Clinical trials: Addiction, Substance
Alcohol Dependence, in Remission, Addiction, Alcohol
Does Treatment With GLP-1 Reduce Alcohol Intake in Patients With Alcohol Dependence?
The study is a double-blinded, randomized, placebo-controlled, 26-weeks clinical trial. The objective of the trial is to investigate the effects of the GLP-1 receptor agonist Bydureon® (exenatide) vs.
- Trial name
- EXALT (NCT03232112)
- Testing
- Exenatide 2 MG Injection, BD PosiFlush (saline)
- Where
- Denmark
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Anders Fink-Jensen, MD, DMSci
Substance Dependence
A Study To Assess The Effects Of A Single Dose Of GSK598809 In Modulating Nicotine Reward
GSK598809 is being developed as an innovative treatment for substance dependence and potentially other compulsive behavioral disorders.
- Trial name
- NCT00605241
- Testing
- GSK598809
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Addiction
Linking fMRI to Mobile Technologies in Addiction Research: Pathophysiology of Executive Deficits, Craving and Substance Use
120 individuals with alcohol, cannabis or nicotine dependence as well as healthy controls will be administered a whole-brain imaging exam.
- Trial name
- MobiCogIm (NCT02334956)
- Testing
- Brain MRI
- Where
- 2 sites in France
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Bipolar Disorder, Mania
Depakote ER Therapy for Mania Comorbid With Substance Abuse
The purpose of this study is to ascertain whether Depakote ER (Divalproex ER) has efficacy in the treatment of patients with bipolar disorder in the manic phase, who also have comorbid substance abuse diagnoses.
- Conditions
- Bipolar Disorder, Mania, Substance Abuse, Substance Dependence
- Trial name
- NCT00208195
- Testing
- Divalproex ER
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Creighton University
Smoking Cessation
Interventions for Smoking Among Persons in Recovery
Examine the efficacy of a stepped-care smoking cessation intervention for current and former smokers in chemical dependency treatment programs.
- Trial name
- INSPIRE (NCT00714896)
- Testing
- Stepped-Care, Control
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Addiction, Substance Use Disorder
Group Version of CRAFT Compared to Self-Directed CRAFT Delivery and Non-intervention: a Three-armed RCT
The aim of this study is to determine whether a group format Community Reinforcement and Family Training (CRAFT) and Self-Directed CRAFT Delivery are more effective than non-intervention in terms of Concerned Significant Others…
- Conditions
- Addiction, Substance Use Disorder, Alcohol Use Disorder, Substance- Related Disorder
- Trial name
- NCT02510508
- Testing
- Group CRAFT, Self-Directed CRAFT Delivery, Non-intervention
- Where
- 6 sites in Netherlands
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- IrisZorg
Tobacco Use Disorder
An fMRI Study of the Effects of Clavulanic Acid on Drug Addiction
This research study is looking into the effects of clavulanic on smoking behavior in adult cigarette smokers. The primary study hypothesis is that, compared to placebo, clavulanic acid will reduce smoking over the course of the…
- Trial name
- NCT03713424
- Testing
- Clavulanic Acid
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Smoking Cessation
Impact of a Gene Test for Susceptibility to Lung Cancer in Smokers
Professor RP Young (Associate Professor of Medicine and Molecular Medicine, School of Biological Sciences, University of Auckland) and his team have developed a reliable genetic test "Respiragene" based on 20 single nucleotide…
- Trial name
- NCT01176383
- Testing
- Respiragene test and risk score
- Where
- United Kingdom
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Sussex NHS Research Consortium
Substance-Related Disorders
Brief Intervention in Primary Care for Problem Drug Use and Abuse
This study will examine the effectiveness of a brief intervention in a primary care setting to reduce drug use or abuse compared to enhanced care as usual.
- Trial name
- NCT00877331
- Testing
- Brief intervention using motivational interviewing
- Where
- United States
- Volunteers
- 868 people, healthy volunteers welcome
- Sponsor
- University of Washington
Physical Exercise
Can Exercise Rewire the Brain Addiction Circuitry?
The aim of the present study is to apply neuroimaging techniques to investigate how physical exercise may influence the addiction circuitry, ultimately reducing alcohol consumption and craving in youth binge drinkers.
