Clinical trials: Addiction, Substance
Opioid-use Disorder
Heterodyned Whole-Body Vibration in Treatment of Opioid Withdrawal-Induced Anxiety
In this randomized, double-blind, controlled, parallel group study (conducted over 12-months), enrollment is expected of up to 60 subjects (30 men and 30 women) ages 18+ who are currently going through withdrawal of OUD and being…
- Trial name
- NCT05056753
- Testing
- HWBV chair
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- PhotoPharmics, Inc.
Nicotine Dependence
Repetitive Transcranial Magnetic Stimulation (rTMS) for Nicotine Addiction
Cigarette smoking remains a significant public health concern. A magnetic field applied to the outside of the skull can produce electrical activity in the brain without significant pain or the need for anesthesia.
- Trial name
- rTMS (NCT02401672)
- Testing
- Transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Opioid Use Disorder
Light Needle for Opioid Use Disorder
This randomized-controlled study investigates the effect of adjuvant light needle in the treatment of heroin addicts. One hundred heroin addicts older than 20 years old enrolled from the Addiction Treatment Center at Kaohsiung…
- Trial name
- OUD (NCT05341219)
- Testing
- Light needle therapy
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Chang Gung Memorial Hospital
PTSD, Addiction
N-acetylcysteine in the Treatment of PTSD and Addiction
Examine the effects of N-acetylcysteine on PTSD symptoms, craving and substance use in veterans with PTSD and comorbid substance use disorders.
- Trial name
- NAC (NCT02499029)
- Testing
- N-acetylcysteine
- Volunteers
- 35 people
- Sponsor
- Medical University of South Carolina
Mental Health, Substance-Related Disorders
First Face Training Evaluation in Tribal Communities
The goal of this study is to evaluate a culturally grounded training curriculum, First Face for Mental Health, in Tribal communities, using a waitlist controlled trial design.
- Trial name
- NCT05998005
- Testing
- First Face Training Program
- Where
- 9 sites in United States
- Volunteers
- 554 people, healthy volunteers welcome
- Sponsor
- Cambridge Health Alliance
Smoking, Nicotine Dependence
Nicotine TMS EFT Smoking Pilot Study
Prior and recent evidence suggests a role of medial prefrontal cortex (MPFC) in cigarette smoking. Episodic Future Thinking (EFT) has also been shown to be associated with increased delayed discounting and reduced cigarette self…
- Conditions
- Smoking, Nicotine Dependence, Addiction, Smoking, Cigarette
- Trial name
- NCT03579953
- Testing
- Real cTBS
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Medical University of South Carolina
Alcohol Use Disorder, Addiction
Portrayal of Hospital Alcohol Detoxification in France
Even if hospital alcohol detoxifications are frequent in France, their caracteristicscharacteristics remain unknown. The investigators aim to describe the clinical and paraclinical caracteristicscharacteristics of their patients…
- Conditions
- Alcohol Use Disorder, Addiction, Alcohol Withdrawal Syndrome
- Trial name
- Alcostop (NCT04973202)
- Testing
- Stay for alcohol detoxification
- Where
- France
- Volunteers
- 50,000 people
- Sponsor
- University Hospital, Montpellier
Posttraumatic Stress Disorder (PTSD), Substance Use Disorders
Efficacy of an EMDR App for PTSD and SUD
The current proposal is aimed to confirm the efficacy of this novel therapeutic method (autonomous eye movement desensitization and reprocessing; A-EMDR) in a patient group (PTSD and SUD), and to assess the feasibility of the…
- Trial name
- NCT07146633
- Testing
- A-EMDR, Treatment as Usual (TAU)
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Centre for Addiction and Mental Health
Substance Dependence
Efficacy of Cognitive Bias Modification in Residential Treatment for Addiction
The purpose of this study is to determine whether computer bias modification for interpretation bias (CBM-I) is effective in the reduction of suicidal ideation in substance use disorders.
- Trial name
- NCT03000699
- Testing
- Cognitive Bias Modification
- Where
- Canada
- Volunteers
- 88 people
- Sponsor
- Centre for Addiction and Mental Health
Alcohol Use Disorder
Peer Support in Alcohol Dependence
Alcohol use disorder (AUD) affects between 4% and 6% of French adults, and requires appropriate medical treatment. However, 20-40% of patients with AUD are lost to follow-up at an early stage.
