Clinical trials: Acute Watery Diarrhea
Diarrhea
Safety, Efficacy and Cost-effectiveness of Racecadotril in Children With Acute Diarrhea in Mexico
Rationale: Acute diarrhea (AD) is still a significant morbidity-mortality problem worldwide. Although oral rehydration therapy is the cornerstone, its anti-diarrheal effect is a controversial subject.
- Trial name
- Raceca-Mex (NCT01153854)
- Testing
- Racecadotril
- Where
- Mexico
- Volunteers
- 454 people
- Sponsor
- National Institute of Pediatrics, Mexico
Acute Watery Diarrhea
Comparison of WHO Treatment of Acute Watery Diarrhea With or Without Probiotic (Bacillus Clausii) in Children
This study aimed to compare WHO treatment of acute watery diarrhea with or without probiotic (bacillus clausii) in term of mean duration of diarrhea in children
- Trial name
- NCT06887374
- Testing
- Probiotic Bacillus Clausii
- Where
- Pakistan
- Volunteers
- 184 people
- Sponsor
- Muhammad Aamir Latif
Diarrhoea;Acute
Effectiveness of Folic Acid Supplementation in Acute Watery Diarrhea Among Children Under 5 Years of Age
Folic acid is a palatable and easily available drug with no serious adverse effects. L-methylfolate is its biologically activated form and is preferred because of its direct availability for certain metabolic processes.
- Trial name
- NCT04782037
- Testing
- L-Methylfolate Calcium
- Where
- Pakistan
- Volunteers
- 324 people
- Sponsor
- King Edward Medical University
Acute Diarrhea, Acute Gastroenteritis
Efficacy of Racecadotril in Acute Watery Diarrhea in Children
The purpose of this study is to determine the effect of racecadotril in acute watery diarrhea in children. The investigators will evaluate the effect of product versus placebo.
- Trial name
- NCT01577043
- Testing
- Racecadotril
- Where
- Bolivia
- Volunteers
- 52 people
- Sponsor
- Centro Pediatrico Albina de Patino
Diarrhoea;Acute, Diarrhea Travelers
Single Dose Antibiotic Treatment of Acute Watery Diarrhea, Rifaximin Versus Azithromycin, With Loperamide Adjunct
The purpose of this study is to compare a single dose of rifaximin with loperamide to the current standard approach of single dose azithromycin with loperamide for the treatment of acute watery traveler's diarrhea (TD).
- Trial name
- TrEAT_TD2 (NCT05677282)
- Testing
- Rifaximin 550 MG, Azithromycin 500 MG, Loperamide
- Where
- 4 sites in Djibouti, Honduras and 2 more
- Volunteers
- 150 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Acute Watery Diarrhea, Dysentery/Febrile Diarrhea
Trial Evaluating Ambulatory Treatment of Travelers' Diarrhea
The purpose of the trial is to develop the evidence on relative efficacy of 3 available single-dose loperamide adjuncted regimens for watery diarrhea and a single-dose regimen, with and without loperamide, for dysentery/febrile…
- Trial name
- TrEAT TD (NCT01618591)
- Testing
- Single dose rifaximin 1650 mg, Single dose azithromycin 500 mg, Single dose levofloxacin 500 mg
- Where
- 5 sites in Afghanistan, Djibouti and 3 more
- Volunteers
- 384 people
- Sponsor
- Uniformed Services University of the Health Sciences
Hypernatremia, Acute Watery Diarrhea
Hypernatremia Fluid Therapy in Childhood Diarrhoea
Hypernatremic dehydration is a life-threatening condition, particularly in children under two years of age, with mortality rates reaching up to as high as 19%.
- Trial name
- HOPE (NCT07884747)
- Testing
- Oral rehydration solution (ORS)
- Where
- Bangladesh
- Volunteers
- 268 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Acute Watery Diarrhea
Anti-Secretory Drug in Treatment of Acute Watery Diarrhea
In conclusion, racecadotril is an anti-secretory drug that exerts its antidiarrheal effect by inhibiting intestinal enkephalinase. It is effective in reducing the volume and frequency of stool output.
- Trial name
- NCT05216822
- Testing
- Racecadotril
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Diarrhoea
Effectiveness of Smecta in Combination With Oral Rehydration in the Treatment of Acute Watery Diarrhoea in Infants and Children
The purpose of this study is to evaluate the effectiveness of Smecta at decreasing stool weight, when compared to placebo, in the treatment of acute diarrhoea in children.
- Trial name
- NCT00352989
- Testing
- Smecta (Diosmectite), duration of treatment - 7 days
- Where
- 19 sites in Malaysia
- Volunteers
- 302 people
- Sponsor
- Ipsen
Cholera
Assessment of a Novel Fixed-dose Combination (FDC) Drug VR-AD-1005 for the Treatment of Acute Watery Diarrhea in Cholera
Cholera still remains a global public health concern affecting both children and adults, and patients can succumb in quick time if remain untreated.
- Trial name
- NCT06193408
- Testing
- VR-AD-1005
- Where
- Bangladesh
- Volunteers
- 150 people
- Sponsor
- Hunazine Biotech S.L.
