Clinical trials: Addiction Opiate
Chronic Pain, Opiate Dependence
Developing Brain Stimulation as a Treatment for Chronic Pain in Opiate Dependent
Effective control of chronic pain is a top priority in the United States, as approximately 10% of adults have severe chronic pain - most of which is chronic lower back pain (CLBP).
- Conditions
- Chronic Pain, Opiate Dependence, Lower Back Pain
- Trial name
- NCT03681769
- Testing
- iTBS to the left dlPFC, cTBS to the mPFC
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Medical University of South Carolina
Opioid Dependence, Addiction
Addiction, HIV and Tuberculosis in Malaysian Criminal Justice Settings
The purpose of this study is to conduct empiric studies of tuberculosis (TB) among people in prison with and without a history of opioid dependence.
- Conditions
- Opioid Dependence, Addiction, HIV/AIDS, Tuberculosis
- Trial name
- HARAPAN II (NCT03089983)
- Testing
- Isoniazid, Rifapentine
- Where
- Malaysia
- Volunteers
- 316 people
- Sponsor
- Yale University
Hepatitis C, Chronic, Hepatitis C
A Pilot Study of Treating HCV at a Psychiatrist-staffed Outpatient Addiction Clinic
The main purpose of this pilot study is to investigate the safety, effectiveness and tolerability of the study medication in the treatment of people with chronic hepatitis C virus infection who regularly attend a…
- Conditions
- Hepatitis C, Chronic, Hepatitis C, Opiate Dependence
- Trial name
- NCT03235154
- Testing
- sofosbuvir/velpatasvir
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Community Research Initiative of New England
Opioid-Related Disorders, Opiate Addiction
Validation of PRISM-5-Op, Measure Of Addiction To Prescription Opioid Medication
The purpose is to validate the PRISM-5-Op as a measurement of prescription opioid substance use disorder.
- Conditions
- Opioid-Related Disorders, Opiate Addiction, Narcotic Abuse, Drug Abuse
- Trial name
- NCT02660619
- Testing
- Psychiatric Research Interview for Substance and Mental Disorders (PRISM-5-Op)
- Volunteers
- 606 people
- Sponsor
- Member Companies of the Opioid PMR Consortium
Opiate Addiction
NAOMI: A Study to Compare Medically-prescribed Heroin With Oral Methadone in Chronic Opiate Addiction
The objective of this study is to determine whether the closely supervised provision of injectable, pharmaceutical-grade heroin (in combination with oral methadone) is more effective than methadone therapy alone in recruiting…
- Trial name
- NCT00175357
- Testing
- Methadone, Diamorphine hydrochloride
- Where
- 2 sites in Canada
- Volunteers
- 192 people
- Sponsor
- University of British Columbia
Opiate Dependence, Hepatitis
HEPMET-1: Evaluate the Feasibility, Mental Sideeffects and the Efficacy of Hepatitis C Treatment in a MMT Group.
To evaluate if weekly psychological follow-up make opioid dependent patients in MMT able to accomplish 14 weeks treatment with Peginterferon alfa-2a (PEG-INF) and ribavirin to the same extent than non-opioid dependents.
- Trial name
- NCT00147784
- Testing
- Ribavirin, Pegylated Interferon
- Where
- 2 sites in Norway
- Volunteers
- 10 people
- Sponsor
- Sorlandet Hospital HF
Acute Post-operative Pain, Chronic Post Operative Pain
Duloxetine Impact on Postoperative Pain Control and Outcomes
1. Evaluate differences between patients taking Duloxetine or placebo following lateral lumbar interbody fusion for postoperative narcotic consumption. 2.
- Conditions
- Acute Post-operative Pain, Chronic Post Operative Pain, Narcotic Use, Opioid Use
- Trial name
- NCT05611749
- Testing
- Duloxetine 60 MG
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Scripps Health
Opioid-use Disorder, Chronic Pain
Advancing STOP: Self-regulation Therapy for Opioid Addiction and Pain
The public health relevance of this proposed project is substantial given the current opioid abuse epidemic as identified by the Centers for Disease Control (CDC).
- Trial name
- NCT03363243
- Testing
- STOP Therapy Treatment group, Treatment as usual (TAU) group
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- University of Colorado, Denver
Intravenous Drug Abuse, Chronic Hepatitis C
Psychoeducation Reaches HCV-infected Methadone/Buprenorphine Substituted Patients in Standard Antiviral Treatment
Study objective: Feasibility and efficacy of a standardised psychosocial intervention (psychoeducation) in substituted opioid dependent patients
- Trial name
- Permit (NCT00844272)
- Testing
- Psychoeducation
- Volunteers
- 189 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Opioid Dependency
Study of Probuphine in Patients With Opioid Dependence
Buprenorphine (BPN) is an approved treatment for opioid dependence; however, in taking oral tablets, patients experience withdrawal and cravings when the variable BPN levels in the blood are low.
