Clinical trials: Acute Traumatic Pain
Pain, Acute, Analgesia
Retrospective Evaluation of Ketamine Effectiveness for the Treatment of Acute Battlefield Related Pain
Using a retrospective review of records, we will conduct a multivariate analysis to examine the relationship between exposure to ketamine, as an analgesic agent in combat related trauma care, the use of additional opioid pain…
- Conditions
- Pain, Acute, Analgesia, Amputation, Traumatic, Post Traumatic Stress Disorder
- Trial name
- NCT04057989
- Testing
- ketamine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Defense and Veterans Center for Integrative Pain Management
Post-Traumatic Headache, Acute Pain
Titrated Versus High and Low Dose Nebulized Morphine to Reduce Pain in Emergency Settings
The investigators test a different technique using morphine to improve pain relief in patient visiting the emergency department with acute trauma pain, for this we are comparing three different methods of morphine administration…
- Trial name
- TIMORNEB (NCT02200185)
- Testing
- IV titrated morphine, Low dose nebulised morphine, High dose nebulised morphine
- Where
- Tunisia
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Monastir
Acne, Bites
Implementation of a Minor Ailment Service in Community Pharmacy Practice
Self-care and self-medication are commonly the treatments of choice for the management of minor ailments. Minor ailments can be treated through community pharmacy using a Minor Ailment Service (MAS).
- Conditions
- Acne, Bites, Burns, Cold
- Trial name
- INDICA+PRO (NCT05247333)
- Testing
- Minor ailment service
- Where
- Spain
- Volunteers
- 20,987 people
- Sponsor
- Universidad de Granada
Pain, Traumatic Limb Injury
Pain Reduction With Intranasal Medications for Extremity Injuries
This study compares the analgesic effect of intranasal sub-dissociative dosing of ketamine and intranasal fentanyl in children presenting to the Emergency Department with acute extremity injuries.
- Trial name
- PRIME (NCT02778880)
- Testing
- Ketamine, Fentanyl
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Acute Myocardial Infarction
Place of Copeptin-troponin Assay in the Elimination Diagnosis of Non-ST+ ACS
The aim of this study is to demonstrate that a combined troponin and copeptin assay can exclude non-ST+ ACS in patients with chest pain less than 6 hours old.
- Trial name
- CopSCA (NCT05902117)
- Testing
- Troponin and Copeptin assay
- Where
- 2 sites in France
- Volunteers
- 270 people
- Sponsor
- Hôpital NOVO
Wound; Abdomen, Abdomen, Acute
Direct Resuscitation of the Open Peritoneum
The DROP trial evaluates two ways of treating patients whose abdomens are left open after their abdominal surgery. The current standard of care at Sanford is for patients to have their wound covered with a sterile dressing…
- Conditions
- Wound; Abdomen, Abdomen, Acute, Wound Surgical
- Trial name
- SH DROP (NCT04887480)
- Testing
- Abthera™ Open Abdomen Negative Pressure Therapy Device System, Dianeal PD-2 with 2.5% Dextrose
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Sanford Health
Pain
Pre-hospital Nebulized Ketamine for Pain
In the situation when intravenous access is not readily available or unobtainable, or when prehospital delays to obtain intravenous access are not warranted, sub-dissociative dose ketamine can be administered via intranasal (IN)…
- Trial name
- NCT04162028
- Testing
- Nebutlized Ketamine
- Where
- United States
- Sponsor
- Antonios Likourezos
Traumatic Brain Injury, Headaches Posttraumatic
Adjunct VR Pain Management in Acute Brain Injury
Severe and refractory pain after acute injury is a known-risk factor for chronic opioid use disorder. In this study, the investigators will use Virtual Reality (VR) immersion as a non-pharmacological adjunct to treat pain…
- Conditions
- Traumatic Brain Injury, Headaches Posttraumatic, Trauma, Pain, Acute
- Trial name
- NCT04356963
- Testing
- Virtual Reality Session (VR Blu), Tablet-based Session (Tablet Blu), Use of Virtual Reality Head Mounted Display without Content (VR Blank)
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of Maryland, Baltimore
Traumatic Injury, Pain, Acute
Evaluation of Dronabinol For Acute Pain Following Traumatic Injury
Single center, non-blinded, randomized controlled trial. Enrollment is based on ≥50 MME within 24 hours of admission, followed by a 24 hour screening/randomization window and a participation period extending through the acute…
- Trial name
- NCT03928015
- Testing
- Adjunctive dronabinol, Systemic analgesics
- Where
- United States
- Sponsor
- CommonSpirit Health
Injuries, Pain
Randomized Double Blind Controlled Trial Comparing a Blind Sciatic Nerve Block in the Popliteal Fossa to Intravenous Morphine for Traumatic Severe Acute Pain in the Prehospital Setting
The purpose of the study is to determine the efficacity of a simple blind technic of loco regional anaesthesia of the sciatic nerve compared to the gold standard in emergency medecine : the intravenous morphine for treated the…
- Conditions
- Injuries, Pain, Emergencies
- Trial name
- BPOP (NCT01522534)
- Testing
- Mepivacaine, Morphine
- Where
- 6 sites in France
- Volunteers
- 26 people
- Sponsor
- Centre Hospitalier Annecy Genevois
Severe Traumatic Pain, Numeric Pain Rating Scale > 5 / 10
Intra Nasal Sufentanil Versus Intravenous Morphine for Acute Severe Traumatic Pain Analgesia in Emergency Setting
Intranasal (IN) administration of opiates is an appealing non-invasive way of treating acute traumatic pain in prehospital and Emergency departments (ED).
