Clinical trials: Acute on Chronic Liver Failure (ACLF), active
Acute-on-Chronic Liver Failure (ACLF)
PT-MSCs Exosome Injection in the Treatment of Chronic-to-acute Liver Failure
The goal of this single-center, prospective, randomized controlled study is to evaluate the safety and efficacy of PT-MSCs Exosome Injection (code: PT-MSCs-EVS-2023-1) in treating patients with acute-on-chronic liver failure…
- Trial name
- NCT07409259
- Testing
- exosome injection, standard comprehensive internal medical treatment,
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Hepatitis B, Acute-On-Chronic Liver Failure
Three Types of Nucleotide/Nucleoside Analogues Treatment in HBV Related ACLF
This study is to investigate the clinical efficacy of three types of nucleotide/nucleoside analogues in treatment of HBV-related acute-on-chronic liver failure.
- Trial name
- HBV (NCT03920618)
- Testing
- Entecavir, Tenofovir Disoproxil Fumarate, Tenofovir Alafenamide
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Acute Liver Failure, Acute on Chronic Liver Failure (ACLF)
Continuous Renal Replacement Therapy Intensity in Hyperammonemia
Acute liver failure (ALF) and acute-on-chronic liver failure (ACLF) are life-threatening conditions often associated with hyperammonemia, hepatic encephalopathy, and multi-organ dysfunction.
- Conditions
- Acute Liver Failure, Acute on Chronic Liver Failure (ACLF), Acute Kidney Injury, Ammonia Metabolism
- Trial name
- CRITICAL (NCT06987604)
- Testing
- High-dose continuous renal replacement therapy, Conventional-dose continuous renal replacement therapy
- Where
- Brazil
- Volunteers
- 152 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Acute-on-Chronic Liver Failure (ACLF), Liver Cirrhosis
Evaluating Novel Scoring Systems to Predict Outcomes in Acute-on-Chronic Liver Failure
Acute-on-chronic liver failure (ACLF) is a serious condition where a patient with long-term liver disease suddenly experiences severe liver worsening and failure of other organ systems, such as the kidneys or lungs.
- Conditions
- Acute-on-Chronic Liver Failure (ACLF), Liver Cirrhosis, End Stage Liver Disease
- Trial name
- NCT07734896
- Volunteers
- 100 people
- Sponsor
- Assiut University
Acute-On-Chronic Liver Failure
Umbilical Cord-derived Mesenchymal Stem Cell Infusion for Treating ACLF
This study is a multicenter, randomized, double-blind, placebo-controlled adaptive design Phase IIb/III clinical trial. It employs a seamless adaptive design, divided into Phase IIb and Phase III, focusing on patients with…
- Trial name
- MSCTACLF (NCT06884904)
- Testing
- Low-dose experimental group, High-dose experimental group
- Volunteers
- 96 people
- Sponsor
- National Engineering Center of Cell Products
Hepatitis B, Chronic, Acute-On-Chronic Liver Failure
Combination of DPMAS and Low Volume PE for Patients With HBV Related ACLF
This study is to investigate investigate the safety and efficacy of Double plasma molecular adsorption system with sequential low-dose plasma exchange in treating hepatitis B virus-related acute-on-chronic liver failure.
- Trial name
- NCT04597164
- Testing
- Artificial liver support system
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Acute-On-Chronic Liver Failure
Risk Factors Affecting MSC Efficacy in ACLF Patients
Mesenchymal stromal cells (MSCs) are potential therapy for many diseases, with the ability of tissue regeneration, repair and immunomodulation. Acute-on-chronic liver failure (ACLF) is a severe disease with high mortality.
