Clinical trials: Acute Stroke Intervention
Stroke
Interventional Management of Stroke (IMS) II Study
The purpose of this study is to examine the effects of delivering intra-arterial recombinant tissue plasminogen activator (rt-PA) and ultrasound to the site of the blood clot blocking blood flow to the brain of stroke patients.
- Trial name
- NCT00243906
- Testing
- Recombinant tissue plasminogen activator, Low-intensity ultrasound
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- University of Cincinnati
Acute Ischemia
Acute Ischemic Apoplexy Syndrome Specificity and Acupuncture Intervention Research
This project optimizes the TCM Symptoms and Symptoms Scale. A curative effect evaluation system of acupuncture in the treatment of acute ischemic stroke is formed to provide clinical evidence by the following indexes…
- Trial name
- AIAI (NCT04528472)
- Testing
- Acupuncture Treatment, Regular Treatment
- Volunteers
- 194 people
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Stroke Due to Basilar Artery Occlusion, Acute Cerebrovascular Accidents
Acute Basilar Artery Occlusion: Endovascular Interventions vs Standard Medical Treatment
This trial will provide valuable insights into the safety and efficacy of endovascular treatment for acute ischemic stroke patients with basilar artery occlusion within 8 hours of estimated occlusion time.
- Trial name
- BEST (NCT02441556)
- Testing
- endovascular treatment, standard medical therapy
- Where
- 44 sites in China
- Volunteers
- 131 people
- Sponsor
- Xinfeng Liu
Stroke
Breakfast Group Interventions in Stroke Rehabilitation
Current evidence shows that many people living with stroke experience major problems with eating and drinking. We know that this can lead to malnutrition, dehydration, reduced muscle strength and depression.
- Trial name
- BISTRo (NCT05102812)
- Testing
- Breakfast Group Intervention
- Where
- United Kingdom
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Acute Ischemic Stroke
First-in-man Study of the Cerebrovascular Interventional Procedural Control System
The objective of this study the first human use of a new device in treatment of acute ischemic stroke, which to evaluate the feasibility, safety, and efficacy of the Cerebrovascular Interventional Procedural Control System.
- Trial name
- NCT05972252
- Testing
- Cerebrovascular Interventional Procedural Control System
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Hangzhou Dinova Neuroscience Technology Co., Ltd
Acute Stroke
New York City Mobile Interventional Stroke Team
Endovascular treatment has recently become the recommended therapy for acute stroke after the publication of five randomized trials (MR CLEAN1, ESCAPE2, EXTEND IA3, SWIFT PRIME4, REVASCAT5) in 2015 that demonstrate its efficacy.
- Trial name
- NYC MIST (NCT03048292)
- Testing
- Acute Endovascular Stroke Treatment
- Where
- 4 sites in United States
- Volunteers
- 191 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Guided Training, Directed Training
Examining Rehabilitation Training Methods
Individuals with cognitive impairments after stroke sustain significant disability in their daily tasks, and account for a significant proportion of stroke-related healthcare costs.
- Trial name
- GUIDE (NCT02766400)
- Testing
- Guided Training, Directed Training
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- University of Pittsburgh
Acute Ischemic Stroke, Cerebral Autoregulation
Ultra-early Identification of Futile Recanalization After Reperfusion Therapy in Acute Ischemic Stroke Based on Cerebral Autoregulation Monitoring
This multicenter, prospective, and interventional diagnostic accuracy study enrolls patients undergoing thrombectomy with intraoperative cerebral autoregulation monitoring and follows them up at predefined time points up to 90…
- Trial name
- FACTOR (NCT07747701)
- Testing
- NIRS-based cerebral oxygenation and blood pressure monitoring, Carotid compression test
- Where
- 4 sites in China
- Volunteers
- 227 people
- Sponsor
- Beijing Shijitan Hospital, Capital Medical University
Acute Ischemic Stroke
Single Arm Trial to Evaluate the Safety and Effectiveness of the Route 92 Medical Reperfusion System
The objective of the study is to evaluate the safety and effectiveness of the Route 92 Medical Monopoint Reperfusion System with the Hi Point 88 and HiPoint 70 Reperfusion Catheters when used to aspirate emboli in acute ischemic…
- Trial name
- SUMMITNZ (NCT05429658)
- Testing
- Thrombectomy
- Where
- 2 sites in New Zealand
- Volunteers
- 66 people
- Sponsor
- Route 92 Medical, Inc.