- Trial name
- ALGOFINE-2 (NCT02095366)
- Testing
- Morphine, Sufentanil
- Where
- 6 sites in France
- Volunteers
- 194 people
- Sponsor
- University Hospital, Grenoble
Acute Pain Due to Trauma
NSAIDs Versus Paracetamol Versus Paracetamol + NSAIDs in Traumatic Pain Management
The purpose of this study is to: Compare the effect of paracetamol alone against NSAIDs alone against the association of paracetamol + NSAIDs in the treatment of traumatic pain.
- Trial name
- NCT03222518
- Testing
- Paracetamol, NSAID, paracetamol-NSAID
- Where
- Tunisia
- Volunteers
- 1,500 people
- Sponsor
- University of Monastir
Pain
Study of Non Inferiority Bi-Profenid® 200mg Versus Bi-Profenid® 300mg Among Patients Presenting of the Post-traumatic or Rheumatologic Acute Affections of the Locomotor Apparatus (BIPROPAIN)
Primary objective: To demonstrate the non-inferiority of Bi-Profenid 100 mg x 2 day versus Bi-Profenid 150 mg x 2 day in patients presenting with pain related to closed, benign, acute post-traumatic conditions of the motor system…
- Trial name
- NCT00810121
- Testing
- ketoprofen 100 mg, ketoprofen
- Where
- France
- Volunteers
- 409 people
- Sponsor
- Sanofi
Acute Stress Disorder, Anxiety
Safety & Efficacy of Intranasal Dexmedetomidine, Fentanyl & Midazolam in the Pediatric Emergency Room
The hypothesis is that intranasal dexmedetomidine will provide significantly more effective analgesia and anxiolysis for subjects undergoing a simple laceration repair when compared to either intranasal fentanyl or intranasal…
- Conditions
- Acute Stress Disorder, Anxiety, Pain
- Trial name
- NCT05057689
- Testing
- Intranasal Dexmedetomidine (4 mcg/kg), Intranasal Fentanyl (2 mcg/kg), Intranasal Midazolam (5 mg/kg)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Nationwide Children's Hospital
Rib Fracture Multiple, Trauma Chest
Lidocaine Infusions for Rib Fractures
Patients with traumatic rib fractures not receiving regional anesthesia through a epidural or nerve block catheter will be recruited for the study.
- Conditions
- Rib Fracture Multiple, Trauma Chest, Pain, Acute
- Trial name
- Lidocare (NCT03571919)
- Testing
- Lidocaine infusion, Saline infusion
- Where
- United States
- Sponsor
- Stanford University
Traumatic Rib Fracture(s), Traumatic Rib Fracture
Erector Spinae Plane vs Serratus Anterior Plane Catheter Infusions for Acute Pain Management in Patients With Traumatic Rib Fractures
Rib fractures happen in about 10-20% of patients with blunt trauma and can be serious, with higher death rates in older adults. These injuries often lead to lung problems like pneumonia, collapsed lung areas (atelectasis), fluid…
- Trial name
- NCT07756047
- Testing
- Erector spinae plane catheter, Serratus plane catheter
- Where
- Canada
- Volunteers
- 66 people
- Sponsor
- Sunnybrook Health Sciences Centre
Rib Fractures, Rib Fracture Multiple
UltrasouNd-guided Percutaneous Intercostal Nerve Cryoneurolysis for Analgesia Following Traumatic Rib Fracture
Traumatic rib fractures (i.e., broken ribs caused by a physical injury) are common and very painful. They also often lead to serious complications, more time spent in hospital, and can even lead to death.
- Conditions
- Rib Fractures, Rib Fracture Multiple, Rib; Fracture, With Flail Chest, Pain
- Trial name
- UNPIN (NCT05865327)
- Testing
- Cryoneurolysis
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Sunnybrook Health Sciences Centre
Pain, Acute
Prehospital Analgesia in Adults Using Inhaled Methoxyflurane Study
This study is about a new pain relief medication called methoxyflurane. Pain from injuries, like broken bones, is a big reason people call ambulances.
- Trial name
- NCT06392087
- Testing
- Methoxyflurane, Standard Care
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Pain
Pain and Anxiety Management of Traumatic Emergency in a Pre-hospital Setting
Unexpected acute pain in an emergency setting causes anxiety, insecurity, and stress that can diminish perceptions of control over pain and diminish ability to decrease pain.
- Trial name
- NCT01151696
- Testing
- Atarax (Hydroxyzine)
- Where
- France
- Volunteers
- 140 people
- Sponsor
- University Hospital, Toulouse
Rib Fracture Multiple, Pain, Chest
RIB PAIN (Rib Fractures Treated With Parental Analgesia With Infused LidocaiNe)
Traumatic rib fractures (RF) are a relatively common occurrence in patients of all ages, with a 10% incidence in all trauma patients and are associated with significant morbidity and mortality.
- Conditions
- Rib Fracture Multiple, Pain, Chest, Pain, Acute, Respiratory Failure
- Trial name
- RIB PAIN (NCT03770208)
- Testing
- Intervention: Lidocaine
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- Western University, Canada