Clinical trials: Addictive
Depression, Addiction
Providing Mental Health Precision Treatment
This research study is being conducted to understand if patients benefit from mobile health interventions while waiting for in-clinic mental health treatments, and to understand which patients receive the most benefit.
- Conditions
- Depression, Addiction, Anxiety, Sleep Disturbance
- Trial name
- PROMPT (NCT04342494)
- Testing
- Enhanced Feedback + Standard Feedback, Headspace app + Standard Feedback, Headspace app + Enhanced Feedback + Standard Feedback
- Where
- United States
- Volunteers
- 2,118 people
- Sponsor
- University of Michigan
Opiod Use Disorder
The Influence of ANS-6637 on Midazolam Pharmacokinetics in Healthy Volunteers
Background: Opioids are medicines that control pain. But they are often misused, which can lead to illness and death. Opioids increase dopamine to the brain, which makes people feel good and often causes them to crave drugs…
- Trial name
- NCT03831971
- Testing
- ANS-6637
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Substance-related Disorders
Women's Treatment and Early Recovery
Approximately 25 million Americans struggle with alcohol or drug problems annually. Abuse of alcohol and drugs is costly to our nation, exacting more than $428 billion in costs related to crime, lost work productivity and health…
- Trial name
- MBRP-W (NCT02977988)
- Testing
- Mindfulness Meditation, Brain and Recovery (B&R)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Southern California
Alcohol Use Disorder (AUD)
AAT-App Outpatient Trial
Cognitive biases contribute to the difficulty experienced by heavy drinkers wishing to reduce their alcohol use. Recent interventions designed to reduce cognitive biases demonstrate efficacy for Approach Bias Modification (ApBM).
- Trial name
- AAT-App (NCT05120856)
- Testing
- AAT-App, Minimal AAT-App
- Where
- 6 sites in Australia
- Volunteers
- 82 people
- Sponsor
- Turning Point
PTSD, Addiction
N-acetylcysteine in the Treatment of PTSD and Addiction
Examine the effects of N-acetylcysteine on PTSD symptoms, craving and substance use in veterans with PTSD and comorbid substance use disorders.
- Trial name
- NAC (NCT02499029)
- Testing
- N-acetylcysteine
- Volunteers
- 35 people
- Sponsor
- Medical University of South Carolina
Opiate Dependence
ALK21-013: Efficacy and Safety of Medisorb® Naltrexone (VIVITROL®) in Adults With Opioid Dependence
This is a Phase 3 multi-center trial designed to evaluate the clinical efficacy and safety of VIVITROL® (Medisorb® naltrexone 380 mg) versus placebo when administered to adults upon discharge from inpatient treatment for opioid…
- Trial name
- NCT00678418
- Testing
- VIVITROL® 380 mg
- Where
- Russia
- Volunteers
- 250 people
- Sponsor
- Alkermes, Inc.
Opioid-use Disorder, Opioid-Related Disorders
Substance Use Treatment and Recovery Team (START)
Despite high prevalence, few hospitalized inpatients with opioid or alcohol use disorders (OAUDs) receive evidence-based treatments while in the hospital or get linked with appropriate follow-up care, leading to poor clinical…
- Conditions
- Opioid-use Disorder, Opioid-Related Disorders, Alcohol Use Disorder, Alcohol-Related Disorders
- Trial name
- START (NCT04314648)
- Testing
- Substance Use Treatment and Recovery Team (START)
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- RAND
Alcohol Dependence
ALK21-018: Effects of Medisorb® Naltrexone (VIVITROL®) on Alcohol Craving in Treatment-seeking, Alcohol-dependent Adults
This was a study of the effects of VIVITROL® on alcohol cue-induced craving and the associated brain activation patterns in alcohol-dependent adults who had recently completed alcohol detoxification and were seeking further…
- Trial name
- NCT00511836
- Testing
- VIVITROL 380 mg
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Alkermes, Inc.
Polymorphism-Genetic, Pain
Genetic Effects on Dopamine Response to an Opiate
Background: Small differences in genes may alter responses to drugs. One gene that has different forms is the mu opioid receptor gene. People with one form of this gene are more sensitive to alcohol.
- Conditions
- Polymorphism-Genetic, Pain, Addiction
- Trial name
- NCT01878006
- Testing
- Morphine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Cocaine Addiction
A Study of the Relationship Between Disulfiram and Cocaine Self-administration.
The problem of cocaine dependence remains a major medical, social, and legal concern. Several studies have suggested that disulfiram may be beneficial for the treatment of cocaine dependence.