Diarrhea, Infantile
Efficacy and Safety of "VS002A" With the Standard WHO-ORS in Non-cholera Acute Watery Diarrhea in Infants and Young Children
Randomized double blinded clinical trial comparing amino acid based oral rehydration solution/medical food and glucose-based oral rehydration solution is infectious diarrhea in pediatric population
- Trial name
- NCT04677296
- Testing
- VS002A, WHO-ORS
- Where
- Bangladesh
- Volunteers
- 312 people
- Sponsor
- Entrinsic Bioscience Inc.
Acute Watery Diarrhea
Bacillus Clausii Versus Multistrain Probiotics for Acute Watery Diarrhea in Children
This randomized controlled trial will compare Bacillus clausii (Enterogermina) and a multistrain probiotic preparation (Ecotec) in children aged 1-5 years with acute watery diarrhea.
- Trial name
- NCT07660367
- Testing
- Enterogermina, Ecotec
- Where
- Pakistan
- Volunteers
- 138 people
- Sponsor
- Children Hospital and Institute of Child Health, Lahore
Acute Watery Diarrhea
Zinc Plus Saccharomyces Boulardii Versus Zinc Alone in the Treatment of Acute Diarrhea
In literature combined therapy of zinc with S. boulardii in the treatment of acute diarrhea has not been addressed satisfactorily in the recent past.
- Trial name
- NCT07168304
- Testing
- S. boulardii
- Where
- Pakistan
- Volunteers
- 276 people
- Sponsor
- Muhammad Aamir Latif
Acute Watery Diarrhoea
Efficacy of Zinc Sulfate With Probiotics for the Treatment of Acute Diarrhea in Children
Diarrheal disease is one of the major causes of morbidity and mortality in children under five. Disease is treated symptomatically with oral rehydration (ORS) as a basic measure.
- Trial name
- Zinc (NCT01140074)
- Testing
- Zinc Sulfate
- Where
- 2 sites in Poland
- Volunteers
- 256 people
- Sponsor
- University Hospital No 1 Wroclaw
Acute Watery Diarrhoea
Efficacy of Zinc Therapy in Acute Diarrhoea in Young Children
Diarrhoea continues to be a major cause of mortality and morbidity in young children especially in many developing countries. Although the mortality burden of diarrhoea has substantially reduced, the morbidity pattern remained…
- Trial name
- NCT00325247
- Testing
- ZINC
- Where
- Bangladesh
- Volunteers
- 2,050 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Acute Watery Diarrhea
Comparison of Bacillus Clausii and Saccharomyces Boulardii for Acute Diarrhea at Day 3
THIS STUDY WILL BE CONDUCTED ON OPD PATIENTS IN CENTRAL PARK TEACHING HOSPITAL LAHORE TO SEE THE EFFECT OF PROBIOTICS ON DIARRHEA ALL PATIENTS INCLUDED WILL HAVE ACUTE WATERY DIARRHEA AND THE OUTCOME WILL BE CHECKED ON THE THIRD…
- Trial name
- NCT07853846
- Testing
- Bacillus clausii, Saccharomyces boulardii
- Where
- Pakistan
- Volunteers
- 86 people
- Sponsor
- Syeda Sabeen Fatima Naqvi
Diarrhea, Cholera
Next Generation ORS: Comparing ORS With Calcium vs Standard ORS in Reducing Severity of Acute Watery Diarrhea
Diarrhea remains a leading killer of children in need of better treatments.
- Trial name
- ORS (NCT05814042)
- Testing
- Current standard control ORS (oral rehydration solution)
- Where
- Bangladesh
- Volunteers
- 396 people
- Sponsor
- University of Florida
Acute Watery Diarrhoea
VS002A in the Treatment of Acute Watery Diarrhea in Infants and Young Children
Background (brief): 1. Burden: Diarrhea is the second deadliest disease for under-five children globally and the situation is more serious in developing countries.
- Trial name
- NCT06179589
- Testing
- VS002A
- Where
- Bangladesh
- Volunteers
- 312 people
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Acute Watery Diarrhea
Comparison of Effectiveness of Zinc Supplementation With ORS and Bacillus Clausii Versus Zinc With ORS and Saccharomyces Boulardii in Acute Watery Diarrhea in Paediatric Patients
The current study was carried out to directly compare the effectiveness of zinc supplementation with ORS and Bacillus clausii versus zinc with ORS and Saccharomyces boulardii among the local pediatric population presenting with…
- Trial name
- NCT06540209
- Testing
- Bacillus clausii, Saccharomyces boulardii, Zinc
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- RESnTEC, Institute of Research
Acute Watery Diarrhea
Safety and Efficacy of Racecadotril in Children With Acute Watery Diarrhea
Acute watery diarrhea is a common cause of illness and hospitalization in children under five years of age, particularly in developing countries.
- Trial name
- NCT07392931
- Testing
- Racecadotril
- Where
- Pakistan
- Volunteers
- 200 people
- Sponsor
- Punjab Rangers Teaching Hospital Lahore