Clinical trials: Addiction, Substance
Cocaine Abuse, Cocaine-Related Disorders
The Effects of GABA Enhancing Medications on Individuals Addicted to Cocaine - 3
Gamma-aminobutyric acid (GABA) is a type of neurotransmitter, which is a chemical that transmits information within and from the brain to all parts of the body.
- Trial name
- NCT00142883
- Testing
- Pregabalin
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Yale University
Posttraumatic Stress Disorder, Substance Use Disorder
Present- Versus Past-focused Therapy for PTSD and Substance Use Disorder
This study compares Creating Change, a new past-focused behavioral therapy for posttraumatic stress disorder (PTSD)/substance use disorder (SUD), to Seeking Safety, an evidence-based present-focused behavioral therapy for…
- Conditions
- Posttraumatic Stress Disorder, Substance Use Disorder, Alcohol Use Disorder
- Trial name
- NCT01274741
- Testing
- Creating Change (CC), Seeking Safety (SS)
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- VA Boston Healthcare System
Psychoactive Substances Consumers
Evaluation of Relationship Between Hypersexuality and Psychostimulant Among Men Who Have Sex With Men
Survey of fifty new psychoactive substances consumers in a context of MTM sexual intercourse. Evaluation using an hetero-assessment questionnaire about the link between hypersexual disorder and the use of synthetic cathinone.
- Trial name
- HYPERCHEM (NCT02969694)
- Testing
- G-STAT questionnaire
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Hospices Civils de Lyon
Opioid Use Disorder
Light Needle for Opioid Use Disorder
This randomized-controlled study investigates the effect of adjuvant light needle in the treatment of heroin addicts. One hundred heroin addicts older than 20 years old enrolled from the Addiction Treatment Center at Kaohsiung…
- Trial name
- OUD (NCT05341219)
- Testing
- Light needle therapy
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Chang Gung Memorial Hospital
Alcohol Use Disorder
Soberlink Within In-Home Addiction Treatment Program
The purpose of this study is to evaluate the impact of use of Soberlink on treatment experience for individuals with alcohol use disorder while enrolled in an In-Home Addiction Treatment program.
- Trial name
- NCT03902171
- Testing
- Soberlink
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- In-Home Addiction Treatment Institute, Inc.
Drug Addiction, Stimulant Dependence
CRAFT Behavior Therapy: Treatment Entry Component
This research compares the benefits of the original treatment, Community Reinforcement and Family Training (CRAFT), with the Treatment Entry Training (TEnT) component of CRAFT to determine if TEnt alone can produce the primary…
- Conditions
- Drug Addiction, Stimulant Dependence, Opiate Dependence, Alcohol Dependence
- Trial name
- NCT00842036
- Testing
- Community Reinforcement and Family Training, Treatment Entry Training, 12- step Al/Nar- Anon Facilitation
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Treatment Research Institute
Alcohol Use Disorder
Alcohol Use Disorder Before and After Bariatric Surgery and the Impact of Considering This Surgery During Addiction Follow-up
A significant number of patients treated for alcohol use disorder have undergone bariatric surgery. Bariatric surgery is a treatment for patients suffering from morbid or severe obesity with comorbidities that can be improved by…
- Trial name
- DAACBC (NCT07273955)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Strasbourg, France
Alcohol Use Disorder
A Dose-Escalation Study to Determine the Maximum Tolerated Dose of Arbaclofen Placarbil in Subjects With Alcohol Use Disorder
This study will determine the maximum tolerated dose (MTD) of arbaclofen placarbil (AP) in the treatment of subjects with Alcohol Use Disorder (AUD). For every two subjects receiving AP, one subject will receive placebo.
- Trial name
- NCT02511886
- Testing
- Arbaclofen Placarbil
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Indivior Inc.
Substance Abuse
Positive Effects of Laser Acupuncture in Methamphetamine Users Undergoing Group Cognitive Behavioral Therapy: A Pilot Study
Methamphetamine (MA) addiction has become a crucial public health issue due to its adverse effects. Acupuncture has been used for drug detoxification for many years. However, some disadvantages are not be suitable for MA users.
- Trial name
- NCT04789772
- Testing
- Laser acupuncture
- Where
- 2 sites in Taiwan
- Volunteers
- 15 people
- Sponsor
- Chang Gung Memorial Hospital
Addiction, Cocaine-Related Disorders
Benefits of Therapy With Virtual Reality Exposure in the Treatment of Cocaine Use Disorders
Cocaine addiction is a multifactorial disease with important consequences: somatic, psychiatric... The number of applications for treatment for cocaine addiction is gradually increasing from year to year but no conventional…
- Trial name
- CORVI (NCT04280900)
- Testing
- Virtual Reality-Enhanced Cognitive Behavioral Therapy (VR-CBT), Treatment as usual
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Clermont-Ferrand
Normal Physiology, Alcohol Use Disorder
Addictions Neuroclinical Assessment (ANA)
Background: Alcohol use disorder (AUD) is a major public health problem. In the U.S., 16 to 18 million adults have an AUD. Researchers want to test an assessment tool called the ANA.
