Clinical trials: Addiction, Substance
Alcohol Use Disorder
Addiction Risk: Psychoeducational Intervention to Change Risk Perception Among Alcohol Patients in Residential Treatment
Based on previous research (Odenwald \& Semrau, 2012) the investigators know that psychoeducation on comorbid mental disorders during residential alcohol detoxification can improve subsequent treatment utilization.
- Trial name
- NCT03339674
- Testing
- Psychoeducational Group Intervention on Alcohol Drinking Related to Stress, Cognitive Training
- Where
- Germany
- Volunteers
- 144 people
- Sponsor
- University of Konstanz
Substance Related Disorders
Effectiveness of a Training Program for Self-management of the Substance Addiction Consequences - a Study Protocol
The substance dependent population has many health needs in which it is necessary to invest in competent approaches with more evidence.
- Trial name
- ADSProgram (NCT05397925)
- Testing
- ADSProgram - Self management for substance dependence program, Treatment as usual - Regular nursing consultation on a medication-based program
- Where
- 2 sites in Portugal
- Volunteers
- 60 people
- Sponsor
- Nursing School of Lisbon
Nicotine Addiction
Effect of Product Characteristics on the Abuse Liability of Nicotine Pouches
The goal of this study is to assess the effects of nicotine concentration and its interplay with pH on sensory experience, product appeal, and abuse liability of NPs among young adults NP users.
- Trial name
- NCT07165808
- Testing
- Nicotine pouch: Low dose, Nicotine pouch: High dose, Low pH
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Emory University
Opioid-Related Disorders, Stimulant-Related Disorder
Preventing Parental Opioid and/or Methamphetamine Addiction Within DHS-Involved Families: PRE-FAIR
Young parents aged 16 to 30, involved in the DHS system for child welfare or self-sufficiency needs are at risk for opioid use disorder and/or methamphetamine use disorder (OUD; MUD).
- Conditions
- Opioid-Related Disorders, Stimulant-Related Disorder, Child Neglect, Mental Health Impairment
- Trial name
- PRE-FAIR (NCT05380440)
- Testing
- Prevention Adaptation of Families Actively Improving Relationships (PRE-FAIR), Standard Case Management and Referral
- Where
- United States
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Chestnut Health Systems
Alcohol Use Disorder
Semaglutide Therapy for Alcohol Reduction - Tulsa
The purpose of this research study is to determine if semaglutide, when compared to placebo, is safe and may reduce alcohol drinking in individuals who endorse symptoms consistent with alcohol use disorder.
- Trial name
- STAR-T (NCT05891587)
- Testing
- Semaglutide
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Oklahoma State University Center for Health Sciences
Cocaine Addiction, Treatment
Effects of Repeated Transcranial Magnetic Stimulation (rTMS) on the Treatment of Cocaine Addicted Patients
Cocaine addiction is a serious disease. Nowadays we still have no efficient method reducing craving and extending the abstinence period of this patients during treatment.
- Conditions
- Cocaine Addiction, Treatment, Transcranial Magnetic Stimilation
- Trial name
- TMSCOCDEPEND (NCT01259362)
- Testing
- Transcranial Magnetic Stimulation
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- University of Sao Paulo General Hospital
Addiction
Deep Brain Stimulation of Nucleus Accumbens to Prevent Opiate Relapse
Nucleus accumbens plays important roles in the process of opiate addiction and initial of relapse after detoxification, deep brain stimulation of nucleus accumbens will inhibit its activity and thus to effectively prevent the…
- Trial name
- NCT01274988
- Testing
- Deep brain stimulation, methadone maintenance treatment
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Tang-Du Hospital
HIV Infection, Pain
Targeting Effective Analgesia in Clinics for HIV - Intervention
The TEACH randomized controlled trial will test the effectiveness of a collaborative care intervention directed towards physicians who provide care for HIV-infected persons to improve the quality of care for prescribing chronic…
- Conditions
- HIV Infection, Pain, Drug Dependence
- Trial name
- TEACH (NCT02564341)
- Testing
- Collaboration with an IT enabled nurse care manager, Education and academic detailing, Facilitated access to a specialist in addictions
- Where
- 2 sites in United States
- Volunteers
- 41 people
- Sponsor
- Boston Medical Center
Addiction
Efficacy of a Smartphone App. Designed to Manage Craving & Individual Predictors of Substance Use/Addictive Behavior
Test the Efficacy of a smartphone application designed to manage craving and individual predictors of substance use / addictive behavior among individuals with addictive disorders
- Trial name
- CRAVINGMANAGER (NCT04732676)
- Testing
- Smartphone application
- Where
- France
- Volunteers
- 274 people
- Sponsor
- Centre Hospitalier Charles Perrens, Bordeaux
Alcohol Use Disorder, Alcohol Dependence
Tech-Enabled CM for AUD at Scale
This Phase II Small Business Innovative Research (SBIR) project is a clinical effectiveness and cost-effectiveness random controlled trial (RCT) of DynamiCare Health's innovative smartphone/smart debit card remote digital…
- Conditions
- Alcohol Use Disorder, Alcohol Dependence, Drug Dependence
- Trial name
