Clinical trials: Addiction, Substance
Cigarette Smoking, Tobacco Smoking
Mindfulness Training for Smoking Cessation
The purpose of this study is to assess the effects of mindfulness training (MT) compared to standard Smoking Cessation Therapy (SCT) on smoking cessation and stress provocation in individuals trying to quit smoking.
- Conditions
- Cigarette Smoking, Tobacco Smoking, Nicotine Dependence, Smoking Cessation
- Trial name
- NCT01144689
- Testing
- Mindfulness Training, Smoking Cessation Therapy
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Yale University
Suicide, Substance-Related Disorders
Preventing Addiction Related Suicide (PARS)
The goal of this study is to evaluate the effectiveness and utility of the investigator's National Institute on Drug Abuse (NIDA) R21 developed "Preventing Addiction Related Suicide" (PARS) program by utilizing a novel stepped…
- Trial name
- PARS (NCT03166709)
- Testing
- Preventing Addiction Related Suicide (PARS), Intensive Outpatient Program standard session
- Where
- 16 sites in United States
- Volunteers
- 906 people, healthy volunteers welcome
- Sponsor
- University of Washington
Insomnia, Alcohol Use Disorder
Sleep Treatment for Addiction Recovery
Project STAR aims to examine the feasibility, acceptability, and initial efficacy of a CBT-I supplement to outpatient alcohol and substance use treatment.
- Conditions
- Insomnia, Alcohol Use Disorder, Substance Use Disorders
- Trial name
- STAR (NCT04198311)
- Testing
- CBT-I
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Missouri-Columbia
Substance Dependence
Efficacy of Cognitive Bias Modification in Residential Treatment for Addiction
The purpose of this study is to determine whether computer bias modification for interpretation bias (CBM-I) is effective in the reduction of suicidal ideation in substance use disorders.
- Trial name
- NCT03000699
- Testing
- Cognitive Bias Modification
- Where
- Canada
- Volunteers
- 88 people
- Sponsor
- Centre for Addiction and Mental Health
Substance Dependence, HIV (Human Immunodeficiency Virus)
Pre-exposure Prophylaxis (PrEP) for Health
This randomized controlled trial will test the efficacy of "PrEP for Health," a behavioral intervention to improve the use of antiretroviral pre-exposure prophylaxis (PrEP) among at-risk people who inject drugs (PWID) in two…
- Trial name
- PrEP (NCT04430257)
- Testing
- HIV and PrEP education, Motivational interviewing, Problem-solving and planning
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Brown University
Opioid Use Disorder, Substance Use Disorders
Strategies to Reduce Addiction Stigma Among Health Professionals
The aim of this study was to evaluate the effects of exposure to stigma reduction message frames communicated by visual campaigns and narrative vignettes among a national sample of health professionals.
- Conditions
- Opioid Use Disorder, Substance Use Disorders, Stigma, Social
- Trial name
- NCT05127707
- Testing
- Words Matter - Visual Campaign, Words Matter - Visual Campaign & Narrative Vignette (Messenger: Person with Opioid Use Disorder) Experimental: Words Matter - Visual Campaign & Narrative Vignette (Messenger: Clinician), Words Matter - Visual Campaign & Narrative Vignette (Messenger: Clinician)
- Where
- United States
- Volunteers
- 1,842 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Substance Use Disorder (SUD), mHealth
Connecting Loved Ones to Support and Empowering Recovery
Substance use disorders are highly prevalent. However, recovery from them is possible. The recovery process can benefit greatly from support from loved ones.
- Trial name
- Project Closer (NCT07740395)
- Testing
- KulaMind-Recovery
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rhode Island Hospital
HIV Infections, Opioid-Related Disorders
Drug Treatment Combined With Drug and Risk Reduction Counseling to Prevent of HIV Infection and Death Among Injection Drug Users
Drug abuse and HIV/AIDS are serious global health problems. Injection drug use is currently the major mode of transmission of HIV in many countries.
- Trial name
- NCT00270257
- Testing
- Buprenorphine/Naloxone
- Where
- 4 sites in China, Thailand
- Volunteers
- 1,251 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Opioid-Related Disorders, Drug Addiction
Medication Treatment for Opioid Use Disorder in Expectant Mothers: Conceptual Model Assessments Sub-study
This is a sub-study of NIDA CTN Protocol 0080: Medication Treatment for Opioid Use Disorder in Expectant Mothers (MOMs; Unique protocol ID: 2019-0429-1).
- Conditions
- Opioid-Related Disorders, Drug Addiction, Pregnancy Related, Substance Abuse
- Trial name
- MOMs-CMA (NCT03911466)
- Testing
- Buprenorphine Injection, Buprenorphine Sublingual Product
- Where
- 12 sites in United States
- Volunteers
- 97 people
- Sponsor
- T. John Winhusen, PhD
Opioid Misuse and Addiction, Pain
Toward Zero Prescribed Opioids for Outpatient General Surgery
Investigators have created an opioid reduction "package" which includes patient education, non-narcotic pain control instructions, and limited (or no) opioid pain prescriptions provided at discharge in an attempt to reduce the…
- Trial name
- NCT05327777
- Testing
- Oxycodone, Zero Opioid Protocol
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Stigma, Social, Behavior
Reducing Stigma Among Individuals With Addiction and Staff in the Criminal Justice System
Stigma is one of the most pervasive barriers to addiction care in the U.S. criminal justice (CJ) system. However, there have been no stigma reduction interventions developed for this context.
