Clinical trials: Acute Variceal Bleed
GastroIntestinal Bleeding, Anemia
Iron Supplementation in Upper Non-variceal Gastrointestinal Bleeding
Anemia is a frequent complication of gastrointestinal bleeding, affecting 61% of the patients. Currently, anemia caused by gastrointestinal bleeding can be treated with iron supplementation.
- Trial name
- FIERCE (NCT05060731)
- Testing
- Oral iron supplementation, Intravenous iron supplementation
- Where
- Hungary
- Volunteers
- 570 people
- Sponsor
- University of Pecs
Liver Cirrhosis, Hepatoma
A Trial of EVL\GVS Alone vs. EVL\GVS Combined Propranolol
New strategy to improve the outcomes in patients with HCC and acute variceal bleeding. NSBB added to endoscopic ligation may further reduce rebleeding in cirrhotic patients.
- Trial name
- NCT01298284
- Testing
- propranolol
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Cirrhosis, Liver, Portal Hypertension
Timing of Endoscopy for Acute Variceal Bleeding in Patients With Cirrhosis
Cirrhotic patients with AVB across 34 university medical centers in 30 cities in China from February 2013 to May 2020 who underwent endoscopy within 24 hours were included in this study.
- Conditions
- Cirrhosis, Liver, Portal Hypertension, Varice Bleed
- Trial name
- NCT04957875
- Testing
- emergency endoscopic therapy
- Where
- China
- Volunteers
- 3,300 people
- Sponsor
- Hepatopancreatobiliary Surgery Institute of Gansu Province
Ulcer, on Gastric Varices, Rebleeding From Gastric Varices
A Prospective, Randomized Trial of Histoacryl Injection Versus Thrombin in the Control of Acute Gastric Variceal Bleeding
Though histoacryl injection is now regarded as treatment of choice in the control of gastric variceal hemorrhage, it may be associated with a lot of complications such as ulcers, ulcer bleeding, bacterial infections, distant site…
- Trial name
- NCT01717612
- Testing
- Thrombin, Histoacryl
- Where
- Taiwan
- Volunteers
- 62 people
- Sponsor
- National Science and Technology Council, Taiwan
Acute on Chronic Liver Failure, Variceal Hemorrhage
Goal-Directed Hemostatic Resuscitation Trial in ACLF Induced Coagulopathy
In this project, we plan to evaluate whether a new, rotational thromboelastometry-guided algorithm (ROTEM) to guide hemostatic resuscitation decreases the use of allogeneic blood products, the total amount of bleeding…
- Conditions
- Acute on Chronic Liver Failure, Variceal Hemorrhage, Cirrhosis, Liver, Thromboelastometry
- Trial name
- GOODHEART-ACLF (NCT05124041)
- Testing
- Rotational thromboelastometry
- Where
- India
- Volunteers
- 262 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Esophageal Varices, Portal Hypertension
Use of Sanvar® With Endoscopic Treatment for the Control of Acute Variceal Bleeding
The main objective of this study is to determine the efficacy of early administration of Sanvar® in combination with endoscopic treatment for the control of acute variceal bleeding.
- Conditions
- Esophageal Varices, Portal Hypertension, Gastric Varices, Esophageal Bleeding
- Trial name
- NCT00331188
- Testing
- Sanvar® (vapreotide)
- Where
- 19 sites in United States
- Volunteers
- 70 people
- Sponsor
- Debiovision
Acute Gastroesophageal Variceal Bleeding
Comparison of Early Vs Delayed Feeding on Rebleeding Following Endoscopic Ligation for Acute Esophageal Variceal Bleeding
Following endoscopic therapy of variceal bleeding, the issue of when to refeed these patients has rarely been investigated. This may imply that feeding is generally regarded as a negligible factor in the management of bleeding…
- Trial name
- EVLF (NCT03306095)
- Testing
- Early refeeding group, Delayed refeeding group
- Where
- India
- Volunteers
- 200 people
- Sponsor
- Dayanand Medical College and Hospital
Acute Bleeding Esophageal Varices
RCT of Stent Versus Standard Therapy in Oesophageal Variceal Haemorrhage
The mortality rates from Acute Variceal Haemorrhage remain significant and first line therapy may fail in 15-25% of patients. The self-expandable metal stent has been described in case series as having a very high efficacy at…
- Trial name
- SOV (NCT01851564)
- Testing
- Self-expanding mesh-metal oesophageal stent (SEMS), Standard Therapy
- Where
- 3 sites in United Kingdom
- Volunteers
- 14 people
- Sponsor
- University College, London
Acute Upper Gastrointestinal Non Variceal Hemorrhage
Endoscopic Diagnosis and Treatment of Acute Nonvariceal Upper Gastrointestinal Bleeding
Acute nonvariceal upper gastrointestinal bleeding (ANVUGIB) is a common critical disease in gastroenterology. Due to the development of modern medical technology, the incidence rate of ANVUGIB has been decreasing in recent years…
- Trial name
- NCT04895904
- Testing
- No intervention
- Volunteers
- 3,200 people
- Sponsor
- The First Affiliated Hospital of Nanchang University
Vasoconstrictor Choice on Acute Variceal Bleeding
Vasoactive Drugs in Real World Practice
Various vasoactive drugs are recommended to use in combination with endoscopic variceal ligation (EVL) in treating acute esophageal variceal bleeding (EVB).
