Clinical trials: Addictive Behaviors
Cocaine-Related Disorders
Effectiveness of N-acetylcysteine in Treating Cocaine Dependent Individuals - 1
Recent findings have suggested that N-acetylcysteine (NAC) substantially reduces cocaine drug-seeking behavior in formerly cocaine dependent rats.
- Trial name
- NCT00136825
- Testing
- N-Acetylcysteine
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Internet Gaming Disorder
Virtual Reality Exercise for Young Adults at Risk of Digital Gaming Addiction
Digital game addiction is associated with reduced physical activity, increased sedentary behavior, and adverse physical and psychosocial health outcomes in young adults.
- Trial name
- VR-GAME (NCT07718763)
- Testing
- Traditional Aerobic Exercise, Virtual Reality-Based Aerobic Exercise
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Istanbul Nisantasi University
Nicotine Use Disorder, Substance Use Disorders
Temporal Interference Neurostimulation and Addiction
This project aims to develop a line of research using new non-invasive neurostimulation technology to treat adults with opioid use disorders (OUDs).
- Trial name
- NCT04432064
- Testing
- Active TI-NDBS, tDCS
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Indiana University
Opioid Misuse and Addiction, Pain
Toward Zero Prescribed Opioids for Outpatient General Surgery
Investigators have created an opioid reduction "package" which includes patient education, non-narcotic pain control instructions, and limited (or no) opioid pain prescriptions provided at discharge in an attempt to reduce the…
- Trial name
- NCT05327777
- Testing
- Oxycodone, Zero Opioid Protocol
- Where
- United States
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Attention Deficit Disorder With Hyperactivity, Amphetamine-Related Disorders
Safety, Tolerability and Abuse Liability Study of Intravenous NRP104 in Adults With Stimulant Abuse Histories
This research is being done to evaluate if NRP 104 is a safe drug. The other purpose is to learn if NRP104, when injected into a vein, produces a high and any other effects like amphetamine and other stimulant drugs that are…
- Conditions
- Attention Deficit Disorder With Hyperactivity, Amphetamine-Related Disorders, Substance-Related Disorders
- Trial name
- NCT00247572
- Testing
- NRP104
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- New River Pharmaceuticals
Alcoholism, Child Abuse, Sexual
Group Therapies for Reducing HIV-risk Behavior in Women Who Have Survived Childhood Sexual Abuse
This study will evaluate the effectiveness of trauma-focused group therapy for reducing HIV-risk behavior and revictimization among adult women survivors of childhood sexual abuse (CSA).
- Conditions
- Alcoholism, Child Abuse, Sexual, Sexual Abuse, Sexual Behavior
- Trial name
- NCT00220597
- Testing
- Trauma-focused group therapy
- Where
- United States
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- Stanford University
Internet Addiction, Game Addiction, Video
Motivational Interviewing and Addiction
The increasing use of the internet makes understanding games among adolescents different by moving it to the virtual environment and increases the digital game addiction risk.
- Trial name
- MI-IA-DGA (NCT06721702)
- Testing
- Motivational interviewing
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Gazi University
Paraphilic Disorders, Sexual Addiction
Paraphilic Disorders and Other Conditions With Risk for Sexual Violence: a Case-control Study
The goal of this case-control study is to compare clinical characteristics in help-seeking individuals with paraphilic disorders or sexsomnia (sexual behaviors during sleep- a diagnosis in the American Psychiatric Association's…
- Conditions
- Paraphilic Disorders, Sexual Addiction, Parasomnia
- Trial name
- NCT05861752
- Testing
- Treatment as usual
- Where
- Sweden
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Region Stockholm
Tobacco Addiction
High Cessation Rates in Smokers Using Personal Vaporizers
E-cigarettes are proving to be an attractive long-term alternative to conventional cigarettes. Although they may also help smokers to remain abstinent during their quit attempt, recent clinical trials with first generation…
- Trial name
- VAPECIG (NCT02124200)
- Testing
- EGO/CE4, 9mg nicotine
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Catania
Alcohol Use Disorder
Impulsivity Domains and Subjective Response
Findings from this project will determine the relationship between two vulnerability factors for Alcohol Use Disorder (AUD) in young adults: impulsivity and subjective response to alcohol.