- Trial name
- NCT07198854
- Testing
- Not applicable- observational study
- Where
- China
- Volunteers
- 446 people
- Sponsor
- Sun Yat-sen University
Acute Liver Failure
ALSS - DPMAS and Therapeutic Plasma Exchange (TPE), Its Effect on Primary Coagulation, Inflammation and the Function of Vital Organs in ALF or ACLF
The artificial liver support system (ALSS) in patients with acute on chronic liver failure - the use of combined molecular adsorption system with double plasma (DPMAS) and therapeutic plasma exchange (TPE), its effect on primary…
- Trial name
- NCT07329036
- Testing
- The artificial liver support system (ALSS) - DPMAS/TPE
- Where
- Czechia
- Volunteers
- 25 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Acute-on-Chronic Liver Failure (ACLF)
Double Plasma Separation and Adsorption in Acute-on-Chronic Liver Failure (DPMAS-ACLF Trial)
Acute-on-chronic liver failure (ACLF) is a serious condition in which patients with chronic liver disease suddenly develop severe liver injury, leading to inflammation, organ failure, and very high short-term mortality.
- Trial name
- DPMAS-ACLF (NCT07178366)
- Testing
- Standard medical therapy (SMT), Double Plasma Molecular Adsorption System (DPMAS)
- Volunteers
- 56 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Acute on Chronic Liver Failure (ACLF), Hepatic Encephalopathy (HE)
RENEW: Study of Porcine Liver Support in Participants With Acute-on-Chronic Liver Failure
This is a Phase 1/2, first-in-human (FIH) safety, proof-of-concept, two-part study of the genetically-engineered EGEN-5784 liver in combination with the metra® extra-corporeal liver cross-circulation (ELC) system in participants…
- Trial name
- NCT07429838
- Testing
- metra® Extracorporeal Liver Cross-Circulation (ELC) system (OrganOx), EGEN-5784 (genetically engineered porcine liver)
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- eGenesis, INC
Cirrhosis, Intensive Care Medicine
Prognosis of Cirrhotic Patients Admitted to the General Intensive Care Unit Between 2014 and 2024: a Regional Retrospective Multicentre Cohort Study
Ten years after our team's publication, practices have changed considerably in the management of severe cirrhotic patients. This study will analyse these practices in primary care hospitals and in a tertiary centre, and assess…
- Conditions
- Cirrhosis, Intensive Care Medicine, Acute on Chronic Liver Failure(ACLF)
- Trial name
- REACIRRHOSE (NCT06948565)
- Testing
- observational study
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Liver Cirrhosis, Decompensated Cirrhosis of Liver
A Novel COMBinATorial Therapy With Albumin and Enoxaparin in Patients With Decompensated Cirrhosis at High-risk of Poor Outcome (COMBAT Trial).
The goal of this clinical trial is to determine primarily whether a combinatorial therapy based on the administration of human albumin and enoxaparin is safe and effective in patients with decompensated cirrhosis discharged from…
- Conditions
- Liver Cirrhosis, Decompensated Cirrhosis of Liver, Acute on Chronic Liver Failure (ACLF)
- Trial name
- COMBAT (NCT05895136)
- Testing
- Human albumin, Enoxaparin, Standard medical treatment
- Where
- 9 sites in France, Germany and 3 more
- Volunteers
- 90 people
- Sponsor
- European Foundation for Study of Chronic Liver Failure
Acute on Chronic Liver Failure (ACLF)
Plasma Exchange Half-dose and Extracorporeal Detoxification for ACLF
Clinical trial The goal of this clinical trial is to learn if a liver support protocol works to treat Liver failure in adults. The main questions it aims to answer are: Does hemoadsorption plus half-dose plasma exchange provide…
- Trial name
- Phoenix (NCT07593638)
- Testing
- DPMAS plus plasma exchange
- Where
- Portugal
- Volunteers
- 240 people
- Sponsor
- Unidade Local de Saude do Nordeste
Liver Diseases, Liver Cirrhosis
Liver Transplantation in Patients With CirrHosis and Severe Acute-on-Chronic Liver Failure: iNdications and outComEs
Management of ACLF is mainly supportive. The poor outcomes lead physicians to consider liver transplantation as an option, even if controversial.
