Clinical trials: Adenosine
Bone Metastases, HER2-positive Breast Cancer
Copper Cu 64-DOTA-Trastuzumab PET in Predicting Response to Treatment With Ado-Trastuzumab Emtansine in Patients With Metastatic HER2 Positive Breast Cancer
This pilot clinical trial studies how well copper Cu 64-tetra-azacyclododecanetetra-acetic acid (DOTA)-trastuzumab positron emission tomography (PET) works in predicting response to treatment with ado-trastuzumab emtansine in…
- Conditions
- Bone Metastases, HER2-positive Breast Cancer, Liver Metastases, Lung Metastases
- Trial name
- NCT02226276
- Testing
- fludeoxyglucose F 18, positron emission tomography, computed tomography
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- City of Hope Medical Center
Atherosclerotic Cardiovascular Disease
Heme Oxygenase (HO) Activity and Adenosine Induced Vasodilation
The purpose of this study is to determine whether heme oxygenase 1 induction by heme arginate treatment is of influence on adenosine induced vasodilation in healthy individuals.
- Trial name
- NCT00856817
- Testing
- L-arginine + heme arginate, Heme arginate + L-arginine
- Where
- Netherlands
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Allergic Rhinitis
To Evaluate Adenosine Monophosphate and Allergen Challenge in Allergic Rhinitis
Allergic rhinitis is a common condition characterize by inflammation of the upper airways. Third generation antihistamines have been demonstrated effective in the treatment of this condition.
- Trial name
- NCT00679250
- Testing
- levocetirizine
- Where
- 2 sites in United Kingdom
- Volunteers
- 25 people
- Sponsor
- Brian J Lipworth
Sickle Cell Disease, Sickle Cell Anemia
Microvascular Blood Flow in Sickle Cell Anemia
Sickle cell disease (SCD) is an inherited blood disorder that causes the red blood cells to change their shape from a round shape to a half-moon/crescent or sickled shape.
- Trial name
- NCT01566890
- Testing
- regadenoson infusion with contrast-enhanced ultrasound, contrast-enhanced ultrasound
- Where
- 2 sites in United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Versiti Blood Health
Adenosine Deaminase Deficiency
Investigation of ADA Enzyme Deficiency
This observational study was designed as a prospective epidemiological screening study. Patients who applied to the centers participating in the study and were found to be lymphopenic in at least one examination will be included…
- Trial name
- NCT05300334
- Testing
- adenosine deaminase test
- Where
- Turkey (Türkiye)
- Volunteers
- 800 people
- Sponsor
- TRPHARM
Dedifferentiated Liposarcoma, Soft Tissue Sarcoma
A Study of Etrumadenant and Zimberelimab in People With Dedifferentiated Liposarcoma
Participants will have a diagnosis of dedifferentiated liposarcoma (DDLS) that has spread beyond its original location (advanced).
- Conditions
- Dedifferentiated Liposarcoma, Soft Tissue Sarcoma, Sarcoma,Soft Tissue, Sarcoma
- Trial name
- NCT05886634
- Testing
- Etrumadenant, Zimberelimab
- Where
- 7 sites in United States
- Volunteers
- 16 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Infection
Interactions of Environmental and Human Microbial Communities in a Pediatric Oncology Hospital
Microorganisms that colonize hospital environments play an important role in the transmission of hospital acquired infections (HAI) and multi-drug resistant organisms.
- Trial name
- NCT02948335
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- St. Jude Children's Research Hospital
Ischemia
AMP as a Better Delivery System of Adenosine
Adenosine and AMP are substances normally present in the body. Adenosine is also given for the treatment of some heart rhythm problems and may be used to reduce heart damage during heart attacks.
- Trial name
- NCT00179010
- Testing
- Adenosine, Adenosine Mono Phosphate (AMP)
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Infertility Unexplained
Effect of Oral Zinc Sulfate Supplementation on Enzymes of Urate Pathway
Although many reports have investigated the relationship between subfertility and uric acid levels in semen, to the best of author knowledge, there is no study have been published to yet focus on the effects of asthenospermia…
- Trial name
- NCT03361618
- Testing
- Zinc Sulfate
- Where
- Iraq
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Babylon University
Psoriasis
Study to Assess the Safety and Tolerability of PBF-1650 in Healthy Volunteers.
Single center, randomized, double-blind, placebo-controlled clinical study to assess the safety and tolerability of PBF-1650 in order to obtain the Maximum Tolerated Dose (MTD).
- Trial name
- ADENOIMMUNE (NCT03798236)
- Testing
- PBF-1650 oral capsules
- Where
- Spain
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Palobiofarma SL
Coronary Artery Disease
Hemodynamic Forces at Rest and Stress vs. Adenosine and Dobutamine Stress Cardiac Magnetic Resonance
Stress perfusion CMR has recently considered as one of the methods of choice for establishing the diagnosis of CAD based on its high diagnostic accuracy, lack of ionizing radiation as well as its ability to simultaneously assess…
- Trial name
- CMR (NCT04247698)
- Where
- Egypt
- Volunteers
- 112 people
- Sponsor
- Assiut University
Blood Flow in Healthy Volunteers
Effect of Polymorphisms in the Adenosine a2a Receptor Gene and AMPD2 Gene on Adenosine-Induced Vasodilation and Reactive Hyperemia
The endogenous nucleoside adenosine can induce various cardiovascular and neurohumoral effects by stimulation of specific adenosine receptors.
