Clinical trials: Addiction, Substance
Substance-Related Disorders, Personality Disorders
Feasibility and Acceptability Study of the "O'Dide" Application in People Suffering From an Addiction
Substance Use Disorders (SUD) are associated with cognitive schemas that lead to care attrition and mistrust towards care. Considering this within SUD management, it is important to establish a confident relation between the…
- Trial name
- FA-O'DIDE (NCT04659954)
- Testing
- Application O'DIDE
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Toulouse
Mental Health Disorders, Substance Use Disorders
Supporting Treatment Access and Recovery Through Linkage and Support
This 3-year Hybrid Type 1 study will randomize 208 people with co-occurring substance use and mental health disorders (COD) referred from the Worcester Hub.
- Trial name
- STAR-LS (NCT05713695)
- Testing
- Full MISSION, Linkage Only Delivered by a Peer Specialist
- Where
- United States
- Volunteers
- 208 people
- Sponsor
- University of Massachusetts, Worcester
HIV/AIDS, Substance Use Disorders
ART-CHESS: A Mobile Health Application to Support People Living With HIV and Addiction
It is now well-accepted that lowering community-level viral load through expansion of antiretroviral therapy (ART) can reduce HIV transmission among people who use drugs.
- Trial name
- NCT03873129
- Testing
- mobile health app (mHealth)
- Where
- United States
- Volunteers
- 208 people
- Sponsor
- University of Wisconsin, Madison
Generalized Anxiety Disorder, Comorbid Opiate Dependence in Remission
Anxiety in Recovering Opiate Dependence
This is a 16 week study of the efficacy of quetiapine in treating symptoms of generalized anxiety disorder (GAD) in subjects with comorbid opiate dependence.
- Conditions
- Generalized Anxiety Disorder, Comorbid Opiate Dependence in Remission, Status Post Methadone-Maintenance Treatment
- Trial name
- NCT00668265
- Testing
- Quetiapine
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Beth Israel Medical Center
Depression, Anxiety
Nexalin Therapy as a Viable Adjunctive Treatment for Substance Use Disorders
The purpose of this research study is to determine whether Nexalin Trans-cranial Electrical Stimulation (TES) is a viable adjunctive treatment of substance use treatments.
- Conditions
- Depression, Anxiety, Insomnia, Substance Abuse
- Trial name
- NCT03540745
- Testing
- TES Treatment
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- University of Arizona
Amphetamine Addiction, Pharmacotherapy
Dextromethorphan, Memantine Monotherapy, or Combined Use of Dextromethorphan and Memantine in Amphetamine Addiction
The investigators will conducted a randomized double-blind placebo-controlled study to investigate the treatment outcomes of add-on low dose dextromethorphan (DM), memantine (MM), or dextromethorphan and memantine combination…
- Trial name
- NCT04687566
- Testing
- Dextromethorphan, Memantine, Dextromethorphan and memantine
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Cheng-Kung University Hospital
Opioid Dependence
An Open Label Study To Assess The Safety And Tolerability Of BEMA® Buprenorphine NX In Opioid Dependent Subjects
This is an open label study in opioid dependent subjects maintained on a stabilized dose of Suboxone tablets or films. The purpose is to assess the safety and tolerability of BEMA Buprenorphine NX administered once daily for 12…
- Trial name
- NCT01666119
- Testing
- BEMA Buprenorphine NX films
- Where
- 10 sites in United States
- Volunteers
- 249 people
- Sponsor
- BioDelivery Sciences International
Opioid Use Disorder, mHealth
Personalized Addiction Treatment enHancement
Many patients stop medication-based treatments for Opioid Use Disorder (OUD) prematurely, placing them at increased risk for overdose and death.
- Conditions
- Opioid Use Disorder, mHealth, Peer Support
- Trial name
- Project Path (NCT07778394)
- Testing
- Vira Platform, Treatment-As-Usual
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Rhode Island Hospital
Opiate Addiction
Buprenorphine Maintenance for Opioid-Addicted Persons in Jail and Post-Release
The purpose of the study is to determine the feasibility of providing buprenorphine maintenance to opioid-dependent offenders in a jail setting and of transitioning those patients to buprenorphine maintenance in the community…
- Trial name
- NCT00367302
- Testing
- buprenorphine, methadone
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- National Development and Research Institutes, Inc.
Normal Physiology, Alcohol Use Disorder
Addictions Neuroclinical Assessment (ANA)
Background: Alcohol use disorder (AUD) is a major public health problem. In the U.S., 16 to 18 million adults have an AUD. Researchers want to test an assessment tool called the ANA.
