Clinical trials: Adenosine
Cocaine Dependence
Caffeine and Cocaine
This study is being done to find out if medicines that affect a neurotransmitter (chemical messenger) in the brain called adenosine improve behavioral problems that are related to drug abuse.
- Trial name
- NCT00733993
- Testing
- Caffeine 150 MG, Amphetamine, Caffeine 300 MG
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Solid Tumor, Adult
New Formulation Study of Inupadenant (EOS100850) in Patients with Cancer
A2A-004 is a three-part multicenter, open-label, Phase I clinical trial intended to evaluate the safety and tolerability, and the pharmacokinetics (PK) and food effect of new formulations of inupadenant (formerly known as…
- Trial name
- NCT05117177
- Testing
- Inupadenant
- Where
- 5 sites in Belgium, United Kingdom
- Volunteers
- 57 people
- Sponsor
- iTeos Therapeutics
Supraventricular Tachycardia, Supraventricular Tachycardias
Comparison of Single-syringe vs. Double-syringe Techniques for Adenosine Administration in PSVT
The purpose of the study is to compare the effectiveness of two different methods of administering adenosine for the treatment of stable supraventricular tachycardia (SVT).
- Conditions
- Supraventricular Tachycardia, Supraventricular Tachycardias, Supraventricular Arrhythmia, SVT
- Trial name
- NCT07554170
- Testing
- Single-syringe Adenosine, Double Syringe Adenosine
- Where
- 2 sites in Iran
- Volunteers
- 131 people
- Sponsor
- Hormozgan University of Medical Sciences
Coronary Artery Disease
Intravenous Regadenoson Versus Intravenous Adenoscan® for Fractional Flow Reserve (FFR)
The purpose of this study is to demonstrate that intravenous regadenoson is equivalent to intravenous Adenoscan® for the physiological assessment of intermediate coronary lesions.
- Trial name
- NCT01482169
- Testing
- FFR Measurement with IV Adenoscan® then with Regadenoson
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Ochsner Health System
Breast Neoplasm
A Study of Ado-trastuzumab Emtansine (T-DM1)-Induced Peripheral Neuropathy in HER2-positive Breast Cancer Patients
Researchers plan to study the natural history of ado-trastuzumab emtansine (T-DM1)-induced neuropathy both in patients without any history of neuropathy or previous neurotoxic agent use and in patients who have such a history.
- Trial name
- NCT05889988
- Where
- 21 sites in United States
- Volunteers
- 36 people
- Sponsor
- Mayo Clinic
Coronary Artery Disease
Adenosine Dual Source Computed Tomography (CT) Versus Adenosine Single Photon Emission Computed Tomography (SPECT)
Researchers hope that this new non-invasive multi-detector scanner (DSCT) will provide diagnostic information comparable to the combination of traditional SPECT (for function and blood flow) and CT imaging (for a precise…
- Trial name
- NCT00892307
- Testing
- Dual Source Multidetector CT (DSCT) w/ Adenosine enhancement
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Cedars-Sinai Medical Center
Pregnancy, IUGR
Effects of High Altitude on AMPK Activation
Pregnancy elicits adaptive changes in uteroplacental blood flow, which are altered at high altitude and may contribute to the observed 3-fold increase in intrauterine growth restriction (IUGR) and preeclampsia (PreE).
- Conditions
- Pregnancy, IUGR, Preeclampsia
- Trial name
- NCT02391519
- Testing
- Collection of myometrial, cord blood, and placental tissue samples
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Healthy Volunteer
Occupancy of Adenosine A2A Receptors Using the PET Radiotracer [18F]MNI-444
The overall goal of this protocol is to evaluate the binding of caffeine to adenosine A2A receptors in the brain of participants at risk for developing PD.
- Trial name
- NCT05009199
- Testing
- [18F]MNI-444
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Invicro
Adenosine Deaminase Deficiency, Severe Combined Immunodeficiency (SCID)
An Observational LTFU Study for Patients Previously Treated With Autologous ex Vivo Gene Therapy for ADA-SCID
This observational long-term follow-up study is designed to collect safety and efficacy data from ADA-SCID patients previously treated with autologous ex vivo gene therapy products based on the EFS-ADA LV encoding for human…
- Trial name
- NCT04049084
- Testing
- autologous ex vivo gene therapy products based on the EFS LV encoding for the human adenosine deaminase (ADA) gene (EFS-ADA LV)
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 70 people
- Sponsor
- University of California, Los Angeles
Severe Combined Immunodeficiency
Gene Transfer Therapy for Severe Combined Immunodeficieny Disease (SCID) Due to Adenosine Deaminase (ADA) Deficiency: A Natural History Study
This study will monitor the long-term effects of gene therapy in patients with severe combined immunodeficiency disease (SCID) due to a deficiency in an enzyme called adenosine deaminase (ADA).
