Clinical trials: Adenomas
Colonic Polyp, Colonic Adenoma
Nationwide Study of Artificial Intelligence in Adenoma Detection for Colonoscopy
The goal of this trial is to determine whether use of a Computer Assisted Detection (CADe) programme leads to an increase in ADR for either units or individual colonoscopists, independent of setting or expertise
- Conditions
- Colonic Polyp, Colonic Adenoma, Colo-rectal Cancer
- Trial name
- NAIAD (NCT05870332)
- Testing
- GI Genius (GIG)
- Where
- United Kingdom
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
Adenoma, Colorectal Cancer
Combination of Artificial Intelligence and Mucosal Exposure Device to Enhance Colorectal Neoplasia Detection
The investigators hypothesize that the combined use of CADe system (ENDOAID) and mucosal exposure device (Endocuff Vision®) would improve the adenoma detection rate when compared to CADe system alone.
- Conditions
- Adenoma, Colorectal Cancer, Colorectal Neoplasms
- Trial name
- AIDEN (NCT05414448)
- Testing
- ENDOCUFF
- Where
- Hong Kong
- Volunteers
- 1,726 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Ampulla of Vater Intestinal-Type Adenoma
The Use of Cap-assisted Forward Viewing Endoscopy for Examination of the Ampulla of Vater
The aim of this study is to compare the visualization rates of the ampulla of Vater using forward- viewing endoscopes with or without cap attached to the distal end in the same patient.
- Trial name
- NCT02867826
- Testing
- Cap
- Where
- Brazil
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Barretos Cancer Hospital
Colorectal Tubular Adenoma
Establishment of Big Data Platform and Biobank for Colorectal Tubular Adenoma Lesions
Colorectal tubular adenoma is the most common precancerous lesion of colorectal cancer, and the point is that its precise prevention and treatment can reduce the incidence of colorectal cancer.However, the epidemiological…
- Trial name
- NCT06322225
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Colorectal Cancer, Adenoma
The Implication of Plasma ctDNA Methylation Haplotypes in Detecting Colorectal Cancer and Adenomas
This is a multicenter, clinical study. This study is to evaluate the sensitivity of plasma ctDNA methylation haplotypes in detecting colorectal cancer, adenoma and the specificity in healthy individuals.
- Trial name
- NCT03737591
- Testing
- Next-generation sequencing (NGS)
- Where
- China
- Volunteers
- 1,138 people, healthy volunteers welcome
- Sponsor
- Fudan University
Colorectal Cancer, Adenomatous Polyps
Multitarget Stool FIT-DNA Study for Colorectal Cancer Early Screening in China
The primary objective is to determine the diagnostic sensitivity and specificity of the newly developed multitarget FIT-DNA Colorectal Cancer (CRC) screening test (ColoClear) for detecting advanced neoplasia (including colorectal…
- Conditions
- Colorectal Cancer, Adenomatous Polyps, Adenoma, Advanced Adenoma
- Trial name
- CLEAR-C (NCT04287335)
- Testing
- Multitarget stool FIT-DNA test - ColoClear, FIT, Colonoscopy
- Where
- 8 sites in China
- Volunteers
- 4,758 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Colonic Polyps, Colorectal Neoplasms
Right Colon Enema to Improve Bowel Preparation Quality During Colonoscopy
Colonoscopy is a test that lets doctors look inside the large bowel to find and remove growths called polyps, which can develop into bowel cancer. Before the test, people take a bowel preparation to empty the bowel.
- Conditions
- Colonic Polyps, Colorectal Neoplasms, Colonoscopy, Bowel Preparation Quality
- Trial name
- RIGHT-CLEAN (NCT07813013)
- Testing
- Sodium phosphate enema, Water instillation
- Where
- 2 sites in Australia
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Westmead Hospital
Polyp, Adenoma
The Impact of Experienced Endoscopy Nurse Participation on Polyp and Adenoma Detection During Colonoscopy
The purpose of this study is to determine whether experienced endoscopy nurse participation during screening colonoscopy could increase polyp and adenoma detection rate.
- Trial name
- NCT02292563
- Testing
- Colonoscopist only, Experienced Endoscopy Nurse Participation
- Where
- China
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- Ningbo No. 1 Hospital
Pituitary Adenoma
Comparison of The Effects of Sevoflurane, Desflurane and Total Intravenous Anaesthesia on Pulmonary Function Tests
This study will compare the effects of sevoflurane, desflurane and total intravenous anaesthesia on pulmonary function tests in patients undergoing endoscopic endonasal transsphenoidal surgery of pituitary gland.
