Clinical trials: Adenomas
Non-Small Cell Lung Cancer, Metastatic Melanoma
A Study to Investigate 14C-bemcentinib in Healthy Male Subjects
The aims of this Study were to determine: How much of the Study Drug (bemcentinib) ends up in urine and faeces How much of the Study Drug and its breakdown products get into the bloodstream The breakdown products (metabolites) of…
- Conditions
- Non-Small Cell Lung Cancer, Metastatic Melanoma, Acute Myeloid Leukemia, Myelodysplastic Syndromes
- Trial name
- 8479217 (NCT06469138)
- Testing
- Bemcentinib
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- BerGenBio ASA
Adenoma
The Impact of Active Nurse Participation on Adenoma Detection During Routine Colonoscopy
Hypothesis-- Nurse observation in addition to the colonoscopist while withdrawing the colonoscope from the cecum leads to a greater adenoma detection rate.
- Trial name
- NCT00859625
- Testing
- nurse observation during colonoscope withdrawal
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Yale University
Familial Cancer, BRCA1-Associated Protein-1 (BAP1) Mutations
Prospective Evaluation of High Resolution Dual Energy Computed Tomographic Imaging, Noninvasive (Liquid) Biopsies, and Minimally Invasive Surgical Surveillance for Early Detection of Mesotheliomas in Patients With BAP1 Tumor Predisposition Syndrome
Background: A germline mutation is a change to a person s genes that is carried through their DNA. These mutations can be passed on from parents to their offspring.
- Conditions
- Familial Cancer, BRCA1-Associated Protein-1 (BAP1) Mutations, Tumor Predisposition Syndrome (TPDS), Mesothelioma
- Trial name
- NCT04431024
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Colon Cancer, Colon Adenomas
Plasma ctDNA in Patients Undergoing Diagnostic Colonoscopy
When the DNA inside of human cells undergoes certain alterations (mutations), the cells may develop into a cancer. The cancer cells may shed this DNA into the blood stream.
- Conditions
- Colon Cancer, Colon Adenomas, Colon Polyps
- Trial name
- NCT02665299
- Where
- United States
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- Pathway Genomics
Colorectal Cancer, Colon Polyps
Prevalence and Topography of Adenomas in 40-49 Year Old Patients With a Family History of Colon Cancer
Conflicting guideline recommendations for screening colonoscopy result due to scant data upon which to develop appropriate recommendations.
- Conditions
- Colorectal Cancer, Colon Polyps, Adenomatous Polyp of Colon
- Trial name
- NCT02289053
- Where
- 6 sites in United States
- Volunteers
- 1,623 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Bowel Disease, Colon Adenoma
Comparison of Low Volume PEG-Asc and Lower Volume PEG-Asc With Bisacodyl
Recently a low-volume polyethylene glycol containing ascorbic acid (PEG-Asc) formulation has proven as safe and effective as traditional 4-L PEG solutions for colonoscopy preparation.
- Trial name
- NCT02980562
- Testing
- Polyethylene Glycols, Bisacodyl
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Korea University Anam Hospital
Colon Adenoma
Surrogate Quality Indicators for Adenoma Detection Rate (ADR)
This study is to evaluate the correlation of adenoma missing rate and quality indicators of colonoscopy including adenoma detection ratee (ADR), polyp detection rate (PDR), adenoma per colonoscopy rate (APC), adenoma per positive…
- Trial name
- NCT03919487
- Testing
- Back to back colonoscopy
- Where
- South Korea
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Soonchunhyang University Hospital
Familial Adenomatous Polyposis, Map Syndrome
Preliminary Evaluation of Septin9 in Patients With Hereditary Colon Cancer Syndromes
This is an observational, case-control study evaluating the quantitative level of Septin9 in plasma pre- and post-colectomy in hereditary colorectal cancer (CRC) syndrome patients (Familial Adenomatous Polyposis (FAP), Lynch…
- Conditions
- Familial Adenomatous Polyposis, Map Syndrome, Lynch Syndrome, Hnpcc
- Trial name
- Septin9 (NCT02198092)
- Testing
- Epi proColon Testing
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Colorectal Adenomatous Polyps
I-scan for Adenoma Detection
This study is a randomized controlled trial to determine whether i-scan can improve the detection of conventional adenomas and sessile serrated adenomas/polyps.
- Trial name
- NCT02811419
- Testing
- i-scan, standard high-definition white light
- Where
- United States
- Volunteers
- 740 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Colorectum
Prospective Trial of Metformin - Chemoprevention Role
The goal of this clinical research study is to learn if metformin extended release (ER) can prevent colonic adenomas from becoming cancerous. Metformin ER will be compared to a placebo.
