Clinical trials: Acute on Chronic Liver Failure (ACLF)
Acute on Chronic Hepatic Failure
Efficacy of Granulocyte Colony-stimulating Factor and Erythropoetin for Patients With Acute-on-chronic Liver Failure
50 patients of Acute-on-chronic liver failure (ACLF) will be enrolled and randomized into G-CSF+EPO or Placebo arms Treatment protocol To administer G-CSF (in prefilled syringe) at a dose of 5 µg/kg s/c at days 1, 2, 3, 4, 5 and…
- Trial name
- NCT01383460
- Testing
- Granulocyte Colony-stimulating Factor (G-CSF) and Erythropoetin (EPO)
- Where
- India
- Volunteers
- 55 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Acute Decompensation of Liver Cirrhosis, Established Acute-on-Chronic Liver Failure
Phase 2 Study of 500 mg BID NTZ on Top of Standard of Care in Patients With Acute Decompensation of Liver Cirrhosis at High Risk of Progression to Acute-on-Chronic Liver Failure or Established Acute-on-Chronic Liver Failure
Phase 2 Study of 500 mg BID NTZ on Top of Standard of Care in Patients with Acute Decompensation of Liver Cirrhosis at High Risk of Progression to Acute-on-Chronic Liver Failure or Established Acute-on-Chronic Liver Failure
- Trial name
- CONTROL-ACLF (NCT07694297)
- Testing
- NTZ 500mg BID on top of SOC
- Volunteers
- 16 people
- Sponsor
- Genfit
Acute on Chronic Liver Failure
Study to Evaluate the Efficacy and Safety of HepaStem in Patients With Acute on Chronic Liver Failure (ACLF)
This is an interventional, double blind, randomized (2:1), and placebo-controlled study of 2 infusions of a 1 dose regimen of HepaStem in patients recently diagnosed (≤1 week) with ACLF grade 1 or 2 on top of Standard of Care…
- Trial name
- DHELIVER (NCT04229901)
- Testing
- HepaStem
- Where
- 47 sites in Austria, Belgium and 12 more
- Volunteers
- 133 people
- Sponsor
- Cellaion SA
Hepatitis B, Acute-On-Chronic Liver Failure
RL-1 Novel Human-derived Bio-artificial Liver Treatment in Patients of HBV Related ACLF
This study is to investigate the clinical efficacy and safety of RL-1 Novel Human-derived Bio-artificial Liver treatment in patients with Hepatitis b virus related acute-on-chronic liver failure.
- Trial name
- NCT04195282
- Testing
- Plasma exchange, RL-1 Novel Human-derived Bio-artificial Liver Treatment
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Acute-On-Chronic Liver Failure, Ascites
Efficacy, Safety and Tolerability of VS-01 in Adult Patients With Acute-on-Chronic Liver Failure and Ascites (UNVEIL-IT)®
A Phase 2, multi-center, randomized, controlled, open-label study to evaluate the effects of the intraperitoneal, liposomal formulation VS-01 in patients with an acute episode of hepatic and/or extrahepatic organ dysfunctions and…
- Trial name
- NCT05900050
- Testing
- VS-01 on top of SOC, SOC (Control Group)
- Where
- 26 sites in United States, Belgium and 5 more
- Volunteers
- 15 people
- Sponsor
- Genfit
Acute-On-Chronic Liver Failure
Comparison of Blood Products Required Using Two Different ROTEM Cut-offs Before Invasive Procedures in Cirrhosis and Acute on Chronic Liver Failure (ACLF) Patients With Severe Coagulopathy
Coagulation system in cirrhotics patients is a fragile state , which is rebalanced hemostasis. Standard tests (INR/aPTT) stop measuring at first stage of coagulation ,when the clot first form.
- Trial name
- NCT06831565
- Testing
- ROTEM
- Where
- India
- Volunteers
- 790 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Acute Liver Failure, Acute on Chronic Liver Failure
Role of 13C Methacetin Breath Test in Predicting Prognosis Among Patients With Acute or Acute on Chronic Liver Failure (ACLF).