- Trial name
- NCT00729300
- Testing
- disulfiram
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Baylor College of Medicine
Cocaine Dependence
Effect of Zonisamide on Cocaine Reinforcement, Craving, and Relapse
This is a residential pilot trial to evaluate the pharmacodynamic interaction between zonisamide and cocaine, with the goal of evaluating zonisamide's potential for the treatment of cocaine dependence.
- Trial name
- NCT01137890
- Testing
- Zonisamide, Cocaine Hydrochloride, Neurocognitive and Performance Battery
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Johns Hopkins University
Methamphetamine Dependence
Effects of Modafinil in Methamphetamine Dependence
Methamphetamine dependence is a serious public health problem with no pharmacologic treatments currently available. Relapse rates are high in this population.
- Trial name
- NCT00751023
- Testing
- Modafinil
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Medical University of South Carolina
Addiction
Journaling and Addiction Recovery: Piloting "Positive Recovery Journaling"
The main objective of this study is to pilot test the Positive Peer Journaling (PPJ) [later renamed "Positive Recovery Journaling" (PRJ)] intervention and its feasibility and acceptability.
- Trial name
- PPJ (NCT04458181)
- Testing
- Positive Peer Journaling (PPJ)
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- University of Minnesota
Cocaine Dependence
Clinical Trial of Topiramate for Cocaine Addiction
This is an outpatient clinical trial of topiramate for addressing cocaine dependence and reduction of cocaine associated behaviors in opiate dependent drug users maintained on methadone treatment.
- Trial name
- NCT00685178
- Testing
- topiramate, Contingency Reinforcement
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Johns Hopkins University
Nicotine Dependence
Study Two on the Effectiveness of Mindfulness Training for Smokers
The MTS2 study enrollment goal is N=240 adult smokers randomized to study treatments. The study design includes two randomized arms to compare matched intensive interventions and a third non-randomized option for participants who…
- Trial name
- MTS2 (NCT01299909)
- Testing
- Integrated Training for Smokers, Mindfulness Training for Smokers, Quitline
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- University of Wisconsin, Madison
Alcoholism, Alcohol Dependence
Baclofen for Treating Anxiety and Alcoholism
Background: Baclofen is a drug used to control muscle stiffness in people with neurological diseases. Some studies suggest that baclofen may reduce alcohol craving and use.
- Conditions
- Alcoholism, Alcohol Dependence, Alcohol Drinking Related Problems, Alcohol Drinking
- Trial name
- NCT01751386
- Testing
- Baclofen
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Opioid Use Disorders
mHealth to Help Pregnant and Postpartum Women in Recovery for Opioid Use Disorder
The opioid epidemic has resulted in widespread detrimental consequences among vulnerable populations in Missouri, especially among pregnant and postpartum women (PPW) with opioid use disorder (OUD).
- Trial name
- NCT06701123
- Testing
- uMAT-R mobile app with coaching component
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Washington University School of Medicine
Opiate Dependence
Low Dose Naltrexone-buprenorphine Transfer to Vivitrol Injection in Opioid Dependence
The purpose of this study is to evaluate a very low dose naltrexone-buprenorphine treatment to transfer opioid dependent individuals to extended release naltrexone injection (Vivitrol).
- Trial name
- BUP/NXT-VIVI (NCT01690546)
- Testing
- very low dose naltrexone, extended release naltrexone, buprenorphine/naloxone
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Paolo Mannelli
Alcohol-Related Disorders, Alcohol Dependence
Corticotropin-Releasing Hormone Receptor 1 (CRH1) Antagonism in Anxious Alcoholics^
Background: Individuals who are dependent on alcohol often have feelings of anxiety, irritability, anger, and depression. These feelings, as well as stress, may contribute to the risk of relapse and continued drinking.
- Conditions
- Alcohol-Related Disorders, Alcohol Dependence, Alcoholism, Anxiety Disorder
- Trial name
- NCT01227980
- Testing
- Pexacerfont
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Opioid Dependence, Addiction
Addiction, HIV and Tuberculosis in Malaysian Criminal Justice Settings
The purpose of this study is to conduct empiric studies of tuberculosis (TB) among people in prison with and without a history of opioid dependence.
- Conditions
- Opioid Dependence, Addiction, HIV/AIDS, Tuberculosis
- Trial name
- HARAPAN II (NCT03089983)
- Testing
- Isoniazid, Rifapentine
- Where
- Malaysia
- Volunteers
- 316 people
- Sponsor
- Yale University