- Trial name
- NCT02709863
- Testing
- Sevoflurane, Desflurane, Propofol
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Colonic Polyps, Adenomatous Polyps
Practice-Based Learning to Predict Polyp Histology at Colonoscopy
Most colorectal cancers arise from polyps. Most polyps removed at colonoscopy are small. New technologies such as narrowband imaging (NBI) offer the possibility of in differentiation between precancerous and unimportant small…
- Trial name
- NCT01638091
- Testing
- Ex vivo module, In vivo practice-base learning phase
- Where
- 2 sites in United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Stanford University
Colorectum
Prospective Trial of Metformin - Chemoprevention Role
The goal of this clinical research study is to learn if metformin extended release (ER) can prevent colonic adenomas from becoming cancerous. Metformin ER will be compared to a placebo.
- Trial name
- NCT01550900
- Testing
- Metformin ER
- Volunteers
- healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Artificial Intelligence, Colonic Adenoma
Artificial Intelligence-Assisted Colonoscopy in Colorectal Cancer Screening in a General Hospital
Cancer can develop in the colon, or large bowel. Examination of the colon with a tube fitted with a camera is called a colonoscopy. Colonoscopy allows detection of small growths in the colon, called "polyps".
- Conditions
- Artificial Intelligence, Colonic Adenoma, Colonic Neoplasms, Colonic Polyp
- Trial name
- Delta-AI (NCT06792292)
- Testing
- conventional colonoscopy procedure, artificial intelligence-assisted colonoscopy procedure
- Where
- Belgium
- Volunteers
- 765 people, healthy volunteers welcome
- Sponsor
- Chirec
Adenoma, Polyps
Prospective Trial to Compare ADR of G-EYE™ Colonoscopy With Standard Colonoscopy
The purpose of this study is to compare the adenoma detection rate (ADR) of the G-EYE™ colonoscopy with that of standard colonoscopy.
- Conditions
- Adenoma, Polyps, Colorectal Cancer
- Trial name
- NCT02545699
- Testing
- G-EYE™ Colonoscopy, Standard Colonoscopy
- Where
- Israel
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Smart Medical Systems Ltd.
Colorectal Neoplasms
Third Eye Panoramic Device Feasibility Evaluation
This study will evaluate the feasibility of using the Third Eye Panoramic device in conjunction with standard colonoscopes in a clinical setting.
- Trial name
- NCT02368977
- Testing
- Third Eye Panoramic device
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Avantis Medical Systems
Colonic Adenoma, Colonic Cancer
R vs L Lateral Decubitus Positioning in Colonoscopy
Colonoscopy continues to be the gold standard in detecting precancerous lesions in the colon. It relies on adequate visualization of the bowel wall to see and remove such lesions.
- Trial name
- NCT03355495
- Testing
- Colonoscopy - Position Change
- Where
- Canada
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Memorial University of Newfoundland
Colon Cancer Screening, Colon Cancer Surveillance
Enchasing Polyp Detection: The Effect of Adding Polyp Detection Attachment Device to Computer Aid Detection System.
Despite the widespread use of colonoscopy, the ongoing challenge of potentially missing polyps remains. Previous studies have independently shown that both Endocuff, a colonoscope attachment device for polyp detection, and…
- Trial name
- NCT06116864
- Testing
- Endocuff and GI Genius, GI Genius
- Where
- United States
- Volunteers
- 1,766 people, healthy volunteers welcome
- Sponsor
- Marshall University
Colon Adenoma
Surrogate Quality Indicators for Adenoma Detection Rate (ADR)
This study is to evaluate the correlation of adenoma missing rate and quality indicators of colonoscopy including adenoma detection ratee (ADR), polyp detection rate (PDR), adenoma per colonoscopy rate (APC), adenoma per positive…
- Trial name
- NCT03919487
- Testing
- Back to back colonoscopy
- Where
- South Korea
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Soonchunhyang University Hospital
Early Diagnosis of Colorectal Cancer and Adenoma
Correlation Between SFRP1 and Colorectal Cancer and Adenoma
In summary, our study demonstrated the methylation sites of SFRP1 gene promoter in patients with colorectal cancer and adenoma and found SFRP1_16_17_18 CpG site was good performance as a diagnostic marker of colorectal cancer.
- Trial name
- NCT05204433
- Testing
- no intervention
- Where
- China
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital of Digestive Diseases
Prolactinoma, Insulin Resistance
Insulin Resistance in Women With Prolactinoma
Prolactin is suggested to influence insulin resistance, but scarce data is available on the metabolic profile of patients with prolactinoma.
- Conditions
- Prolactinoma, Insulin Resistance, Hyperlipidemia
- Trial name
- NCT00481299
- Where
- Brazil
- Volunteers
- 2,004 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Adenomatous Polyps
Does Cap Assisted Colonoscopy Improve Detection of Adenomatous Polyps? (CAP Trial)
Effectiveness of screening colonoscopy in cancer prevention relies on the detection and removal of adenomatous polyps. However, a substantial rate of adenomas is missed during a colonoscopy.
- Trial name
- CAP (NCT01935180)
- Testing
- Colonoscopy Cap
- Where
- 2 sites in United States
- Volunteers
- 1,148 people, healthy volunteers welcome
- Sponsor
- White River Junction Veterans Affairs Medical Center