- Trial name
- NCT00001255
- Testing
- ADA PBSC, ADA Umbilical Cord Blood Cells, Transduced Lymphocytes
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Rheumatoid Arthritis, Psoriatic Arthritis
CD73+ Th1.17 in Rheumatoid Arthritis and Psoriatic Arthritis
Prospective study to investigate the correlation between CD39/CD73 expression by the different T lymphocyte subpopulations in the blood and synovial fluid (if available) into patients with chronic inflammatory rheumatism RA and…
- Trial name
- LAdoRIC (NCT03953378)
- Testing
- Multi-parametric Flow Cytometry analysis on patients and healthy donors samples
- Where
- France
- Volunteers
- 41 people
- Sponsor
- Hospices Civils de Lyon
Headache, Migraine
The Effect of Adenosine on Cranial Hemodynamic, Headache and Migraine Induction Properties.
Adenosine is a nucleoside that plays a role in both vascular and nociceptive systems, and it has been proposed that adenosine may cause headache in particularly sensitive subjects.
- Trial name
- NCT04577443
- Testing
- Adenosine, Saline
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Fractional Flow Reserve
Effect of Ticagrelor on Fractional Flow Reserve
Fractional flow reserve (FFR) is an established invasive method for assessing the physiological significance of coronary artery stenosis.
- Trial name
- NCT02108808
- Testing
- Ticagrelor, Prasugrel or Clopidogrel
- Where
- Greece
- Volunteers
- 76 people
- Sponsor
- University of Patras
Asthma
Effects of QVAR in Smokers With Asthma
We hypothesize that extra-fine particle treatment with HFA-QVAR will be superior in improving small airways dysfunction, especially in ex-smokers and smokers with asthma.
- Trial name
- OLiVIA (NCT01741285)
- Testing
- Beclomethasone (QVAR), Beclomethasone (Clenil), Fluticasone
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- University Medical Center Groningen
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Asthma
AMP-BPT and His-BPT for Assessment of Asthma
Adenosine monophosphate (AMP) may reflect airway inflammation and hyperresponsiveness, but relationship between AMP and histamine (His, a conventional stimulus) bronchial provocation test (BPT) in asthma is not fully elucidated.
- Trial name
- AMPHis (NCT02318043)
- Testing
- inhaled corticosteroids (usually budesonide/fomorterol 160/4.5mcg; fluticasone/salmeterol 250/50mcg)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Guangzhou Institute of Respiratory Disease
Adenosine Deaminase Deficiency, Severe Combined Immunodeficiencies (SCID)
Lentiviral (LV) Gene Therapy for Adenosine Deaminase (ADA) Deficiency
This is a historically controlled, non-randomized Phase I/II clinical trial to assess the safety and efficacy of autologous transplantation of CD34+ hematopoietic stem/progenitor cells (HSPCs), obtained from infants affected by…
- Trial name
- NCT01380990
- Testing
- Infusion of autologous EFS-ADA LV CD34+ cells, Haematopoietic Stem Cell Transplantation (HSCT), Busulfan
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
ADA-SCID
Autologous CD34+ Hematopoietic Stem Cells Transduced ex Vivo With Elongation Factor 1 Alpha Shortened (EFS) Lentiviral Vector Encoding for the Human ADA Gene
The aim of this study is to assess the safety and efficacy of autologous transplantation of hematopoietic stem cells (CD34+ cells) from the bone marrow (BM) of ADA-deficient SCID infants and children following human ADA cDNA…
- Trial name
- NCT01852071
- Testing
- Infusion of autologous EFS-ADA LV CD34+ (OTL-101), busulfan, PEG-ADA ERT
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- University of California, Los Angeles
Asthma
Determining the Optimal Adenosine Provocation Test
Asthma is a frequently occurring inflammatory lung disease that affects the whole bronchial tree including the small airways (<2mm).
- Trial name
- impact (NCT01610921)
- Testing
- Bronchial provocation test
- Where
- 2 sites in Netherlands
- Volunteers
- 11 people
- Sponsor
- University Medical Center Groningen
Takotsubo Cardiomyopathy, Takotsubo Syndrome
Adenosin to Rapidly Reverse Left Ventricle Impairment in Takotsubo Syndrome
The investigators will randomize patients admitted to hospital with Takotsubo diagnosis to systematic high-dose adenosine infusion for 3 minutes (in addition to standard of care) vs. standard of care.
- Trial name
- TITAN (NCT02867878)
- Testing
- Adenosine, Saline solution
- Where
- Italy
- Volunteers
- 5 people
- Sponsor
- University Hospital of Ferrara