Clinical trials: Addiction, Substance
Addictive Behavior, Food Preferences
Food Choices in Healthy Weight Women
This study will examine differences in habituation to foods high in sugar and fat content versus those that are not, in normal weight women.
- Conditions
- Addictive Behavior, Food Preferences, Food Habits, Healthy
- Trial name
- NCT02481362
- Testing
- CAKE, APRICOTS
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- The University of Tennessee, Knoxville
Opioid Abuse, Opioid Addiction
The Discriminative Effects of Tramadol in Humans
This research is part of a set of studies whose purpose is to test whether tramadol can be used for the treatment of opioid addiction. Tramadol is already available in the United States as a pain medicine marketed as Ultram.
- Conditions
- Opioid Abuse, Opioid Addiction, Stimulant Abuse, Stimulant Addiction
- Trial name
- NCT00499746
- Testing
- tramadol, Hydromorphone, Methylphenidate
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Substance Use Disorders, Alcohol Abuse
Reinforcement of Abstinence and Continuing Care in Substance Abuse Treatment
The Contracts, Prompts, and Social Reinforcement (CPR) intervention was designed to address the continuing care adherence needs of veterans presenting for substance use disorder (SUD) treatment.
- Conditions
- Substance Use Disorders, Alcohol Abuse, Alcoholism, Substance Dependence
- Trial name
- NCT00288886
- Testing
- Contracting, Prompting and Reinforcement arm, Control arm
- Where
- 2 sites in United States
- Volunteers
- 183 people
- Sponsor
- US Department of Veterans Affairs
Addiction, Opioid-use Disorder
Comprehensive CBT (Cognitive Behavioral Therapy) Via reSET App
This research is being done to find out whether an app based cognitive behavior therapy called reSET improves the adherence to and outcome of buprenorphine treatment for opioid use disorder (OUD) in the setting of a Hub and Spoke…
- Trial name
- NCT03826966
- Testing
- reSET
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Milton S. Hershey Medical Center
Nicotine Dependence
Electronic Nicotine Delivery Systems as a Smoking Cessation Treatment
The purpose of this research study is to determine whether combining electronic nicotine delivery systems (ENDS) with nicotine patch treatment will augment abstinence rates compared to either treatment alone.
- Trial name
- ENDS-P50 (NCT02487953)
- Testing
- Nicotine patch, ENDS
- Where
- United States
- Sponsor
- Duke University
Substance Abuse
Computer-assisted Delivery of Cognitive Behavioral Therapy for Mental Health and Addictions in Canada
Computer-based Training for Cognitive Behavioural Therapy (CBT4CBT) is a new on-line addiction treatment developed by Dr Kathleen Carroll at the Yale School of Medicine in New Haven, Connecticut.
- Trial name
- NCT03230669
- Testing
- cbt4cbt
- Where
- Canada
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- University of Prince Edward Island
Alcohol Use Disorder, Hazardous Alcohol Use
LDART for Alcohol Use Disorder
This study is a pilot randomized controlled trial to evaluate feasibility, acceptability, and preliminary efficacy of a digital intervention called Let's Do Addiction Recovery Together! (LDART) in adults with alcohol use…
- Trial name
- LDART (NCT07221383)
- Testing
- LDART, Psychoeducational control
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Yale University
Drug Addiction, Executive Dysfunction
Bilateral Prefrontal Modulation in Crack-cocaine Addiction
In this study, eligible crack-cocaine addicted inpatients recruited from specialized clinics for substance abuse disorder treatment, filling inclusion criteria and not showing any exclusion criteria, were randomized to receive…
- Trial name
- tDCS_CRACK (NCT02091167)
- Testing
- transcranial Direct Current Stimulation
- Where
- Brazil
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Federal University of Espirito Santo
Cocaine Abuse
Dopamine Rhythms in Health and Addiction
Background: Dopamine is a chemical signal linked to the rewarding effects of drugs. Certain genes make these effects sensitive to the time of day they are taken. Cocaine can affect these genes in the brain.
- Trial name
- NCT02233829
- Testing
- Brain Dopamine Reactivity, Brain Dopamine Receptor
- Where
- United States
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Cocaine Addiction
Effects of tDCS on Craving, Relapse and Cognitive Functions Among Patients With Cocaine Use Disorder
Repetitive bilateral (left cathodal/ right anodal) transcranial Direct Current Stimulation (tDCS) over the dorsolateral prefrontal cortex (DLPFC) reduces craving and seems to decrease relapse risk in addiction.