- Trial name
- NCT02757703
- Testing
- Somatostatin, Terlipressin, Pantoprazole
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Gastric Variceal Bleeding
Comparison of Endoscopic Injection of Conventional and Double Doses Cyanoacrylate for Gastric Variceal Hemorrhage
The recent practice guideline recommends endoscopic injection of cyanoacrylate (GVO) is the preferred method to treat acute gastric variceal bleeding.
- Trial name
- NCT00735358
- Testing
- Cyanoacrylate
- Volunteers
- 105 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Gastric Varices
Acute Gastric Variceal Bleeding: Endoscopic Treatment Versus BRTO
The purpose of this study is to study the efficacy of endoscopic cyanoacrylate injection versus balloon-occluded retrograde transvenous obliteration in the management of acute gastric bleeding.
- Trial name
- NCT02468167
- Testing
- Balloon-occluded retrograde transvenous obliteration, Endoscopic cyanoacrylate injection, N-butyl-2-cyanoacrylate
- Where
- China
- Volunteers
- 70 people
- Sponsor
- West China Hospital
Upper Gastrointestinal Bleeding, Acute Kidney Injury
Acute Kidney Injury in Upper GI Bleeding Patients
This study aims to evaluate the incidence of acute kidney injury (AKI) among patients presenting with acute upper gastrointestinal bleeding (UGIB) at Sohag University Hospitals, and to identify predictors associated with renal…
- Trial name
- NCT07636083
- Testing
- Observational assessment
- Where
- Egypt
- Volunteers
- 200 people
- Sponsor
- Sohag University
Gastric Variceal Bleeding
Removable Titanium Clip Treatment for Acute Variceal Hemorrhage from the Gastric Fundus
Removable Titanium Clip Treatment for Acute Variceal Hemorrhage from the Gastric Fundus
- Trial name
- NCT06736314
- Testing
- a removable titanium clip
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Shupei Li
Esophageal Varicose Veins
Early TIPS in Real Life for Patient Admitted to Intensive Care Unit
Acute esophageal variceal bleeding (AEVB) is a serious complication of cirrhosis, with high morbidity and mortality. The latest European recommendations(1) recommend the early implementation, within 72 hours following esophageal…
- Trial name
- REALYTIPS (NCT04173299)
- Testing
- early tips
- Volunteers
- 100 people
- Sponsor
- Nantes University Hospital
Acute Non-variceal Upper Gastrointestinal Hemorrhage, Coronary Heart Disease
Timing of Endoscopy in Coronary Heart Disease Patients Taking Antiplatelet Drugs With Acute Non-variceal Upper Gastrointestinal Bleeding
This is a prospective randomized controlled trial (RCT) evaluating the optimal timing of endoscopy in patients with coronary heart disease who are taking antiplatelet drugs and present with acute non-variceal upper…
- Trial name
- PACT-UGIB (NCT07507162)
- Testing
- Urgent Endoscopy (Within 12 Hours of Admission), Early Endoscopy (12-24 Hours After Admission)
- Volunteers
- 212 people
- Sponsor
- Beijing Anzhen Hospital
Gastrointestinal Hemorrhage
Bipolar Hemostatic Forceps Versus Standard Therapy in Acute Non-variceal Upper GI Bleeding
Bipolar hemostatic forceps will be tested against standard therapy in active, non-variceal, upper gastrointestinal bleeding by a prospective, randomized trial
- Trial name
- BeBop (NCT05353062)
- Testing
- Hemostatic therapy, Endoscopic therapy with hemoclip +/- injection of epinephrine solution
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- Theresienkrankenhaus und St. Hedwig-Klinik GmbH
Variceal Hemorrhage
Efficacy of Continuous Terlipressin Therapy After Endoscopic Variceal Ligation
Upper gastrointestinal (UGI) bleed of variceal origin is a common medical emergency. Prompt endoscopic variceal ligation (EVL) is therapeutic as well as diagnostic.
- Trial name
- TERLEVL (NCT06027970)
- Testing
- Terlipressin, 0.9% normal saline (NS)
- Where
- India
- Volunteers
- 165 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Hemorrhage, Esophageal Varices
Short Course Terlipressin for Control of Acute Variceal Bleeding
The purpose of this study is to determine whether 24 hours of Terlipressin is as effective as 72 hours of Terlipressin in preventing re-bleed once esophageal variceal bleed has been controlled with endoscopic therapy (variceal…
- Conditions
- Hemorrhage, Esophageal Varices, Portal Hypertension
- Trial name
- NCT00369694
- Testing
- Terlipressin, Terlipressin & then Dummy
- Where
- Pakistan
- Volunteers
- 130 people
- Sponsor
- Aga Khan University
Cirrhosis, Portal Vein Thrombosis
Safety of Anticoagulant Therapy After Endoscopic Treatment
The investigators aimed to verify the efficacy and safety of nadroparin calcium warfarin sequential (NWS) anticoagulation therapy after endoscopic therapy in PVT patients with cirrhosis and AVB.
- Conditions
- Cirrhosis, Portal Vein Thrombosis, Esophageal and Gastric Varices, Anticoagulant-induced Bleeding
- Trial name
- NCT04976543
- Testing
- nadroparin calcium-warfarin sequential anticoagulation
- Where
- China
- Volunteers
- 86 people
- Sponsor
- Qilu Hospital of Shandong University