Clinical trials: Addiction Opiate
Opiate Addiction
Onsite Buprenorphine Treatment at Syringe Exchange Programs
This trial will recruit syringe exchange participants with opioid use disorder in New York City and test whether starting buprenorphine treatment at the syringe exchange program is more effective than referral to a community…
- Trial name
- O-BMT (NCT03150173)
- Testing
- Onsite treatment, Enhanced referral, Buprenorphine
- Where
- 3 sites in United States
- Volunteers
- 97 people
- Sponsor
- Montefiore Medical Center
Addiction Opiate
Evaluating the Safety of Acute Baclofen in Methadone-maintained Individuals With Opiate Dependence.
Opiate addiction is a major health challenge. The mainstay of treatment is opiate substitution therapy (OST), typically methadone, but many desire to be opiate-free.
- Trial name
- FORWARDS-1 (NCT05161351)
- Testing
- Baclofen, Vitamin D3
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- Imperial College London
Opiate Addiction, Pregnancy
Pharmacologically-based Strategies for Opioid Substitution Therapy During Pregnancy
This study is a pharmacodynamic study in pregnant women evaluating the relationship between buprenorphine concentration and outcome such as opioid withdrawal symptoms , NAS scores, neurodevelopmental and neuroanatomic outcomes.
- Trial name
- NCT03831113
- Testing
- Magnitude Group, Frequency Group
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- Steve N. Caritis, MD
Low Back Pain, Opiate Addiction
Study of Opioid Use After Lumbar and Cervical Spine Surgery
The purpose of this project is to assess the impact of an educational video on the use of prescription opioid medication during a 6-month period following spine surgery.
- Conditions
- Low Back Pain, Opiate Addiction, Neck Pain
- Trial name
- SOULCS (NCT02674711)
- Testing
- Educational Video
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Brooke Army Medical Center
Opiate Addiction
Acute and Short-term Effects of CBD on Cue-induced Craving in Drug-abstinent Heroin-dependent Humans
Despite the current available therapies for opioid-dependent patients, most patients relapse. This research project focuses on the development of a novel compound, cannabidiol, to modulate opioid craving in humans based on animal…
- Trial name
- NCT02539823
- Testing
- CBD 400 mg, CBD 800 mg
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Hurd,Yasmin, Ph.D.
Opiate Addiction
Efficacy of Computer Delivered Community Reinforcement Approach (CRA) (Bup II)
This study is designed to examine the effects of combined buprenorphine and voucher incentives to promote abstinence from illicit opiate use, along with or without computer-delivered therapy, during treatment of opioid dependence.
- Trial name
- CAT (NCT00929253)
- Testing
- Suboxone, CRA, Therapy
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- Virginia Polytechnic Institute and State University
Anxiety Disorders, Opiate Addiction
Study of Treatment for Opioid Dependence and Anxiety Disorders
Anxiety is highly prevalent among individuals with opioid dependence and confers greater risk for continued opioid use and poor treatment outcomes.
- Trial name
- NCT02252068
- Testing
- I-CBT, IDC
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Mclean Hospital
Opiate Addiction
Acute and Short-term Effects of Cannabidiol Admin on Cue-induced Craving in Drug-abstinent Heroin Dependent Humans
Despite the current available therapies for opioid-dependent patients, most patients relapse. This research project focuses on the development of a novel compound, cannabidiol, to modulate opioid craving in humans based on animal…
- Trial name
- NCT01605539
- Testing
- Cannabidiol 400, Cannabidiol 800, Control
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Hurd,Yasmin, Ph.D.
Human Immunodeficiency Virus, Acquired Immunodeficiency Syndrome
HIV, Buprenorphine, and the Criminal Justice System
The aims of STRIDE were changed as of July, 2014. The revised project, called STRIDE2, has a longitudinal, non-randomized, observational study design.
- Conditions
- Human Immunodeficiency Virus, Acquired Immunodeficiency Syndrome, Opiate Addiction, Drug Dependence
- Trial name
- STRIDE (NCT01550341)
- Testing
- Buprenorphine/naloxone
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Yale University
Opiate Addiction
Models of Screening, Brief Intervention With a Facilitated Referral to Treatment (SBIRT) for Opioid Patients in the Emergency Department
Patients with heroin and prescription opioid dependence are at increased risk for adverse health consequences and often utilize the Emergency Department (ED) as their source of medical care.
- Trial name
- NCT00913770
- Testing
- Brief Negotiation Interview (BNI), Buprenorphine Initiation
- Where
- 2 sites in United States
- Volunteers
- 329 people
- Sponsor
- Yale University
Opioid-Related Disorders, Opiate Addiction
Discontinuation vs Continuation of Long-term Opioid Therapy in Suboptimal and Optimal Responders With Chronic Pain
The purpose of this study is to evaluate the effect on pain intensity (PI) of structured discontinuation of long-term opioid analgesic therapy compared to continuation of opioid therapy in Suboptimal and Optimal Responders to…
- Conditions
- Opioid-Related Disorders, Opiate Addiction, Narcotic Abuse, Drug Abuse
- Trial name
- NCT02741076
- Testing
- Structured discontinuation of opioid therapy (morphine sulfate ER, oxycodone ER, oxymorphone ER), Continuation of opioid therapy (morphine sulfate ER, oxycodone ER, oxymorphone ER)
- Where
- 61 sites in United States
- Volunteers
- 44 people
- Sponsor
- Member Companies of the Opioid PMR Consortium
Opiate Addiction
Treatment Study Using Depot Naltrexone (1/6) Philadelphia Coord/Data Mgmt Site
The aim of this project is to conduct a multi-site effectiveness study to determine whether the addition of a monthly injection of depot naltrexone to treatment as usual (TAU) will significantly improve outcome in parolees and…
- Trial name
- NCT00781898
- Testing
- Depot naltrexone, Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Pain, Opiate Addiction
Methadone Monitoring for Insights Into Adverse Events
Methadone has been an effective and inexpensive therapy in the management of chronic pain and opioid dependence. However it has been associated with sudden, unexpected deaths.
- Trial name
- MEMORIES (NCT01191242)
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- Intermountain Health Care, Inc.
Poor Quality Sleep, Opiate Addiction
Insomnia and Drug Relapse Risk
The purposes of this study are: 1. to evaluate the relationship between subjective complaints of sleep and objective measures of sleep quality, as measured through polysomnography, and 2.
- Trial name
- NCT00253890
- Testing
- Trazodone
- Where
- United States
- Volunteers
- 137 people
- Sponsor
- Butler Hospital
Opiate Addiction
Buprenorphine and Methadone for Opioid Dependent Chronic Pain Patients
The purpose of this study is to determine if buprenorphine or methadone is better for the treatment of chronic pain among patients who have become addicted to prescription narcotics.
- Trial name
- NCT00879996
- Testing
- Methadone, Buprenorphine/naloxone
- Where
- 2 sites in United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Opiate Addiction, Refractory Pain
Buprenorphine as a Treatment in Opiate Dependent Pain Patients
This study is designed to determine if different doses of buprenorphine (either tapering doses or steady doses) are effective in managing chronic, non-cancer pain in individuals who also are addicted to opiate pain medicines.
- Trial name
- NCT00552578
- Testing
- buprenorphine/naloxone
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- State University of New York at Buffalo