Clinical trials: Adenomatous Polyps
Colorectal Adenomatous Polyps
Calcium and Vitamin D vs Markers of Adenomatous Polyps
The purpose of this study is to test whether calcium and/or vitamin D supplementation favorably affects a set of biomarkers of risk for colon cancer in persons who are at higher than average risk for colon cancer (ie, have…
- Trial name
- CaDvMAP (NCT00208793)
- Testing
- Calcium and vitamin D3 combined, Calcium, Vitamin D3
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Emory University
Adenomatous Polyposis Coli
Trial In Pediatric Patients With Familial Adenomatous Polyposis (FAP)
To test whether celecoxib can be used to prevent colon polyp formation in children with familial adenomatous polyposis (FAP).
- Trial name
- CHIP (NCT00585312)
- Testing
- Celecoxib
- Where
- 42 sites in United States, Belgium and 12 more
- Volunteers
- 106 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Adenomatous Polyps
Comparison of Two Devices During Colonoscopy
Colonoscopy is the gold standard investigation for the diagnosis of bowel pathology and colorectal cancer screening. Adenoma detection rate is a marker of high quality colonoscopy.
- Trial name
- COLONAUX (NCT03197987)
- Testing
- Endocuff, cap
- Where
- Spain
- Volunteers
- 710 people
- Sponsor
- Hospital General Universitario Elche
Colorectal Neoplasms, Colorectal Cancer
Screening for Colorectal Cancer in Average and High Risk Population
The existing evidence from epidemiological studies and randomized controlled trials has consistently assures the cost effectiveness and the influential role of screening in reducing incidence rates and deaths caused by Colorectal…
- Conditions
- Colorectal Neoplasms, Colorectal Cancer, Adenomatous Polyp of Colon
- Trial name
- NCT04017845
- Testing
- FIT, Precolonoscopy cleansing regimen, Conventional Colonoscopy
- Where
- Iraq
- Volunteers
- 537 people, healthy volunteers welcome
- Sponsor
- Lewai Sharki Abdulaziz, MSc PhD
Colorectal Cancer, Colon Cancer
Pilot Study of Colon Cancer Screening Tests
Colon cancer is the second leading cause of cancer death in North America. These deaths are preventable with proper screening. Fecal occult blood testing, virtual colonoscopy, and standard (optical) colonoscopy are all options…
- Conditions
- Colorectal Cancer, Colon Cancer, Adenomatous Polyps
- Trial name
- NCT00865527
- Testing
- Fecal occult blood test, Virtual colonoscopy, Optical colonoscopy
- Where
- Canada
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Colonic Adenomatous Polyps
Effectiveness and Safety of the Endoscopic Removal of Large and Flat Colonic Polyps With LumenR RetractorTM
Colorectal cancer accounted for 142,570 new cancer cases and 51,370 cancer deaths in USA in 2010 and worldwide has become the third most common cancer and second leading cause of cancer related deaths.
- Trial name
- NCT02051465
- Testing
- LumenR Retractor, Removal without overtube
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Mercy Medical Center
Adenomatous Polyps
Chemoprevention of Colorectal Adenomas
The purpose of the study is to investigate if long-term treatment with three known drugs (acetylsalicylic acid, 1α 25-dihydroxy cholecalciferol, and calcium carbonate) prevents recurrence of colorectal adenomas.
- Trial name
- NCT00486512
- Testing
- 0.5 mg calcitriol (1a -25-dihydroxycholecalciferol), 75 mg acetylsalicylic acid (ASA) + 1250 mg calcium carbonate (CaCO3), Colonoscopy
- Where
- 39 sites in United States, Russia
- Volunteers
- 350 people
- Sponsor
- Colotech A/S
Rectal Cancer, Ulcerative Colitis
Bioabsorbable Staple Line Reinforcement in Colorectal,Coloanal and Ileoanal Anastomoses
The primary purpose of this prospective, randomized multicenter center study is to evaluate and compare the outcomes of colorectal, coloanal and ileoanal anastomoses reinforced with a bioabsorbable staple line reinforcement…
- Conditions
- Rectal Cancer, Ulcerative Colitis, Familial Adenomatous Polyposis, Diverticulitis
- Trial name
- NCT00663819
- Testing
- GORE SEAMGUARD® Bioabsorbable Staple Line Reinforcement, Staple line without reinforcement
- Where
- 16 sites in United States
- Volunteers
- 258 people
- Sponsor
- W.L.Gore & Associates
Adenomatous Polyps
Managing Colorectal Cancer Prevention Procedure Wait Lists During the COVID-19 Pandemic
The main objective of this study is to offer and evaluate an interim triage approach for patients waiting for surveillance colonoscopies.
- Trial name
- NCT04964596
- Testing
- colonoscopy, FIT test, CT colonography
- Where
- Canada
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Colorectal Cancer, Precancerous Condition
Celecoxib in Preventing Colorectal Cancer in Young Patients With a Genetic Predisposition for Familial Adenomatous Polyposis
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming. The use of celecoxib may keep polyps and colorectal cancer from forming in patients with familial adenomatous polyposis.