- Trial name
- REWIRED (NCT06317753)
- Testing
- Aerobic Exercise, Agility-Cognitive Exercise, Stretching/relaxation
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Minho
Opioid-Related Disorders, Narcotic-Related Disorders
Safe Prescription of Opioids in Primary Care
Opioid analgesics are commonly prescribed addictive narcotics intended for the treatment of pain. Inappropriate prescription of opioids in quantities and for conditions which lack clinical evidence contributes to the risk of…
- Conditions
- Opioid-Related Disorders, Narcotic-Related Disorders, Addiction
- Trial name
- NCT05577026
- Testing
- Educational intervention and prescription feedback, General information on treatment guidelines
- Where
- Sweden
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Region Stockholm
Drug Misuse, Addiction
Construction of a Risk Screening Tool for New Psychoactive Substance Misuse Among Adolescents and Young Adults
The goal of this observational study is to construct a risk tool available for screening young adults and adolescents at high risk of drug misuse and provides a chance for early intervention to young adults and adolescents at…
- Trial name
- NCT06714578
- Testing
- Questionnaire and Physical Exam
- Where
- China
- Volunteers
- 1,035 people, healthy volunteers welcome
- Sponsor
- Wei XIA, PhD
Nicotine Dependence
Studying Nicotine Addiction With Transcranial Magnetic Stimulation
Background: Nicotine addiction often makes it difficult to stop smoking. Researchers want to understand the areas of the brain that are important in nicotine addiction.
- Trial name
- NCT01702948
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Mental Health, Substance-Related Disorders
First Face Training Evaluation in Tribal Communities
The goal of this study is to evaluate a culturally grounded training curriculum, First Face for Mental Health, in Tribal communities, using a waitlist controlled trial design.
- Trial name
- NCT05998005
- Testing
- First Face Training Program
- Where
- 9 sites in United States
- Volunteers
- 554 people, healthy volunteers welcome
- Sponsor
- Cambridge Health Alliance
OCD, Major Depressive Disorder (MDD)
Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics
This is an observational study which does NOT directly administer a psychedelic substance but rather recruits participants who are already participating in another clinical trial in which they may receive a serotonergic…
- Conditions
- OCD, Major Depressive Disorder (MDD), Alcohol Use Disorder (AUD), Healthy Volunteer
- Trial name
- NCT06624137
- Testing
- Serotonergic Psychedelic
- Where
- 2 sites in United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Yale University
Normal Physiology, Alcohol Use Disorder
Addictions Neuroclinical Assessment (ANA)
Background: Alcohol use disorder (AUD) is a major public health problem. In the U.S., 16 to 18 million adults have an AUD. Researchers want to test an assessment tool called the ANA.
- Trial name
- NCT04946851
- Where
- United States
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Opiate Dependence, Cocaine Dependence
Imaging Synaptic Density in Cocaine and Opiate Addiction In Vivo Using 11UCB-J PET
This study aims to measure synaptic density in the brains (including in ventral striatum [VS] and medial prefrontal cortex [mPFC]) of abstinent subjects with Cocaine Use Disorder (CUD) or Opiate Use Disorder (OUD) as compared to…
- Trial name
- NCT03527485
- Testing
- 11UCB-J PET Scan
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Yale University
Nicotine Dependence, Smoking
Exercise Training for Smoking Students
Smoking can damage lung functions as a result of high carbon monoxide and low hemoglobin oxygen carrying capacity in the blood. Smoking between young people continues to increase, which can cause respiratory function problems and…
- Conditions
- Nicotine Dependence, Smoking, Physical Inactivity, Depression
- Trial name
- NCT06291558
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kırklareli University
Alcoholism
To Evaluate the Influence of the A118G Polymorphism in the mu Opioid Receptor Gene (OPRM1) on Effects of GSK1521498 and Naltrexone on Physiological and Behavioural Markers of Brain Function in Healthy Social Drinkers
A total of at least 48 healthy subjects with a history of social drinking will be recruited into this single-centre, randomized, double-blind, cross-over study.
- Trial name
- NCT01738867
- Testing
- GSK1521498, Naltrexone (NTX)
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Alcohol Addiction, Opiate Addiction
Effectiveness of a Hospital Addiction Service in Treating Opioid and Alcohol Addiction
Hypothesis: Patients who are addicted to opioids or alcohol will have reduced substance use, health care utilization if they have immediate and convenient access to pharmacotherapy and addiction counselling.
- Trial name
- H-SOAP (NCT01934751)
- Testing
- Delayed Intervention (DI), Rapid Intervention (RI)
- Where
- Canada
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Women's College Hospital