Clinical trials: Adaptive Trial
Mental Health Care, AMBIT
My Avenue to helP - Adaptive Mentalization-based Integrative Treatment Compared to Management as Usual for Youths With Multiple Problems: a Non-Randomized Controlled Feasibility Trial
My Avenue to HelP (MAP) is a non-randomized feasibility study testing the implementation of a cross-sectoral collaboration targeted youths, aged 12-17 years, with multiple social and psychological problems.
- Conditions
- Mental Health Care, AMBIT, Adaptive Mentalization-Based Integrative Treatment, Child and Adolescent Psychiatry
- Trial name
- MAP (NCT06886165)
- Testing
- My Avenue to HelP, Management as Usual
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Pia Jeppesen
School Attendance, School Climate
The University of Oregon ACCESS Project
The goal of this clinical trial is to learn if two behavioral interventions work to reduce office disciplinary referrals, improve attendance, and reduce depression and anxiety in 7th grade students.
- Conditions
- School Attendance, School Climate, School Engagement, School Exclusion
- Trial name
- NCT07264621
- Testing
- Inclusive Skill-building Learning Approach (ISLA), Family Check-Up Online (FCU-O), FCU-Online with telehealth coaching
- Where
- 13 sites in United States
- Volunteers
- 1,440 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Sleep Apnea, Obstructive, Sleep Apnea, Central
Early Sleep Apnea Treatment in Stroke
Investigating the interrelation of stroke and sleep-disordered breathing (SDB) is of major importance. First because of the high occurrence rate of stroke and the fact that it is a frequent cause of long-term disability in…
- Conditions
- Sleep Apnea, Obstructive, Sleep Apnea, Central, Stroke
- Trial name
- eSATIS (NCT02554487)
- Testing
- AirCurveTM10 CS PACEWAVE Adaptive-Servo-Ventilator (ResMed Ldt., Australia)
- Where
- 6 sites in France, Germany and 2 more
- Volunteers
- 201 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Advanced Solid Tumor
A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors
This study will evaluate the safety, efficacy, optimal dose, and pharmacokinetics (PK) of BNT326 as monotherapy (Part 1) and as combination treatment with immunotherapeutic agents (Part 2) in participants with histologically or…
- Trial name
- NCT07070232
- Testing
- BNT326, Pumitamig, Itraconazole
- Where
- 77 sites in United States, Australia and 7 more
- Volunteers
- 1,438 people
- Sponsor
- BioNTech SE
Covid19
Study to Select the Dose and Evaluate Safety and Efficacy of Monoclonal Antibody in Adult With Recently Diagnosed Asymptomatic to Moderately Severe COVID-19.
MAD0004J08, the experimental drug, is a potent neutralizing IgG1 monoclonal antibody (mAb) targeting the spike protein of SARS-CoV-2. MAD0004J08 blocks viral attachment and entry into human cells and neutralizes the virus.
- Trial name
- NCT04952805
- Testing
- MAD0004J08
- Where
- 14 sites in Italy
- Volunteers
- 800 people
- Sponsor
- Toscana Life Sciences Sviluppo s.r.l.
Transfemoral Amputation
Use of Passive, Adaptive, and Active Prosthetic Knees in Persons With Unilateral, Transfemoral Amputation
The goals of this study are to assess measured, observed, and self-reported outcomes achieved through the use of passive (mechanical), active(motorized) and adaptive (magnetorheological) prosthetic knee control systems in…
- Trial name
- OPK (NCT02219230)
- Testing
- Active knee (Ossur Power Knee II), Adaptive knee (Ossur Rheo), Passive knee (Various manufacturers)
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Washington
Solid Tumors, Carcinoma, Non-Small Cell Lung
Talazoparib in Combination With Gemcitabine and Cisplatin in Patients With Advanced Solid Tumors
In this proposed study the investigators will combine gemcitabine and cisplatin with talazoparib to determine the recommended Phase 2 dose (RP2D) of this combination regimen.
- Conditions
- Solid Tumors, Carcinoma, Non-Small Cell Lung, Non-Small Cell Lung Cancer, Non-Small-Cell Lung Carcinoma
- Trial name
- NCT02537561
- Testing
- Cisplatin, Gemcitabine, Talazoparib
- Sponsor
- Washington University School of Medicine
Bipolar Disorder, Mania
Clocks in Sync - Circadian Rhythm and Bipolar Mania
The sleep-wake cycle is severely disrupted during an episode of mania. Often mania is treated with medications that can come with significant side effects.
- Trial name
- CIS (NCT06504342)
- Testing
- Blue-blocking glasses, Time-restricted eating, Lightly tinted glasses
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- Ottawa Hospital Research Institute
Acute Graft Versus Host Disease
Dose-finding Study Using Pentostatin for Injection in the Treatment of Steroid-refractory aGvHD
To determine a safe and effective dose of pentostatin in steroid-refractory aGvHD and to identify the minimal effective dose of pentostatin defined as the lowest dose that produces a response in 20% or more of patients while…
- Trial name
- NCT00032773
- Testing
- pentostatin for injection
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Astex Pharmaceuticals, Inc.
Surgical Site Infection
Duration of Cardiac Antimicrobial Prophylaxis Outcomes Study
This multicentre, adaptive, pragmatic, double-blind, three-arm, placebo-controlled, randomised, non-inferiority clinical trial will compare the incidence of surgical site infection and other healthcare associated infections…
- Trial name
- CALIPSO (NCT05447559)
- Testing
- Cefazolin, Water for injection
- Where
- 27 sites in United States, Australia and 3 more
- Volunteers
- 9,180 people
- Sponsor
- Monash University
Behavior, Adaptive, Decision Analysis
Protocol Lab for Online Trial Delphi and Question Effects
This study nested as a randomized controlled trial within an online Delphi and will assess the impact of using different question section groupings to provide aggregate feedback to participants in an online Delphi study.
