Clinical trials: Adaptive Trial
Age-related Cognitive Decline
Cognitive Engagement and Aging Mind
The purpose of this research is to examine whether and to what extent training of different types of cognitive engagement will improve performance on fluid cognitive abilities that typically decline with age.
- Trial name
- NCT05924490
- Testing
- Real-time strategy-based videogame training, Semantic Knowledge training
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Dallas
COVID-19
Effectiveness of a Second COVID-19 Vaccine Booster in Chinese Adults
This is a multicenter, parallel groups, partially randomized, open-label, blank-controlled adaptive platform study to evaluate the effectiveness of a second COVID-19 vaccine booster in Chinese adults who are charactered as the…
- Trial name
- NCT05855408
- Testing
- Intramuscularly administered Ad5-nCoV vaccine, Aerosolized Ad5-nCoV, DelNS1-2019-nCoV-RBD-OPT1
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Jiangsu Province Centers for Disease Control and Prevention
Advanced Cancer, Cervical Cancer
ASTEROID: A Trial of ASTX660 in Combination With Pembrolizumab
This is a multi-centre Phase I dose finding and proof-of-concept study of the combination of ASTX660 together with Pembrolizumab with expansion cohorts testing preliminary efficacy in immune-refractory cancers, triple negative…
- Conditions
- Advanced Cancer, Cervical Cancer, Triple Negative Breast Cancer
- Trial name
- ASTEROID (NCT05082259)
- Testing
- ASTX660, Pembrolizumab
- Where
- 3 sites in United Kingdom
- Volunteers
- 61 people
- Sponsor
- Institute of Cancer Research, United Kingdom
Multiple Sclerosis, Neurorehabilitation
Neurorehabilitation of Cognitive Deficits in Multiple Sclerosis Using an Adaptive Cognitive Exergame
Approximately 2.8 million people worldwide suffer from multiple sclerosis (MS). In 40 to 70% of cases, individuals with MS experience cognitive impairments that significantly interfere with their personal lives, careers, and…
- Trial name
- REALISE-MS (NCT07086950)
- Testing
- Body Brain Trainer software, RehaCom software
- Where
- Switzerland
- Volunteers
- 190 people
- Sponsor
- Prof. Arseny Sokolov, MD, PhD
Covid19
Accelerating COVID-19 Therapeutic Interventions and Vaccines 4 ACUTE
This is a randomized, open label, adaptive platform trial to compare the effectiveness of antithrombotic and additional strategies for prevention of adverse outcomes in COVID-19 positive inpatients
- Trial name
- ACTIV-4A (NCT04505774)
- Testing
- theraputic heparin, prophylactic heparin, P2Y12
- Where
- 101 sites in United States, Brazil and 2 more
- Volunteers
- 3,591 people
- Sponsor
- Matthew Neal MD
Rectal Cancer
Ultra-fractionated Radiotherapy for Rectal Cancer
The rationale of this clinical trial is to assess the feasibility of selective non-operative management for locally advanced rectal cancer using dose-escalated ultra-fractionated short course radiation therapy interdigitated with…
- Trial name
- NCT04677413
- Testing
- Ultrafractionated radiotherapy for rectal cancer
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Texas Southwestern Medical Center
Parkinson's Disease, Parkinson
Comparing Biomarker-Guided DBS Programming With Standard Clinical Monopolar Programming
The goal of this clinical trial is to learn whether an objective, data-guided approach to programming deep brain stimulation (DBS) can improve motor outcomes in people with Parkinson's disease who undergo DBS surgery.
- Conditions
- Parkinson's Disease, Parkinson, Parkinsons Disease (PD), Motor Fluctuations
- Trial name
- NCT07369310
- Testing
- Conventional DBS Programming (Monopolar Review), Objective-Guided DBS Programming (Imaging and Local Field Potential-Based)
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Acne Vulgaris, Acne Vulgaris on the Face
Study of New Antiandrogenic Progestogen + Low-dose Estrogen for Moderate Acne Vulgaris
This Phase III randomized, double-blind, placebo-controlled, adaptive, multicenter study evaluates the efficacy and safety of a new concentration of the fixed-dose combination EF190 in women with moderate acne vulgaris over six…
- Trial name
- PANDORA (NCT06905210)
- Testing
- Experimental drug (Cyproterone Acetate 2 mg and Ethinyl Estradiol 0.02 mg)
- Where
- 18 sites in Brazil
- Volunteers
- 531 people
- Sponsor
- Eurofarma Laboratorios S.A.
Cerebral Visual Impairment
A Computerized, Adaptive Therapeutic Gaming Approach Training Visual Perceptual Skills in Children With CVI
This clinical trial aims to compare the effectiveness of our adaptive, therapeutic game to the effectiveness of the same game, without the adaptive component.
- Trial name
- iVision2_WP3 (NCT05014503)
- Testing
- Adaptive Therapeutic gaming, Non-adaptive Therapeutic gaming
- Where
- Belgium
- Volunteers
- 73 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Stroke, Intracerebra Hemorrhage
APEX-STROKE EAGLE Domain (EAGLE)
In this domain of APEX-STROKE, participants with acute spontaneous supratentorial intracerebral haemorrhage (ICH) who meet the domain-specific eligibility criteria will be randomised to either an early surgical bundle or…
- Trial name
- EAGLE (NCT07790354)
- Testing
- Early surgical bundle, Guideline-Based Standard Care
- Volunteers
- 878 people
- Sponsor
- Fudan University
Breast Cancer
CAR T Cells in Mesothelin-Expressing Breast Cancer
Phase 1 - Safety and Proof of Concept
- Trial name
- NCT05623488
- Testing
- huCART-meso cells, Mesothelin Expression Testing
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Pennsylvania
HCC
Efficacy and Safety of Pracytarabine Versus Regorafenib in the Treatment of Patients With Hepatocellular Carcinoma
This is a Phase 2/3 study evaluating the efficacy and safety of Pracytarabine versus regorafenib in patients with advanced hepatocellular carcinoma (HCC) who have experienced treatment failure with standard systemic therapies…
- Trial name
- NCT07300488
- Testing
- Pracytarabine, regorafenib
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xi'an Xintong Pharmaceutical Research Co.,Ltd.
Multimorbidity
Enhanced Care for Patients With Complex Multimorbidity in Primary Care
Introduction Patients living with a chronic disease often have more than one chronic condition, which is referred to as multimorbidity.
- Trial name
- MM600-DK (NCT05676541)
- Testing
- Complex intervention to enhance care for patients with multimorbidity in general practice consisting of an extended overview consultation and supporting elements
- Where
- Denmark
- Volunteers
- 117,000 people
- Sponsor
- University of Copenhagen
Recurrent or Metastatic Nasopharyngeal Carcinoma
Combination Therapy for PD-1 Resistant Recurrent or Metastatic Nasopharyngeal Carcinoma: A Bayesian Adaptive Phase II Trial
This is a prospective, Bayesian adaptive, phase II clinical trial designed to evaluate the safety and efficacy of four treatment regimens in patients with recurrent (unamenable to local therapy) or metastatic nasopharyngeal…
- Trial name
- NCT07070479
- Testing
- Ivonescimab, Nimotuzumab, Irinotecan liposome
- Where
- 6 sites in China
- Volunteers
- 208 people
- Sponsor
- Ming-Yuan Chen
Myocarditis Acute
Pulse Corticosteroids Or/and Immunoglobulins to Treat Fulminant Myocarditis
Fulminant myocarditis (FM) is the most severe manifestation of acute myocarditis, an acute inflammatory myocardial disease most often triggered by viral infections.
- Trial name
- CORIUM (NCT06896253)
- Testing
- Pulse bolus corticosteroids, Pulse bolus corticosteroids and IVIG, Pulse bolus corticosteroids (G5%) and IVIG (G5 %)
- Volunteers
- 120 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
HIV Infections
Adherence Interventions for HIV Youth Via Text & Cell Phone - Sequential Multiple Assignment Randomized Trial (SMART)
The purpose of this study is to test an adaptive adherence intervention, which utilizes two mobile health (mHealth) intervention designs, in an effort to promote adherence to antiretroviral therapy (ART) and achieve and maintain…
- Trial name
- SMART (NCT03535337)
- Testing
- CPS, SMS
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Florida State University
Covid19
Survival TRial Using CytoKines in COVID-19 (STRUCK Trial)
Currently, there are few approved treatments for COVID-19, antiretroviral (remdesivir) and corticoids. With about 15% of COVID-19 patients suffering from severe disease health system will be overwhelmed.
- Trial name
- STRUCK (NCT04724629)
- Testing
- Ixekizumab, Aldesleukin, Colchicine
- Where
- 2 sites in Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
COVID-19, Emerging Infectious Disease
EU SolidAct: An Adaptive Pandemic and Emerging Infection Platform Trial
EU SolidAct is a randomized, multifactorial, adaptive platform trial for COVID-19 and emerging infectious diseases and pandemics.
- Trial name
- Bari-SolidAct (NCT04891133)
- Testing
- Baricitinib
- Where
- 92 sites in Austria, Belgium and 13 more
- Volunteers
- 290 people
- Sponsor
- Oslo University Hospital
Acute Ischemic Stroke Due to Medium-vessel-occlusion
IAT-MeVO Trial Domain Within the ACT-GLOBAL Adaptive Platform Trial
IAT-MeVO is an international, multicenter, prospective, randomised, open-label, blinded end-point assessed (PROBE) trial, to evaluate the efficacy and safety of endovascular therapy (EVT) [intra-arterial thrombolysis (IAT)-based]…
- Trial name
- IAT-MeVO (NCT07336927)
- Testing
- Endovascular Treatment
- Where
- China
- Volunteers
- 614 people
- Sponsor
- Bo Wu
Large Vessel Occlusion, Stroke
Head of Bed After Ischemic Stroke Thrombectomy (HoBIT)
Endovascular thrombectomy (EVT), also known as clot retrieval, is a procedure that improves recovery for people who suffer a stroke by removing blood clots from large blood vessels in the brain.
- Conditions
- Large Vessel Occlusion, Stroke, Ischemic Stroke
- Trial name
- HoBIT (NCT07367633)
- Testing
- Head of bed position of 0-degrees, Head of bed position of 30-degrees or greater
- Where
- 2 sites in Canada
- Volunteers
- 2,240 people
- Sponsor
- Population Health Research Institute