Clinical trials: Adaptive Behavior
Effects of Different Meals on the QT/QTc Interval, Insulin and Oral Hypoglycemic [Antidiabetic] Drugs Causing Adverse Effects in Therapeutic Use
Food and Insulin Effect on QT/QTC Interval of ECG
Moxifloxacin is routinely used as a probe to confirm assay sensitivity in thorough electrocardiogram (ECG) studies. It has been shown that a meal shortens the QT interval, which may affect pharmacokinetics (PK) and/or…
- Conditions
- Effects of Different Meals on the QT/QTc Interval, Insulin and Oral Hypoglycemic [Antidiabetic] Drugs Causing Adverse Effects in Therapeutic Use, C-Peptide Effects on the QT/QTc Interval, Moxifloxacin ECG Profile in Fed and Fasted State
- Trial name
- C11035 (NCT01642485)
- Testing
- Moxifloxacin 400 mg fasted, FDA breakfast, Continental breakfast
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Richmond Pharmacology Limited
Hypertension, Medication Adherence
Medication Adherence Program
Randomized controlled trial testing the efficacy of the Supporting Tailored Adaptive change and Reinforcement for Medication Adherence Program (STAR-MAP), a health coaching approach that aims to improve antihypertensive…
- Conditions
- Hypertension, Medication Adherence, Behavior and Behavior Mechanisms
- Trial name
- MAP (NCT05183763)
- Testing
- STAR-MAP health coaching, Medication reminder tools
- Where
- 5 sites in United States
- Volunteers
- 402 people
- Sponsor
- Tulane University
Suicide
CAMPUS - Feasibility Sub-Study
Suicide is the 2nd leading cause of death among college students and suicidal ideation and suicide-related behaviors are a frequent presenting problem at college counseling centers (CCCs), which are overburdened.
- Trial name
- CAMPUS-Feas (NCT04728815)
- Testing
- TAU - Phase 1, CAMS - Phase 1, DBT - Phase 1 and 2
- Where
- 4 sites in United States
- Volunteers
- 84 people
- Sponsor
- Duke University
Binge Eating, Obesity
Trial to Optimize Just-in-Time Adaptive Intervention for Binge Eating & Weight-related Behaviors
The purpose of this study is to conduct a micro-randomized trial to learn which evidence-based targets within a mobile intervention for binge eating and weight-related behaviors are most impactful for which people and in what…
- Trial name
- NCT06349460
- Testing
- FoodSteps behavioral intervention
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Northwestern University
Intellectual Disability
Psychomotor Therapy Effects in Adaptive Behavior and Motor Proficiency in Intellectual Disability
People with intellectual and developmental disabilities (IDD) usually present limitations at adaptive behavior and motor skills, which lead to limitations/barriers in the daily independent functioning of this population.
- Trial name
- NCT02746614
- Testing
- Psychomotor Therapy
- Volunteers
- 15 people
- Sponsor
- Faculdade de Motricidade Humana
Healthy Volunteer
Neural Mechanisms of Emotion-behaviour Interactions
Deciding what to do when for how long - self-organizing one's behaviour - is an important feature of daily life. Emotions arise providing short-cuts for the computational complexities.
- Trial name
- EMOBB (NCT07623746)
- Testing
- Functional Magnetic Resonance Imaging (fMRI)
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Suicidal, Suicide, Attempted
Improving Coping to Reduce Suicide Risk Following ED Discharge
The researchers hope to learn whether an electronic safety plan (ESP) and a supportive text messaging program are feasible and acceptable to adult patients with recent suicidal thoughts or behavior after emergency department (ED)…
- Conditions
- Suicidal, Suicide, Attempted, Suicidal Ideation
- Trial name
- NCT06614946
- Testing
- Electronic Safety Plan (ESP), Text support
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Michigan
Autism Spectrum Disorder (ASD
RCT of SCERTS (Social Communication, Emotional Regulation, Transactional Support) Program for Children With Autism Spectrum Disorder
This randomized control trial aims to assess the efficacy of the SCERTS intervention in children aged 3-6 years diagnosed with mild to moderate Autism Spectrum Disorder (ASD).
- Trial name
- NCT06733324
- Testing
- SCERTS (Social Communication, Emotional Regulation, Transactional Support), Behavioral Treatment, Speech Therapy
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Aisha Saleem
Eating Behavior, Chronic Disease
JITAIs: Optimization of Effectiveness
The goal of this feasibility study is to get insight into the receptivity of a JITAI aimed at healthy dietary intake in inhabitants of a small city in the Netherlands.