Blood will be collected after venepuncture from all patients for complete blood counts, Serum bilirubin (direct and indirect), aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma glutamyl…
- Trial name
- NCT01946360
- Testing
- Methacetin Breath Test in ACLF and ALF patients
- Where
- India
- Volunteers
- 24 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Acute-On-Chronic Liver Failure
Risk Factors Affecting MSC Efficacy in ACLF Patients
Mesenchymal stromal cells (MSCs) are potential therapy for many diseases, with the ability of tissue regeneration, repair and immunomodulation. Acute-on-chronic liver failure (ACLF) is a severe disease with high mortality.
- Trial name
- NCT07198854
- Testing
- Not applicable- observational study
- Where
- China
- Volunteers
- 446 people
- Sponsor
- Sun Yat-sen University
Acute-On-Chronic Liver Failure, Liver Cirrhosis
Transplantation for EASL-CLIF and APASL ACLF Patients: a Retrospective Cohort Study
The definition and diagnostic criteria of acute-on chronic liver failure (ACLF) differed evidently between the East and the West due to the difference in the underlying etiology.
- Conditions
- Acute-On-Chronic Liver Failure, Liver Cirrhosis, Liver Transplant; Complications
- Trial name
- TEA-ACLF (NCT05036031)
- Volunteers
- 500 people
- Sponsor
- RenJi Hospital
Liver Cirrhosis, Decompensated Cirrhosis of Liver
A Novel COMBinATorial Therapy With Albumin and Enoxaparin in Patients With Decompensated Cirrhosis at High-risk of Poor Outcome (COMBAT Trial).
The goal of this clinical trial is to determine primarily whether a combinatorial therapy based on the administration of human albumin and enoxaparin is safe and effective in patients with decompensated cirrhosis discharged from…
- Conditions
- Liver Cirrhosis, Decompensated Cirrhosis of Liver, Acute on Chronic Liver Failure (ACLF)
- Trial name
- COMBAT (NCT05895136)
- Testing
- Human albumin, Enoxaparin, Standard medical treatment
- Where
- 9 sites in France, Germany and 3 more
- Volunteers
- 90 people
- Sponsor
- European Foundation for Study of Chronic Liver Failure
Acute-On-Chronic Liver Failure
Usefulness of the Variation of the CLIF-C ACLF Score in Patients With Acute on Chronic Liver Failure
Patients with Acute on Chronic Liver Failure (ACLF) have high short-term mortality. The use of a severity score could define the patient's prognosis and would help determine in whom the treatment is effective or futile.
- Trial name
- ARIHAC (NCT04186572)
- Volunteers
- 30 people
- Sponsor
- Hospital El Cruce
Acute-On-Chronic Liver Failure
Comparison of Efficacy and Safety of Ceftazidime Avibactam Versus Extended Infusions of High Dose Meropenem in Patients of ACLF With Nosocomial Infections.
Acute on chronic liver failure patients are at high risk for nosocomial infections due to liver dysfunction, which impairs immune responses and increases vulnerability to infections.
- Trial name
- NCT06818565
- Testing
- Meropenem Injection, Ceftazidime-avibactam, Teicoplanin
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Acute on Chronic Liver Failure, HBV
A Study of AARC Standards on Diagnosis and Treatment of Patients With HBV-ACLF in China (AARC China Study)
The AARC China Study is to establish a widely recognized and harmonized standard of patients with HBV-ACLF in the Asia Pacific region.
- Trial name
- NCT04054037
- Testing
- No intervention
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Qin Ning
Acute-On-Chronic Liver Failure
Chinese Phase II Trail of AS1501 in Acute-on-chronic Liver Failure (ACLF) Patients
Document Name: This Trial is a Phase II Clinical Study.docx Document Content: This trial is a Phase II clinical study, conducted in two stages: Phase IIa: A sentinel, single-arm design will be employed.