- Trial name
- NCT01550900
- Testing
- Metformin ER
- Volunteers
- healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Pleural Effusion, Malignant, Pleural Mesothelioma
A Comparative Study Between Regional Anesthesia in Thoracoscopes and the Conventional General Anesthesia
Video-assisted thoracic surgery (VATS) is usually performed with general anesthesia and single lung ventilation. However, performing thoracic surgery under awake regional anesthesia has several potential advantages including…
- Conditions
- Pleural Effusion, Malignant, Pleural Mesothelioma, Pleural Empyema, Pulmonary Diseases or Conditions
- Trial name
- VATS (NCT05077111)
- Testing
- Thoracic Epidural Anesthesia, General Anesthesia with One Lung Ventilation
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mohamed Reda Ashour
Adenoma, Polyps
Inspection of the Colon Using a Retrograde Viewing Device for Detection of Colorectal Polyps
During standard colonoscopy a substantial number of colorectal polyps may be missed. Previous studies have found a 12-28% of miss rate for all polyps, a 31% for hyperplastic polyps and 6-27% for adenomas.
- Trial name
- NCT04107376
- Testing
- Retroviewing endoscopy
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Pituitary Neoplasms, Prolactinoma
Interdisciplinary Pituitary Disorders Centre of Excellence: Assessment of Patient Education Tools
The purpose of this research study is to determine the utility of educational materials designed to inform patients of their pituitary condition, in an effort to assist the patients, families, and staff deal with pituitary…
- Conditions
- Pituitary Neoplasms, Prolactinoma, ACTH-Secreting Pituitary Adenoma, Gigantism
- Trial name
- NCT01775332
- Testing
- Educational Intervention
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Adenoma, Colorectal Cancer
Combination of Artificial Intelligence and Mucosal Exposure Device to Enhance Colorectal Neoplasia Detection
The investigators hypothesize that the combined use of CADe system (ENDOAID) and mucosal exposure device (Endocuff Vision®) would improve the adenoma detection rate when compared to CADe system alone.
- Conditions
- Adenoma, Colorectal Cancer, Colorectal Neoplasms
- Trial name
- AIDEN (NCT05414448)
- Testing
- ENDOCUFF
- Where
- Hong Kong
- Volunteers
- 1,726 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Screening Colonoscopy
Does AI-assisted Colonoscopy Improve Adenoma Detection in Screening Colonoscopy?
To date, there is a lack of large-scale randomized controlled study using AI assistance in the detection of polyps/adenoma in a screening population.
- Trial name
- NCT04422548
- Testing
- AI-assisted Colonoscopy, Standard Colonoscopy
- Where
- Hong Kong
- Volunteers
- 2,994 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Colonic Adenoma, Colonic Cancer
R vs L Lateral Decubitus Positioning in Colonoscopy
Colonoscopy continues to be the gold standard in detecting precancerous lesions in the colon. It relies on adequate visualization of the bowel wall to see and remove such lesions.
- Trial name
- NCT03355495
- Testing
- Colonoscopy - Position Change
- Where
- Canada
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Memorial University of Newfoundland
Adrenal Gland Neoplasm, Hypertension
Clinical and Molecular Characteristics of Primary Aldosteronism in Blacks
Background: The adrenal gland makes the hormone aldosterone. This helps regulate blood pressure. An adrenal gland tumor that makes too much aldosterone can cause high blood pressure and low potassium.
- Conditions
- Adrenal Gland Neoplasm, Hypertension, Bone Diseases, Metabolic, Cardiovascular Disease
- Trial name
- NCT03374215
- Where
- United States
- Volunteers
- 1,150 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Carcinoma Ex Pleomorphic Adenoma of Salivary Glands, Pleomorphic Adenoma of Salivary Glands
Diagnostic and Prognostic Accuracy of Gold Nanoparticles in Salivary Gland Tumours
Nano-based diagnostic tool can provide promising highly sensitive, specific biomarker for early detection and treatment of salivary gland tumours compared to non-conjugated biomarkers and in turn improves patient prognosis and…
- Trial name
- NCT04907422
- Testing
- CD24-Gold Nanocomposite expression using Real-time quantitative polymerase chain reaction, non-conjugated CD24 expression using Real-time quantitative polymerase chain reaction
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Amina Fouad Farag
Panhypopituitarism, Gigantism/Acromegaly
An Investigation of Pituitary Tumors and Related Hypothalmic Disorders
There is a variety of tumors affecting the pituitary gland in childhood; some of these tumors (eg craniopharyngioma) are included among the most common central nervous system tumors in childhood.
- Conditions
- Panhypopituitarism, Gigantism/Acromegaly, Prolactinoma, Cushing Disease
- Trial name
- NCT00001595
- Testing
- Tissue specimen collection, MRI
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Lung Cancer, Mesothelioma
Screening of Alberta Asbestos Exposed Workers for Lung Cancer and Mesothelioma
Asbestos defines a group of naturally occurring mineral silicate fibers which are easily inhaled, resulting in a variety of diseases of the respiratory system including lung cancer and malignant mesothelioma.
- Trial name
- NCT02385812
- Testing
- Low-dose computed tomography Annual scan x3, Low-dose computed tomography Baseline scan only
- Where
- 2 sites in Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Calgary