Clinical trials: Addiction, Substance
Cocaine Dependence, Cocaine Addiction
Clavulanic Acid (CLAV) and Cocaine Interaction Safety Study
The main purpose of this study is to determine if it is safe to use the study drug, clavulanic acid, in combination with cocaine.
- Conditions
- Cocaine Dependence, Cocaine Addiction, Cocaine Abuse, Cocaine-Related Disorders
- Trial name
- NCT02563769
- Testing
- Clavulanic acid, Intravenous cocaine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Temple University
Substance Use Disorders, Comorbidities and Coexisting Conditions
Adaptation of Community Reinforcement Approach for the Treatment of Drug Addiction
Central idea of the study is to adapt a treatment program for drug addiction treatment indigenously and relapse prevention, and to establish its efficacy.
- Trial name
- NCT06559631
- Testing
- Indigenously Adapted CRA
- Where
- 2 sites in Pakistan
- Volunteers
- 59 people
- Sponsor
- Muhammad Saghir
Addiction, Opioid-use Disorder
Comprehensive CBT (Cognitive Behavioral Therapy) Via reSET App
This research is being done to find out whether an app based cognitive behavior therapy called reSET improves the adherence to and outcome of buprenorphine treatment for opioid use disorder (OUD) in the setting of a Hub and Spoke…
- Trial name
- NCT03826966
- Testing
- reSET
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Milton S. Hershey Medical Center
Methamphetamine Dependence, Substance Abuse
Varenicline vs Placebo for the Treatment of Methamphetamine Dependence
Methamphetamine (MA) abuse is the fastest growing drug problem in the United States and is responsible for significant public health complications, including HIV infection.
- Conditions
- Methamphetamine Dependence, Substance Abuse, Methamphetamine Abuse
- Trial name
- RAVEN (NCT01011829)
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Los Angeles
Opioid Addiction
Ultra-rapid Opiate Detoxification Using Deep Sedation and Prior Oral Buprenorphine Preparation.
The methods of detoxification under general anesthesia have been criticized because of limited data on safety and long-term follow-up. Premedication with buprenorphine has been advocated to improve safety.
- Trial name
- NCT01008072
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Assaf-Harofeh Medical Center
Drug Overdose, Opioid-Related Disorders
A Tailored, Peer-delivered Intervention to Reduce Recurring Opioid Overdoses
This project will further develop and test the Tailored Telephone Intervention delivered by Peers to Prevent Recurring Opioid Overdoses (TTIP-PRO), a promising, low-cost, intervention to facilitate entry into medication assisted…
- Conditions
- Drug Overdose, Opioid-Related Disorders, Drug Addiction, Drug Abuse
- Trial name
- TTIP-PRO (NCT02922959)
- Testing
- Peer Intervention, naloxone nasal spray kit, Personally-tailored opioid overdose prevention education (information packet)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Cincinnati
Pregnancy, Mental Disorder
Woman Mental Health and Addictions on Pregnancy
The study intend to achieve the following objectives Objective 1: Develop a collaborative infrastructure among different hospital services to support research that improves the accessibility, quality, and outcomes of integrated…
- Conditions
- Pregnancy, Mental Disorder, Substance Abuse
- Trial name
- WOMAP (NCT06965270)
- Testing
- Standardized clinical intervention, Internet/App intervention, Treatment as usual
- Volunteers
- 2,014 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Chronic Pain, Post-traumatic Stress Disorder
The Norwegian Addiction, Pain and Trauma Study
In populations with substance use disorders (SUD), there is a high prevalence of chronic pain with various underlying causes. Chronic pain can complicate the treatment of SUD and lead to poorer treatment outcomes.
- Conditions
- Chronic Pain, Post-traumatic Stress Disorder, Substance Use Disorders
- Trial name
- NOR-APT (NCT04908410)
- Where
- 4 sites in Norway
- Volunteers
- 1,650 people
- Sponsor
- University Hospital, Akershus
Addiction, Addiction Disorders
Can Selfcompassion Training Reduce Alcohol Consumption in Patients With Alcohol Use Disosrder ?
The objective of this interventional study is to evaluate the effectiveness of the Mindful Self-Compassion (MSC) program in reducing alcohol consumption in a population of individuals with Alcohol Use Disorder (AUD), six months…
- Conditions
- Addiction, Addiction Disorders, Alcohol Use Disorders, Alcohol Dependence
- Trial name
- COMPAL (NCT07131124)
- Testing
- Mindful Self-Compassion program, Treatment As Usual (TAU) program
- Where
- France
- Volunteers
- 152 people
- Sponsor
- Etablissement Public de Santé Barthélemy Durand
Alcohol Abuse, Alcohol Addiction
Internet-Based Relapse Prevention vs Face to Face Therapy at an Employee Assistance Program
Objectives: This study will evaluate the efficacy of internet-based relapse prevention with therapist support, as compared to face-to-face therapy at an employee assistance program.