- NCT04581499
- Testing
- DynamiCare Motivation Support Program, Untreated or Routine Care Control Group
- Where
- United States
- Volunteers
- 236 people
- Sponsor
- DynamiCare Health
Opioid Use Disorder, Opioid Use
HMP for Addictions Study
The goal of this clinical trial is to see whether the Healthy Minds Program for Addictions could be used to help veterans with moderate-severe opioid use disorder and post-traumatic stress disorder stay on buprenorphine…
- Conditions
- Opioid Use Disorder, Opioid Use, Buprenorphine Dependence
- Trial name
- NCT06063499
- Testing
- Healthy Minds Program for Addictions
- Sponsor
- University of Wisconsin, Madison
Smoking, Smoking Cessation
Implementation Science to Reduce the Disparity in Tobacco Treatment Among Individuals With Serious Mental Illness
This is a pilot trial to examine the feasibility and preliminary effect of a multilevel intervention 'Nudges to Quit' on smoking cessation in patients with serious mental illness who smoke in a community mental health center…
- Conditions
- Smoking, Smoking Cessation, Tobacco Use Cessation
- Trial name
- ISRAISE (NCT05952401)
- Testing
- Usual Care, "Nudges"
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Washington University School of Medicine
Posttraumatic Stress Disorder, Substance Dependence
Trial of a Novel Cognitive-Behavioral Treatment for Posttraumatic Stress and Substance Dependence
The purpose of the study is to determine whether a novel integrated cognitive-behavioral treatment for posttraumatic stress disorder (PTSD) and substance dependence (i.e., Treatment for Integrated Posttraumatic Stress and…
- Trial name
- NCT02461732
- Testing
- Treatment for Integrated Posttraumatic Stress and Substance Use (TIPSS), Cognitive-Behavioral Therapy for Substance Dependence
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cocaine Dependence
Double Blind Study of Vigabatrin for the Treatment of Cocaine Dependence
The primary objective of this study is to assess the efficacy of vigabatrin for the treatment of cocaine dependence, based on the twice-weekly qualitative urine toxicologies for cocaine.
- Trial name
- NCT00527683
- Testing
- Vigabatrin, Group therapy
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- NYU Langone Health
Alcohol Use Disorder
Deep Brain Stimulation to Understand and Treat Addiction
This study is testing whether deep brain stimulation (DBS) can safely help people with severe alcohol use disorder who have not improved with standard treatments.
- Trial name
- Brain-PACER (NCT07341230)
- Testing
- Dual-Target Deep Brain Stimulation, Nucleus Accumbens Deep Brain Stimulation, Ventral Internal Capsule Deep Brain Stimulation
- Where
- 2 sites in United Kingdom
- Volunteers
- 9 people
- Sponsor
- University of Cambridge
Nicotine Dependance, Serious Mental Illness
Evaluation of Community Health Worker Support to Help People With Serious Mental Illness to Quit Smoking
The purpose of this study is to learn whether providing additional smoking cessation support through specially trained members of behavioral healthcare team helps people quit smoking and improve their health.
- Conditions
- Nicotine Dependance, Serious Mental Illness, Smoking (Tobacco) Addiction, Tobacco Cessation
- Trial name
- NCT07789132
- Testing
- Integrated CHW Support intervention, Enhanced usual care (EUC)
- Where
- United States
- Volunteers
- 937 people
- Sponsor
- Massachusetts General Hospital
Alcohol Dependence
CRF1 Antagonist GSK561679 in Alcoholism
Objective: To evaluate GSK561679, an orally available, brain penetrant selective CRH1 antagonist for its ability to reduce alcohol craving in recently detoxified alcohol dependent women in response to stress or alcohol-associated…
- Trial name
- NCT01187511
- Testing
- GSK561679
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Opioid Dependency
Re-Treatment Study of Probuphine in Opioid Addiction
Probuphine (buprenorphine implant) is an investigational implant placed just below the skin containing buprenorphine (BPN). BPN is an approved treatment for opioid dependence.
- Trial name
- NCT01262261
- Testing
- Probuphine (buprenorphine implant)
- Where
- 18 sites in United States
- Volunteers
- 85 people
- Sponsor
- Titan Pharmaceuticals
HIV Infections, Substance Use Disorders
Peer Supported Collaborative Care Mental Health and Substance Use Disorder Care
This is a research study to assess the effectiveness of a peer-led collaborative care model for integrating treatment for substance use and or mental health disorders into HIV care settings.
- Conditions
- HIV Infections, Substance Use Disorders, Mental Health Disorder, Addiction
- Trial name
- NCT04601064
- Testing
- Collaborative Care Model
- Where
- United States
- Volunteers
- 405 people
- Sponsor
- Johns Hopkins University
Opioid Related Disorders, Pregnancy
RCT Comparing Methadone and Buprenorphine in Pregnant Women
Children born to women who abuse drugs have a high risk of being born with birth defects and developmental problems. Methadone is a drug that is commonly used for treating opioid dependence.
- Conditions
- Opioid Related Disorders, Pregnancy, Opioid Dependence
- Trial name
- NCT00271219
- Testing
- Methadone, Buprenorphine
- Where
- 8 sites in United States, Austria and 1 more
- Volunteers
- 175 people
- Sponsor
- Johns Hopkins University