Clinical trials: Acute Traumatic Pain
Acute Traumatic Pain
Trauma Acute Pain Treatment With Methoxyflurane Vaporized (PENTHROX®): Efficacy and Safety Study (MEDITA)
The prompt treatment of pain due to minor trauma is often an unmet need in both Emergency Room Department and Ambulance Rescue. Most of the available drugs are intravenously administered and such route of administration may…
- Trial name
- MEDITA (NCT03585374)
- Testing
- Methoxyflurane and Penthrox inhaler, Morphine, Paracetamol
- Where
- 16 sites in Italy
- Volunteers
- 272 people
- Sponsor
- Mundipharma Pharmaceuticals srl
Concussion, Headache
Use of Ibuprofen and Acetaminophen for Treatment of Acute Headache Post Concussion in Children
Concussions and headache are a significant problem for children and athletes. While headache generally resolves within 7-10 days; a significant proportion of children, 72-93% experience prolonged headache as a symptom of Post…
- Trial name
- NCT02268058
- Testing
- Acetaminophen, Ibuprofen
- Volunteers
- 80 people
- Sponsor
- McMaster Children's Hospital
Acute Headache, Migraine
High- vs Standard-Dose Intravenous Magnesium for Acute Headache
Headache is one of the most common reasons for consultation in emergency departments and represents a significant cause of disability, particularly in patients with migraine and other primary headache disorders.
- Conditions
- Acute Headache, Migraine, Tension-type Headache, Cluster Headache
- Trial name
- MAGHEAD (NCT07779486)
- Testing
- Magnesium Sulfate 2 grams, Magnesium Sulfate 4 G, Paracetamol 1 g
- Where
- Tunisia
- Volunteers
- 300 people
- Sponsor
- University of Monastir
Musculoskeletal Pain
Comparison of Efficacy of Intravenous Paracetamol and Dexketoprofen for Acute Traumatic Musculoskeletal Pain
Currently, paracetamol and nonsteroidal antiinflammatory drugs are widely used by emergency physicians in Turkey for the treatment of patients with acute traumatic musculoskeletal pain.
- Trial name
- NCT03428503
- Testing
- Paracetamol, Dexketoprofen
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Pamukkale University
Multiple Trauma, Pain, Acute
Intranasal Ketamine Versus Intranasal Fentanyl
Abstract Background: Given the inadequate control of pain in patients with injury that refer to the emergency departments, the rapid onset of action of intranasal administration in pain management, and the avoidance of…
- Trial name
- NCT04414800
- Testing
- Ketamine, Fentanyl
- Where
- Iran
- Volunteers
- 125 people
- Sponsor
- Isfahan University of Medical Sciences
Patients With Traumatic Pain, Post-surgical Pain and Tooth Extract Pain
Celecoxib Japan Observational Study for the Patients With Acute Pain
This study is to assess the safety and efficacy of celecoxib on the pain relief from acute pain.
- Trial name
- NCT01876121
- Testing
- Celecoxib
- Where
- 7 sites in Japan
- Volunteers
- 784 people
- Sponsor
- Astellas Pharma Inc
Single Traumatic Limb Injury With Severe Pain (Score > 5/10 on Numerical Pain Scale)
Intranasal Sufentanil Pain-management at Entrance of Emergency Department : Influence on Pain-relief Delay
Non-invasive and simple, intranasal (IN) route of administration seems promising for pain management in the Emergency Department (ED), especially when used precociously by triage nurse to rapidly deliver the first opioid dose to…
- Trial name
- InSPEED (NCT01954368)
- Testing
- Sufentanil
- Where
- France
- Volunteers
- 144 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Rib Fracture, Rib Fracture Multiple
Orthosis of Acute Traumatic Rib Fractures Via RibFx Belt for Pain Alleviation and Improved Pulmonary Function
Acute traumatic rib fractures are a common issue for patients of trauma surgeons. They inflict substantial morbidity, the most dreaded and consequential of which are pulmonary complications.
- Conditions
- Rib Fracture, Rib Fracture Multiple, Trauma, Trauma Chest
- Trial name
- RibFx (NCT03846024)
- Testing
- RibFx Orthosis Belt
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Vermont Medical Center
Chronic Pain, Acute Pain Due to Trauma
The Mobile PTSD Coach App in Acute Injury Survivors
This project is a preliminary randomized controlled trial testing the potential impact of the PTSD Coach mobile application at reducing posttraumatic stress and pain symptoms among acutely injured trauma patients.
- Conditions
- Chronic Pain, Acute Pain Due to Trauma, Posttraumatic Stress Disorder
- Trial name
- NCT03247179
- Testing
- PTSD Coach mobile application
- Where
- 2 sites in United States
- Volunteers
- 64 people
- Sponsor
- University of Pittsburgh
Amputation, Traumatic, Pain, Phantom
Feasibility of Using an App for Managing Phantom Limb Pain Associated with Combat Injury in Ukraine (PAMELA)
In Ukraine, since the beginning of the full-scale war on February 24, 2022, a large number of individuals have lost a limb(s). Many of these amputees cannot access appropriate care in terms of pain management and rehabilitation.