- Trial name
- NCT03498677
- Testing
- presentation order, alternative presentation order
- Where
- United Kingdom
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- ThinkWell
SARS-CoV Infection
Chemoprevention Clinical Trial of COVID-19: Hydroxychloroquine Post Exposure Prophylaxis
Protocol summary Title A Prospective, randomized, adaptive phase II/III clinical trial, controlled, open-label, chemoprevention, 3-arms, parallel, multi-centred, to A Prospective, randomized, clinical trial, controlled…
- Trial name
- APCC-19 (NCT04597775)
- Testing
- hydroxychloroquine
- Volunteers
- 93 people
- Sponsor
- Regional Center for Disease Control and Prevention, Jordan
Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia, Relapsed/Refractory B-cell Non-Hodgkin Lymphoma or CLL/SLL
Adaptive Dual-Target CAR-T Cells for Relapsed or Refractory Hematologic Malignancies
Phase 1/2 umbrella study evaluates biomarker-selected dual-target CAR-T cell modules for adults with relapsed or refractory hematologic malignancies.
- Conditions
- Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia, Relapsed/Refractory B-cell Non-Hodgkin Lymphoma or CLL/SLL, Relapsed/Refractory Multiple Myeloma or Plasma Cell Leukemia, Relapsed/Refractory Acute Myeloid Leukemia, High-risk Myelodysplastic Neoplasm
- Trial name
- ADAPT-HEM (NCT07523555)
- Testing
- Autologous CD19/CD22 dual-target CAR-T module, Autologous CD19/CD20 dual-target CAR-T module, Autologous BCMA/CD19 dual-target CAR-T module
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Beijing Biotech
Malignant Tumor, Advanced Solid Tumor
First-in-human Trial of PhOx430, a First-in-class Acetylglucosaminyltransferase V Inhibitor, in Advanced Solid Tumours
The PhAST Trial is an adaptive first-in-human clinical trial of the acetylglucosaminyltransferase V inhibitor PhOx430 in patients with advanced solid tumours conceived and designed with the contribution of the Gianni Bonadonna…
- Conditions
- Malignant Tumor, Advanced Solid Tumor, Glioblastoma Multiforme, Metastatic Cancer
- Trial name
- PhAST (NCT05495295)
- Testing
- PhOx430
- Where
- 4 sites in France, Italy
- Volunteers
- 149 people
- Sponsor
- Phost'In Therapeutics
Depression
An Adaptive Intervention for Depression Among Latinos Living With HIV
This study will use a pilot sequential multiple assignment randomized trial (SMART) design to build an adaptive treatment strategy (ATS) for depression and engagement in HIV among Latinos living with HIV.
- Trial name
- Latino-SMART (NCT03668379)
- Testing
- Augment w/mHealth, Maintenance, Switch to CBT & mHealth
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Breast Cancer, Invasive Breast Carcinoma
Adaptive Training Exercise Programs for Improving Cardiorespiratory Fitness After Breast Cancer Treatment, The ACTIVATE Trial
This clinical trial studies the feasibility of implementing various adaptive training exercise programs to improve cardiorespiratory fitness in patients after receiving breast cancer treatment.
- Trial name
- ACTIVATE (NCT04667481)
- Testing
- Aerobic Exercise Intervention, Resistance Exercise Intervention, Exercise Intervention: Digital copies and outline of sessions
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Washington
Emotional Regulation, Alcohol Drinking in College
Momentary Coping Prompts and Hair Steroids in College Students
This study looks at the moments when college students feel a strong emotional swing, and how those moments relate to reacting online when upset, drinking alcohol, and eating in response to emotions.
- Conditions
- Emotional Regulation, Alcohol Drinking in College, Emotional Eating, Aggression
- Trial name
- REACT-Bio (NCT07782398)
- Testing
- Momentary coping prompt, Active control message
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Florida
COVID-19
COVID-19 Variant Immunologic Landscape Trial (COVAIL Trial)
This phase 2 clinical trial will evaluate the safety and immunogenicity of additional doses of prototype and variant (alone or in combination) vaccine candidates in previously vaccinated participants with or without prior severe…
- Trial name
- NCT05289037
- Testing
- AS03, BNT162b2, BNT162b2 (B.1.1.529)
- Where
- 22 sites in United States
- Volunteers
- 1,270 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Mental Health, Addictions
Better Access to and Integration of Mental Health and Addiction Services Through Navigation: A Mixed-Methods Adaptive Pragmatic Clinical Trial
The Family Navigation Project (FNP), a youth and family mental health and addictions (MHA) navigation service that currently operates in the Greater Toronto Area (GTA), is expanding to northern Ontario by setting up a new site in…
- Conditions
- Mental Health, Addictions, Patient Navigation, Health Services
- Trial name
- BEAM (NCT07707492)
- Testing
- Family Navigation Project
- Where
- 2 sites in Canada
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
Cardiac Arrest, Out-Of-Hospital, Hypothermia, Induced
Pediatric Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients (P-ICECAP)
This is a multicenter trial to establish the efficacy of cooling and the optimal duration of induced hypothermia for neuroprotection in pediatric comatose survivors of cardiac arrest.
- Conditions
- Cardiac Arrest, Out-Of-Hospital, Hypothermia, Induced, Hypoxia-Ischemia, Brain
- Trial name
- NCT05376267
- Testing
- Therapeutic Hypothermia
- Where
- 65 sites in United States, Australia and 3 more
- Volunteers
- 900 people
- Sponsor
- University of Michigan