Drugs and Clinical Outcomes in Patients With Acute Anterior Circulation Thrombectomy
Ischemic stroke accounts for a relatively high proportion of strokes. In recent years, intravenous thrombolysis and endovascular therapy have significantly improved the revascularization rate in patients with large vessel…
- Trial name
- NCT05845372
- Where
- 19 sites in China
- Volunteers
- 2,592 people
- Sponsor
- Nanfang Hospital, Southern Medical University