Clinical trials: Adenoma of Large Intestine
Colorectal Adenoma
Phase II Clinical Study of AC591 in Preventing Oxaliplatin-Induced Peripheral Neuropathy
A randomized, double-blind, placebo-controlled, multicenter, Phase II clinical study of AC591 in preventing Oxaliplatin-Induced Peripheral Neuropathy
- Trial name
- NCT06722950
- Testing
- CAPEOX, AC591
- Volunteers
- 120 people
- Sponsor
- Shandong New Time Pharmaceutical Co., LTD
Cancer
Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain
This is a phase III, randomized, double-blind, placebo-controlled, multicenter study of the clinical response to fentanyl sublingual spray as a treatment for breakthrough cancer pain.
- Trial name
- NCT00538850
- Testing
- Fentanyl sublingual spray
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- INSYS Therapeutics Inc
Colorectal Adenoma, Sessile Serrated Lesion
Evaluation of 'WAYMED Endo CL CS' for Automated Detection and Diagnosis of Colorectal Adenoma and Non-Adenoma Lesions
The purpose of this clinical trial is to evaluate the effectiveness of the computer-aided diagnosis (CADx) software, 'WAYMED endo CL CS', which assists medical specialists by automatically analyzing colorectal endoscopic images…
- Conditions
- Colorectal Adenoma, Sessile Serrated Lesion, Hyperplastic Polyp, Carcinoma
- Trial name
- NCT07470827
- Testing
- WAYMED endo CL CS, Reference standard review
- Where
- South Korea
- Volunteers
- 1,178 people
- Sponsor
- WAYCEN Inc
Colorectal Adenoma, TCM
Shenbai Granules for Preventing Recurrence of Low-Risk Colorectal Adenomas
A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial of Shenbai Granules for Preventing Recurrence of Low-Risk Colorectal Adenomas（LRCRA）.
- Conditions
- Colorectal Adenoma, TCM, Low Risk
- Trial name
- NCT07123116
- Testing
- Shenbai Granules
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Jiangsu Famous Medical Technology Co., Ltd.
Colorectal Adenoma, Colorectal Polyp
To Compare Artificial Intelligence Software Aided Adenoma Detection in Screening Colonoscopies Versus Standard Colonoscopy Without Artificial Intelligence Software Assistance in Participants Between 45 and 75 Years of Age
The aim of this study is to assess the efficacy of Ultivision Artificial Intelligence (AI) Software in detecting adenomas in screening colonoscopy procedures. The safety of Ultivision AI Software will also be assessed.
- Conditions
- Colorectal Adenoma, Colorectal Polyp, Colorectal Adenocarcinoma, Colorectal SSA
- Trial name
- AIDA (NCT04196088)
- Testing
- Ultivision Artificial Intelligence Software, No Artificial Intelligence Software enhancement
- Where
- 9 sites in United States
- Volunteers
- 978 people, healthy volunteers welcome
- Sponsor
- Docbot, Inc.
Colorectal Adenoma, Colorectal Cancer (CRC)
Evaluation of Gixam's Performance in a FIT Negative Population
In the United States, colorectal cancer ranks second to lung cancer as a cause of cancer death and is the third most commonly occurring cancer in both men and women.
- Conditions
- Colorectal Adenoma, Colorectal Cancer (CRC), Colorectal Cancer (CRC) Screening
- Trial name
- NCT06612281
- Testing
- colorectal cancer (CRC) screening, colorectal cancer screening, Colonoscopy after bowel cleansing
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Jubaan Ltd.
Colorectal Cancer, Colorectal Polyp
Feasibility and Safety of MiWEndo-assisted Colonoscopy
The study involves the planned use of a new microwave-based device during colonoscopy procedures in a small group of patients to assess the preliminary safety of its use and lack of normal clinical practice modification.
- Conditions
- Colorectal Cancer, Colorectal Polyp, Colorectal Adenoma, Colorectal Neoplasms
- Trial name
- MiWEndo1 (NCT05477836)
- Testing
- MiWEndo-assisted colonoscopy
- Where
- Spain
- Volunteers
- 15 people
- Sponsor
- MiWEndo Solutions S.L.
Colorectal Adenoma, High Risk
Shenbai Granules for Preventing Malignant Transformation of High-risk Colorectal Adenomas
This multicenter, randomized, double-blind, placebo-controlled trial will enroll 450 patients with completely resected high-risk colorectal adenoma (HR-CRA), randomly assigned (1:1) to 6 months of Shenbai Granules (SBG) or…
- Conditions
- Colorectal Adenoma, High Risk, TCM
- Trial name
- NCT07129499
- Testing
- Shenbai Granules
- Where
- China
- Volunteers
- 450 people
- Sponsor
- Jiangsu Famous Medical Technology Co., Ltd.