- Trial name
- FoBeMA (NCT02014779)
- Testing
- eChange, Face-to-face therapy
- Where
- Sweden
- Volunteers
- 1 people
- Sponsor
- Karolinska Institutet
Opioid Use Disorder, Opioid Misuse
Natural Language Processing for Screening Opioid Misuse
This is a clinical study to implement and evaluate a hospital-wide, operational intervention for a real-time natural language processing (NLP)-driven clinical decision support (CDS) tool, called Substance Misuse Algorithm for…
- Trial name
- NCT05745480
- Testing
- Opioid Misuse Screening with an Addiction Consult Service
- Where
- United States
- Volunteers
- 47,502 people
- Sponsor
- University of Wisconsin, Madison
Cocaine Addiction, Cocaine Abuse
Psychology of Reward and Punishment: Functional and Molecular Brain Imaging and Monoaminergic Correlates
Background: Brain imaging studies, genetic research, and investigations of stress have provided more information about the role of dopamine in processing reward and punishment, and in vulnerability to substance dependence.
- Trial name
- NCT00865332
- Where
- 2 sites in United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Addiction
Deep Brain Stimulation of the Nucleus Accumbens and the Ventral Anterior Internal Capsule for Severe Alcohol Addiction
The main objective of this study is to assess the efficacy of bilateral deep brain stimulation (DBS) of the nucleus accumbens (NAc) and the ventral anterior internal capsule (VC) as a novel treatment in severe alcohol addiction.
- Trial name
- NCT01658592
- Testing
- Deep brain stimulation
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Guodong Gao
Opioid-Related Disorders, Opiate Addiction
Validation of PRISM-5-Op, Measure Of Addiction To Prescription Opioid Medication
The purpose is to validate the PRISM-5-Op as a measurement of prescription opioid substance use disorder.
- Conditions
- Opioid-Related Disorders, Opiate Addiction, Narcotic Abuse, Drug Abuse
- Trial name
- NCT02660619
- Testing
- Psychiatric Research Interview for Substance and Mental Disorders (PRISM-5-Op)
- Volunteers
- 606 people
- Sponsor
- Member Companies of the Opioid PMR Consortium
Alcoholism
Alcohol Addiction: A Systems-oriented Approach
The goal of the multicenter subproject (SP) 10 of the eMED Alcohol Addiction Consortium - A Systems-Oriented Approach is to study neuroimaging x genetics predictions in an existing sample (NGFNplus) of tightly endophenotyped and…
- Trial name
- eMedAlcohol (NCT02910193)
- Where
- Germany
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
HIV Infections, Drug Use
INTEGRA: A Vanguard Study of Health Service Delivery in a Mobile Health Delivery Unit
The purpose of this study is to determine the efficacy of using a mobile health delivery unit ("mobile unit") to deliver "one stop" integrated health services - particularly medication for opioid use disorder (MOUD) and…
- Conditions
- HIV Infections, Drug Use, Opioid Use, Opioid-use Disorder
- Trial name
- INTEGRA (NCT04804072)
- Testing
- Medication for opioid-use disorder (MOUD) for opioid-use disorder (OUD), HIV testing, HIV treatment for participants living with HIV not already in care
- Where
- 5 sites in United States
- Volunteers
- 447 people
- Sponsor
- HIV Prevention Trials Network
Opioid Related Disorders, Opioid Dependence
Medications Development for Drug Abuse Disorders
This is a study of tramadol as an agent for short-term opioid withdrawal treatment. A randomized, double blind clinical trial comparing the efficacy and safety of tramadol to clonidine and buprenorphine in the short-term…
- Conditions
- Opioid Related Disorders, Opioid Dependence, Opioid Addiction
- Trial name
- NCT01188421
- Testing
- Buprenorphine/naloxone, Clonidine, Tramadol ER
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Johns Hopkins University
Cocaine Use Disorder, Cocaine Dependence
Low-Intensity Focused Ultrasound for Cocaine Use Disorder
This study aims to understand the role of Low-Intensity Focused Ultrasound on craving levels for cocaine as evidenced by diagnostic imaging of the dorsal anterior insula (dAI) and subjective ratings.
- Conditions
- Cocaine Use Disorder, Cocaine Dependence, Cocaine Abuse, Ultrasound
- Trial name
- NCT05857852
- Testing
- Low-Intensity Focused Ultrasound
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Alcoholism
Overcoming Addictions: A Randomized Clinical Trial of a Web Application Based on SMART Recovery
The objective of this research project is to develop, evaluate, and disseminate an Internet-based (web) application for SMART Recovery: Overcoming Addictions (OA).
- Trial name
- NCT01389297
- Testing
- SMART Recovery face-to-face meetings, Overcoming Addictions web application
- Where
- United States
- Volunteers
- 189 people
- Sponsor
- Behavior Therapy Associates, LLP
Hepatitis C, Heroin Dependence
Bridging Active Heroin Users to Hepatitis C Treatment Using Buprenorphine - 1
The purpose of this study is to see whether street-recruited heroin users can be successfully treated for hepatitis C after stabilizing them on buprenorphine.
- Trial name
- NCT00249574
- Testing
- Buprenorphine/naloxone, pegInterferon
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Institute on Drug Abuse (NIDA)