- Trial name
- NCT00253929
- Testing
- Intra-arterial infusion of adenosine, intra-arterial infusion of caffeine, intra-arterial infusion of acetylcholine
- Where
- Netherlands
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Perioperative Pain
Dose-Response of Adenosine for Perioperative Pain
Adenosine A1 and A2 receptors are widely distributed in the brain and spinal cord and represent a non-opiate target for pain management.
- Trial name
- NCT00298636
- Testing
- adenosine
- Where
- 8 sites in United States
- Volunteers
- 160 people
- Sponsor
- Xsira Pharmaceuticals
Rheumatoid Arthritis, Adjuvant Arthritis
Antifolate Effectiveness in Arthritis
This study looks at how the arthritis drug methotrexate works in low doses to treat rheumatoid arthritis. (High doses of methotrexate are used to treat some types of cancer.) Methotrexate blocks the action of the B-vitamin known…
- Trial name
- NCT00000395
- Testing
- Methotrexate, Folinic acid, Folic acid
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham
Breast Cancer, Brain Metastasis
T-DM1 Alone Versus T-DM1 and Metronomic Temozolomide in Secondary Prevention of HER2-Positive Breast Cancer Brain Metastases Following Stereotactic Radiosurgery
Background: Sometimes breast cancer spreads (metastasizes) to the brain. Researchers want to study new treatments for brain metastases. The drug Temozolomide is approved to treat brain tumors.
- Conditions
- Breast Cancer, Brain Metastasis, Brain Cancer
- Trial name
- NCT03190967
- Testing
- T-DM1, TMZ
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Cancer Institute (NCI)
Asthma
Study to Assess the Efficacy of a Single PBF-680 Oral Administration to Attenuate Adenosine 5'-Monophosphate Challenge-induced Airway Hyperresponsiveness in Mild-to-moderate Asthmatics
This is a single-center, double-blind, randomized trial utilizing a three-period, balanced block design, with each period comprising a unique study product administration.
- Trial name
- NCT01939587
- Testing
- PBF-680 5 mg, PBF-680 20 mg
- Where
- 2 sites in Spain
- Volunteers
- 21 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Osteoporosis
Mechanical Bone Stimulation and Adenosine 5'-Triphosphate (ATP) Release in Humans
Rationale: Mechanical loading is well-known to have a strong anabolic effect on bone. It has therefore been proposed that a mechanical intervention could be an effective non-pharmacological approach to treat bone loss associated…
- Trial name
- NCT01130428
- Testing
- Juvent 1000 Vibration Platform
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Antiplatelet Therapy, Coronary Artery Disease
LOwer Maintenance Dose TICagrelor in Acute Coronary Syndrome Patients Undergoing Percutaneous Coronary Intervention
The hypothesis in this study was that ticagrelor switched to 60 mg after 1 month of standard dose, with antiplatelet activity that is not inferior to the standard dose and better than 75 mg clopidogrel for patients with ACS after…
- Conditions
- Antiplatelet Therapy, Coronary Artery Disease, Percutaneous Coronary Intervention
- Trial name
- LOTIC (NCT04060914)
- Testing
- Ticagrelor 90mg, Ticagrelor 90mg/60mg, Clopidogrel 75mg
- Where
- China
- Volunteers
- 225 people
- Sponsor
- Beijing Anzhen Hospital
Coronary Artery Disease, Stable Angina
MR INFORM - MR Perfusion Imaging to Guide Management of Patients With Stable Coronary Artery Disease
The purpose of this study is to determine if MR Perfusion Imaging is non-inferior to coronary angiography with measurement of Fractional Flow Reserve (FFR) in guiding management of patients with stable chest pain.
- Conditions
- Coronary Artery Disease, Stable Angina, Myocardial Ischaemia
- Trial name
- NCT01236807
- Testing
- MR perfusion guidance, FFR guidance
- Where
- United Kingdom
- Volunteers
- 915 people
- Sponsor
- King's College London
Acute Myocardial Infarction
Myocardial Protection With Adenosine During Primary Percutaneous Coronary Intervention in Pts With STEMI
OBJECTIVE: to evaluate the safety and efficacy of a brief intracoronary infusion of ADO applied at the time of reperfusion to limit infarct size and LV remodelling in patients with ACSST submitted to primary ACTP.
- Trial name
- PROMISE (NCT00781404)
- Testing
- Adenosine
- Where
- Spain
- Volunteers
- 201 people
- Sponsor
- David Garcia-Dorado