- Trial name
- NCT04946851
- Where
- United States
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Opiate Dependence
ALK21-013: Efficacy and Safety of Medisorb® Naltrexone (VIVITROL®) in Adults With Opioid Dependence
This is a Phase 3 multi-center trial designed to evaluate the clinical efficacy and safety of VIVITROL® (Medisorb® naltrexone 380 mg) versus placebo when administered to adults upon discharge from inpatient treatment for opioid…
- Trial name
- NCT00678418
- Testing
- VIVITROL® 380 mg
- Where
- Russia
- Volunteers
- 250 people
- Sponsor
- Alkermes, Inc.
Substance Use Disorders, Opiate Dependence
The Effect of Self-Forgiveness on Self-Stigma in Addiction.
This study has an experimental design and will examine the difference in pre-test and post-test data on the Self-Forgiveness Dual Process Scale (SFDPS) (Griffin, Worthington, Davis, Hook, \& Maguen, 2018) and the Substance Abuse…
- Conditions
- Substance Use Disorders, Opiate Dependence, Opiate Withdrawal Syndrome, Opioid-use Disorder
- Trial name
- NCT03971097
- Testing
- Six Step Model of Self-Forgiveness, Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- University of Pittsburgh
Opioid Abuse, Opioid Addiction
The Discriminative Effects of Tramadol in Humans
This research is part of a set of studies whose purpose is to test whether tramadol can be used for the treatment of opioid addiction. Tramadol is already available in the United States as a pain medicine marketed as Ultram.
- Conditions
- Opioid Abuse, Opioid Addiction, Stimulant Abuse, Stimulant Addiction
- Trial name
- NCT00499746
- Testing
- tramadol, Hydromorphone, Methylphenidate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Opioid Use Disorder
Biopsychosocial Markers of Addiction in Opioid Users: an Integrated Approach
BEBOP is a prospective, multicenter, national, comparative, non-randomized, open cohort study aiming to characterize opioid use disorder (OUD) severity and psychosocial severity among adults who use opioids, and to identify…
- Trial name
- BEBOP (NCT06021548)
- Testing
- Blood sample, Saliva sample, Hair sample
- Where
- 3 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Strasbourg, France
Opiate Dependence, Cocaine Dependence
Imaging Synaptic Density in Cocaine and Opiate Addiction In Vivo Using 11UCB-J PET
This study aims to measure synaptic density in the brains (including in ventral striatum [VS] and medial prefrontal cortex [mPFC]) of abstinent subjects with Cocaine Use Disorder (CUD) or Opiate Use Disorder (OUD) as compared to…
- Trial name
- NCT03527485
- Testing
- 11UCB-J PET Scan
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Yale University
Heroin Dependence, Opioid-Related Disorders
Addiction Treatment in Russia: Oral vs. Naltrexone Implant
Heroin addiction is a growing problem in Russia; individuals who enter heroin addiction treatment often relapse. Therefore, effective heroin addiction treatments are necessary to prevent relapse.
- Trial name
- NCT00218426
- Testing
- naltrexone implant, oral naltrexone
- Where
- 2 sites in United States, Russia
- Volunteers
- 306 people
- Sponsor
- University of Pennsylvania
Substance Use, Substance Use Disorders
Developing a Telehealth Model to Improve Treatment Access for Rural Veterans With Substance Use Disorders
This project will pilot-test and obtain stakeholder input on a telehealth-delivered substance use disorder (SUD) care model (with initial engagement and ongoing MI-CBT treatment) with the goal of increasing treatment utilization…
- Conditions
- Substance Use, Substance Use Disorders, Substance Dependence, Veterans
- Trial name
- VetReach (NCT05348317)
- Testing
- VetReach
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- VA Office of Research and Development
Drug-withdrawal., Drug Abuse
Clinical Studies on the Therapeutic Effects of Mirtazapine on Drug-craving in Cocaine Addicts.
INTRODUCTION. One of the main problems of the treatment of cocaine-dependent patients is the high rate of relapses occurs within the first months after detoxification.
- Conditions
- Drug-withdrawal., Drug Abuse, Drug-induced Depressive State, AOD Craving
- Trial name
- MADC (NCT01949571)
- Testing
- Mirtazapine (REMERON, Schering-Plough-Organon)
- Where
- Mexico
- Volunteers
- 64 people
- Sponsor
- Instituto Nacional de Psiquiatría Dr. Ramón de la Fuente
Tobacco Use Disorder
Nicotine Replacement Treatment for Pregnant Smokers - 1
Smoking during pregnancy is an important modifiable cause of poor pregnancy outcomes. Even with augmented behavioral interventions, smoking cessation rates in pregnancy trials rarely exceed 20%.
- Trial name
- NCT00115687
- Testing
- 2 mg nicotine polacrilex
- Where
- 4 sites in United States
- Volunteers
- 250 people
- Sponsor
- National Institute on Drug Abuse (NIDA)