Clinical trials: Adenocarcinoma of Rectum
Colorectal Cancer
Follow-Up Care With or Without CEA Assessments in Patients Who Have Undergone Surgery for Stage II or Stage III Colorectal Cancer
RATIONALE: Diagnostic procedures, such as ultrasound, x-ray, colonoscopy, CT scan, and CEA assessment, may help monitor a patient's response to surgery.
- Trial name
- SURVEILLANCE (NCT00995202)
- Testing
- Standard Monitoring CEA, Intensive Monitoring CEA, Standard Monitoring Imagery
- Where
- 117 sites in Belgium, France and 1 more
- Volunteers
- 1,997 people
- Sponsor
- Federation Francophone de Cancerologie Digestive
Rectal Carcinoma
Phase II Study of Up-front Chemotherapy and Neo-adjuvant Short-course Radiotherapy for Resectable Rectal Carcinoma (COLORE)
Phase II study of up-front chemotherapy and neo-adjuvant shortcourse radiotherapy for resectable rectal carcinoma. Study Design: Phase II, open-label, single-arm, multi-centre study.
- Trial name
- COLORE (NCT02000050)
- Testing
- FOLFOX4, Tomotherapy, TME (Total Mesorectal Excision)
- Where
- 2 sites in Italy
- Volunteers
- 52 people
- Sponsor
- Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
pMMR, MSS
Serplulimab Combined With CAPEOX + Celecoxib as Neoadjuvant Treatment for Locally Advanced Rectal Cancer
Colorectal cancer of Mismatch Repair-proficient (pMMR)/ Microsatellite Stability (MSS) accounts for approximately 85% of all colorectal cancer patients, which might be insensitive to immunotherapy.
- Conditions
- pMMR, MSS, MSI-L, Locally Advanced Rectal Carcinoma
- Trial name
- NCT05731726
- Testing
- Serplulimab, Capecitabine, Oxaliplatin
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zhejiang University
Cancer, Metastatic, Cancer
SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
International registry for cancer patients evaluating the feasibility and clinical utility of an Artificial Intelligence-based precision oncology clinical trial matching tool, powered by a virtual tumor boards (VTB) program, and…
- Conditions
- Cancer, Metastatic, Cancer, Cancer of Pancreas, Cancer of Liver
- Trial name
- NCT03452774
- Testing
- Clinical Trial Matching
- Where
- 68 sites in United States, Puerto Rico
- Volunteers
- 50,000 people
- Sponsor
- Massive Bio, Inc.
Rectal Cancer
Study of Therapeutic Targets Tailored Ch and IMRT as Neoadjuvant Treatment in Rectal Carcinoma Patients
The parameter that best correlates with 5 years disease-free survival (DFS ) in patients (pts) with localized rectal cancer (RC) is the pathological TNM staging (ypTNM) after chemo-radiotherapy (Ch-RT).
- Trial name
- TT (NCT01366118)
- Testing
- Therapeutic target tailored chemotherapy
- Where
- Spain
- Volunteers
- 16 people
- Sponsor
- Grupo Hospital de Madrid
Rectal Cancer, Locally Advanced Rectal Carcinoma
MRI T1 Relaxation Time in Rectal Cancer
The goal of this observational study is to learn about the T1 relaxation time and T1 relaxation time properties of the disease in people with locally advanced rectal cancer.
- Trial name
- NCT05876026
- Where
- Denmark
- Volunteers
- 44 people
- Sponsor
- Vejle Hospital
Rectal Adenocarcinoma
Prospective Pilot Study of Multimodal Radiological Evaluation Feasibility During Chemoradiotherapy of Rectal Adenocarcinomas
The objective of the present project is to validate the feasibility of a multimodal radiological pathway while on chemoradiotherapy, in order to validate potentially predictive factors for chemoradiotherapy sensitivity of rectal…
- Trial name
- NCT01619696
- Testing
- Pelvic MRI and F MISO TEP
- Where
- France
- Volunteers
- 3 people
- Sponsor
- University Hospital, Toulouse
Rectal Cancer, Rectal Carcinoma
A Clinical Trial Comparing Staged Turnbull-Cutait Pull-through Anastomosis With Direct Anastomosis Plus Prophylactic Ileostomy in the Treatment of Low Rectal Cancer After Internal Sphincter Resection
This study targets patients undergoing ultra-low rectal cancer surgery, which requires internal sphincter resection for sphincter-saving procedures.
- Trial name
- STAR-TAR (NCT06662643)
- Testing
- Delayed transanal pull-through anastomosis, Direct Anastomosis Plus Prophylactic Ileostomy
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Zhongnan Hospital
Colorectal Cancer
Gemcitabine, Capecitabine, and Oxaliplatin as Second-Line Therapy in Treating Patients With Advanced Colorectal Cancer Previously Treated With Irinotecan
RATIONALE: Drugs used in chemotherapy, such as gemcitabine, capecitabine, and oxaliplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00496704
- Testing
- capecitabine, gemcitabine hydrochloride, oxaliplatin
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- Yonsei University
Locally Advanced Malignant Neoplasm, Rectal Carcinoma
Multicenter Phase 2 Trial: a Tailored Strategy for Locally Advanced Rectal Carcinoma
The purpose of this study is to determine whether the tailored management of locally advanced rectal carcinoma can improve the oncologic and functional outcome.