- Trial name
- PRO-809 (NCT00772785)
- Testing
- Probuphine (buprenorphine implant)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Titan Pharmaceuticals
Opiate Dependence
Buprenorphine Maintenance vs. Detoxification in Prescription Opioid Dependence
The aim of the study is to determine whether buprenorphine/naloxone maintenance versus detoxification using buprenorphine/naloxone, in prescription opioid dependent patients receiving primary care management and drug counseling…
- Trial name
- NCT00555425
- Testing
- Behavioral: Buprenorphine/naloxone maintenance (Mtn), Behavioral: Buprenorphine/naloxone detoxification (Dtx)
- Where
- 2 sites in United States
- Volunteers
- 113 people
- Sponsor
- Yale University
Opioid Dependence
Community Studies of Long Acting Buprenorphine (CoLAB)
Despite research demonstrating the efficacy of buprenorphine (BPN), effectiveness in real-world settings has been limited by shorter retention than for methadone, and the need for daily or near-daily dosing (frequently supervised…
- Trial name
- CoLAB (NCT03809143)
- Testing
- RBP-6000
- Where
- 6 sites in Australia
- Volunteers
- 100 people
- Sponsor
- The University of New South Wales
Opiate Addiction
Study to Test the Safety and Efficacy of Cannabidiol as a Treatment Intervention for Opioid Relapse
Despite the current available therapies for opioid-dependent patients, most patients relapse. This research project focuses on the development of a novel compound, cannabidiol, to modulate opioid craving in humans based on animal…
- Trial name
- NCT01311778
- Testing
- Cannabidiol, Fentanyl
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Hurd,Yasmin, Ph.D.
Opioid-use Disorder, Opioid Dependence
Prevention of Opioid Use Disorder After Surgery
The objective of this study is to design, implement, and pilot test a multi-faceted intervention to support safer opioid prescribing, self-administration, and monitoring and reduce persistent opioid use and opioid use disorder…
- Conditions
- Opioid-use Disorder, Opioid Dependence, Opioid Use
- Trial name
- NCT04394559
- Testing
- Discharge Order Sets, Pharmacist-Led Discharge Counseling and Communication, Post-discharge Pain Management Follow-up
- Where
- United States
- Volunteers
- 204 people
- Sponsor
- Brigham and Women's Hospital
Human Immunodeficiency Virus, Acquired Immunodeficiency Syndrome
Intervention of HIV, Drug Use and the Criminal Justice System in Malaysia
The purpose of this study is to evaluate the relative impact a medical drug (methadone) or behavioral counseling program (Holistic Health Recovery Program) or both (methadone and Holistic Health Recovery Program) has on reducing…
- Conditions
- Human Immunodeficiency Virus, Acquired Immunodeficiency Syndrome, Opiate Addiction, Drug Dependence
- Trial name
- Harapan (NCT02396979)
- Testing
- Methadone, Holistic Health Recovery Program
- Volunteers
- 300 people
- Sponsor
- Yale University
HIV, Opiate Dependence
Project FIRST - Financial Incentives to Reduce Substance Use and Improve Treatment
This study will test whether contingency management (monetary vouchers contingent on abstinence from drugs) that reinforces one behavior (achieving abstinence from drugs) leads to improved outcomes in other related behaviors…
- Trial name
- Project FIRST (NCT01376570)
- Testing
- Abstinence-reinforcing contingency management intervention, Performance Feedback intervention
- Where
- 3 sites in United States
- Volunteers
- 242 people
- Sponsor
- Albert Einstein College of Medicine
Opioid-Related Disorders, Pregnancy
Opioid Dependence Treatment Therapies in Pregnancy
The incidence of opioid dependence in pregnancy increased over the last decade from 1.2 to 5.8 per 1,000 hospital births per year.1 While methadone is the current, standard treatment for opioid dependent (OD) pregnant women…
- Trial name
- NCT03098407
- Testing
- Buprenorphine, Methadone
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Opioid Dependence
Safety and Efficacy of Probuphine in the Treatment of Opioid Dependence
Buprenorphine (BPN) is an approved treatment for opioid dependence, however, in taking oral tablets, patients experience withdrawal and cravings when the variable BPN levels in the blood are low.
- Trial name
- NCT00447564
- Testing
- Probuphine
- Where
- 18 sites in United States
- Volunteers
- 163 people
- Sponsor
- Titan Pharmaceuticals
Opioid-Related Disorders
Neurobiology of Opioid Dependence: 4 - 4
The purpose of this study is to determine the effect of chronic naltrexone pre-treatment on the response to yohimbine in healthy volunteers.
- Trial name
- NCT00000195
- Testing
- Naltrexone
- Where
- United States
- Sponsor
- Yale University
Chronic Pain
Effectiveness of Buprenorphine/Naloxone
Long-term use of opioids for chronic pain is a growing health and social problem, mainly because of the risk of dependence. Buprenorphine/naloxone is used as substitution therapy for opioid dependence.
- Trial name
- NCT02882412
- Testing
- observational
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center