- Trial name
- NCT06916585
- Testing
- AS1501 for injection
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Shenzhen Third People's Hospital
Hepatic Encephalopathy, Acute on Chronic Liver Failure (ACLF)
A Study to See if an Investigational Medicine Called VS-01 Can Help and How Safe it is in the Treatment of Patients With Overt Hepatic Encephalopathy
A Phase 2, Randomized, Controlled, Open-Label, Adaptive Dose Design, Proof-of-Concept Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Two Different Dwell Times of VS-01 on Top of Standard of Care versus Standard…
- Conditions
- Hepatic Encephalopathy, Acute on Chronic Liver Failure (ACLF), Decompensated Cirrhosis
- Trial name
- NCT06987968
- Testing
- VS-01 on top of SOC (Active Treatment Group), SOC
- Where
- 6 sites in United States, France and 1 more
- Volunteers
- 3 people
- Sponsor
- Genfit
Acute-on-Chronic Liver Failure (ACLF), Liver Cirrhosis
A Novel Extracorporeal Liver Support Therapy In ALCF and to Evaluate the Efficacy of DIALIVE 2.0, a Liver Dialysis Device.
This study is intended to demonstrate the efficacy and safety of the DIALIVE Liver Dialysis Device when incorporated into the standard management plan for participants with A-TANGO ACLF grade 2-4.
- Trial name
- NCT07347275
- Testing
- Standard of Care (Investigator Choice), DIALIVE 2.0 liver dialysis Device plus available Standard of Care
- Where
- United Kingdom
- Volunteers
- 72 people
- Sponsor
- Yaqrit Ltd
Liver Cirrhosis, Portal Hypertension
Predicting Acute-on-Chronic Liver Failure After Surgical Intervention in Chronic Liver Disease
Prospective, observational study to define precipitants and predictors of development of Acute-on-Chronic Liver Failure (ACLF) after surgical interventions, allowing to develop a risk stratification for elective procedures in…
- Conditions
- Liver Cirrhosis, Portal Hypertension, Surgery, Acute-On-Chronic Liver Failure
- Trial name
- PERSEVERE (NCT04578301)
- Testing
- No Intervention
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University Hospital, Bonn
Acute on Chronic Liver Failure(ACLF)
Intravenous NAC Use in ACLF Patients
Primary Objective To evaluate the efficacy and safety of 72 hour NAC treatment regimen in the management of ACLF Secondary Objective To evaluate the six weeks mortality and length of hospital stay in ACLF patients treated with…
- Trial name
- NCT05089981
- Testing
- N acetyl cysteine
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Aga Khan University
Acute on Chronic Liver Failure
To Study the Role of Plasma Von Willebrand Factor Antigen (vWF) to A Disintegrin-like and Metalloproteinase With Thrombospondin Type-1 Motifs 13 (ADAMTS-13) Activity Ratio as a Predictor of Development of Extrahepatic Organ Failure in Acute on Chronic Liver Failure (ACLF) Patients.
Acute on chronic liver failure (ACLF) is a syndrome characterized by acute decompensation of chronic liver disease associated with organ failures and high short- term mortality.
- Trial name
- NCT06066814
- Where
- India
- Volunteers
- 50 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Acute-On-Chronic Liver Failure
National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Evaluating Mesenchymal Stem-Cell (MSC) Therapy in Non-viral Acute on Chronic Liver Failure (ACLF) Patients - Phase-III Trial
Liver disease deaths are rising, but transplants remain scarce in India. With over 100,000 needed annually and only ~2,500 performed, non-transplant options are urgently needed.
- Trial name
- NC-CHRM (NCT07075315)
- Testing
- Umbilical cord Mesenchymal stem cell, Steroid, Standard Medical Treatment
- Where
- 3 sites in India
- Volunteers
- 100 people
- Sponsor
- Institute of Liver and Biliary Sciences, India