- Trial name
- NCT05152342
- Testing
- Stigma Awareness Training for Legal System Staff, Acceptance and Commitment Therapy for self-stigma
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- East Tennessee State University
Post Traumatic Stress Disorder (PTSD), Addiction
Clinical Trial for Alcohol Use Disorder and Post Traumatic Stress Disorder (PTSD)
This is a randomized controlled Phase II clinical trial designed to evaluate the effects of N-acetylcysteine (NAC) in reducing Alcohol Use Disorder (AUD) severity and Post Traumatic Stress Disorder (PTSD) symptomatology among…
- Conditions
- Post Traumatic Stress Disorder (PTSD), Addiction, Alcohol Abuse
- Trial name
- NCT02966873
- Testing
- N-Acetylcysteine (NAC) Treatment, Cognitive Behavioral Therapy (CBT), Functional magnetic resonance imaging (fMRI)
- Where
- 2 sites in United States
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Alcohol Use Disorder, Alcoholism
Oxytocin and Naltrexone: Investigation of Combined Effects on Stress- and Alcohol Cue-induced Craving in Alcohol Use Disorder
Alcohol use disorder (AUD) is a chronic relapsing disorder. Alcohol craving, a hallmark symptom of AUD that drives relapse in patients, is only insufficiently treated by existing medication.
- Conditions
- Alcohol Use Disorder, Alcoholism, Alcohol Addiction
- Trial name
- ON-ICE (NCT05093296)
- Testing
- Oxytocin nasal spray, Naltrexone Pill
- Where
- Germany
- Volunteers
- 62 people
- Sponsor
- Central Institute of Mental Health, Mannheim
Alcoholic Intoxication
Interest of tDCS in Help for Supporting Alcohol Abstinence
The aim of the study is to evaluate in patients with alcohol disorder and forehand weaned the efficiency of 10 active tDCS sessions versus 10 sham (placebo) sessions in the support of abstinence at 3 months.
- Trial name
- ITAMAA (NCT03287154)
- Testing
- Active tDCS stimulations
- Where
- 2 sites in France
- Volunteers
- 90 people
- Sponsor
- Centre Hospitalier Henri Laborit
Opioid Dependence
Safety and Efficacy of Probuphine in the Treatment of Opioid Dependence
Buprenorphine (BPN) is an approved treatment for opioid dependence, however, in taking oral tablets, patients experience withdrawal and cravings when the variable BPN levels in the blood are low.
- Trial name
- NCT00447564
- Testing
- Probuphine
- Where
- 18 sites in United States
- Volunteers
- 163 people
- Sponsor
- Titan Pharmaceuticals
Nicotine Addiction
Pharmacogenetics of Nicotine Addiction Treatment
The purpose of this research program is to understand how a biomarker called the "nicotine metabolite ratio" (also referred to as NMR) may influence a smoker's ability to quit smoking.
- Trial name
- NCT01314001
- Testing
- Varenicline, Transdermal Nicotine
- Where
- 4 sites in United States, Canada
- Volunteers
- 1,246 people
- Sponsor
- University of Pennsylvania
Nicotine Dependence, Opiate Dependence
Developing a Smoking Cessation Intervention for Methadone Maintained Smokers
The purpose of this study is to pilot and evaluate, in a randomized controlled trial, the immediate and long-term effects of a newly developed, tailored, intensive smoking cessation intervention among methadone maintained smokers…
- Trial name
- NCT01393392
- Testing
- Intensive, tailored intervention, NJ Quitline Referral
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Rutgers, The State University of New Jersey
Opioid-use Disorder
Treatment for Opiate Addiction: Prognostic fActors of Responsiveness to Maintenance Treatment
A global and integrative treatment of opioid-use disorders (OUD) with opiate maintenance therapy (OMT) and psychosocial interventions is recommended by all current guidelines.
- Trial name
- TOPAZE (NCT03729388)
- Testing
- Prognosis factor associated with good outcome.
- Where
- 2 sites in France
- Volunteers
- 29 people
- Sponsor
- Nantes University Hospital
Marijuana Dependence
Effectiveness Study of Dronabinol and BRENDA for the Treatment of Cannabis Withdrawal
This treatment study is targeted specifically for those who want to stop using marijuana. We want to find out if patients who are dependent on marijuana and want to stop using are helped by a combination of the drug dronabinol…
- Trial name
- NCT00480441
- Testing
- Dronabinol, BRENDA therapy
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- University of Pennsylvania
Usage of Prescription Opioids
Determining Genetic Biomarkers Predictive of the Development of Prescription Opioid Addiction
This is a clinical study on patients who have been prescribed opioids (narcotic pain relievers) for the treatment of pain, to determine what genetic factors influence outcome of treatment.
- Trial name
- NCT01562353
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Analgesic Solutions