- Trial name
- NCT05929677
- Testing
- Alcohol
- Where
- 2 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Jessica Weafer
Alcohol Use Disorder (AUD)
The Zonisamide and Reinforcement for Reducing Alcohol Use (ZARRA) Study
A phase II randomized, double-blind, placebo-controlled clinical trial (RCT) to evaluate the ability of zonisamide (ZON) to decrease alcohol use among treatment-seeking adults with an alcohol use disorder (AUD).
- Trial name
- NCT05134857
- Testing
- Zonisamide
- Where
- United States
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- Washington State University
Exercise Addiction
Effects of Supplementation With Ginseng and BCAA Improved Central Fatigue and Enhanced Attention During Exercise
The main purpose of the present study is to determine the effects of acute and short-term (14 days) ginseng combined with branch chained amino acids supplementation on endurance exercise performance and the ability of…
- Trial name
- NCT05129917
- Testing
- Gojinsen® drinks
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- TCI Co., Ltd.
Adolescent - Emotional Problem
Adapted and Translated, Adolescent Depression, Internet Intervention
Objectives : The key objective of this study is to develop new interventions that addresses the diverse needs and circumstances of Hong Kong adolescents with depressive symptoms in community settings.
- Trial name
- NCT01783652
- Testing
- Intervention group
- Where
- China
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Game Addiction, Video
Efficacy of Digital Game Addiction Awareness Training for Parent
The study will be conducted with the randomized controlled experimental method. The purpose of this research is to determine the effect of digital game addiction awareness training given to parents of 6th-grade secondary school…
- Trial name
- NCT06188117
- Testing
- 'Digital Game Addiction Awareness Training'
- Where
- Turkey (Türkiye)
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Maltepe University
Apnea, Obstructive, Exercise Addiction
Development and Investigation of the ApneaTheraPlay
Obstructive Sleep Apnea Syndrome (OSAS) is commonly treated with CPAP devices, but adherence rates are low. Exercise has been shown to strengthen respiratory muscles, improve upper airway function, and enhance sleep quality.
- Conditions
- Apnea, Obstructive, Exercise Addiction, Physiotherapy and Rehabilitation
- Trial name
- NCT07214636
- Testing
- Structured Pre-Sleep Exercise, ApneaTheraPlay (ATP)
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Medipol University
Cocaine Dependence
Clinical Neurobiology of Serotonin and Addiction
The purpose of this study is to examine the relationship between 5-HT2R function, impulsivity and cue reactivity in cocaine dependent subjects and healthy controls and examine specific effects of escitalopram and mirtazapine on…
- Trial name
- NCT00732901
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Substance Use Disorder (SUD), Alcohol Use Disorder (AUD)
Metabolome and Gut Microbiome Changes During Smoking Cessation in Long-term Drug Therapy in a Therapeutic Community
Theoretical Framework: Cigarette smoking is the leading preventable cause of death worldwide, with nicotine dependence notably common among individuals with Substance Use Disorders (SUD).
- Conditions
- Substance Use Disorder (SUD), Alcohol Use Disorder (AUD), Nicotine Addiction, Healthy Adult Participants
- Trial name
- NCT06803706
- Testing
- 6-weeks CBT smoking cessation programme, Long-term drug therapy within a therapeutic community
- Where
- 3 sites in Austria
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Sigmund Freud PrivatUniversitat
Tobacco Smoking
The Effects of Sedatives on Tobacco Use Disorder Version 2
Double-blind, placebo-controlled, randomized mechanistic clinical trial to test an intravenous dose of either ketamine, midazolam, dexmedetomidine, or a placebo (saline) on cigarette smoking behavior, craving, and neural effects.
- Trial name
- SED-TUD2 (NCT05505630)
- Testing
- Ketamine, Midazolam, Dexmedetomidine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Social Stigma Towards People With Addiction
Short, Animated Storytelling (SAS) for Addiction Stigma Reduction
Stigma towards people with addiction is a well-documented problem that negatively impacts help-seeking, treatment and recovery. Social contact with people recovering from addiction can promote empathy and reduce stigma, but…
- Trial name
- SAS (NCT06705205)
- Testing
- SAS video
- Where
- United States
- Volunteers
- 13,397 people, healthy volunteers welcome
- Sponsor
- Stanford University
Internet Addiction Disorder
Examining of Occupational Balance, Executive Functions, and Quality of Life of Adolescents with Internet Gaming Disorder
Internet gaming disorder leads to social problems and isolation, neglect of daily responsibilities, behavioral disorders, and cognitive and physical impairments.
- Trial name
- NCT06497166
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University