- Trial name
- NCT05773625
- Testing
- Just-In-Time Adaptive Intervention
- Where
- Netherlands
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Wageningen University and Research
Smoking
Program on Lung Cancer Screening and Tobacco Cessation
In this sequential, multiple assignment, randomized trial (SMART) current smokers who are eligible for lung cancer screening will be identified using the electronic medical record at the University of Minnesota and Minneapolis VA…
- Trial name
- PLUTO (NCT02597491)
- Testing
- TLC monthly, TLC quarterly, MTM
- Volunteers
- 1,000 people
- Sponsor
- University of Minnesota
Speech
Behavioral and Neural Characteristics of Adaptive Speech Motor Control
This study meets the NIH definition of a clinical trial, but is not a treatment study. Instead, the goal of this study is to investigate how hearing ourselves speak affects the planning and execution of speech movements.
- Trial name
- NCT06164717
- Testing
- Auditory feedback perturbation during speech, Visual feedback perturbation during reaching, DBS stimulation ON/OFF
- Where
- United States
- Volunteers
- 507 people, healthy volunteers welcome
- Sponsor
- University of Washington
Behavior, Adaptive, Mental Illness
IPS/Peer Support Intervention in the DTES
Individual placement support (IPS) is an evidence-based supported employment model for people with severe mental illness, designed to achieve employment in mainstream competitive jobs, either part-time or full-time.
- Conditions
- Behavior, Adaptive, Mental Illness, Substance Use
- Trial name
- NCT03748004
- Testing
- IPS/SP, WorkBC
- Where
- 3 sites in Canada
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Violence, Domestic, Violence-Related Symptom
It's WeWomen Plus Intervention for Health, Safety and Empowerment
This study evaluates the impact of adaptive technology-based intervention (online, text and phone) "weWomenPlus" on safety, mental health and empowerment of abused immigrant women.
- Conditions
- Violence, Domestic, Violence-Related Symptom, Violence, Physical, Violence, Sexual
- Trial name
- IWWP (NCT04098276)
- Testing
- WeWomen Plus technology based intervention
- Where
- United States
- Volunteers
- 1,265 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Spinal Cord Injuries
Just-in-time Adaptive Feedback Systems to Assist Individuals With Spinal Cord Injury
The objective of this study is to develop algorithms that incorporate each individual's automatically detected physical activity (PA) level and a clinician's PA level recommendation to provide a smartphone application that helps…
- Trial name
- NCT03773692
- Testing
- Passive feedback and JITAI
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Temple University
Substance Use Disorder (SUD), Opioid Use Disorder (OUD)
Individualized Adaptive Deep Brain Stimulation in Opioid Use Disorder
The purpose of this study is to determine if personalized (adaptive) Deep Brain Stimulation (DBS) based upon invasive brain mapping is safe and can lead to better outcomes like reductions in craving and opioid use.
- Trial name
- aDBS OUD (NCT07214467)
- Testing
- Deep Brain Stimulation
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of California, San Francisco
Inflammation, Aging
Adaptive Stress Response: The Hot Yoga Study
This is a small intervention study which is aimed at characterizing what is known as the adaptive stress response (also know as "hormesis") in women aged 30-45 years.
- Conditions
- Inflammation, Aging, Depression, Anxiety
- Trial name
- NCT06395376
- Testing
- Bikram Hot Yoga Intervention, Hot Yoga Washout
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Parkinson Disease
Speed Manipulated Adaptive Rehabilitation Therapy Bike for Parkinson's Disease
Parkinson's disease (PD) is a progressive neurological disorder that results in slowness of movement, muscle stiffness, tremor, and postural instability.
- Trial name
- SMART (NCT05361200)
- Testing
- Dynamic high-cadence cycling
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Kent State University
PreDiabetes, Obesity
Development of an Adaptive Treatment for Weight Loss in People With Prediabetes
This 16-week study will use an experimental approach called the Sequential Multiple Assignment Randomized Trial to help determine which combination and sequence of weight loss program features are most effective in people who are…
- Trial name
- NCT04745572
- Testing
- High Carbohydrate Diet, Reduced Carbohydrate Diet
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Suicide
Developing Adaptive Interventions for Suicidal College Students Seeking Treatment - SMART
This pilot study tested the feasibility of utilizing an adaptive intervention strategy for college students who are suicidal when first seeking treatment at a campus clinic.
- Trial name
- SMART (NCT02442869)
- Testing
- Stage 1 Treatment as usual (TAU), Stage 1 CAMS, Stage 2 CAMS
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Nevada, Reno
Alcohol Drinking
Alcohol Screening and Preoperative Intervention Research Study - 2
This sequential, multiple assignment, randomized trial will test treatments designed to reduce alcohol use before and after surgery to promote surgical health and long-term wellness.
- Trial name
- ASPIRE-2 (NCT05783635)
- Testing
- Enhanced Usual Care (pre-operative), Preoperative Virtual Health Coaching, Usual surgical care (post-operative)
- Where
- United States
- Volunteers
- 440 people
- Sponsor
- University of Michigan