- Trial name
- GRECCAR4 (NCT01333709)
- Testing
- Induction trichemotherapy - FOLFIRINOX regimen, Early tumor response evaluation by MRI volumetry, Radiochemotherapy Cap 50
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Colorectal Cancer
Radiation Therapy and Fluorouracil With or Without Combination Chemotherapy Followed by Surgery in Treating Patients With Stage II or Stage III Rectal Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs used in chemotherapy, such as fluorouracil, oxaliplatin, and leucovorin, work in different ways to stop the growth of tumor cells, either by killing…
- Trial name
- NCT00335816
- Testing
- fluorouracil, leucovorin calcium, oxaliplatin
- Where
- 15 sites in United States, Canada
- Volunteers
- 248 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Colorectal Cancer, Metastatic Cancer
Sunitinib Malate and Combination Chemotherapy as Front-Line Therapy in Treating Patients With Metastatic Rectal Cancer That Cannot Be Removed by Surgery
RATIONALE: Sunitinib malate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.
- Trial name
- NCT00936832
- Testing
- FOLFIRI regimen, fluorouracil, irinotecan hydrochloride
- Where
- France
- Sponsor
- Federation Francophone de Cancerologie Digestive
Rectal Adenocarcinoma, LARS - Low Anterior Resection Syndrome
ProLARS Trial: Prospective Longitudinal Follow-up of Low Anterior Resection Syndrome (LARS) and COREFO Score After Rectum Surgery in Patients Undergoing Upfront Surgery or Different Neo-adjuvant Treatment Regimens
OBJECTIVE Low anterior resection syndrome (LARS) is a term for functional bowel complaints occurring after low anterior resection.
- Conditions
- Rectal Adenocarcinoma, LARS - Low Anterior Resection Syndrome, Rectal Resection, Low Anterior Resection
- Trial name
- ProLARS (NCT07339904)
- Testing
- Questionnaire
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- University Hospital, Antwerp
Colorectal Cancer
Irinotecan, Fluorouracil, Leucovorin, and Oxaliplatin as First-Line Therapy in Treating Patients With Metastatic Colorectal Cancer
RATIONALE: Drugs used in chemotherapy, such as irinotecan, fluorouracil, leucovorin, and oxaliplatin, work in different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00080951
- Testing
- fluorouracil, irinotecan hydrochloride, leucovorin calcium
- Volunteers
- 14 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Colorectal Cancer
Studying a Quality of Life Questionnaire in Patients With Colorectal Cancer
RATIONALE: Collecting information about the quality of life of patients with colorectal cancer may help doctors learn more about the disease.
- Trial name
- NCT00564694
- Testing
- psychosocial assessment and care, quality-of-life assessment
- Where
- 5 sites in France, Germany and 1 more
- Volunteers
- 350 people
- Sponsor
- National Cancer Institute (NCI)
Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum
Irinotecan and Alisertib in Treating Patients With Advanced Solid Tumors or Colorectal Cancer
This phase I trial studies the side effects and best dose of alisertib when given together with irinotecan hydrochloride in treating patients with advanced solid tumors or colorectal cancer.
- Conditions
- Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum, Recurrent Colon Cancer, Recurrent Rectal Cancer
- Trial name
- NCT01923337
- Testing
- irinotecan hydrochloride, alisertib
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- University of California, Davis
Locally Advanced Rectal Carcinoma
Preoperative, Adaptive Radiotherapy Concomitant to Chemotherapy for Rectal Adenocarcinoma (Adaptive Rectal Cancer Trial 02)
The aim of this clinical study is to increase the rate of pathological responses up to 70% by means of improved patient selection operated by a radiobiological index called ERI_TCP and by an increase in the dose of radiotherapy…
- Trial name
- NCT07580027
- Testing
- Preoperative, adaptive radiotherapy
- Where
- Italy
- Volunteers
- 33 people
- Sponsor
- IRCCS San Raffaele
Low Anterior Resection Syndrome, Quality of Life
Low Anterior Resection Syndrome After Rectum Resection for Rectal Carcinoma.
The ACO-ASSO (Austrian Society of Surgical Oncology) colorectal group and Austrian Working Group for Coloproctology present the LARS Austria study. It is a prospective, multicenter observational study.
- Conditions
- Low Anterior Resection Syndrome, Quality of Life, Incontinence
- Trial name
- LARS-Austria (NCT05506111)
- Where
- 3 sites in Austria
- Volunteers
- 100 people
- Sponsor
- Paracelsus Medical University
Colorectal Cancer, Metastatic Cancer
Adjuvant Hepatic Arterial Infusion and Combination Chemotherapy in Treating Patients With Resectable Hepatic Metastases From Colorectal Cancer
The purpose of this study is to find the highest dose that can be given safely to people who have had liver disease resected. This is a Phase I study.
- Trial name
- NCT00059930
- Testing
- FOLFOX regimen, dexamethasone, floxuridine
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Colorectal Cancer
Capecitabine, Panitumumab, and Radiation Therapy With or Without Irinotecan Hydrochloride in Treating Patients Undergoing Surgery for Localized Rectal Cancer
RATIONALE: Drugs used in chemotherapy, such as capecitabine and irinotecan hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00967655
- Testing
- panitumumab, capecitabine, irinotecan hydrochloride
- Where
- 4 sites in United States
- Volunteers
- 54 people
- Sponsor
- Loma Linda Oncology Medical Group, Inc.