- Trial name
- NCT03025321
- Testing
- transcranial Direct Current Stimulation (tDCS)
- Where
- Netherlands
- Volunteers
- 59 people
- Sponsor
- Erasmus Medical Center
Posttraumatic Stress Disorder, Substance Dependence
Trial of a Novel Cognitive-Behavioral Treatment for Posttraumatic Stress and Substance Dependence
The purpose of the study is to determine whether a novel integrated cognitive-behavioral treatment for posttraumatic stress disorder (PTSD) and substance dependence (i.e., Treatment for Integrated Posttraumatic Stress and…
- Trial name
- NCT02461732
- Testing
- Treatment for Integrated Posttraumatic Stress and Substance Use (TIPSS), Cognitive-Behavioral Therapy for Substance Dependence
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The University of Texas Health Science Center, Houston
Heroin Addiction
Decision Making Deficit and DNA Methylation in Opioid Receptor Genes Among Community Heroin Addicts
Heroin addiction has emerged as a serious problem with tremendous impacts on the addicts and the society. Since the introduction of opioids substitutive treatment in 2006, more than 30,000 heroin addicts had received treatment…
- Trial name
- NCT01668732
- Volunteers
- 1 people
- Sponsor
- National Health Research Institutes, Taiwan
Tobacco Use Disorder, Nicotine Dependence
The MATCH (Medication Aids for Tobacco Cessation and Health) Study
Clinically proven medications such as nicotine replacement therapy, bupropion and varenicline are available to help smokers quit but there are not widely used.
- Trial name
- MATCH (NCT02146911)
- Testing
- Bupropion, Varenicline, Weekly Motivational Emails
- Where
- Canada
- Volunteers
- 968 people
- Sponsor
- Centre for Addiction and Mental Health
Health Services Research, Quality of Life
Quality of Life and Addiction Among Hospital Night Workers
The current context of the Covid-19 health crisis leads to an over-solicitation of health systems, with hospital staff in the front line.
- Conditions
- Health Services Research, Quality of Life, Addiction, Substance-Related Disorders
- Trial name
- ALADDIN (NCT04291534)
- Where
- 2 sites in France
- Volunteers
- 1,800 people
- Sponsor
- University Paris 7 - Denis Diderot
Tobacco Use Disorder
Smoking Cessation Behavioral Treatment Study
The purpose of this study is to evaluate the effectiveness of two behavioral interventions on smoking behavior - Mindfulness-Oriented Recovery Enhancement (MORE) and Cognitive Behavioral Therapy (CBT).
- Trial name
- NCT03948893
- Testing
- Mindfulness-Oriented Recovery Enhancement (MORE), Cognitive Behavioral Therapy (CBT)
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Alcohol Use Disorder, Insomnia
Daridorexant for People With Insomnia and Alcohol Use Disorder Study
The goal of this clinical trial is to see if a sleep medication, daridorexant (DTX), can help decrease drinking in people who have alcohol use disorder (AUD) and insomnia.
- Trial name
- DIAS (NCT07701928)
- Testing
- Daridorexant, Brief Counseling, MEMS and Medication Accounting
- Where
- United States
- Volunteers
- 205 people
- Sponsor
- Sterling McPherson
Alcohol Addiction
Disulfiram as a Modulator of Amyloid Precursor Protein-processing
A causal therapeutic approach for treatment of Alzheimer's disease has not been established so far. The protein ADAM10 represents a promising target for an A-beta peptide preventing strategy.
- Trial name
- DIMAP (NCT03212599)
- Testing
- Disulfiram
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Johannes Gutenberg University Mainz
Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
Stop Addiction Stigma
This clinical trial evaluates the impact of a Stop Addiction Stigma (SAS) training workshop with a short description of the conditions related to addiction (vignettes) on stigmatizing attitudes toward individuals with substance…
- Trial name
- NCT06582030
- Testing
- Assessment, Educational Activity, Training
- Where
- United States
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
HIV Infections, Alcohol Drinking
Boston Alcohol Research Collaboration on HIV/AIDS (ARCH) Cohort: The 4F Study
The purpose of this study is to follow a cohort of HIV-infected adults who have alcohol and/or drug use to: 1) test the associations between alcohol (and illicit drugs and polypharmacy (multiple prescribed medications)) and falls…
- Conditions
- HIV Infections, Alcohol Drinking, Substance-Related Disorders, Bone Diseases
- Trial name
- NCT03414411
- Where
- United States
- Volunteers
- 251 people
- Sponsor
- Boston University
HIV Infection, Alcohol Use
Boston Alcohol Research Collaboration on HIV/AIDS (ARCH) Cohort
The purpose of this study is to expand and continue a cohort of HIV-infected adults to establish the longitudinal Boston ARCH Cohort of 250 HIV-infected men and women with current substance dependence or ever injection drug use…
- Conditions
- HIV Infection, Alcohol Use, Bone Disease, Substance-Related Disorders
- Trial name
- NCT01740115
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Boston Medical Center