- Conditions
- Liver Diseases, Liver Cirrhosis, Acute-On-Chronic Liver Failure, Liver Transplant; Complications
- Trial name
- CHANCE (NCT04613921)
- Testing
- Observational Protocol
- Where
- 106 sites in United States, Argentina and 25 more
- Volunteers
- 3,000 people
- Sponsor
- European Foundation for Study of Chronic Liver Failure
Acute-On-Chronic Liver Failure
Comparison of Blood Products Required Using Two Different ROTEM Cut-offs Before Invasive Procedures in Cirrhosis and Acute on Chronic Liver Failure (ACLF) Patients With Severe Coagulopathy
Coagulation system in cirrhotics patients is a fragile state , which is rebalanced hemostasis. Standard tests (INR/aPTT) stop measuring at first stage of coagulation ,when the clot first form.
- Trial name
- NCT06831565
- Testing
- ROTEM
- Where
- India
- Volunteers
- 790 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Acute-On-Chronic Liver Failure
National Collaborative Centre for Hepatic Regenerative Medicine (NC-CHRM): Evaluating Mesenchymal Stem-Cell (MSC) Therapy in Non-viral Acute on Chronic Liver Failure (ACLF) Patients - Phase-III Trial
Liver disease deaths are rising, but transplants remain scarce in India. With over 100,000 needed annually and only ~2,500 performed, non-transplant options are urgently needed.
- Trial name
- NC-CHRM (NCT07075315)
- Testing
- Umbilical cord Mesenchymal stem cell, Steroid, Standard Medical Treatment
- Where
- 3 sites in India
- Volunteers
- 100 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Acute-on-Chronic Liver Failure (ACLF)
Vitamin C for Acute Kidney Injury in ACLF With Septic Shock: A Randomized Controlled Trial
This study is testing whether Vitamin C can help improve kidney function and survival in very sick patients with liver disease. Patients with acute-on-chronic liver failure (ACLF) often develop serious infections that can lead to…
- Trial name
- VITAKI-ACLF (NCT07184866)
- Testing
- Vitamin C, Standard of Care (SOC)
- Volunteers
- 110 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Acute on Chronic Liver Failure
An Open-label Randomized Controlled Trial Comparing the Role of Therapeutic Plasma-exchange in Ameliorating Secondary Organ Dysfunctions in Patients With ACLF and Develop Biomarkers of Treatment Response
Rationale: Current understanding of the pathophysiology of ACLF suggests that unresolved injury, poor infection control, and liver regeneration result in persistent systemic inflammation and cytokine storm, which subsequently…
- Trial name
- NCT06276907
- Testing
- Plasma Exchange, Standard Medical Treatment
- Where
- India
- Volunteers
- 190 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Acute on Chronic Liver Failure
Efficacy and Safety of Continuous Infusion of Terlipressin vs Bolus Terlipressin in ACLF Patients With Acute Esophageal Variceal Bleed
Acute portal hypertension, as measured by rapid rise in hepatic venous pressure gradient (HVPG) can lead to further dreaded complications, including acute variceal bleeding (AVB) AVB: 6-week mortality rates of around 15-20% in…
- Trial name
- NCT06815770
- Testing
- Terlipressin Injectable Product
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Liver Cirrhosis, Portal Hypertension
Predicting Acute-on-Chronic Liver Failure After Surgical Intervention in Chronic Liver Disease
Prospective, observational study to define precipitants and predictors of development of Acute-on-Chronic Liver Failure (ACLF) after surgical interventions, allowing to develop a risk stratification for elective procedures in…
- Conditions
- Liver Cirrhosis, Portal Hypertension, Surgery, Acute-On-Chronic Liver Failure
- Trial name
- PERSEVERE (NCT04578301)
- Testing
- No Intervention
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- University Hospital, Bonn