- Trial name
- PEERSIAD (NCT06381609)
- Testing
- Quality life questionnaire AQoLS, Quality life questionnaire Euroqol EQ-5D-5L, Peer support consultations
- Where
- 5 sites in France
- Volunteers
- 626 people
- Sponsor
- Hospices Civils de Lyon
Opioid Related Disorders, Opioid Dependence
Medications Development for Drug Abuse Disorders
This is a study of tramadol as an agent for short-term opioid withdrawal treatment. A randomized, double blind clinical trial comparing the efficacy and safety of tramadol to clonidine and buprenorphine in the short-term…
- Conditions
- Opioid Related Disorders, Opioid Dependence, Opioid Addiction
- Trial name
- NCT01188421
- Testing
- Buprenorphine/naloxone, Clonidine, Tramadol ER
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Johns Hopkins University
Cocaine Dependence, Cocaine Addiction
Rivastigmine and Huperzine A as Treatments for Cocaine Dependence
The purpose of this study is to determine the safety and effects of rivastigmine and huperzine A (HupA), potential treatments for cocaine abuse, when used before experimental administration of cocaine, on a number of physical and…
- Conditions
- Cocaine Dependence, Cocaine Addiction, Cocaine Abuse, Substance Abuse
- Trial name
- NCT01030692
- Testing
- Rivastigmine 3 mg, Huperzine A 0.4 mg, Rivastigmine 6 mg
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Baylor College of Medicine
Drug Addiction, Executive Dysfunction
Bilateral Prefrontal Modulation in Crack-cocaine Addiction
In this study, eligible crack-cocaine addicted inpatients recruited from specialized clinics for substance abuse disorder treatment, filling inclusion criteria and not showing any exclusion criteria, were randomized to receive…
- Trial name
- tDCS_CRACK (NCT02091167)
- Testing
- transcranial Direct Current Stimulation
- Where
- Brazil
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Federal University of Espirito Santo
Drug Addiction, Polysubstance Addiction
Mapping And Preventing Relapse Risk in Polydrug Users
This Interventional two-arm comparative study will evaluate whether a mindfulness-based strategy (MBS) improves outcomes for adults with substance use disorders (polydrug users) compared with treatment-as-usual (TAU).
- Trial name
- NCT07161986
- Testing
- Mindfullness based Sobriety (MBS)
- Where
- Pakistan
- Volunteers
- 130 people
- Sponsor
- Institute of Psychology, Chinese Academy of Sciences
Pain, Opiate Addiction
Methadone Monitoring for Insights Into Adverse Events
Methadone has been an effective and inexpensive therapy in the management of chronic pain and opioid dependence. However it has been associated with sudden, unexpected deaths.
- Trial name
- MEMORIES (NCT01191242)
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- Intermountain Health Care, Inc.
Hepatitis C, Transmission, Intravenous Drug Abuser
Acceptability of Simultaneous Screening for Viral Hepatitis B, C and HIV Among Drug Users in Non-conventional Structures
The principle is to propose dedicated monthly screening days bringing together the health personnel involved (hepatologist, addictologist, nurse in charge of the program, addictology nurse and social worker) and to propose…
- Conditions
- Hepatitis C, Transmission, Intravenous Drug Abuser, Addiction, Alcohol, Addiction Opiate
- Trial name
- SCANVIR (NCT05361603)
- Where
- France
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University Hospital, Limoges
Substance-related Disorders
Women's Treatment and Early Recovery
Approximately 25 million Americans struggle with alcohol or drug problems annually. Abuse of alcohol and drugs is costly to our nation, exacting more than $428 billion in costs related to crime, lost work productivity and health…
- Trial name
- MBRP-W (NCT02977988)
- Testing
- Mindfulness Meditation, Brain and Recovery (B&R)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Southern California
Opioid-Related Disorders
Effectiveness of Lofexidine to Prevent Stress-Related Opiate Relapse During Naltrexone Treatment - 1
Lofexidine is an experimental medication that may be beneficial in reducing opiate withdrawal symptoms, such as sleep difficulty, anxiety, and tension.
- Trial name
- NCT00142909
- Testing
- Lofexidine
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Yale University
Substance Addiction
Maternal Acupuncture for Substance Abuse
To determine the efficacy of daily maternal acupuncture treatments in reducing the frequency and severity of neonatal abstinence syndrome among infants born to substance-using women..
- Trial name
- NCT00225316
- Testing
- Acupuncture
- Where
- Canada
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Opiate Addiction, Pregnancy
Immediate Postpartum Nexplanon Placement in Opioid Dependent Women
The investigators have designed a single site, Phase IV open label, prospective observational clinical trial to compare the effect of immediate postpartum Nexplanon placement (IPP) versus standard postpartum contraceptive care…
- Conditions
- Opiate Addiction, Pregnancy, Contraceptive Behavior, Sexual Behavior
- Trial name
- NCT02657148
- Testing
- Nexplanon (etonogestrel contraceptive implant), Standard postpartum contraceptive care
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Pittsburgh