Colorectal Neoplasms, Colorectal Polyp
A Prospective Investigation of the ColubrisMX ELS System
This study is a prospective, single-arm, open-label, multi-center, feasibility study to evaluate the safety and efficacy of the ColubrisMX ELS System in patients undergoing transanal endoluminal procedures, specifically…
- Conditions
- Colorectal Neoplasms, Colorectal Polyp, Colorectal Adenoma, Colorectal Adenomatous Polyp
- Trial name
- NCT04192565
- Testing
- ColubrisMX Endoluminal Surgical (ELS) System
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- ColubrisMX
Colorectal Cancer, Colorectal Neoplasms
Clinical Performance of the Mainz Biomed Colorectal Cancer Screening Test for Colorectal Cancer and Advanced Adenoma
This study is to determine how the Mainz Biomed Colorectal Cancer Screening Test works when used in people aged ≥45 years of age and at an average risk of developing colorectal cancer.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Polyp, Colorectal Adenoma
- Trial name
- reconAAsense (NCT05636085)
- Testing
- Mainz Biomed Colorectal Cancer Screening Test
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Mainz Biomed
Colorectal Adenoma
Prevention of Colorectal Sporadic Adenomatous Polyps (PRESAP)
This study is a prospective, randomized, double-blind, placebo-controlled, multi-center trial to compare the efficacy and safety of celecoxib 400mg QD versus placebo in reducing the occurrence of new colorectal adenomas…
- Trial name
- PRESAP (NCT00141193)
- Testing
- Celecoxib
- Where
- 106 sites in United States, Australia and 30 more
- Volunteers
- 1,561 people
- Sponsor
- Pfizer
Colorectal Cancer, Colorectal Polyp
Performance and Safety of MiWEndo-assisted Colonoscopy (MiWEndo II)
The study involves the planned use of a new microwave-based device during colonoscopy procedures in 50 patients to assess the performance and safety of its use for detection of colorectal polyps and lack of normal clinical…
- Conditions
- Colorectal Cancer, Colorectal Polyp, Colorectal Adenoma, Colorectal Adenomatous Polyp
- Trial name
- NCT05988645
- Testing
- MiWEndo System
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- MiWEndo Solutions S.L.
Adenomatous Polyps
Chemoprevention of Colorectal Adenomas
The purpose of the study is to investigate if long-term treatment with three known drugs (acetylsalicylic acid, 1α 25-dihydroxy cholecalciferol, and calcium carbonate) prevents recurrence of colorectal adenomas.
- Trial name
- NCT00486512
- Testing
- 0.5 mg calcitriol (1a -25-dihydroxycholecalciferol), 75 mg acetylsalicylic acid (ASA) + 1250 mg calcium carbonate (CaCO3), Colonoscopy
- Where
- 39 sites in United States, Russia
- Volunteers
- 350 people
- Sponsor
- Colotech A/S
Colorectal Adenoma
A Study to Evaluate the Effect of MK0966 (Rofecoxib) on the Recurrence of Colorectal Adenomas (0966-122)
This study was to compare the effect of 156 weeks of treatment with MK-0966 (Rofecoxib) versus placebo on the recurrence of colorectal adenomas (growths that occur on the inside (the lining) of the large intestine, also known as…
- Trial name
- NCT00282386
- Testing
- MK0966; Rofecoxib / Duration of Treatment: 156 weeks
- Volunteers
- 2,586 people
- Sponsor
- Merck Sharp & Dohme LLC
Colorectal Cancer, Colorectal Adenoma
Integrated Chinese and Western Medicine Specialized Disease Cohort for Colorectal Cancer
This is a nationwide cohort study on integrated traditional Chinese and Western medicine for colorectal cancer. The aim is to elucidate the distribution patterns of TCM syndromes in colorectal cancer and colorectal adenoma…
- Trial name
- NCT06136026
- Volunteers
- 50,000 people
- Sponsor
- Jiangsu Famous Medical Technology Co., Ltd.
Colorectal Lesion, Colorectal Adenoma
PARADIGM - En Bloc Trial With the EndoQuest Endoluminal Surgical (ELS) System
The objective of this study is to evaluate the safety and effectiveness of the Endoluminal Surgical (ELS) System in subjects undergoing specified transanal endoluminal procedures in the rectum and sigmoid colon.
- Conditions
- Colorectal Lesion, Colorectal Adenoma, Colorectal Polyp, Rectal Lesion
- Trial name
- PARADIGM (NCT06133387)
- Testing
- Endoscopic submucosal dissection using the ELS System
- Where
- 6 sites in United States
- Volunteers
- 56 people
- Sponsor
- EndoQuest Robotics, Inc.
Colorectal Cancer, Colorectal Adenoma
Protocol to Validate the Performance of the LifeKit® Prevent Colorectal Neoplasia Test for CRC Screening
The purpose of this study is to determine the sensitivity and specificity for LifeKit Prevent Colorectal Neoplasia Test for colorectal cancer (CRC) and for adenoma, including advanced adenoma.
- Trial name
- PREVENT (NCT04693546)
- Testing
- LifeKit Prevent Colorectal Neoplasia Test, FIT Test
- Where
- United States
- Volunteers
- 12,000 people, healthy volunteers welcome
- Sponsor
- Metabiomics Corp
Gastroenterology
A Randomized Clinical Trial of Shenbai Granules in Reducing Recurrence of Colorectal Adenoma
This study evaluates Shenbai Granules in Prevention of Colorectal Adenomatous Polyp Recurrence After Colonoscopy.Half of participants will receive Shenbai Granules,while the other half will receive a placebo.
- Trial name
- NCT03616444
- Testing
- Shenbai Granules
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Jiangsu Famous Medical Technology Co., Ltd.