Acute Ischaemic Stroke
Efficacy and Security of an Endovascular Treatment as First Choice Procedure Compared With a Standard Intravenous Thrombolytic Therapy Treatment for Patients With Acute Ischemic Stroke Within 4.5 Hours After Onset
This study will compare two ways of treatment for acute ischemic stroke: an endovascular treatment (EVT), defined as intraarterial thrombolysis and/or mechanical thrombectomy as a first choice treatment versus intravenous…
- Trial name
- FUN-TPA (NCT02164357)
- Testing
- EVT (endovascular treatment ), IVT (intravenous thrombolytic therapy)
- Where
- 5 sites in Spain
- Volunteers
- 124 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Neurology, Interventional Therapy
A Retrospective Study of Reco Thrombectomy Stent for Intravascular Treatment of Acute Ischemic Stroke
To explore the differences in the green channel process of stroke in various regions of the same province, to target and shorten the time delay of emergency process, and to explore the key technologies of endovascular treatment…
- Trial name
- NCT05166733
- Where
- China
- Volunteers
- 300 people
- Sponsor
- PengYa
Ischemic Stroke, Acute, Thrombectomy
Total Intravenous Anesthesia Versus Sevoflurane Anesthesia for Endovascular Thrombectomy in Acute Ischemic Stroke
The present clinical trial compares the effect of two general anesthesia (GA) modalities, the one with volatile anesthetic sevoflurane (endotracheal-intubated) and the other integrating total intravenous anesthesia (TIVA) with…
- Conditions
- Ischemic Stroke, Acute, Thrombectomy, General Anesthesia, Total Intravenous Anesthesia
- Trial name
- NCT05493813
- Testing
- Cognitive function and delirium evaluation, Neurological functional assessment
- Where
- Taiwan
- Volunteers
- 298 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Acute Stroke
A Randomized Clinical Trial of Oral Health Promotion Interventions Among Patients After Stroke
The main aim of this oral health intervention project is to compare the effect of providing 1) professional oral hygiene instruction alone versus 2) professional oral hygiene instruction plus adjunctive Chlorhexidine mouth rinse…
- Trial name
- NCT01265043
- Testing
- Oral hygiene intervention
- Where
- Hong Kong
- Volunteers
- 102 people
- Sponsor
- The University of Hong Kong
Acute Stroke
Evaluation of Physical Therapy Interventions and Patient Characteristics on Outcomes
Data collection for this study will be done by clinicians working in inpatient rehabilitation units with persons with acute stroke. No interventions are included in this study.
- Trial name
- PBE (NCT02098083)
- Where
- 4 sites in United States
- Sponsor
- University of Texas Southwestern Medical Center
Ischemic Stroke, Acute Stroke
The Imperative Trial: Treatment of Acute Ischemic Stroke With the Zoom Reperfusion System
The trial is designed to assess the safety and efficacy of using the Zoom Reperfusion System in subjects diagnosed with acute ischemic stroke and undergoing a thrombectomy procedure within 8 hours of last known well.
- Trial name
- NCT04129125
- Testing
- Zoom Reperfusion System
- Where
- 28 sites in United States
- Volunteers
- 328 people
- Sponsor
- Imperative Care, Inc.
Stroke, Acute
Validation of Aspiration Risk Assessment in Stroke Units
The purpose of the study is to test the validity of a modified Daniels swallow test. The original test serves as reference method, the swallow endoscopy (FEES) as "gold standard".
- Trial name
- ARAS (NCT06162910)
- Testing
- Daniels Water Swallow Test, Flexible Endoscopic Evaluation of Swallowing
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- University of Giessen
Acute Ischemic Stroke
The Effectiveness of Early Mobilization for Acute Ischemic Stroke Treated With Rt-PA or IA Thrombectomy
The purpose of the study will to test the hypothesis that combining early out-of-bed mobilization within 72 hours of stroke onset with treated by intravenous recombinant tissue-type plasminogen activator (IV-rtPA) or endovascular…
- Trial name
- NCT03680469
- Testing
- standard early rehabilitation, adding early out-of-bed mobilization
- Where
- Taiwan
- Volunteers
- 122 people
- Sponsor
- National Taiwan University Hospital
Stroke
Study to Assess the Safety and Effectiveness of the Penumbra System
This clinical evaluation is a prospective, single-arm, multi-center trial. The purpose of this clinical evaluation is to assess the safety and effectiveness of the Penumbra System in the revascularization of patients presenting…
- Trial name
- NCT00334061
- Testing
- Penumbra System
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Penumbra Inc.