Clinical trials: Adenosine
Pharmacodynamics
Eplerenone and Extracellular Adenosine Formation
Various studies have reported cardioprotective effects of mineralocorticoid receptor (MR) antagonists in the setting of an acute myocardial infarction.
- Trial name
- eplerenone01 (NCT01837108)
- Testing
- Eplerenone
- Where
- Netherlands
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Study Genetic Basis of Infantile Onset Diabetes Mellitus
Gene Study for Infantile Onset Diabetes
Diabetes mellitus is a group of metabolic diseases characterized by chronic hyperglycemia resulting from defects in insulin secretion, insulin action, or both.
- Trial name
- NCT03169413
- Testing
- Human Leucocytic antigen typing and mutation of adenosine triphosphate sensitive K channel gene in diabetic patients diagnosed under the age of one year.
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Ocular Physiology, Microcirculation
Role of Adenosine in the Control of Choroidal Blood Flow During Changes in Ocular Perfusion Pressure.
Autoregulation is the ability of a vascular bed to maintain blood flow despite changes in perfusion pressure. For a long time it had been assumed that the choroid is a strictly passive vascular bed, which shows no autoregulation.
- Trial name
- NCT00712764
- Testing
- Adenosine
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Platelet Aggregation, ADP Blockers
Aggreguide A-100 ADP Assay Evaluation
The study is to characterize the AggreGuide ADP Assay's performance.
- Trial name
- NCT02112539
- Testing
- platelet aggregation measurement
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Aggredyne, Inc.
Endotoxemia
A Possible Therapeutic Role for Adenosine During Inflammation
The adenosine receptor is known for its anti-inflammatory actions and could therefore be a potential target in the treatment of sepsis and septic shock.
- Trial name
- NCT00513110
- Testing
- AMPD1 polymorphism, Caffeine infusion
- Where
- Netherlands
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Moderate Hepatic Impairment
A Study of TMC207 in Patients With Moderately Impaired Hepatic Function
The purpose of this study is to assess the pharmacokinetics (what the body does to the medication), safety and tolerability of TMC207 and its N-monodesmethyl metabolite (M2) in healthy participants and in patients with moderate…
- Trial name
- NCT01012284
- Testing
- TMC207
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Tibotec BVBA
Health
Phase I Dose-Escalation Study to Evaluate Tolerability, Safety & PK of INO-8875 in Healthy Older-Adult Volunteers
The purpose of this study is to evaluate how tolerable and safe it is to give INO-8875 eye drops at different concentrations to normal older healthy adult volunteers for two weeks.
- Trial name
- NCT01123772
- Testing
- INO-8875
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Inotek Pharmaceuticals Corporation
Asthma
"First-in-human" Study To Assess the Safety and Tolerability of PBF-680 in Male Healthy Volunteers
This is a phase I, single-center, randomized, double-blind, dose escalation study without therapeutic benefit, in which PBF-680 will be administered as single oral ascending dose to young male healthy volunteers.
- Trial name
- NCT01845181
- Testing
- PBF-680
- Where
- 2 sites in Spain
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Obesity
Adenosine and A2A Receptors in Human Brown Adipose Tissue
This study investigates the significance of adenosine and A2A receptors in human brown adipose tissue (BAT) in vivo. Using positron emission tomography (PET), perfusion and the density of A2A receptors will be measured in…
- Trial name
- AdenoBAT (NCT03327168)
- Testing
- Adenosine, Cold exposure
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Asthma, Healthy
Effects of Allergen Inhalation on Adenosine Receptor Expression in Sputum and Peripheral Blood
The purpose of this study is to determine whether asthmatics have different adenosine receptor expression profiles than healthy controls.