- Trial name
- NCT00685568
- Testing
- celecoxib
- Where
- 4 sites in United States
- Volunteers
- 22 people
- Sponsor
- M.D. Anderson Cancer Center
Familial Adenomatous Polyposis
A Trial of Low Dose Sulindac Combined With Eflornithine in Patients With Familial Adenomatous Polyposis (FAP)
The purpose of this phase III study is to evaluate the safety and efficacy of the combination of eflornithine and sulindac compared to single agent sulindac or eflornithine in reducing the number of polyps in patients with…
- Trial name
- NCT01245816
- Testing
- Eflornithine plus Sulindac
- Sponsor
- Cancer Prevention Pharmaceuticals, Inc.
Ulcerative Colitis, Familial Polyposis
An Evaluation of SprayShield in Reducing Post-Operative Adhesion Formation Following Major Open Abdominal Surgery
This will be a prospective, multi-center, randomized, single blind study to collect and evaluate post-market clinical data on the SprayShield Adhesion Barrier System as an adjuvant to good surgical technique for the reduction of…
- Trial name
- NCT01002287
- Testing
- SprayShield Adhesion Barrier System, Good Surgical Technique Alone
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Integra LifeSciences Corporation
Adenomatous Polyp, Colorectal Carcinoma
Macrogol 3350-based Oral Osmotic Laxative in Preventing Cancer in Patients at Risk of Colorectal Cancer
This randomized phase II trial studies how well macrogol 3350-based oral osmotic laxative (polyethylene glycol 3350) works in preventing cancer in patients at risk of colorectal cancer.
- Trial name
- NCT00828984
- Testing
- macrogol 3350-based oral osmotic laxative, Laboratory Biomarker Analysis
- Where
- 3 sites in United States
- Volunteers
- 87 people
- Sponsor
- National Cancer Institute (NCI)
Intestinal Polyps
Phytoestrogens and Colonic Adenomatous Polyps
INTRODUCTION: The data obtained by experimental studies about the influence of phytoestrogens on colorectal cancer (CRC) have been very promising. On the other hand, clinical trials have produced conflicting results.
- Trial name
- FITOPOL (NCT03417258)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Bari
Gastric Polyps, Intestinal Polyps
Recurrence After Gastric and Intestinal Polyp Resection
This is a retrospective and prospective cohort study designed to evaluate the recurrence rate and identify risk factors after endoscopic resection of gastric and intestinal polyps.
- Conditions
- Gastric Polyps, Intestinal Polyps, Colon Polyps, Colorectal Polyps
- Trial name
- RAGIP (NCT07314554)
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- LanZhou University
Colitis,Ulcerative, Adenomatous Polyposis Coli
Registry With Information About Colitis Ulcerosa and Familial Adenomatous Polyposis Patients
The purpose of this registry is to collect information about patients in which a pouch has been created to improve in the future the quality of the surgery of the pouch.
- Conditions
- Colitis,Ulcerative, Adenomatous Polyposis Coli, Reservoir, Ileoanal
- Trial name
- KOPOF (NCT01604564)
- Where
- Belgium
- Volunteers
- 207 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Adenomatous Polyps
Non-invasive Risk Stratification of CR AMN/SSP
The purpose of this study is to determine the clinical utility of stool and blood methylation tests for detection of advanced mucosal neoplasia (AMN) and sessile serrated polyps (SSP).
- Trial name
- FIT (NCT02476682)
- Testing
- blood or stool samples will be collected
- Where
- Australia
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- Professor Michael Bourke
Familial Adenomatous Polyposis, Colorectal Cancer
Multimedia Intervention in Patients With Familial Adenomatous Polyposis (FAP)
The goal of this research study is to test the first version of a website that will offer information and support for adolescents and young adults with FAP.
- Trial name
- NCT00525655
- Testing
- Web-Based Multimedia Intervention, Questionnaire
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- M.D. Anderson Cancer Center
Metastatic Colorectal Carcinoma (mCRC), Colorectal Cancer (CRC)
Safety and Efficacy of Tegavivint in Patients With Metastatic Colorectal Carcinoma
This trial will evaluate the safety, tolerability, and preliminary efficacy of tegavivint as monotherapy (single) and in combination with standard therapies in patients with metastatic colorectal carcinoma (mCRC).
- Conditions
- Metastatic Colorectal Carcinoma (mCRC), Colorectal Cancer (CRC), Adenomatous Polyposis Coli (APC) Gene Mutation, Catenin Beta-1 (CTNNB1) Gene Mutation
- Trial name
- NCT07463599
- Testing
- Tegavivint
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- HonorHealth Research Institute
Cancer
Incidental Cancer in Familial Adenomatous Polyposis
Colectomy is life-saving in patients with familial adenomatous polyposis (FAP) because cancer development is inevitable in individuals with this disease.
- Trial name
- NCT05171426
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Dr. Ersin Arslan Education and Training Hospital