- Conditions
- Amputation, Traumatic, Pain, Phantom, Pain, Acute, Pain, Chronic
- Trial name
- PAMELA (NCT06604507)
- Testing
- non-pharmacological app
- Where
- 5 sites in Ukraine
- Volunteers
- 200 people
- Sponsor
- Winfried Meißner
Acute Traumatic Pain
A Pilot Study on the Use of Methoxyflurane (Penthrox®) for Pain Control in the Emergency Department
Patients commonly visit the emergency department (ED) for pain after musculoskeletal injury and need early treatment with analgesic.
- Trial name
- NCT04618497
- Testing
- Methoxyflurane, Ketorolac
- Where
- Hong Kong
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hospital Authority, Hong Kong
Hip Fractures, Acute Pain
PENG Block for Traumatic Hip Fracture in the Emergency Department
The study is a multicenter single-blinded randomized comparative trial. Adult patients older than 20 years of age presenting with acute hip fracture in emergency department between January 1st, 2021 and December 31st, 2021 will…
- Conditions
- Hip Fractures, Acute Pain, Emergency Department
- Trial name
- NCT04997785
- Testing
- Ultrasound-guided Pericapsular Nerve Group (PENG) Block
- Where
- Taiwan
- Volunteers
- 65 people
- Sponsor
- Dalin Tzu Chi General Hospital
Acute Pain, Wound Care
RCT: Fentanyl Plus Ketamine Versus Fentanyl Alone for Acute Burn Pain
The Ketamine for Acute Pain in Burns study is a randomized, double-blind, parallel group trial (RCT) with active control (usual care) contrasting the efficacy and safety of "Ketamine Plus Opiate-based usual care" (O+K) with the…
- Conditions
- Acute Pain, Wound Care, Posttraumatic Stress Disorder
- Trial name
- NCT03305055
- Testing
- ketamine, Fentanyl
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Johns Hopkins University
Chronic Pain, Chronic Pain Syndrome
Outcomes Mandate National Integration With Cannabis as Medicine
This will be a multistate, multicenter clinical study to determine the efficacy and safety of medical cannabis for a wide variety of chronic medical conditions.
- Conditions
- Chronic Pain, Chronic Pain Syndrome, Chronic Pain Due to Injury, Chronic Pain Due to Trauma
- Trial name
- OMNI-Can (NCT03944447)
- Testing
- Cannabis, Medical, RYAH-Medtech Inhaler
- Where
- 17 sites in United States
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- OMNI Medical Services, LLC
Low Back Pain
Orphenadrine and Methocarbamol for LBP
Low back pain is a common cause of visit to emergency department. It is not clear if skeletal muscle relaxants are of benefit for patients with acute low back pain.
- Trial name
- NCT02665286
- Testing
- Orphenadrine, Methocarbamol, Naproxen
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Montefiore Medical Center
Acute Flank Pain
TCHCCT-Zhong-Xing-Emergency-Department Ultrasound With IV Contrast in Acute Flank Pain
To evaluate the efficiency of ultrasound with IV contrast and compare this with the Computed Tomography in acute flank pain patient at Emergency Department.
- Trial name
- NCT04877886
- Testing
- Ultrasound with IV contrast, CT with IV contrast, Ultrasound without IV contrast
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Taipei City Hospital
Injury Traumatic, Pain, Acute
Safety and Efficacy of Sufentanil Administration by Paramedics in Acute Trauma
The safety and efficacy of competence of paramedics to administer sufentanil intravenously in adult acute trauma patients without presence or without phone-call consult with an emergency medical doctor will be assessed in this…
- Trial name
- NCT06514469
- Testing
- Sufentanil intravenous administration followed consultation of remote physician, Sufentanil intravenous administration based on paramedic competency
- Where
- Czechia
- Volunteers
- 300 people
- Sponsor
- Zdravotnicka Zachranna Sluzba Karlovarskeho Kraje, P.O.
Acute Traumatic Pain
Morphine-Midazolam in Pre-hospital Traumatic Patients With Severe Acute Pain
Administration of midazolam with morphine in patients with severe acute pain is a routine practice in the management of pre- and post-operative patients but has not been evaluated in pre-hospital setting.
- Trial name
- Morphine-Mida (NCT01731184)
- Testing
- Midazolam
- Where
- 4 sites in France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier de Cornouaille
Head Pain
Intravenous Magnesium Sulfate Vs Placebo to Treat Non -Traumatic Acute Headaches in the Emergency Department
Intravenous Magnesium Sulfate Vs Placebo to Treat Non -Traumatic Acute Headaches in the Emergency Department
- Trial name
- NCT05325580
- Testing
- Magnesium sulfate
- Where
- Tunisia
- Volunteers
- 424 people
- Sponsor
- University of Monastir
Non-traumatic Low Back Pain
Comprehensive Biopsychosocial Approach for Acute Low Back Pain Management in the Emergency Department: a Stepped-wedge Cluster-randomized Clinical Trial
Acute low back pain, the second leading cause of medical consultations in France, poses a major public health challenge, particularly because of its high risk of progressing to chronic low back pain-the leading cause worldwide of…
- Trial name
- CALM-ED (NCT07375914)
- Testing
- Biopsychosocial intervention
- Where
- France
- Volunteers
- 782 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris