Clinical trials: Adenosine
Overactive Bladder
Urinary Nerve Growth Factor (NGF), Prostaglandin E2 (PGE2)and Adenosine Triphosphate (ATP): Potential Biomarkers in Overactive Bladder Patients
Nerve growth factor (NGF), prostaglandin E2 (PGE2)and adenosine triphosphate (ATP) levels in urine were reported to increase in patients with overactive bladder (OAB).
- Trial name
- NCT01499069
- Testing
- Oxybutinin, Fesoterodine, Solifenacin, Propiverin, Trospium
- Where
- South Korea
- Volunteers
- 191 people
- Sponsor
- Samsung Medical Center
Myocardial Infarction, Myocardial Fibrosis
Modulation of Fibrosis-inducing Pathways in Acute Myocardial Infarction
This is a single-center, prospective, observational controlled cohort study designed to describe the role of WNT/B-catenin signaling and adenosine system after an acute myocardial infarction, correlating it with clinical markers…
- Conditions
- Myocardial Infarction, Myocardial Fibrosis, Myocardial Remodeling, Ventricular
- Trial name
- BETA-MI (NCT05122741)
- Testing
- P2Y12 Potent Inhibitor + Aspirin for STEMI patients, Clopidogrel + Aspirin for CCS patients
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Messina
Adenosine Deaminase Deficiency
Investigation of ADA Enzyme Deficiency
This observational study was designed as a prospective epidemiological screening study. Patients who applied to the centers participating in the study and were found to be lymphopenic in at least one examination will be included…
- Trial name
- NCT05300334
- Testing
- adenosine deaminase test
- Where
- Turkey (Türkiye)
- Volunteers
- 800 people
- Sponsor
- TRPHARM
Ischemia-Reperfusion Injury
Adenosine Receptors Influence Ischemia-Reperfusion Injury
Ischemic preconditioning is defined as the development of tolerance to ischemia-reperfusion injury by a previous short bout of ischemia resulting in a marked reduction in infarct size.
- Trial name
- NCT00184847
- Testing
- acetylcholine, twenty minutes of forearm ischemia, three 5-minute periods of forearm ischemia
- Where
- Netherlands
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
SCID, ADA-SCID
Patients Treated for SCID (1968-Present)
Individuals with a past diagnosis of severe combined immune deficiency (including many cases of "leaky SCID", Omenn syndrome, and reticular dysgenesis) who have undergone blood and marrow transplant, gene therapy, or enzyme…
- Conditions
- SCID, ADA-SCID, XSCID, Leaky SCID
- Trial name
- NCT01346150
- Where
- 36 sites in United States, Canada
- Volunteers
- 1,007 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Asthma, Bronchial Hyperresponsiveness
The Effect of HFA - Beclomethasone Dipropionate Qvar on Bronchial Hyperreactivity in Preschool Children
Respiratory diseases including Asthma are high prevalent among preschool children. Specific treatment, nowadays, include steroid inhalers and anti leukotrienes.
- Trial name
- NCT01006655
- Testing
- Beclomethasone dipropionate HFA
- Where
- Israel
- Volunteers
- 21 people
- Sponsor
- Rambam Health Care Campus
Breast Cancer
ATOP TRIAL: T-DM1 in HER2 Positive Breast Cancer
This research study is studying an investigational drug as a possible treatment for breast cancer that is positive for the protein Human Epidermal Growth Factor Receptor 2, also known as HER2-positive breast cancer.
- Trial name
- NCT03587740
- Testing
- T-DM1
- Where
- 14 sites in United States
- Volunteers
- 111 people
- Sponsor
- Dana-Farber Cancer Institute
Coronary Artery Disease
Adenosine Dual Source Computed Tomography (CT) Versus Adenosine Single Photon Emission Computed Tomography (SPECT)
Researchers hope that this new non-invasive multi-detector scanner (DSCT) will provide diagnostic information comparable to the combination of traditional SPECT (for function and blood flow) and CT imaging (for a precise…
- Trial name
- NCT00892307
- Testing
- Dual Source Multidetector CT (DSCT) w/ Adenosine enhancement
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Cedars-Sinai Medical Center
Supraventricular Tachycardia, Supraventricular Tachycardias
Comparison of Single-syringe vs. Double-syringe Techniques for Adenosine Administration in PSVT
The purpose of the study is to compare the effectiveness of two different methods of administering adenosine for the treatment of stable supraventricular tachycardia (SVT).
- Conditions
- Supraventricular Tachycardia, Supraventricular Tachycardias, Supraventricular Arrhythmia, SVT
- Trial name
- NCT07554170
- Testing
- Single-syringe Adenosine, Double Syringe Adenosine
- Where
- 2 sites in Iran
- Volunteers
- 131 people
- Sponsor
- Hormozgan University of Medical Sciences
Heart Failure, Coronary Artery Disease
Dobutamine vs Adenosine CMR Study
This is a single centre, prospective diagnostic accuracy study to assess the comparative sensitivity of dobutamine versus adenosine for detection of severe non-infarct epicardial coronary artery stenosis in subjects with reduced…
- Conditions
- Heart Failure, Coronary Artery Disease, Cardiac MRI
- Trial name
- DISCORDANCE (NCT03661827)
- Testing
- Stress Cardiac MRI
- Where
- United Kingdom
- Volunteers
- 69 people
- Sponsor
- University of Leicester
Leukemia, Chronic Lymphocytic Leukemia
8-Chloro-Adenosine in Chronic Lymphocytic Leukemia
The goal of this clinical research study is to find the highest safe dose of the drug 8-chloro-adenosine that can be given in the treatment of chronic lymphocytic leukemia (CLL).
- Trial name
- NCT00714103
- Testing
- 8-Chloro-Adenosine
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- M.D. Anderson Cancer Center
Coronary Artery Disease
Differential Effect of High (200μg/kg/Min) Adenosine Dose on Fractional Flow Reserve in Patients Presenting Variation of FFR ≥0.05 During the Usual Dose of Adenosine Infusion (140μg/kg/Min).
Fractional flow reserve (FFR) is an established invasive method for assessing the physiological significance of coronary artery stenosis.
- Trial name
- NCT02350439
- Testing
- Adenosine infusion at 200μg/Kg/min
- Where
- Greece
- Volunteers
- 30 people
- Sponsor
- University of Patras
Metastatic Solid Tumor, Brain Metastases
A Phase II Study of Tucatinib and Ado-trastuzumab Emtansine (T-DM1) in Patients With HER2-positive Metastatic Solid Tumors and Metastases to Brain (TUCATEMEB)
To learn if the study drugs, tucatinib and adotrastuzumab emtansine (T-DM1), can help to control solid tumors that have spread to the brain.
- Trial name
- NCT05673928
- Testing
- Trastuzumab emtansine, Tucatinib
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- M.D. Anderson Cancer Center
Psoriasis
Study to Assess the Safety and Tolerability of PBF-1650 in Healthy Volunteers.
Single center, randomized, double-blind, placebo-controlled clinical study to assess the safety and tolerability of PBF-1650 in order to obtain the Maximum Tolerated Dose (MTD).
- Trial name
- ADENOIMMUNE (NCT03798236)
- Testing
- PBF-1650 oral capsules
- Where
- Spain
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Palobiofarma SL
Heart Failure and Reduced Ejection Fraction, Heart Failure
PRIMA-HF: Predicting Myocardial Recovery in Heart Failure Using Cardiac Imaging HAI-HF: High Dosing vs. Standard Dosing Adenosine During Myocardial Perfusion in Heart Failure
Background: Heart failure with reduced ejection fraction (HFrEF) is a heterogeneous condition with variable potential for left ventricular ejection fraction (LVEF) recovery.
- Trial name
- PRIMA-HF (NCT07243119)
- Testing
- HAI-HF: Adenosine Stress [¹⁵O]H₂O PET Imaging, Two different doses of adenosine
- Where
- Denmark
- Volunteers
- 180 people
- Sponsor
- Gødstrup Hospital
Panic Disorder
Genetic Causes of Panic Disorder
This study will try to identify genes that increase the risk of developing panic disorder-an anxiety disorder characterized by recurrent unexpected panic attacks-and that contribute to the abnormalities associated with it.
- Trial name
- NCT00083265
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- National Institute of Mental Health (NIMH)
Cachexia, Unspecified Adult Solid Tumor, Protocol Specific
Adenosine Triphosphate in Treating Patients With Advanced Solid Tumors
RATIONALE: Adenosine triphosphate may decrease weight loss and improve muscle strength in patients with advanced solid tumors. PURPOSE: Phase I trial to study the effectiveness of adenosine triphosphate in controlling loss of…
- Trial name
- NCT00014248
- Testing
- adenosine triphosphate, quality-of-life assessment
- Where
- United States
- Sponsor
- Dartmouth-Hitchcock Medical Center
Parkinson's Disease
A Study in Healthy Male Volunteers to Investigate a New Drug for the Treatment of Parkinson's Disease
The main purpose of the study is to identify the best dose of V81444 to use in future trials in patients with Parkinson's disease.
- Trial name
- NCT02764892
- Testing
- V81444
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Vernalis (R&D) Ltd
Coronary Angioplasty
Intracoronary Adenosine Administration to Prevent Periprocedural Myonecrosis in Elective Coronary Angioplasty
Aim of the study is to evaluate the benefits from adjunctive intracoronary administration of adenosin in elective patients undergoing coronary angioplasty.
- Trial name
- PREVENT-ICARUS (NCT01148147)
- Testing
- Adenosine
- Where
- Italy
- Volunteers
- 260 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Rheumatoid Arthritis, Psoriatic Arthritis
CD73+ Th1.17 in Rheumatoid Arthritis and Psoriatic Arthritis
Prospective study to investigate the correlation between CD39/CD73 expression by the different T lymphocyte subpopulations in the blood and synovial fluid (if available) into patients with chronic inflammatory rheumatism RA and…
- Trial name
- LAdoRIC (NCT03953378)
- Testing
- Multi-parametric Flow Cytometry analysis on patients and healthy donors samples
- Where
- France
- Volunteers
- 41 people
- Sponsor
- Hospices Civils de Lyon