- Trial name
- NCT00116311
- Testing
- allergen inhalation, withdrawal of medication, sputum induction
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Groningen Research Institute for Asthma and COPD
Chronic Kidney Disease stage3
Effect of Empagliflozin on Urinary Excretion of Adenosine and Osteocyte Function in Patients With Chronic Kidney Disease
Sodium-glucose cotransporter 2 (SGLT2) inhibitors are the newest class of orally drugs for the treatment of type 2 diabetes. These drugs decrease plasma glucose levels by inhibiting its reabsorption in the proximal tubules of the…
- Trial name
- NCT04961931
- Testing
- Empagliflozin 10 MG
- Where
- Poland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Medical University of Lodz
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
ALS
Adenosine 2A Receptor Antagonism and AIH in ALS
The purpose of this research study is to determine the effects of a medication, istradefylline, in conjunction with breathing air with reduced oxygen for short periods of time (called acute intermittent hypoxia, or AIH), on…
- Trial name
- NCT05377424
- Testing
- Consume 20mg of istradefylline, Low Oxygen therapy
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Florida
Ischemia-Reperfusion Injury
Adenosine Receptors Influence Ischemia-Reperfusion Injury
Ischemic preconditioning is defined as the development of tolerance to ischemia-reperfusion injury by a previous short bout of ischemia resulting in a marked reduction in infarct size.
- Trial name
- NCT00184847
- Testing
- acetylcholine, twenty minutes of forearm ischemia, three 5-minute periods of forearm ischemia
- Where
- Netherlands
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Endothelial Dysfunction, Myocardial Perfusion Abnormalities
Cardiac Magnetic Resonance Imaging for Detecting Endothelial Dysfunction
The goal of this research study is to demonstrate that Cardiac Perfusion MRI with Vasomotor Stress may serve as a non-invasive and less risky imaging technique for detecting non-obstructive perfusion deficits and/or abnormalities…
- Conditions
- Endothelial Dysfunction, Myocardial Perfusion Abnormalities, Cardiac MRI Perfusion With Vasomotor Stress, Diabetes
- Trial name
- NCT00808535
- Testing
- Cardiac Perfusion MRI w Vasomotor Stress
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Healthy
Ticagrelor and Adenosine
Preclinical studies have shown that the P2Y12 receptor antagonist ticagrelor can increase the extracellular concentration of the endogenous nucleoside adenosine by inhibiting the cellular uptake of adenosine via the equilibrative…
- Trial name
- NCT01996735
- Testing
- Ticagrelor 180 mg single dose
- Where
- Netherlands
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Retinal Artery Occlusion
The Effect of A2A Adrenoceptor Stimulation on the Diameter of Retinal Arterioles During Hypoxia in Vivo
The purpose is to investigate how the adenosine affects the diameter regulation of retinal arterioles during changes in oxygen tension.
- Trial name
- NCT03090087
- Testing
- Hypoxia, Regadenoson
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Obesity, Endothelial Dysfunction
Effects of Body Mass Index on the Hyperemic Response to Regadenoson
We will test the hypothesis that a single dose of Regadenoson will produce equivalent degrees of coronary hyperemia in patients of widely different body size.
- Conditions
- Obesity, Endothelial Dysfunction, Decreased Vascular Flow
- Trial name
- NCT00859833
- Testing
- Adenosine, Regadenoson
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Utah
Rheumatoid Arthritis
Atherosclerosis in Rheumatoid Arthritis and Lupus: Restoring Cholesterol Balance
Hypothesis: SLE and RA increase risk of myocardial infarction (MI, heart attack). Immune reactants in the circulation of SLE patients downregulate cholesterol efflux proteins 27-hydroxylase and ABCA1 and upregulate scavenger…
- Trial name
- NCT01180361
- Where
- United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Coronary Artery Disease, Heart Infarction
Effects of Personalized Training Program on Coronary Flow Reserve in Healthy Volunteers
This study investigates whether an individualized exercise program, including a personal trainer, can improve cardiovascular status quantified with ultrasound to assess coronary flow reserve and other non-invasive techniques.
- Trial name
- NCT02713724
- Testing
- physical exercise, limited physical exercise
- Where
- Sweden
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Göteborg University