- Trial name
- NCT04946851
- Where
- United States
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Substance Use Disorder
OPAL: "Opiates and PhArmacoLogy"
The aim of this study is to determine the current prevalence of co-addictions, including problem/pathological gambling, in patients receiving Opiate Substitution Treatment (OST), and to then compare patients receiving OST with or…
- Trial name
- OPAL (NCT01847729)
- Where
- 7 sites in France
- Volunteers
- 263 people
- Sponsor
- Nantes University Hospital
Alcohol Dependence, Alcohol Drinking
Behavioral and Functional Task Development, Implementation, and Testing
Background: Scientists know that alcohol use disorders affect brain structure. They want to know more about the effects of alcohol use disorders on a person s behavior.
- Conditions
- Alcohol Dependence, Alcohol Drinking, Alcoholism, Alcohol Use Disorder
- Trial name
- NCT02108054
- Testing
- 7T MRI
- Where
- United States
- Volunteers
- 173 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Nicotine Addiction, Drug Addiction
Clinical Trial of Smoking Cessation Mobile Phone Program
The Sponsor is doing a research study to assess the effects of a smartphone program designed to help users smoke less and eventually quit. When participants join, their involvement in the core study will last 8 weeks.
- Conditions
- Nicotine Addiction, Drug Addiction, Drug Dependence, Substance Use Disorder
- Trial name
- NCT02656745
- Testing
- Mobile Smoking Cessation Solution
- Where
- United States
- Volunteers
- 416 people
- Sponsor
- Click Therapeutics, Inc.
Smoking Cessation
Impact of a Gene Test for Susceptibility to Lung Cancer in Smokers
Professor RP Young (Associate Professor of Medicine and Molecular Medicine, School of Biological Sciences, University of Auckland) and his team have developed a reliable genetic test "Respiragene" based on 20 single nucleotide…
- Trial name
- NCT01176383
- Testing
- Respiragene test and risk score
- Where
- United Kingdom
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Sussex NHS Research Consortium
Nicotine Dependence
Treatment for Nicotine Addiction in Women
The purpose of this study is to use a medication tolcapone and or placebo to test if the symptoms of nicotine withdrawal lessens , and or changes in smoking urges, and mental reasoning in female smokers over a 72 hour period.
- Trial name
- NCT02448654
- Testing
- Tolcapone, Sugar Pill
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Yale University
Tobacco Dependence, Smoking Cessation
Using Non-invasive Brain Stimulation (tDCS) With Varenicline for Treating Tobacco Dependence
The addition of tDCS as an adjunct to pharmacotherapy is a novel approach but one that is grounded in a growing evidence-base.The primary objective of this research is to provide preliminary evidence of the effectiveness of tDCS…
- Conditions
- Tobacco Dependence, Smoking Cessation, Tobacco Smoking, Tobacco Use Disorder
- Trial name
- NCT03841292
- Testing
- Varenicline, Active tDCS
- Where
- Canada
- Volunteers
- 41 people
- Sponsor
- Centre for Addiction and Mental Health
Opioid Addiction
Transitions Clinic Network: Post Incarceration Addiction Treatment, Healthcare, and Social Support
TCN PATHS will recruit an anticipated 400 participants who are prescribed MOUD who are released from detention facilities. Each individual will be randomized to either 1) standard primary care (SPC) or 2) a Transitions Clinic…
- Trial name
- TCN-PATHS (NCT04309565)
- Testing
- Transitions Clinic Network Primary Care, Standard Primary Care
- Where
- 5 sites in United States, Puerto Rico
- Volunteers
- 398 people
- Sponsor
- Yale University
Nicotine Dependence
A Study to Help People Quit Smoking.
You are invited to participate in a research study at the VA Connecticut Healthcare System (West Haven campus) that examines whether a medication called galantamine can improve your learning and memory, and also help you to quit…
- Trial name
- NCT01880099
- Testing
- Galantamine 8mg, Galantamine 16mg
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Yale University
Opioid-Related Disorders, Opiate Addiction
A Survey to Eval the Relation Between Doctor/Pharmacy Shopping and Outcomes Suggestive of Misuse, Abuse and/or Diversion
To evaluate the reasons patients go to more than one prescriber or more than one pharmacy to obtain prescriptions opioids and assess whether the percentage of patients reporting misuse, abuse and/or diversion increases across…
- Conditions
- Opioid-Related Disorders, Opiate Addiction, Narcotic Abuse, Drug Abuse
- Trial name
- NCT02667158
- Testing
- Survey to Eval Relation between Shopping and Misuse, Abuse
- Volunteers
- 1,085 people
- Sponsor
- Member Companies of the Opioid PMR Consortium
Cocaine Dependence, Cocaine Addiction
A Placebo-Controlled Study of a Combination of Metyrapone and Oxazepam in Cocaine Addiction
Subjects will be randomly assigned to receive either one of the two potential dose combinations of the study medications or placebo over 6 weeks.
- Trial name
- NCT00567814
- Testing
- Metyrapone, Oxazepam
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Embera NeuroTherapeutics, Inc.